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Scutellarin obtained from thymus plant

A technology of scutellarin and thyme, which is applied in the field of medicine and can solve the problem that the research on chemical components of non-volatile parts and their biological activities is blank and so on.

Active Publication Date: 2015-11-11
安徽省双辉生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the research on Thyme plants such as Thyme or Ground Pepper is mostly focused on the study of their volatile oil components and their pharmacological activities, but the research on the chemical components of their non-volatile parts and their biological activities is basically blank.

Method used

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  • Scutellarin obtained from thymus plant
  • Scutellarin obtained from thymus plant
  • Scutellarin obtained from thymus plant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Preparation of scutellarin in ground pepper

[0039] First, take 1.0 kg of ground pepper medicinal material, and reflux extraction with 30 times the amount of ethanol with a mass fraction of 70% for 3 times, each time for 1.5 hours. Filter the extract from the previous step, reduce the pressure to 0.08MPa, recover ethanol, and obtain 200g of extract. The content of scutellarin in the extract is 5.6%. Get extractum 20g to be dissolved in water and be mixed with the solution that weight fraction is 15%, filter, get upper column liquid; This upper column liquid passes through AB-8 macroporous adsorption resin (400g) post, after 4Bv water washing, discard water washing liquid; 50% ethanol, eluted at a flow rate of 1Bv / hr, and the eluate was collected; the enrichment rate and purity of scutellarin in the eluate were detected with high performance liquid; the content of scutellarin after enrichment was 68.8%. 10 times the amount of acetone was added to the above ...

Embodiment 2

[0040] Example 2: Preparation of scutellarin in ground pepper

[0041] Take 1.0 kg of ground pepper medicinal material, and warm-immerse and extract with 40 times the amount of methanol with a mass fraction of 80% for 3 times, each time for 1.5 hours. Filter the extract from the previous step, reduce the pressure to 0.07MPa, recover methanol, and obtain about 195g of extract. The content of scutellarin in the extract is 5.1%. Extraction extract 20g is dissolved in water and is mixed with the solution that weight fraction is 20%, filters, and gets upper column liquid; This last column liquid passes through HPD200A macroporous adsorption resin (600g) column, after 5Bv water washes, discards water washing liquid; Use 60% methanol , eluted with a flow rate of 1Bv / hr, and collected the eluent; the enrichment rate and purity of scutellarin in the eluent were detected by high performance liquid chromatography; the content of scutellarin after enrichment was 69.4% , adding 10 times ...

Embodiment 3

[0042] Example 3: Preparation of scutellarin in ground pepper

[0043] Take 1.0 kg of ground pepper medicinal material, and use 30 times the amount of methanol with a mass fraction of 60% to ultrasonically extract 3 times, each time for 1.5 hours. Filter the extract from the previous step, reduce the pressure to 0.06MPa, recover methanol, and obtain about 190g of extract. The content of scutellarin in the extract is 4.6%. Get extractum 20g to be dissolved in water and be mixed with the solution that weight fraction is 15%, filter, get upper column liquid; This upper column liquid passes through HPD722 macroporous adsorption resin (600g) column, after 4Bv water washes, discards water washing liquid; Use 55% Methanol, eluted with a flow rate of 1Bv / hr, and collected the eluent; the enrichment rate and purity of scutellarin in the eluent were detected with high performance liquid; the content of scutellarin after enrichment was 66.7%, and in the above 10 times the amount of aceto...

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Abstract

The invention relates to a method for obtaining scutellarin from a thymus plant. The extractive is derived from labiatae thymus plant. Particularly, high-purity scutellarin is prepared by taking thymus quinquecostatus, thymus quinquecostatus var. przewalskii, thymus quinquecostatus var. asiaticus, thymus mongolicus or thymus altaicus as a raw material through processing steps such as solvent extraction, macroporous resin separation, and recrystallization. The scutellarin can treat cardiovascular and cerebrovascular diseases such as acute myocardial infarction, ischemic cerebrovascular disease, coronary heart disease, and angina pectoris. The preparation method has abundant raw material resources, simple technology, and low cost. The requirement of the medical market for scutellarin can be satisfied. Non-volatilizing parts of the thymus plant, such as thymus quinquecostatus, thymus quinquecostatus var. przewalskii, thymus quinquecostatus var. asiaticus, thymus mongolicus or thymus altaicus can be developed, so that many things can be achieved at one stroke, and the method has a bright industrial application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an extract of scutellarin, especially a kind of scutellarin extracted from plants of the genus Thyme of Lamiaceae. Background technique [0002] There are about 300 to 400 species of Thyme in the Lamiaceae family in the world, and they are mainly distributed in North Africa, Europe and Asia in temperate regions, such as France and Spain. There are cultivars all over the world. Thyme plants distributed in my country mainly include Thyme ( Thymus ruongolicus ), Altai thyme ( Thymus altaicus ), ground pepper ( Thymus quinquelostatus ) and other 12 species and the development of capsicum ( Thymusquinque costatus var. przewalskii ), Asian ground pepper ( Thymusquinque costatus var. asiaticus ) two varieties, roughly distributed in Heilongjiang, Hebei, Shandong, Gansu and Shaanxi, Qinghai, Xinjiang and other places. It is warm in nature, pungent in taste, slightly toxi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08A61K36/53A61P9/10
Inventor 折改梅田玉欣王晓宏谢梦刘子祯
Owner 安徽省双辉生物科技有限公司
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