19 results about "Iontopheresis" patented technology

The invention relates to the technical field of biomedical sensing and health monitoring, and discloses a noninvasive glucose detection system. The system comprises an interstitial fluid extraction device, a photoelectric sensing module and a main control circuit which are integrated on a flexible substrate. The interstitial fluid extraction device drives subcutaneous interstitial fluid to migrate to the hydrogel interface layer under the action of reverse ion electroosmosis; the photoelectric sensing module receives interstitial fluid through a hydrogel interface layer, a working electrode of the photoelectric sensing module comprises a Cu monatomic imprinting recognition layer, and imprinting holes formed by Cu monatomic sites are specifically coordinated with glucose molecules. The master control circuit controls sampling and determines the glucose concentration based on the photocurrent signal. Noninvasive sampling and monatomic imprinting photoelectric detection are fused, sampling-detection integration is achieved, and the device has the advantages of being noninvasive, painless, high in selectivity, high in interference resistance, comfortable to wear and the like and is suitable for continuous monitoring of blood glucose.

This invention discloses an iontophoresis gel scleral contact lens and its preparation method, comprising a contact lens frame, a polymer porous microsphere drug-carrying layer loaded with nano-sustained-release drugs, an electrode layer, and a flexible material covering the electrode layer on the contact lens frame, and a gel layer covering the outer side of the contact lens frame. This iontophoresis gel scleral contact lens has a simple structure, facilitates convenient and rapid drug delivery, and provides sustained-release efficacy. It allows patients to self-administer the drug, directly delivering it to the intraocular lesion site, avoiding adverse reactions in other tissues or the whole body, and has a sustained-release function to reduce the frequency of drug administration.

An iontophoresis device includes an outer housing, and a swab subassembly slidingly received within the outer housing that includes an elongated rod, a swab, a conductor extending along the rod and coupled to the swab. The iontophoresis device also includes an additional device subassembly, such as a syringe subassembly, that is slidingly received within the outer housing. The syringe subassembly includes an elongated body for holding a substance, a needle, and a plunger.

Proposed is a self-current-generating skin-applicable patch with a first area in contact with the skin and a second area adjacent to and spaced apart from it, where either area contains a biodegradable metal, decomposable and absorbable through skin contact or reaction with tissue moisture. The patch includes a first electrode layer directly contacts the skin as a thin sheet integrated with the first area and has at least one fluid-transferable penetration part, a second electrode layer of a material with a different standard reduction potential is positioned opposite a skin-contacting side, partially extending to connect electrically to the second area, and a support layer, a hydrophilic sheet of predetermined thickness, is positioned opposite the skin-contacting side, having an ionic solution supported. Thus, sufficient iontophoresis and other micro-current effects with active ingredients are achieved through self-generated micro-current, even without a battery-like external power source.

A self-powered intelligent adhesive bandage capable of detecting temperature in real time and dosing according to needs is applied to detection and treatment of skin wound infection and can detect the temperature of a wound and surrounding skin in real time and conduct dosing according to needs. According to the intelligent adhesive bandage, the piezoelectric nanometer generator is combined, mechanical energy generated in the daily activity process of a wearer can be converted into electric energy, and the electric energy is used for driving the whole intelligent adhesive bandage to operate. The two temperature measuring units are used for detecting the temperature of the wound and the surrounding skin at the same time, the temperature difference value serves as a relative index for judging whether the wound is infected or not, and the influence of environmental factors on detection is reduced. A three-electrode structure is adopted, on-demand drug delivery is achieved through iontophoresis, and high drug permeability, dosage controllability and drug delivery uniformity are all considered. After the intelligent adhesive bandage is used for treating a mouse with wound infection for three days, the wound recovery rate of the mouse reaches 90.3%, and the realization of temperature detection and on-demand administration is proved. The intelligent adhesive bandage has a good application prospect in detection and treatment of wound infection.

Embodiments of the present invention relate to a microcurrent ion patch comprising an electrochromic unit, which allows users to visually confirm the usage state. A microcurrent ion patch comprising an electrochromic unit according to an embodiment of the present invention includes an iontophoresis ion patch and an electrochromic unit electrically connected to both electrodes of the ion patch. The electrochromic unit may comprise: a base thin film; an electrochromic material layer formed on the base thin film; and a hydrogel electrolyte layer formed on the electrochromic material layer.

Non-gas emitting electrodes having a very high surface area, high electric capacitance, and low electric resistance are integrated with silver and / or silver chloride for use in electrodialysis / electrodeionization cells, or in any other system requiring the generation of electric fields through electrolyte solutions, and are capable generating an electric field for extensive periods of time without generation of gases, and without the occurrence of electrode reactions. Each electrode is highly porous and highly conductive, such as a carbon aerogel electrode, and thus has a very large internal surface area, which is coated, deposited, or otherwise covered with silver and / or silver chloride. This combination supercapacitor and pseudocapacitor electrode can sustain electrode reactions for longer periods of time, and at much higher current densities, as compared to conventional (solid) silver / silver chloride electrodes.

