135 results about "Iontopheresis" patented technology

The invention relates to the technical field of biomedical sensing and health monitoring, and discloses a noninvasive glucose detection system. The system comprises an interstitial fluid extraction device, a photoelectric sensing module and a main control circuit which are integrated on a flexible substrate. The interstitial fluid extraction device drives subcutaneous interstitial fluid to migrate to the hydrogel interface layer under the action of reverse ion electroosmosis; the photoelectric sensing module receives interstitial fluid through a hydrogel interface layer, a working electrode of the photoelectric sensing module comprises a Cu monatomic imprinting recognition layer, and imprinting holes formed by Cu monatomic sites are specifically coordinated with glucose molecules. The master control circuit controls sampling and determines the glucose concentration based on the photocurrent signal. Noninvasive sampling and monatomic imprinting photoelectric detection are fused, sampling-detection integration is achieved, and the device has the advantages of being noninvasive, painless, high in selectivity, high in interference resistance, comfortable to wear and the like and is suitable for continuous monitoring of blood glucose.

The invention discloses a wearable sweat glucose detection system based on multi-shell metal organic framework encapsulated enzyme and a preparation method of the wearable sweat glucose detection system. The detection system comprises a sweat collection and sensing module, an electrochemical detection module and an iontophoresis module, the sweat collecting and sensing module comprises a micro-fluidic channel and a screen-printed electrode; the micro-fluidic channel is used for collecting sweat; the screen-printed electrode comprises a working electrode for detecting glucose, a counter electrode and a reference electrode to form a three-electrode system; wherein the working electrode for detecting the glucose is provided with a functional layer, and the functional layer is modified by multi-shell metal organic framework layered encapsulation enzyme for detecting the glucose and chitosan for fixing the multi-shell metal organic framework layered encapsulation enzyme; the electrochemical detection module is used for obtaining electrochemical sensing detection data; and the iontophoresis module is used for outputting an adjustable constant current source to enable iontophoresis to stimulate skin to sweat. The portable long-time continuous detection of sweat glucose can be realized, and the detection method is rapid and convenient.

Systems and methods for a wearable stress response assessment system may include an iontophoresis module, a multi-inlet microfluidic sweat sampling component, and a sensor patch configured to detect concentrations of electrolytes and metabolites present in a sweat sample and monitor physiological signs prevalent in a human patient. An iontophoresis module may provide for stimulation of a biofluid sample. A biofluid may be a sweat sample. Stimulation may be achieved via electrostimulation and / or application of a stimulating agent. A microfluidic sweat sampling component may include adhesive and PDMS layers with carefully designed inlets and channels for efficient collection and sampling of biofluid. Enzymatic and ISE biosensors may quickly and accurately identify concentrations of key biomarkers present in a biofluid sample which may assess, in combination with monitored physiological signs, a human patient's stress response.

The invention belongs to the technical field of medical instruments, and particularly relates to a curative effect evaluation and control system and method of an electro-therapeutic apparatus. The system comprises a power supply unit, an electrode assembly and a main control unit, as well as a man-machine interaction assembly, an electric pulse signal generation module, a physiological electrical parameter acquisition unit and a signal switching unit which are electrically connected with the main control unit, the electric pulse signal generation module and the physiological electrical parameter acquisition unit are electrically connected with the electrode assembly through the signal switching unit. A curative effect evaluation operation program and a project service program supporting electric treatment, electroporation and iontophoresis medicine guiding are operated in the main control unit, and deep analysis and comprehensive evaluation of human body physiological parameters collected in different working modes are supported. Therefore, according to the technical scheme, the electrotherapy, electroporation and iontophoresis drug guiding effects can be accurately quantified, deep evaluation is carried out according to multi-mode data, a scientific basis is provided for personalized treatment, and the technical scheme has important significance on improvement of treatment accuracy and effectiveness.

