34 results about "Iontopheresis" patented technology

The invention relates to the technical field of biomedical sensing and health monitoring, and discloses a noninvasive glucose detection system. The system comprises an interstitial fluid extraction device, a photoelectric sensing module and a main control circuit which are integrated on a flexible substrate. The interstitial fluid extraction device drives subcutaneous interstitial fluid to migrate to the hydrogel interface layer under the action of reverse ion electroosmosis; the photoelectric sensing module receives interstitial fluid through a hydrogel interface layer, a working electrode of the photoelectric sensing module comprises a Cu monatomic imprinting recognition layer, and imprinting holes formed by Cu monatomic sites are specifically coordinated with glucose molecules. The master control circuit controls sampling and determines the glucose concentration based on the photocurrent signal. Noninvasive sampling and monatomic imprinting photoelectric detection are fused, sampling-detection integration is achieved, and the device has the advantages of being noninvasive, painless, high in selectivity, high in interference resistance, comfortable to wear and the like and is suitable for continuous monitoring of blood glucose.

This invention discloses an iontophoresis gel scleral contact lens and its preparation method, comprising a contact lens frame, a polymer porous microsphere drug-carrying layer loaded with nano-sustained-release drugs, an electrode layer, and a flexible material covering the electrode layer on the contact lens frame, and a gel layer covering the outer side of the contact lens frame. This iontophoresis gel scleral contact lens has a simple structure, facilitates convenient and rapid drug delivery, and provides sustained-release efficacy. It allows patients to self-administer the drug, directly delivering it to the intraocular lesion site, avoiding adverse reactions in other tissues or the whole body, and has a sustained-release function to reduce the frequency of drug administration.

An iontophoresis device includes an outer housing, and a swab subassembly slidingly received within the outer housing that includes an elongated rod, a swab, a conductor extending along the rod and coupled to the swab. The iontophoresis device also includes an additional device subassembly, such as a syringe subassembly, that is slidingly received within the outer housing. The syringe subassembly includes an elongated body for holding a substance, a needle, and a plunger.

Proposed is a self-current-generating skin-applicable patch with a first area in contact with the skin and a second area adjacent to and spaced apart from it, where either area contains a biodegradable metal, decomposable and absorbable through skin contact or reaction with tissue moisture. The patch includes a first electrode layer directly contacts the skin as a thin sheet integrated with the first area and has at least one fluid-transferable penetration part, a second electrode layer of a material with a different standard reduction potential is positioned opposite a skin-contacting side, partially extending to connect electrically to the second area, and a support layer, a hydrophilic sheet of predetermined thickness, is positioned opposite the skin-contacting side, having an ionic solution supported. Thus, sufficient iontophoresis and other micro-current effects with active ingredients are achieved through self-generated micro-current, even without a battery-like external power source.

A self-powered intelligent adhesive bandage capable of detecting temperature in real time and dosing according to needs is applied to detection and treatment of skin wound infection and can detect the temperature of a wound and surrounding skin in real time and conduct dosing according to needs. According to the intelligent adhesive bandage, the piezoelectric nanometer generator is combined, mechanical energy generated in the daily activity process of a wearer can be converted into electric energy, and the electric energy is used for driving the whole intelligent adhesive bandage to operate. The two temperature measuring units are used for detecting the temperature of the wound and the surrounding skin at the same time, the temperature difference value serves as a relative index for judging whether the wound is infected or not, and the influence of environmental factors on detection is reduced. A three-electrode structure is adopted, on-demand drug delivery is achieved through iontophoresis, and high drug permeability, dosage controllability and drug delivery uniformity are all considered. After the intelligent adhesive bandage is used for treating a mouse with wound infection for three days, the wound recovery rate of the mouse reaches 90.3%, and the realization of temperature detection and on-demand administration is proved. The intelligent adhesive bandage has a good application prospect in detection and treatment of wound infection.

An iontophoresis device capable of reducing skin irritability due to an applied current while enhancing skin permeability of a drug is provided. The iontophoresis device includes a power supply, an electrode electrically connected to the power supply, a drug disposed between skin and the electrode, and a control unit configured to control a current applied to the skin via the electrode. The control unit controls the current so that a pulse current having a pulse frequency of 0.5 Hz or more and 50 Hz or less is applied to the skin.