The application relates to the technical field of intelligent devices, and discloses a wearable continuous dynamic uric acid intelligent monitoring device, which comprises a device body and is worn on a human body; a skin adhesion layer, a bionic micro-fluidic gel layer and an integrated ion electrophoresis electrode substrate are sequentially arranged on the device body from outside to inside; the skin adhesion layer is in contact with the human skin; the bionic micro-fluidic gel layer is used for collecting sweat on the human skin and guiding the sweat into a detection area on the bionic micro-fluidic gel layer; an electrochemical detection unit is arranged on the integrated ion electrophoresis electrode substrate; the electrochemical detection unit is used for detecting the sweat in the detection area; an analysis feedback module is arranged on the device body; and data detected by the electrochemical detection unit is fed back to a wearer after being analyzed by the analysis feedback module. The application can realize real-time dynamic monitoring of uric acid levels and meet the comfortable, convenient and accurate uric acid monitoring requirements of gout patients.

A computer-implemented method for measuring skin conductance of a writing instrument's user, including: applying a DC voltage to user's fingers contacting the writing instrument during a writing session with the writing instrument; measuring a current generated by reverse iontophoresis following applying the DC voltage; calculating an average skin conductance over a specific timeframe from the measured current; storing calculated average skin conductance data as historical data; comparing the average skin conductance to historical data from the same user or to reference data from a group of users; and providing an indication to the user in case that the skin conductance has decreased and / or the calculation results.

The present application relates to the technical field of transdermal drug delivery, and in particular to an iontophoresis patch with current homogenization function and an iontophoresis system. The iontophoresis patch comprises a substrate support layer, a first electrode, a second electrode, an electric field homogenization ring, and a drug-loaded layer. The first electrode has a hollow annular structure with a center, and the second electrode is insulated and separated from the first electrode. The electric field homogenization ring is located on the inner side of the first electrode and is insulated and separated from the first electrode. The volume conductivity of the electric field homogenization ring is greater than the volume conductivity of the stratum corneum of human skin and less than the volume conductivity of the first electrode and the second electrode. The drug-loaded layer covers the surface of the first electrode or covers the surfaces of the first electrode and the second electrode, respectively. The present application solves the problems of current hot spots caused by the umbilical depression of traditional electrodes and the skin irritation and low drug transdermal efficiency caused by the edge electric field concentration of the annular electrode.

Systems and methods for a microfluidic biosensor patch and health monitoring system may include an iontophoresis module, a multi-inlet microfluidic sweat collection and sampling module, and a molecularly imprinted polymer (MIP) organic compound sensor module. An iontophoresis module may provide for stimulation of a biofluid sample. A biofluid may be a sweat sample. Stimulation may be achieved via electrostimulation and / or application of a stimulating agent. A microfluidic sweat collection and sample module may include several adhesive layers with carefully designed inlets, channels, a reservoir, and an outlet for the efficient collection and sampling of biofluid. A MIP sensor module may quickly and accurately identify concentrations of key metabolites present in a biofluid sample which may indicate certain health conditions.

This disclosure provides an iontophoresis drug delivery device. The iontophoresis drug delivery device includes: a power source for generating pulsed direct current required to penetrate a drug agent into a drug delivery area of ​​a biological organism, wherein the power source generates a positive pulsed direct current in a first time period and a reverse pulsed direct current in a second time period; a dielectric layer for contacting the drug delivery area, wherein the dielectric layer includes or has an active agent attached thereto, the active agent being used to penetrate into the drug delivery area via the pulsed direct current; and at least two electrodes for receiving the pulsed direct current output from the power source to provide the received pulsed direct current to the dielectric layer. The iontophoresis drug delivery device provided by this disclosure not only improves transdermal efficiency but also minimizes skin irritation or damage.

The MBene nano-enzyme-based sweat dopamine fully-integrated wearable detection system comprises a sweat induction module which supports two working modes of passive induction sweating and active induction, the passive induction sweating depends on movement and other modes for natural sweating, the active induction sweating adopts an iontophoresis method, and the active induction sweating adopts an iontophoresis method; the human body can still generate sweat for detection in a resting state; the micro-fluidic sweat collection module is used for collecting sweat on the skin surface and updating sweat data measured in real time, the purpose of in-situ measurement is achieved, and meanwhile detection lag caused by sweat residues and cross contamination of new sweat and old sweat can be avoided. Through programmable excitation signal generation and multi-mode signal acquisition and processing, the equipment supports various electrochemical analysis technologies such as CV, DPV and SWV, a user can balance the detection speed, sensitivity and resolution according to needs, the requirements of different application scenes such as rapid screening and accurate quantification are met, and the applicability and detection precision of the equipment are improved.

