63 results about "Iontopheresis" patented technology

Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes (at physiologic pH, but can become active toward cell membranes if the environment is acidified below ca. pH 6.8), coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents.

The present invention is of an apparatus and method for enhancing skin, muscle and nerve stimulation and controlled delivery of an active substance to a subject's skin. Moreover, the present invention is of an apparatus, featuring a combination of a stimulating device and an exothermic heating source. Preferably, the stimulating device is an iontophoretic device, or an electrical stimulation device, such as, but not limited to TENS, IFC and GC devices or a combination thereof. The present invention also provides a method of using such an apparatus for enhancing skin, muscle and nerve stimulation. Furthermore, the present invention provides a method of use of such an apparatus for enhancing controlled delivery of an active substance.

Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents.

Cosmetic facial treatment delivery system with skincare benefit agents and iontophoresis micro-current zones are provided for delivering skincare treatments to multiple targeted areas of the skin to treat different concerns of an individual user. The system includes a sheet substrate with skincare agents and a micro-current generator secured to the sheet. The micro-current generator includes an oxidation agent, a reduction agent and a hydrogel with salt. The generator is activated by wetting to produce micro-current. The sheet is applied to skin. The micro-current generated facilitates delivery of skin benefit agents from the sheet by iontophoresis, or directly affects treatment by delivery of iontophoresis micro-current to the skin.

The present disclosure relates to an iontophoretic device. In one aspect, the device includes a barrier layer between the drug reservoir and wearer. In another aspect, the device includes a counterelectrode opposite the driving electrode relative to the drug reservoir.

An electrotransport device is provided for the site specific delivery of drugs or other beneficial agents across or under a skin or tissue surface. In one embodiment, the electrotransport device is configured in whole, or in part, to be implanted under a subject's stratum corneum, and uses an electrical current to facilitate drug or other beneficial agent delivery through a semipermeable membrane and into the tissue of the subject. In another embodiment, a device for intraocular delivery of drug or beneficial agent is disclosed which device is placed on the conjunctiva of a subject, wherein lacrimal fluid completes a circuit for delivering the drug or beneficial agent. Methods of using the devices of the present invention are also provided.

By using a composition comprising rotigotine and at least one chloride salt in a concentration of 1 to 140 mmol/l, the composition having a pH of 4 to 6.5 in a iontophoretic device for the treatment of Parkinson's disease, it became possible to obtain a rotigotine flux across the human stratum corneum which was higher than the one previously obtained with conventional passive diffusion systems.

The present invention discloses a wave energy and solar energy coupled iontophoresis power generation device and method. In the device, the top of a first chamber is a high-light-transmission wall surface, the side surface of the first chamber is in open communication with seawater, and the first chamber is provided with a first electrode immersed into the seawater; a second chamber comprises a closed lightproof wall surface and is provided with a second electrode immersed into seawater; an external circuit is connected with the first electrode and the second electrode; a composite nano-film capable of generating the photoelectric poising effect comprises a cation selective channel, a transmembrane potential difference is generated on the first side, close to the first chamber, of the composite nano-film through sunlight irradiation; and based on the pressure difference generated by the waves and the transmembrane potential difference, cations in the seawater directionally migrate fromthe first chamber to the second chamber through the cation selective channel to form ionic current, and electrons in an external circuit flow from the first electrode to the second electrode to formcurrent.

An comprising (A) a working electrode structure being equipped with a working electrode, an ion-exchange membrane and a medicine-containing portion which contains an ionic medicine, (B) a counter electrode structure being equipped with an electrode opposing said working electrode and (C) a power source unit electrically connected to the working electrode structure and to the counter electrode structure, said ionic medicine being permeated into a living body by the electrophoresis through the ion-exchange membrane; wherein said ion-exchange membrane has, as an ion-exchange resin, a crosslinked (meth)acrylic resin having a (meth)acrylic structural unit A to which an ion-exchange group is bonded. The iontophoresis device using the above ion-exchange membrane is capable of efficiently administering ionic medicines having ionic formula weights of not smaller than 500 into the living body.