The invention provides a partitioned iontophoresis and self-power-generation micro-current composite mask which comprises a mask base body, an iontophoresis functional area and a control module and further comprises a self-power-generation micro-current functional area. The self-generating micro-current functional area is not electrically connected with an external power supply, comprises at least one primary battery unit made of two different metal materials and an electrolyte medium, and spontaneously generates micro-current through an electrochemical principle. Multiple effects of moisturizing, whitening, wrinkle resisting, lifting and tightening and the like are achieved at the same time through one-time nursing, and energy distribution is more reasonable.

Embodiments of the present invention relate to a microcurrent ion patch comprising an electrochromic unit, which allows users to visually confirm the usage state. A microcurrent ion patch comprising an electrochromic unit according to an embodiment of the present invention includes an iontophoresis ion patch and an electrochromic unit electrically connected to both electrodes of the ion patch. The electrochromic unit may comprise: a base thin film; an electrochromic material layer formed on the base thin film; and a hydrogel electrolyte layer formed on the electrochromic material layer.

Non-gas emitting electrodes having a very high surface area, high electric capacitance, and low electric resistance are integrated with silver and / or silver chloride for use in electrodialysis / electrodeionization cells, or in any other system requiring the generation of electric fields through electrolyte solutions, and are capable generating an electric field for extensive periods of time without generation of gases, and without the occurrence of electrode reactions. Each electrode is highly porous and highly conductive, such as a carbon aerogel electrode, and thus has a very large internal surface area, which is coated, deposited, or otherwise covered with silver and / or silver chloride. This combination supercapacitor and pseudocapacitor electrode can sustain electrode reactions for longer periods of time, and at much higher current densities, as compared to conventional (solid) silver / silver chloride electrodes.

The application provides an integrated wearable transdermal iontophoresis patch powered by a moisture generator and a preparation method thereof, and belongs to the technical field of medical devices and biomedical materials. The problems of high distance requirement, large energy loss in the transmission process, inability to provide stable power supply, long-term use, complex device structure and operation of the existing iontophoresis transdermal drug delivery equipment are solved. It comprises a flexible circuit board and two electrode sheets, the flexible circuit board is provided with a power generation module, the positive and negative levels of the power generation module are connected with the two electrode sheets respectively, the power generation module comprises a moisture generator array, the moisture generator array comprises a plurality of moisture generator groups arranged side by side in parallel, the moisture generator group comprises a plurality of moisture generator devices arranged in series, and the moisture generator device comprises an active material, a steel mesh electrode and a graphite paper electrode. It is mainly used for transdermal drug delivery.

Disclosed herein is an advanced anesthetic gel formulation designed for painless, non-invasive dental procedures. The gel incorporates lidocaine hydrochloride and prilocaine hydrochloride as the primary anesthetics, supported by carbomer 940 for viscosity control. Sodium chloride is added to improve electrical conductivity, while triethanolamine maintains an optimal pH balance. Glycerin functions as a humectant to reduce tissue irritation, and allantoin offers anti-inflammatory properties. Phenoxyethanol is included to prevent microbial growth, ensuring the gel's safety and stability. The preparation method involves dissolving these components in purified water, creating a gel that enables effective, non-invasive dental anesthesia through iontophoresis, significantly enhancing patient comfort and procedural efficiency.

The invention discloses a paper-based microfluidic cavity structure and method for in-situ sweat collection and detection, and belongs to the field of wearable body surface sweat monitoring equipment. According to the paper-based microfluidic cavity structure, the sweat reaction area and the flexible hydrophilic substrate layer are connected through the double faced adhesive tape, a hollow cavity micro space for sweat storage and detection is formed, and sufficient sweat can be enriched for accurate detection of a paper-based electrochemical sensor. One-step preparation of the paper-based electrochemical sensor is realized by using the mixed conductive ink prepared from PEDOT: PSS / D-sorbitol / MWCNTS / PB NPs, so that the preparation steps of the sensor are greatly simplified, and the stability and biocompatibility of the sensor are improved. The wearable device can be worn on each part of a human body and is used for local sweat collection and accurate detection in the autonomous sweating process of the human body or after iontophoresis.

The application relates to the technical field of intelligent devices, and discloses a wearable continuous dynamic uric acid intelligent monitoring device, which comprises a device body and is worn on a human body; a skin adhesion layer, a bionic micro-fluidic gel layer and an integrated ion electrophoresis electrode substrate are sequentially arranged on the device body from outside to inside; the skin adhesion layer is in contact with the human skin; the bionic micro-fluidic gel layer is used for collecting sweat on the human skin and guiding the sweat into a detection area on the bionic micro-fluidic gel layer; an electrochemical detection unit is arranged on the integrated ion electrophoresis electrode substrate; the electrochemical detection unit is used for detecting the sweat in the detection area; an analysis feedback module is arranged on the device body; and data detected by the electrochemical detection unit is fed back to a wearer after being analyzed by the analysis feedback module. The application can realize real-time dynamic monitoring of uric acid levels and meet the comfortable, convenient and accurate uric acid monitoring requirements of gout patients.

