Medical composite for preventing and curing Alzheimer's disease

A technology of Alzheimer's disease and composition, which is applied in the field of pharmaceutical composition for prevention and treatment of Alzheimer's disease, can solve the problems of not delaying the development of the disease, liver toxicity and side effects, and expensive drugs, and achieves the improvement of cognitive dysfunction, memory, The effect of delaying development

Active Publication Date: 2010-08-11
PEKING UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The thinking of the Western medical circles to study anti-mild cognitive impairment and senile dementia drugs based on Alzheimer's disease mainly revolves around four anti-inflammatory (anti-inflammatory, anti-oxidation, anti-cholesterol, anti-β-amyloid protein) and two anti-( Currently, drugs approved by the US Food and Drug Administration for the treatment of Alzheimer's disease (AD) include tacrine, donepezil, rivastigmine, galantami

Method used

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  • Medical composite for preventing and curing Alzheimer's disease
  • Medical composite for preventing and curing Alzheimer's disease
  • Medical composite for preventing and curing Alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, the capsule of preparation pharmaceutical composition

[0029] The raw materials are weighed according to the following parts by mass: hyperinin 20, icariin 40, schisandrin B 10; the above drugs are mixed and prepared by adding conventional auxiliary materials according to the conventional capsule preparation process.

Embodiment 2

[0030] Embodiment 2, the tablet of preparation pharmaceutical composition

[0031] The raw materials are weighed according to the following parts by mass: hyperinin 40, icariin 20, schisandrin B 15; the above drugs are mixed and prepared by adding conventional excipients according to the conventional tablet preparation process.

Embodiment 3

[0032] Embodiment 3, the capsule of preparation pharmaceutical composition

[0033] The raw materials are weighed according to the following parts by mass: hyperoside 10, icariin 80, schisandra B 5; the above drugs are mixed and prepared by adding conventional auxiliary materials according to the conventional capsule preparation process.

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Abstract

The invention discloses a medical composite for preventing and curing Alzheimer's disease (AD). The composite comprises the following raw materials in parts by weight: 10-40 parts of hyperin, 20-80 parts of icariin and 5-20 parts of Schisandrin B. Experiments of rat place navigation and space exploration prove that the medical composite of the invention can increase the ability of spatial learning and memory of AD rat model, namely reduce the escape latency and scouting distance and obviously increase the percent of scouting time in quadrant of original platform to total time and the percent of scouting distance in quadrant of original platform to total distance in space exploration experiments. Therefore, the extract composite can be used for preventing and curing AD.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating senile dementia. Background technique [0002] With the continuous acceleration of the pace of the world's entry into the aging society, various neurodegenerative senile diseases, such as mild cognitive impairment and Alzheimer's disease, have become important risk factors that threaten the health of human beings in their later years and reduce the quality of life of the elderly. The society and family have brought serious economic burden and heavy mental pressure. Therefore, the development of drugs for improving cognitive dysfunction and treating Alzheimer's disease has become the research focus of medical workers in various countries around the world, and has been highly valued by Chinese and Western medical circles. [0003] The thinking of the Western medical circles to study anti-mild cognitive impairment and senile dementia drugs based on Alzheimer's disease mainl...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/36A61P25/28
Inventor 王学美黎巍威李娌曾克武富宏杨金霞张泰刘庚信
Owner PEKING UNIV FIRST HOSPITAL
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