This invention discloses an iontophoresis gel scleral contact lens and its preparation method, comprising a contact lens frame, a polymer porous microsphere drug-carrying layer loaded with nano-sustained-release drugs, an electrode layer, and a flexible material covering the electrode layer on the contact lens frame, and a gel layer covering the outer side of the contact lens frame. This iontophoresis gel scleral contact lens has a simple structure, facilitates convenient and rapid drug delivery, and provides sustained-release efficacy. It allows patients to self-administer the drug, directly delivering it to the intraocular lesion site, avoiding adverse reactions in other tissues or the whole body, and has a sustained-release function to reduce the frequency of drug administration.

An iontophoresis device includes an outer housing, and a swab subassembly slidingly received within the outer housing that includes an elongated rod, a swab, a conductor extending along the rod and coupled to the swab. The iontophoresis device also includes an additional device subassembly, such as a syringe subassembly, that is slidingly received within the outer housing. The syringe subassembly includes an elongated body for holding a substance, a needle, and a plunger.

Proposed is a self-current-generating skin-applicable patch with a first area in contact with the skin and a second area adjacent to and spaced apart from it, where either area contains a biodegradable metal, decomposable and absorbable through skin contact or reaction with tissue moisture. The patch includes a first electrode layer directly contacts the skin as a thin sheet integrated with the first area and has at least one fluid-transferable penetration part, a second electrode layer of a material with a different standard reduction potential is positioned opposite a skin-contacting side, partially extending to connect electrically to the second area, and a support layer, a hydrophilic sheet of predetermined thickness, is positioned opposite the skin-contacting side, having an ionic solution supported. Thus, sufficient iontophoresis and other micro-current effects with active ingredients are achieved through self-generated micro-current, even without a battery-like external power source.

The present disclosure relates to devices and systems for targeted and controlled delivery of a therapeutic agent to a treatment site of an eye. Particularly, aspects are directed to a therapeutic agent delivery device that includes a polymeric substrate having a release region, a delivery region, and a receiving region; one or more reservoirs formed within the release region; a therapeutic agent disposed within the one or more reservoirs; an active, passive, or combination thereof controlled release mechanism for release of the therapeutic agent from the one or more reservoirs into the delivery region; and a circuit formed on the polymeric substrate, the circuit having a current source, a first iontophoresis electrode located within the delivery region for transport of the therapeutic agent from the delivery region into a target tissue via electromigration, and a second iontophoresis electrode located within the receiving region for maintaining electroneutrality within the tissue.

A self-powered intelligent adhesive bandage capable of detecting temperature in real time and dosing according to needs is applied to detection and treatment of skin wound infection and can detect the temperature of a wound and surrounding skin in real time and conduct dosing according to needs. According to the intelligent adhesive bandage, the piezoelectric nanometer generator is combined, mechanical energy generated in the daily activity process of a wearer can be converted into electric energy, and the electric energy is used for driving the whole intelligent adhesive bandage to operate. The two temperature measuring units are used for detecting the temperature of the wound and the surrounding skin at the same time, the temperature difference value serves as a relative index for judging whether the wound is infected or not, and the influence of environmental factors on detection is reduced. A three-electrode structure is adopted, on-demand drug delivery is achieved through iontophoresis, and high drug permeability, dosage controllability and drug delivery uniformity are all considered. After the intelligent adhesive bandage is used for treating a mouse with wound infection for three days, the wound recovery rate of the mouse reaches 90.3%, and the realization of temperature detection and on-demand administration is proved. The intelligent adhesive bandage has a good application prospect in detection and treatment of wound infection.

An iontophoresis device capable of reducing skin irritability due to an applied current while enhancing skin permeability of a drug is provided. The iontophoresis device includes a power supply, an electrode electrically connected to the power supply, a drug disposed between skin and the electrode, and a control unit configured to control a current applied to the skin via the electrode. The control unit controls the current so that a pulse current having a pulse frequency of 0.5 Hz or more and 50 Hz or less is applied to the skin.

