Noninvasive glucose detection system

By integrating an interstitial fluid extraction device and a photoelectric sensing module on a flexible substrate, and utilizing reverse ion electroosmosis and a Cu single-atom imprinted recognition layer, the low sampling efficiency and insufficient stability of existing non-invasive glucose detection methods are solved, achieving non-invasive, continuous, and accurate glucose detection, which is suitable for health monitoring of diabetic patients.

CN121533723APending Publication Date: 2026-02-17JUJIAOXINCHUANG MEDICAL ELECTRONICS (SHANGHAI) CO LTD +1
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Patent Information

Application Number
CN202512051664.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-31
Publication Date
2026-02-17

AI Technical Summary

Technical Problem

Existing non-invasive glucose detection technologies suffer from low sampling efficiency, poor anti-interference ability, and insufficient stability, making it difficult to achieve continuous and accurate glucose detection.

Method used

The system employs an interstitial fluid extraction device and photoelectric sensing module integrated on a flexible substrate. It utilizes reverse ion electroosmosis technology to extract subcutaneous interstitial fluid, and specifically captures glucose molecules through a Cu single-atom imprinted recognition layer. The system then combines a titanium dioxide photosensitive semiconductor substrate for photoelectric signal conversion, and the main control circuit performs data processing and correction.

Benefits of technology

It enables non-invasive, continuous, and accurate glucose testing, reduces the risk of pain and infection, and improves the selectivity and stability of the test, making it suitable for home health monitoring for diabetic patients.

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Abstract

The invention relates to the technical field of biomedical sensing and health monitoring, and discloses a noninvasive glucose detection system. The system comprises an interstitial fluid extraction device, a photoelectric sensing module and a main control circuit which are integrated on a flexible substrate. The interstitial fluid extraction device drives subcutaneous interstitial fluid to migrate to the hydrogel interface layer under the action of reverse ion electroosmosis; the photoelectric sensing module receives interstitial fluid through a hydrogel interface layer, a working electrode of the photoelectric sensing module comprises a Cu monatomic imprinting recognition layer, and imprinting holes formed by Cu monatomic sites are specifically coordinated with glucose molecules. The master control circuit controls sampling and determines the glucose concentration based on the photocurrent signal. Noninvasive sampling and monatomic imprinting photoelectric detection are fused, sampling-detection integration is achieved, and the device has the advantages of being noninvasive, painless, high in selectivity, high in interference resistance, comfortable to wear and the like and is suitable for continuous monitoring of blood glucose.
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