Provided is a smart contact lens for non-invasive drug delivery including a platform configured to be worn on an eye, a reservoir installed within the platform, and having a receiving part in which a drug is received, to provide the eye with the drug, an electrode for iontophoresis installed in the reservoir to make iontophoresis work, to provide the eye with the drug from the reservoir, and an activation chip electrically connected to the electrode for iontophoresis to activate iontophoresis.

The present disclosure relates to devices and systems for targeted and controlled delivery of a therapeutic agent to a treatment site of an eye. Particularly, aspects are directed to a therapeutic agent delivery device that includes a polymeric substrate having a release region, a delivery region, and a receiving region; one or more reservoirs formed within the release region; a therapeutic agent disposed within the one or more reservoirs; an active, passive, or combination thereof controlled release mechanism for release of the therapeutic agent from the one or more reservoirs into the delivery region; and a circuit formed on the polymeric substrate, the circuit having a current source, a first iontophoresis electrode located within the delivery region for transport of the therapeutic agent from the delivery region into a target tissue via electromigration, and a second iontophoresis electrode located within the receiving region for maintaining electroneutrality within the tissue.

The invention discloses an iontophoresis device for skin and a patch thereof. The iontophoresis device comprises a power supply module and the patch, and the patch comprises an adsorption layer, a first electrode circuit and a second electrode circuit, and the adsorption layer is configured to be capable of adsorbing fluid containing positive ions or negative ions; the first electrode circuit is arranged on one side of the adsorption layer and provided with one or more conductive contacts; and the second electrode circuit is arranged on the other side, used for making contact with the skin, of the adsorption layer, the first electrode circuit can be electrically connected with one of the positive electrode and the negative electrode of a power source, the second electrode circuit can be electrically connected with the other one of the positive electrode and the negative electrode connected with the power source, at least one of the conductive contacts and the second electrode circuit are arranged in a staggered mode relative to the adsorption layer, and the part, except the conductive contacts, of the first electrode circuit and the second electrode circuit are both electrically insulated relative to the adsorption layer. The iontophoresis device for the skin is compact in structure, and drugs or skin care products can be introduced into the skin from multiple points at the same time.

An iontophoresis device may include a flexible support layer, an electrode layer, having at least two electrically isolated electrodes, fixed to the support layer. A return electrode is separated from the electrode layer and the flexible support layer. A control module is detachably connected to the electrode layer and to the return electrode. The control module is configured to provide a variable current source or a variable voltage source only to a selected proper subset of the at least two electrically isolated electrodes while not providing the variable current source to other electrodes of the at least two electrically isolated electrodes.

The invention relates to an iontophoresis device adopting an efficient environment-friendly biocompatible ion battery, in particular to an efficient environment-friendly biocompatible iontophoresis device driven by a reverse electrodialysis ion battery, which is made of substances, such as sediments, gas or non-ionidizable substances in water solution, formed through a reaction..

The invention belongs to the technical field of medical diagnostic instruments, and particularly relates to a noninvasive subcutaneous tissue fluid extraction-detection device and method, the extraction-detection device comprises an adhesive substrate, a first electrode assembly and a second electrode assembly, the first electrode assembly comprises an extraction/detection electrode layer, and the extraction/detection electrode layer comprises double electrodes; the second electrode assembly comprises an extraction electrode positive electrode which is used for being matched with one electrode in the double electrodes so as to percutaneously extract subcutaneous tissue fluid through a reverse iontophoresis technology; the extraction electrode positive electrode coats the extraction/detection electrode layer, and the extraction electrode positive electrode extends along the coated edge of the extraction/detection electrode layer. The extraction-detection device provided by the invention can provide an electrode system with a more uniform electric field, can extract a detected amount of tissue fluid sample under a working current as low as 0.1 mA, and reduces discomfort such as skin irritation and injury; the electrode is compact in structure and high in measurement accuracy.