The utility model provides a joint used for an ion electroosmosis patch and the ion electroosmosis patch, the joint is used for connecting a first electrode and a wire layer, and the joint comprises a bottom layer, a joint body and a covering layer; the bottom layer is an insulating layer and is printed on the first electrode surface; the first end of the bottom layer covers the surface of the first electrode, and the first end of the bottom layer is provided with a first hollow; the lead layer is printed on the bottom layer; the joint body is printed on the bottom layer and the wire layer, and the first end of the joint body partially or completely covers the first hollow part; the second end of the joint body covers the first end of the wire layer; the covering layer is an insulating layer and covers the bottom layer, the connector body and the wire layer. The utility model has the technical effects that the design is reasonable, and the joint of the first electrode and the wire layer is effectively prevented from being contaminated by essence or liquid medicine for beauty to cause oxidation and electrolytic reaction.

The invention provides a partitioned iontophoresis and self-power-generation micro-current composite mask which comprises a mask base body, an iontophoresis functional area and a control module and further comprises a self-power-generation micro-current functional area. The self-generating micro-current functional area is not electrically connected with an external power supply, comprises at least one primary battery unit made of two different metal materials and an electrolyte medium, and spontaneously generates micro-current through an electrochemical principle. Multiple effects of moisturizing, whitening, wrinkle resisting, lifting and tightening and the like are achieved at the same time through one-time nursing, and energy distribution is more reasonable.

Embodiments of the present invention relate to a microcurrent ion patch comprising an electrochromic unit, which allows users to visually confirm the usage state. A microcurrent ion patch comprising an electrochromic unit according to an embodiment of the present invention includes an iontophoresis ion patch and an electrochromic unit electrically connected to both electrodes of the ion patch. The electrochromic unit may comprise: a base thin film; an electrochromic material layer formed on the base thin film; and a hydrogel electrolyte layer formed on the electrochromic material layer.

Non-gas emitting electrodes having a very high surface area, high electric capacitance, and low electric resistance are integrated with silver and / or silver chloride for use in electrodialysis / electrodeionization cells, or in any other system requiring the generation of electric fields through electrolyte solutions, and are capable generating an electric field for extensive periods of time without generation of gases, and without the occurrence of electrode reactions. Each electrode is highly porous and highly conductive, such as a carbon aerogel electrode, and thus has a very large internal surface area, which is coated, deposited, or otherwise covered with silver and / or silver chloride. This combination supercapacitor and pseudocapacitor electrode can sustain electrode reactions for longer periods of time, and at much higher current densities, as compared to conventional (solid) silver / silver chloride electrodes.

The present invention relates to a cosmetic method for delivering ascorbic acid and / or one of its derivatives through the skin by iontophoresis, preferably bipolar, and / or electrostimulation comprising the following steps: Providing a device comprising a main electrode, a counter-electrode and a power supply electrically connected to the main electrode on one side and to the counter-electrode on the other, the main electrode and the counter-electrode being intended to be in direct or indirect contact with the skin and being separated from each other by a free space; Applying a cosmetic composition comprising ascorbic acid and / or one of its derivatives and one or more cosmetically acceptable additives to the main electrode and the counter-electrode but not to said free space;Apply the device to the skin so that the main electrode and the counter-electrode with the cosmetic formulation are in direct or indirect contact with the skin; Apply a continuous current with an average current density of 0.03 mA / cm² to 0.5 mA / cm², preferably 0.1 mA / cm² to 0.2 mA / cm², over a certain time range. The present invention also relates to an iontophoretic kit for implementing this method.

