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Scutellaria baicalensis flower extract as well as preparation method and application thereof

A technology of extracting flowers and scutellaria baicalensis, applied in the field of extracts of Chinese herbal medicines, to achieve the effect of expanding medicinal resources and facilitating comprehensive development and utilization

Inactive Publication Date: 2018-09-18
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on the anti-aging research of Scutellaria baicalensis extract

Method used

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  • Scutellaria baicalensis flower extract as well as preparation method and application thereof
  • Scutellaria baicalensis flower extract as well as preparation method and application thereof
  • Scutellaria baicalensis flower extract as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation method of embodiment 1 Scutellaria baicalensis extract

[0017] Scutellaria baicalensis 400g was reflux extracted twice with 4L of 60% ethanol as solvent, each time for 2 hours, the two extracts were combined, concentrated under reduced pressure, and freeze-dried to obtain powder.

Embodiment 2

[0018] Example 2 Scutellaria baicalensis extract chemical composition analysis

[0019] Using UPLC-MS technology and electrospray ionization source (ESI), the chemical components in the extract of Scutellaria baicalensis were analyzed by multi-level mass spectrometry. Through comparison of reference substances and databases, combined with existing literature reports, a total of 12 chemical components were identified (see figure 1 and Table 1).

[0020] Liquid phase conditions: mobile phase: A (acetonitrile), B (water, containing 0.1% formic acid); mobile phase gradient: 0 ~ 4min, 15% ~ 20% A; 4 ~ 8min, 20 ~ 23% A; 8 ~ 10min ,23~25%A; 10~14min, 25~50%A; 14~18min, 50~52%A; 18~20min, 52~90%A; 20~22min, 90%A; 22~22.5min, 90~15%A; 22.5~25min, 15%A. Flow rate 0.30ml / min, 2μL injection volume, 40℃ column temperature, Acquity UPLC HSS T3 column (2.1×100mm, 1.8μm).

[0021] Mass spectrometry conditions: Ionization mode using ESI electrospray negative ion detection, scan mode: Full ...

Embodiment 3

[0024] Example 3 Anti-aging effect of Scutellaria baicalensis extract on aging model rats

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Abstract

The invention relates to a new medicinal part of scutellaria baicalensis, and discloses a scutellaria baicalensis flower extract as well as a preparation method thereof and application thereof. The preparation method of the scutellaria baicalensis flower extract comprises the steps: taking a certain amount of scutellaria baicalensis flowers, using 8 to 10 times the mass of 50 to 90% ethanol as a solvent for reflux extraction 2 to 3 times correspondingly, each time lasts for 1 to 3 hours, combining the extract, concentrating under reduced pressure and freeze-drying to obtain powder. The pharmacodynamic experiments proves that the scutellaria baicalensis flower extract prepared by the invention can improve spatial learning and memory abilities and oxidative damage of aging rats, and can be applied in the preparation of anti-aging medicines and health care products.

Description

technical field [0001] The invention relates to extracts of Chinese medicinal materials, in particular to new medicinal parts of Scutellaria baicalensis, specifically to an extract of Scutellaria baicalensis and a preparation method thereof, and the application of the extract of Scutellaria baicalensis in anti-aging. Background technique [0002] The commonly used medicinal part of Scutellaria baicalensis is the dry root of Scutellaria baicalensis Georgi. It has the effects of clearing away heat and dampness, purging fire and detoxification, stopping bleeding and preventing miscarriage. Modern scholars' research on its pharmacological activity mainly focuses on antibacterial, antiviral, anti-inflammatory, anticancer, antioxidative, free radical scavenging and protective effects on ischemia-reperfusion injury. From the perspective of rational utilization of Chinese herbal medicine resources, other parts of the medicinal material can be considered to be developed. There are s...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61P39/06A61K133/00
CPCA61K36/539A61K2236/333A61K2236/39A61K2236/51A61P39/06
Inventor 周玉枝宋佳秦雪梅张丽增杜冠华
Owner SHANXI UNIV
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