A computer-implemented method for measuring skin conductance of a writing instrument's user, including: applying a DC voltage to user's fingers contacting the writing instrument during a writing session with the writing instrument; measuring a current generated by reverse iontophoresis following applying the DC voltage; calculating an average skin conductance over a specific timeframe from the measured current; storing calculated average skin conductance data as historical data; comparing the average skin conductance to historical data from the same user or to reference data from a group of users; and providing an indication to the user in case that the skin conductance has decreased and / or the calculation results.

The invention relates to a skin-like chip simulation platform based on a microfluidic technology. The skin-like chip simulation platform sequentially comprises a skin-like layer, a skin-like layer, a cytoplasm matrix simulation layer and an interstitial fluid circulation layer from top to bottom, a hole array is arranged on the imitated skin layer; an interstitial fluid enrichment cavity communicated with the hole array is formed in the simulated cortex, and the interstitial fluid enrichment cavity is provided with an enrichment outlet and an enrichment inlet; an interstitial fluid micro-channel is arranged in the cytoplasm matrix simulation layer, one end of the interstitial fluid micro-channel is communicated to the enrichment inlet, and the other end of the interstitial fluid micro-channel is communicated to the interstitial fluid flowing layer; an interstitial fluid storage cavity is formed in the interstitial fluid circulation layer and is provided with a storage cavity outlet and a storage cavity inlet; the device further comprises an interstitial fluid circulation channel. The skin-like chip simulation platform designed by the invention can accurately simulate the human skin environment, provides a simulation test platform for novel extraction electrode design, parameter optimization and safety evaluation of a counter ion electroosmosis technology, and remarkably reduces the preclinical research risk and cost of new technology development.

The present application relates to the technical field of transdermal drug delivery, and in particular to an iontophoresis patch with current homogenization function and an iontophoresis system. The iontophoresis patch comprises a substrate support layer, a first electrode, a second electrode, an electric field homogenization ring, and a drug-loaded layer. The first electrode has a hollow annular structure with a center, and the second electrode is insulated and separated from the first electrode. The electric field homogenization ring is located on the inner side of the first electrode and is insulated and separated from the first electrode. The volume conductivity of the electric field homogenization ring is greater than the volume conductivity of the stratum corneum of human skin and less than the volume conductivity of the first electrode and the second electrode. The drug-loaded layer covers the surface of the first electrode or covers the surfaces of the first electrode and the second electrode, respectively. The present application solves the problems of current hot spots caused by the umbilical depression of traditional electrodes and the skin irritation and low drug transdermal efficiency caused by the edge electric field concentration of the annular electrode.

The invention relates to a myopia intervention device and a treatment method thereof. The myopia intervention device comprises a host and a replaceable intelligent eye pad connected with the host, the intelligent eye pad is designed to be of a multi-layer structure, and sequentially comprises a hydrogel contact layer used for being attached to the skin and conducting electricity from the contact eye skin to the inside; the iontophoresis layer is used for generating pulse current to drive nutrient substances in blood to directionally permeate to sclera tissues; the optical layer is used for emitting monochromatic light with different wavelengths to act on cells of the retina; the micro magnetic field layer is used for generating a micro magnetic field with specific form and strength; the host is used for controlling the iontophoresis electrode layer, the optical layer and the micro-magnetic field layer to work cooperatively according to a preset time sequence and performing intervention treatment on eyes; according to the technical scheme, the myopia intervention treatment effect can be improved.

Systems and methods for a microfluidic biosensor patch and health monitoring system may include an iontophoresis module, a multi-inlet microfluidic sweat collection and sampling module, and a molecularly imprinted polymer (MIP) organic compound sensor module. An iontophoresis module may provide for stimulation of a biofluid sample. A biofluid may be a sweat sample. Stimulation may be achieved via electrostimulation and / or application of a stimulating agent. A microfluidic sweat collection and sample module may include several adhesive layers with carefully designed inlets, channels, a reservoir, and an outlet for the efficient collection and sampling of biofluid. A MIP sensor module may quickly and accurately identify concentrations of key metabolites present in a biofluid sample which may indicate certain health conditions.