This presentation relates to a device (1) for cosmetic skin treatment (100) of a user by iontophoresis and / or electrostimulation, the device (1) being intended to be applied to the user's skin (100) and comprising: a support (2); a main electrode (22); a counter electrode (23); and a current generator (24). Figure for the abstract: Fig. 4

An iontophoresis apparatus including a host, at least two accommodation modules, and a processor is provided. The host includes a housing, a switch mechanism connected to the housing, and at least two host contacts arranged on a side surface of the housing. The accommodation modules each includes a tank body having two side plates arranged oppositely, where a recess is defined in the tank body; an electrode arranged in the recess; and a tank contact arranged on one of the two side plates and electrically connected to the electrode. Two front-end plates of the tank bodies are adapted to be coupled to each other, and the accommodation modules are connected to the host through the tank contacts and the host contacts. The processor is configured to change the value of the current transmitted between the host and the two electrodes in response to that a user triggers the switch mechanism.

The application provides an integrated wearable transdermal iontophoresis patch powered by a moisture generator and a preparation method thereof, and belongs to the technical field of medical devices and biomedical materials. The problems of high distance requirement, large energy loss in the transmission process, inability to provide stable power supply, long-term use, complex device structure and operation of the existing iontophoresis transdermal drug delivery equipment are solved. It comprises a flexible circuit board and two electrode sheets, the flexible circuit board is provided with a power generation module, the positive and negative levels of the power generation module are connected with the two electrode sheets respectively, the power generation module comprises a moisture generator array, the moisture generator array comprises a plurality of moisture generator groups arranged side by side in parallel, the moisture generator group comprises a plurality of moisture generator devices arranged in series, and the moisture generator device comprises an active material, a steel mesh electrode and a graphite paper electrode. It is mainly used for transdermal drug delivery.

Device (1) for treating a user's skin by iontophoresis and / or electrostimulation intended to be applied to the user's skin, the device (1) comprising: - a support layer (2) comprising at least one support film (21) and comprising a main electrode (22), a counter electrode (23) and a current generator (24) electrically connected to the main electrode (22) on the one hand and to the counter electrode (23) on the other hand, the current generator (24) comprising at least one galvanic couple, the galvanic couple being formed of a first conducting pole (241) forming a cathode and a second conducting pole (242) forming an anode separated from each other by a primary free space (243);- an impregnation layer (4) comprising at least one main impregnation film (400), the main impregnation film (400) connecting, by exclusively covering, a part of the first conducting pole (241), a part of the primary free space (243) and a part of the second conducting pole (242). Figure for the abbreviation: Fig. 3.;

The utility model provides an ionic electroosmosis patch for facial skin. The ionic electroosmosis patch comprises a substrate, a first electrode, a first sub-separation strip, a second electrode, a second sub-separation strip and a wire unit, at least one netted first electrode is printed on the surface of the first electrode surface; a first sub-separation strip is printed on the first connecting surface; at least one second electrode is printed on the surface of the second electrode surface; a second sub-separation belt is printed on the second connecting surface; the second electrode and the first electrode are separated by the separation belt; the plurality of wire units are arranged on the first electrode surface; the first end of the wire unit is connected with the first electrode, and the second end is used as a positive electrode contact; the first hollow part is filled with a conductive material to serve as a negative electrode contact, and the positive electrode contact and the negative electrode contact are both located on the first electrode face of the substrate. The utility model has the technical effects that the design is reasonable, the poor connection is effectively avoided, and the beauty or medical effect is well ensured.

Disclosed herein is an advanced anesthetic gel formulation designed for painless, non-invasive dental procedures. The gel incorporates lidocaine hydrochloride and prilocaine hydrochloride as the primary anesthetics, supported by carbomer 940 for viscosity control. Sodium chloride is added to improve electrical conductivity, while triethanolamine maintains an optimal pH balance. Glycerin functions as a humectant to reduce tissue irritation, and allantoin offers anti-inflammatory properties. Phenoxyethanol is included to prevent microbial growth, ensuring the gel's safety and stability. The preparation method involves dissolving these components in purified water, creating a gel that enables effective, non-invasive dental anesthesia through iontophoresis, significantly enhancing patient comfort and procedural efficiency.

