Systems and methods for vessel reactivity to guide diagnosis or treatment of cardiovascular disease

Abstract

Systems and methods are disclosed for using vessel reactivity to guide diagnosis or treatment for cardiovascular disease. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; determining, by measurement or estimation, a first vessel size at one or more locations of a vessel of the patient-specific vascular model at a first physiological state; determining a second vessel size at the one or more locations of the vessel of the patient-specific vascular model at a second physiological state using a simulation or learned information; comparing the first vessel size to the corresponding second vessel size; and estimating a characteristic of the vessel of the patient-specific vascular model based on the comparison.

Description

RELATED APPLICATION(S)[0001]This application is a continuation application of U.S. application Ser. No. 14 / 592,546, filed Jan. 8, 2015, which claims priority to U.S. Provisional Application No. 62 / 072,256 filed Oct. 29, 2014, the entire disclosure of which are hereby incorporated herein by reference in their entireties.FIELD OF THE DISCLOSURE[0002]Various embodiments of the present disclosure relate generally to disease assessment, treatment planning, and related methods. More specifically, particular embodiments of the present disclosure relate to systems and methods for using vessel reactivity to guide diagnosis or treatment for cardiovascular disease.BACKGROUND[0003]Coronary artery disease is a common ailment that affects millions of people. Coronary artery disease may cause the blood vessels providing blood to the heart to develop lesions, such as a stenosis (abnormal narrowing of a blood vessel). As a result, blood flow to the heart may be restricted. A patient suffering from c...

AI Technical Summary

Benefits of technology

[0007]One method includes: receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; determining, by measurement or estimation, a first vessel size at one or more locations of a vessel of the patient-specific vascular model at a first physiological state; determining a second vessel size at the one or more locations of the vessel of the patient-specific vascular model at a second physiological state using a simulation or learned information; comparing the first vessel size to the corresponding second vessel size; and estimating a characteristic of the vessel of the patient-specific vascular model based on the comparison.

[0008]In accordance with another embodiment, a system for using vessel reactivity in diagnosing or treating disease comprises: a data storage device storing instructions for using vessel reactivity in diagnosing or treating disease; and a processor configured for: receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; determining, by measurement or estimation, a first vessel size at one or more locations of a vessel of the patient-specific vascular model at a first physiological state; determining a second vessel size at th

Problems solved by technology

As a result, blood flow to the heart may be restricted.

A more severe man

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