The application provides a micropore surface charge density measurement method based on ion current rectification effect, which is based on ion current rectification effect (ICR), ion electroosmotic flow (EOF) in a micropore is driven by applying a voltage, and a rectification phenomenon of ion current will be formed under a concentration gradient. Since the ion solution in the high and low concentration liquid pools under positive and negative polarity voltages cannot fill the entire micropore, the ion current rectification ratio cannot be represented by the ratio of bulk solution conductivity. However, according to the ion concentration at different positions in the micropore, the resistance ratio under different polarity voltages can be used to effectively characterize the ion current rectification. The ion current rectification ratio can also be calculated through the current-voltage curve. Thus, the relationship between the micropore surface charge density and the ion current rectification ratio is established. The surface charge density is accurately predicted by measuring the ion current rectification ratio of the micropore.

This disclosure provides an iontophoresis drug delivery device. The iontophoresis drug delivery device includes: a power source for generating pulsed direct current required to penetrate a drug agent into a drug delivery area of ​​a biological organism, wherein the power source generates a positive pulsed direct current in a first time period and a reverse pulsed direct current in a second time period; a dielectric layer for contacting the drug delivery area, wherein the dielectric layer includes or has an active agent attached thereto, the active agent being used to penetrate into the drug delivery area via the pulsed direct current; and at least two electrodes for receiving the pulsed direct current output from the power source to provide the received pulsed direct current to the dielectric layer. The iontophoresis drug delivery device provided by this disclosure not only improves transdermal efficiency but also minimizes skin irritation or damage.

The invention provides a flexible intelligent drug delivery device based on moisture power generation, which comprises a moisture power generation unit, the moisture power generation unit comprises an anode and a cathode, one side of the anode facing the cathode is provided with a polycation layer, one side of the cathode facing the anode is provided with a polyanion layer, and the polycation layer and the polyanion layer are attached to each other; the polycation layer is formed by printing a poly (diallyldimethylammonium chloride) aqueous solution on a corresponding position and then drying to form a film; the polyanion layer is formed by printing a mixed aqueous solution of polystyrolsulfon acid and polyvinyl alcohol at a corresponding position and then drying to form a film; one side of the drug-loaded hydrogel is used for being attached to the skin of a drug administration object; the iontophoresis electrode is used for applying an electric field to the drug-loaded hydrogel, so that the drug permeates into the skin of a drug administration object from the drug-loaded hydrogel. The polycation layer and the polyanion layer are formed through printing, the operation is simple, and the flexible intelligent drug delivery device is easy to produce in batches.

A metabolite sensing device (104, 200) is used in combination with an electrical device (102) for non-invasive measurement of metabolite concentration in interstitial fluid with improved consistency and signal-to-noise ratio. An electrical device determines an impedance of the skin (304, 408, 606) in static state using an electrode (106, 206, 302, 502A to 502N) placed on the skin and provides an electrical current to the electrode to initiate reverse iontophoresis in the interstitial fluid under the skin. Then, the electrical device monitors a change in the impedance of the skin over time under the action of the current, and the metabolite sensing device measures a metabolite concentration in the interstitial fluid under the skin when predefined conditions regarding the change in the impedance are met.

Systems and methods for application of a composition to the skin of a subject using electroporation, iontophoresis, and in at least some instances, radiofrequency (RF) warming to facilitate penetration of the skin by one or more compounds of the composition, such as one or more drugs. A system includes an applicator capsule that includes a rollerball configured for a rolling contact with the portion of skin of the subject and a plurality of electrodes configured for a transmission of an electrical current through the portion of skin of the subject. A reservoir of the system is reversibly attachable to the body and is configured to hold and release the composition therefrom to fluidly connect the interior of the applicator capsule to an exterior of the applicator capsule for delivery of the composition from the interior of the applicator capsule to the portion of skin.

The invention relates to the technical field of measurement for diagnosis, and discloses a homocysteine detection system for noninvasive body fluid sampling, which comprises a noninvasive body fluid sampling module integrated on a flexible substrate, a photoelectrochemical detection module and a signal processing and control unit. The noninvasive body fluid sampling module applies micro current through an electroosmosis electrode to execute reverse ion electroosmosis, and drives subcutaneous interstitial fluid to directionally migrate and be enriched in the hydrogel layer; the photoelectrochemical detection module is in fluid communication with the hydrogel layer, and the surface of a photoelectrochemical electrode assembly of the photoelectrochemical detection module is provided with a double-monatomic imprinting recognition layer. The recognition layer constructs a recognition hole with highly complementary spatial configuration and electronic structure based on the double-site synergistic coordination effect of sulfydryl and Au site and amino and Zn site of homocysteine molecules. Under the condition that invasive blood sampling is not needed, interference of molecules with similar structures in a complex body fluid matrix is overcome, and high-selectivity, high-sensitivity and continuous dynamic monitoring of homocysteine is achieved.