The utility model provides an ion electroosmosis patch for local skin, which comprises a substrate, a first electrode, a separation belt, a second electrode and a wire unit, and is characterized in that the flexible substrate is provided with a main body part and an interface part which are integrally formed; the substrate is provided with a first electrode surface opposite to the facial skin and a second electrode surface facing the facial skin; one first electrode is printed on the surface of the first electrode surface; the second electrode and the first electrode are separated by the separation belt; the interface part is positioned on one side, far away from the separation strip, of the second electrode; the second electrode is provided with a connecting end; the first hollowed-out part is filled with a conductive material and serves as a negative electrode contact, the negative electrode contact is connected with the second electrode, and the positive electrode contact and the negative electrode contact are both located on the first electrode face of the substrate. The utility model has the technical effects that the design is reasonable, and long-time and high-dose key nursing can be conveniently carried out on a part needing key nursing.

The invention discloses a paper-based microfluidic cavity structure and method for in-situ sweat collection and detection, and belongs to the field of wearable body surface sweat monitoring equipment. According to the paper-based microfluidic cavity structure, the sweat reaction area and the flexible hydrophilic substrate layer are connected through the double faced adhesive tape, a hollow cavity micro space for sweat storage and detection is formed, and sufficient sweat can be enriched for accurate detection of a paper-based electrochemical sensor. One-step preparation of the paper-based electrochemical sensor is realized by using the mixed conductive ink prepared from PEDOT: PSS / D-sorbitol / MWCNTS / PB NPs, so that the preparation steps of the sensor are greatly simplified, and the stability and biocompatibility of the sensor are improved. The wearable device can be worn on each part of a human body and is used for local sweat collection and accurate detection in the autonomous sweating process of the human body or after iontophoresis.

The present invention relates to a cosmetic method for delivering ascorbic acid and / or one of its derivatives through the skin via iontophoresis, preferably bipolar iontophoresis, and / or electrostimulation, the method comprising the following steps: • providing a device comprising a main electrode, a counter-electrode and a power source electrically connected to the main electrode on the one hand and to the counter-electrode on the other hand, the main electrode and the counter-electrode being intended to be in direct or indirect contact with the skin and being separated from one another by a free space; • applying a cosmetic composition comprising ascorbic acid and / or one of its derivatives and one or more cosmetically acceptable additives to the main electrode and the counter-electrode but not to the free space; • applying the device to the skin such that the main electrode and the counter-electrode with the cosmetic formulation are in direct or indirect contact with the skin; • applying, over a certain time period, a direct current with an average current density of 0.03 mA / cm2 to 0.5 mA / cm2, preferably 0.1 mA / cm2 to 0.2 mA / cm2. The present invention also relates to an iontophoresis kit for implementing this method.

The present invention relates to a supracutaneous self-adhesive patch sensor (S1, S2) which, when coupled to an electronic circuit (C1, C2), is capable of continuously monitoring blood glucose levels in the human body via the interstitial fluid without any invasion of the patient's body, since it uses reverse iontophoresis, wherein continuous monitoring is possible for a predetermined time period without the need to change the adhesive patch, using the same electronic circuit (C1, C2).

The application relates to the technical field of intelligent devices, and discloses a wearable continuous dynamic uric acid intelligent monitoring device, which comprises a device body and is worn on a human body; a skin adhesion layer, a bionic micro-fluidic gel layer and an integrated ion electrophoresis electrode substrate are sequentially arranged on the device body from outside to inside; the skin adhesion layer is in contact with the human skin; the bionic micro-fluidic gel layer is used for collecting sweat on the human skin and guiding the sweat into a detection area on the bionic micro-fluidic gel layer; an electrochemical detection unit is arranged on the integrated ion electrophoresis electrode substrate; the electrochemical detection unit is used for detecting the sweat in the detection area; an analysis feedback module is arranged on the device body; and data detected by the electrochemical detection unit is fed back to a wearer after being analyzed by the analysis feedback module. The application can realize real-time dynamic monitoring of uric acid levels and meet the comfortable, convenient and accurate uric acid monitoring requirements of gout patients.