The invention discloses a self-energized supercapacitor, a preparation method thereof and an application of the self-energized supercapacitor in driving reverse iontophoresis, and belongs to the technical field of reverse iontophoresis and capacitors. The self-energized super capacitor comprises a Co / MXene-Co / LIG anode and a Cu / MXene-Co / LIG cathode. The MXene and Co-MOF composite modified laser-induced graphene electrode solves the problems that a traditional biological capacitor is insufficient in capacitive performance and low in energy storage efficiency, the pseudo-capacitive performance and the charge storage capacity of the electrode are remarkably improved, efficient energy storage and stable release are achieved, and the requirement of counter ion electroosmosis for continuous current is met. Therefore, the method has good application prospect and value in the technical field of reverse iontophoresis and capacitors.

An iontophoresis device includes an outer housing, and a swab subassembly slidingly received within the outer housing that includes an elongated rod, a swab, a conductor extending along the rod and coupled to the swab. The iontophoresis device also includes an additional device subassembly, such as a syringe subassembly, that is slidingly received within the outer housing. The syringe subassembly includes an elongated body for holding a substance, a needle, and a plunger.

A surgically implantable reservoir is provided for implantation into a patient for use in an iontophoresis system for local drug delivery through a target site of internal body tissue. The reservoir comprises a housing having an inner surface defining an enclosed chamber and an inlet opening and an outlet opening for flow of fluid including the drug through the chamber. The housing is capable of interacting with a localized electric field to release the drug. A platform holding an electrode extends inwardly into the chamber from the inner surface of the housing such that the platform and an adjacent portion of the inner surface of the housing define a trough surrounding the platform. Fluid flow through the reservoir from the inlet opening to the outlet opening moves gas bubbles formed by electrolysis from the surface of the electrode and carries the bubbles through the outlet opening.

The application relates to the field of measurement technology for diagnostic purposes, and discloses a homocysteine detection system for non-invasive body fluid sampling, which comprises a non-invasive body fluid sampling module, a photoelectrochemical detection module and a signal processing and control unit integrated on a flexible substrate. The non-invasive body fluid sampling module performs reverse iontophoresis by applying a micro-current through an electroosmosis electrode, drives the directional migration of subcutaneous interstitial fluid and enriches the interstitial fluid in a hydrogel layer; the photoelectrochemical detection module is in fluid communication with the hydrogel layer, and a double-atom imprinting recognition layer is arranged on the surface of a photoelectrochemical electrode assembly of the photoelectrochemical detection module. The recognition layer is based on the double-site synergistic coordination of the sulfhydryl and Au sites and the amino and Zn sites of homocysteine molecules, and constructs a recognition cavity with a highly complementary spatial configuration and electronic structure. Without the need for invasive blood sampling, the application overcomes the interference of structure-approximate molecules in a complex body fluid matrix, and realizes the high selectivity, high sensitivity and continuous dynamic monitoring of homocysteine.

The invention relates to the field of medical auxiliary instruments, in particular to a multi-mode upper limb correction exerciser. The device mainly comprises a correction vest, a main control unit and upper limb rehabilitation executing mechanisms which are symmetrically arranged. The executing mechanism is composed of a large arm supporting plate and a small arm supporting plate which are connected in series through a hinge, and a bearing air bag on the inner side of the executing mechanism is provided with an electrical stimulation and targeted drug delivery module. Each treatment unit of a microneedle electrode array in the electrical stimulation and targeted drug delivery module adopts a positive and negative microneedle group partition layout, and a directional electric field can be formed subcutaneously in combination with positive and negative electrode micro liquid medicine cavity groups which are isolated from each other and are internally communicated, so that drug ions with different charges can be driven to efficiently transdermal along a definite path. The mechanical medicine supply pump is linked with the joint hinge, and limb movement is converted into pumping power. And the main control unit intelligently coordinates electrical stimulation and drug administration to realize synchronous treatment. According to the invention, the coordination of electrical stimulation, iontophoresis administration and rehabilitation exercise is realized, and the drug transdermal efficiency, the treatment targeting and the overall rehabilitation effect are remarkably improved.

This invention discloses an iontophoresis device and a method for iontophoresis delivery of an active composition, relating to the field of active ingredient penetration technology. The method includes: delivering a skin active composition to a target area using a composite pulse wave and / or a biphasic compensated pulse wave output by the iontophoresis device; the composite pulse wave, within a single cycle, sequentially includes a positive gradual rise segment, a negative main action segment, and a zero-recovery segment; the biphasic compensated pulse wave, within a single cycle, includes a negative main pulse and a positive compensated pulse. By employing a composite pulse wave and / or a biphasic compensated pulse wave to deliver the skin active composition to the target area, the problem of interfacial polarization accumulation is improved, and the delivery stability of the active substance is enhanced; by matching the waveform parameters of the active composition with the composite pulse wave and / or the biphasic compensated pulse wave used, the skin penetration of the active ingredient is increased; and by mixing the first and second substances immediately before use, the risk of inactivation of some active ingredients in a long-term aqueous environment is reduced.