The MBene nano-enzyme-based sweat dopamine fully-integrated wearable detection system comprises a sweat induction module which supports two working modes of passive induction sweating and active induction, the passive induction sweating depends on movement and other modes for natural sweating, the active induction sweating adopts an iontophoresis method, and the active induction sweating adopts an iontophoresis method; the human body can still generate sweat for detection in a resting state; the micro-fluidic sweat collection module is used for collecting sweat on the skin surface and updating sweat data measured in real time, the purpose of in-situ measurement is achieved, and meanwhile detection lag caused by sweat residues and cross contamination of new sweat and old sweat can be avoided. Through programmable excitation signal generation and multi-mode signal acquisition and processing, the equipment supports various electrochemical analysis technologies such as CV, DPV and SWV, a user can balance the detection speed, sensitivity and resolution according to needs, the requirements of different application scenes such as rapid screening and accurate quantification are met, and the applicability and detection precision of the equipment are improved.

The invention discloses a self-energized supercapacitor, a preparation method thereof and an application of the self-energized supercapacitor in driving reverse iontophoresis, and belongs to the technical field of reverse iontophoresis and capacitors. The self-energized super capacitor comprises a Co / MXene-Co / LIG anode and a Cu / MXene-Co / LIG cathode. The MXene and Co-MOF composite modified laser-induced graphene electrode solves the problems that a traditional biological capacitor is insufficient in capacitive performance and low in energy storage efficiency, the pseudo-capacitive performance and the charge storage capacity of the electrode are remarkably improved, efficient energy storage and stable release are achieved, and the requirement of counter ion electroosmosis for continuous current is met. Therefore, the method has good application prospect and value in the technical field of reverse iontophoresis and capacitors.

Systems and methods for application of a composition to the skin of a subject using electroporation, iontophoresis, and in at least some instances, sonophoresis to facilitate penetration of the skin by one or more compounds of the composition, such as one or more drugs. A system includes an applicator capsule that includes a rollerball configured for a rolling contact with the portion of skin of the subject and a plurality of electrodes and / or ultrasound transducers that are configured for a transmission of an electrical current and / or ultrasound through the portion of skin of the subject. A formula pod of the system is reversibly attachable to the body and is configured to hold and release the composition therefrom for delivery of the composition from the formula pod to the portion of skin.

An iontophoresis device includes an outer housing, and a swab subassembly slidingly received within the outer housing that includes an elongated rod, a swab, a conductor extending along the rod and coupled to the swab. The iontophoresis device also includes an additional device subassembly, such as a syringe subassembly, that is slidingly received within the outer housing. The syringe subassembly includes an elongated body for holding a substance, a needle, and a plunger.

The invention discloses a noninvasive tissue fluid extraction-detection device and method, and relates to the technical field of tissue fluid detection.The noninvasive tissue fluid extraction-detection device comprises a gel substrate used for being attached to the skin surface of a user, an extraction electrode assembly and a first detection electrode assembly, and the extraction electrode assembly and the first detection electrode assembly are arranged on the gel substrate; the extraction electrode assembly comprises a cathode and an anode and is used for extracting target molecules from subcutaneous tissue liquid of a user into the gel substrate through counter ion electroosmosis; the first detection electrode assembly is arranged adjacent to the cathode and used for detecting the content of target molecules in the gel substrate through an electrochemical method. According to the technical scheme, the extraction time of the target molecules in the tissue fluid can be shortened, so that the detection sensitivity is improved.

A surgically implantable reservoir is provided for implantation into a patient for use in an iontophoresis system for local drug delivery through a target site of internal body tissue. The reservoir comprises a housing having an inner surface defining an enclosed chamber and an inlet opening and an outlet opening for flow of fluid including the drug through the chamber. The housing is capable of interacting with a localized electric field to release the drug. A platform holding an electrode extends inwardly into the chamber from the inner surface of the housing such that the platform and an adjacent portion of the inner surface of the housing define a trough surrounding the platform. Fluid flow through the reservoir from the inlet opening to the outlet opening moves gas bubbles formed by electrolysis from the surface of the electrode and carries the bubbles through the outlet opening.