The invention relates to a device (1) for treating the skin of a user by iontophoresis and / or electrostimulation intended to be applied to the skin of the user, the device (1) comprising: - a support layer (2) comprising at least one support film (21) and comprising a main electrode, a counter-electrode and a current generator electrically connected to the main electrode as well as to the counter-electrode, the current generator comprising a plurality of galvanic couples connected in series, each galvanic couple being formed by a first conductive pole forming a cathode and a second conductive pole forming an anode, separated from each other by a free space, the first conductive pole and the second conductive pole being intended to be electrically connected by an electrically conductive activation product, and wherein the galvanic couples are adjacent pairwise and electrically connected pairwise via a couple connector, the first conductive pole of one of the galvanic couples being electrically connected to the second conductive pole of an adjacent galvanic couple; and - an impregnation layer (4) comprising a preferably one-piece impregnation film (41), covering at least the main electrode, the counter-electrode and the current generator, the impregnation film (41) comprising a first primary non-impregnatable zone (46a) positioned between the main electrode and the current generator in order to separate them and / or a second primary non-impregnatable zone (46b) positioned between the counter-electrode and the current generator in order to separate them.

A computer-implemented method for measuring skin conductance of a writing instrument's user, including: applying a DC voltage to user's fingers contacting the writing instrument during a writing session with the writing instrument; measuring a current generated by reverse iontophoresis following applying the DC voltage; calculating an average skin conductance over a specific timeframe from the measured current; storing calculated average skin conductance data as historical data; comparing the average skin conductance to historical data from the same user or to reference data from a group of users; and providing an indication to the user in case that the skin conductance has decreased and / or the calculation results.

The invention relates to a skin-like chip simulation platform based on a microfluidic technology. The skin-like chip simulation platform sequentially comprises a skin-like layer, a skin-like layer, a cytoplasm matrix simulation layer and an interstitial fluid circulation layer from top to bottom, a hole array is arranged on the imitated skin layer; an interstitial fluid enrichment cavity communicated with the hole array is formed in the simulated cortex, and the interstitial fluid enrichment cavity is provided with an enrichment outlet and an enrichment inlet; an interstitial fluid micro-channel is arranged in the cytoplasm matrix simulation layer, one end of the interstitial fluid micro-channel is communicated to the enrichment inlet, and the other end of the interstitial fluid micro-channel is communicated to the interstitial fluid flowing layer; an interstitial fluid storage cavity is formed in the interstitial fluid circulation layer and is provided with a storage cavity outlet and a storage cavity inlet; the device further comprises an interstitial fluid circulation channel. The skin-like chip simulation platform designed by the invention can accurately simulate the human skin environment, provides a simulation test platform for novel extraction electrode design, parameter optimization and safety evaluation of a counter ion electroosmosis technology, and remarkably reduces the preclinical research risk and cost of new technology development.

The present application relates to the technical field of transdermal drug delivery, and in particular to an iontophoresis patch with current homogenization function and an iontophoresis system. The iontophoresis patch comprises a substrate support layer, a first electrode, a second electrode, an electric field homogenization ring, and a drug-loaded layer. The first electrode has a hollow annular structure with a center, and the second electrode is insulated and separated from the first electrode. The electric field homogenization ring is located on the inner side of the first electrode and is insulated and separated from the first electrode. The volume conductivity of the electric field homogenization ring is greater than the volume conductivity of the stratum corneum of human skin and less than the volume conductivity of the first electrode and the second electrode. The drug-loaded layer covers the surface of the first electrode or covers the surfaces of the first electrode and the second electrode, respectively. The present application solves the problems of current hot spots caused by the umbilical depression of traditional electrodes and the skin irritation and low drug transdermal efficiency caused by the edge electric field concentration of the annular electrode.