78 results about "Iontopheresis" patented technology

Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and / or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and / or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and / or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and / or electrophereis can also be used with the disrupting agents.

An electrode for use in an iontophoretic drug delivery having a substantially uniform distribution of current about the electrode. One such electrode includes a substrate, at least one first conductive layer of material disposed upon the substrate and at least one dielectric layer of material disposed upon at least a portion of the at least one conductive layer of material. The dielectric layer cooperates with the conductive layer of material to promote the substantially uniform distribution of current. Another such electrode includes a substrate, a conductive layer of material and a sacrificial layer of material.

Electroporation electrodes are laminated to a permeable membrane to form an electrode membrane. Such an electrode membrane is useful for a continuous controlled delivery of a therapeutic agent through the skin or mucosa, when placed in direct contact with the skin or mucosa and by application of electric field pulses at specified intervals. An electrode membrane can be assembled such that it incorporates an iontophoretic electrode in the same device. This device can be jointly utilized for electroporation and iontophoretic drug delivery through the skin and mucosal membrane.

A method is provided for low cost, accurate, iontophoretic fluid delivery. The method includes providing an electronic circuit coupling a plurality of electrodes, charging a chargeable electromotive cell to a selected potential and / or charge in response to a selected quantity of beneficial agent to be delivered, the chargeable electromotive cell being electronically coupled with the electronic circuit, applying the selected quantity of beneficial agent to at least one electrode, placing the at least one electrode in contact with skin, and delivering the selected quantity of beneficial agent. The method may also include preparing the skin using a skin preparation device in order to enhance the delivery of the beneficial agent.

The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises:(a) a positive electrode;(b) a negative electrode, and(c) electrical insulation between subpart (a) and (b), wherein the positive electrode, and the negative electrode, and electrical insulation are positioned on the same side of the membrane sample.The present invention also relates to a device for the removal of or delivery of ionized substances to a mammal through intact skin or mucosal membrane without mechanical penetration, which device comprises: (a) a positive electrode, (b) a negative electrode, and (c) an electrically insulating material between subpart (a) and (b), wherein the positive electrode, negative electrode and insulating material are physically positioned so that each present a common surface of the device for contact with the same surface of the skin or mucosal membrane of the mammal.The present invention also relates to the use of iontophoresis to determine the level of a charged molecule in a living mammal, and with the use of a feedback mechanism, administer appropriate levels of therapeutic substances.

A solar photo-thermal driven seawater desalination and iontophoresis power generation system and method are disclosed. In the system, a first electrode immersed in seawater is arranged in a first solution chamber, a second solution chamber is connected with the first solution chamber through a cation selective nano-film, a second electrode immersed in seawater is arranged in a third solution chamber, and the third solution chamber is connected with the second solution chamber through an anion selective nano-film. An adjustable shading plate shades the cation selective nano-film to form a firstpreset part of sunlight irradiation and shields the anion selective nano-film to form a second preset part of sunlight irradiation, so that the cation selective nano-film and the anion selective nano-film are respectively under asymmetric illumination to generate a temperature gradient.

The present invention includes methods and devices for non-invasively delivering an active agent to the eye of a subject. In one aspect, for example, a device for delivering an active agent to an eye of a subject may include an ocular lens-shaped housing configured to contact a surface of the eye, and a reservoir coupled to the housing and configured to deliver an active agent to the eye, wherein the reservoir is located entirely within a 180 degree section of the housing. In another aspect, the reservoir is located entirely within a 150 degree section of the housing.