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Efficient perindopril tablet and production process thereof

A technology of indopril tablet and production process, applied in the field of high-efficiency perindopril tablet and its production process, can solve the problems of nephrotoxicity, loss of taste, less adverse reactions and the like, and achieve prevention, development, control Blood pressure, the effect of controlling the occurrence of kidney disease

Active Publication Date: 2014-06-18
SHANGHAI PHARMA DONGYING JIANGSU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first-generation ACEI has disadvantages such as loss of taste and nephrotoxicity, s

Method used

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  • Efficient perindopril tablet and production process thereof
  • Efficient perindopril tablet and production process thereof
  • Efficient perindopril tablet and production process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A high-efficiency perindopril tablet comprises the following components:

[0027]

[0028] Finally, a tablet with a total tablet weight of 70-80 mg is obtained, and its preparation process comprises the following steps:

[0029] (1) Perindopril tert-butylamine salt is successively mixed with sodium starch glycolate, lactose, and magnesium oxide in equal amounts;

[0030] (2) above-mentioned mixture is mixed with microcrystalline cellulose;

[0031] (3) Add an appropriate amount of binder to make soft materials, and dry and granulate at 70°C;

[0032] (4) Add additional auxiliary materials and mix for 45 minutes;

[0033] (5) Sampling and testing the content and content uniformity of intermediate products, ∮6mm punch for tableting, aluminum-plastic packaging.

Embodiment 2

[0035] A high-efficiency perindopril tablet comprises the following components:

[0036]

[0037] Finally, a tablet with a total tablet weight of 70-80 mg is obtained, and its preparation process comprises the following steps:

[0038] (1) Perindopril tert-butylamine salt is successively mixed with sodium starch glycolate, lactose, and magnesium oxide in equal amounts;

[0039] (2) above-mentioned mixture is mixed with microcrystalline cellulose;

[0040] (3) Add an appropriate amount of adhesive to make soft materials, and carry out drying and sizing at 50°C;

[0041] (4) Add additional auxiliary materials and mix for 15 minutes;

[0042] (5) Sampling and testing the content and content uniformity of intermediate products, ∮6mm punch for tableting, aluminum-plastic packaging.

Embodiment 3

[0044] A high-efficiency perindopril tablet comprises the following components:

[0045]

[0046]

[0047] Finally, a tablet with a total tablet weight of 70-80 mg is obtained, and its preparation process comprises the following steps:

[0048] (1) Perindopril tert-butylamine salt is successively mixed with sodium starch glycolate, lactose, and magnesium oxide in equal amounts;

[0049] (2) above-mentioned mixture is mixed with microcrystalline cellulose;

[0050] (3) Add an appropriate amount of adhesive to make soft materials, and dry and granulate at 60°C;

[0051] (4) Add additional auxiliary materials and mix for 30 minutes;

[0052] (5) Sampling and testing the content and content uniformity of intermediate products, ∮6mm punch for tableting, aluminum-plastic packaging.

[0053] Below in conjunction with specific clinical use the present invention will be further described:

[0054] 1.1 Case selection

[0055]Randomly select 60 patients who meet the 1999 WHO / I...

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PUM

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Abstract

The invention discloses an efficient perindopril tablet and a production process thereof. The tablet consists of the following components: perindopril tert-butylamine, microcrystalline cellulose, lactose, sodium carboxy methyl starch, pregelatinized starch, magnesium oxide, magnesium stearate and appropriate adhesives. The perindopril tablet is prepared by adopting a method in which internal addition and external addition are carried out separately. The invention provides an efficient and convenient treatment medicine for patients with hypertension and has an important significance in controlling blood pressure of patients, preventing generation and development of cardiovascular diseases of patents, controlling generation of renal lesions of hypertension patients accompanying with diabetes, improving the cardiac function of patients and reducing the occurrence ratio of serious incidents of myocardial infarction and the like.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical manufacturing, and in particular relates to a high-efficiency perindopril tablet and a production process thereof. Background technique [0002] Angiotensin converting enzyme inhibitors (Angiotensin Converting Enzyme Inhibitors, ACEI) is a class of new and most widely used antihypertensive drugs and anti-congestive heart failure drugs developed in the 1980s. Since Brazilian scientists isolated a variety of substances that can inhibit angiotensin converting enzyme (Angiotesion Converting Enzyme, ACE) from snake venom in 1970, in the same year, from a series of synthetic analogs, the carboxyl group of succinic acid was easily combined with The first ACEI named captopril was marketed by the substitution of metal ion-binding sulfhydryl groups. The first-generation ACEI has disadvantages such as loss of taste and nephrotoxicity, so it is necessary to find compounds with peripheral properties an...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61K9/20A61P9/12A61P9/00A61P9/10A61P13/12
Inventor 陈丽姜允菊张秋姜丽华
Owner SHANGHAI PHARMA DONGYING JIANGSU PHARMA CO LTD
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