23results about How to "Fill in the application gap" patented technology

The application belongs to the technical field of biological medicine, and discloses application of high galangal polysaccharide in preparation of a preparation for improving alcohol-induced intestinal flora disorder. The application prepares an oral preparation with high galangal polysaccharide as an active ingredient, and aims at alcohol-induced intestinal flora disorder. According to a dosing amount of 125-250 mg / kg body weight / day, the alcohol-induced intestinal barrier damage can be repaired, the expression of tight junction proteins can be up-regulated, the intestinal flora alpha diversity can be improved, the intestinal flora structure can be regulated, the relative abundance of beneficial bacteria can be up-regulated, the relative abundance of harmful bacteria can be down-regulated, the alcohol-induced flora structure deviation can be reversed, and the intestinal short-chain fatty acid content can be increased, so that the alcohol-induced intestinal flora disorder can be well regulated.

The invention provides a global asset pricing method considering a cross-market overflow effect and heterogeneity adaptation, and the method comprises the steps: constructing a three-layer heterogeneous graph covering global macroscopic nodes, regional market nodes and individual share asset nodes, and achieving the multi-level message passing through a heterogeneous graph neural network; end-to-end modeling of nonlinear overflow effects among global markets, among large-class assets and among individual stocks is realized for the first time; by designing a feature embedding layer, an interaction adaptation layer and a normalization layer exclusive to the market, adaptive adaptation is carried out for system features, data distribution and pricing logic of different markets, and stable and accurate pricing of mature markets and emerging markets is realized; according to the method, global systematic risk information and regional specificity alpha information are effectively separated and deeply fused through a double-attention aggregation mechanism of a global attention branch and a local attention branch, so that the income prediction precision is improved, and the systematic risk exposure degree and a regional alpha score can be directly output.

The application discloses a kind of preparation and application of lime key component extract with the effect of relieving psychological stress, belong to medical technical field.The application uses Rutaceae citrus plant lime as raw material, and water phase crude extract is prepared by washing and juicing, and the residue is extracted by ultrasonic-assisted ethanol to obtain alcohol phase extract, the two phases are combined and concentrated under reduced pressure, then purified by D101 macroporous resin, to obtain extract rich in active ingredients such as tangeretin, geniposide B, neohesperidin, etc.The application has simple process and high extraction efficiency, and the obtained extract is natural in origin and safe in composition.Animal experiments have verified that the extract can significantly improve anxiety-like behavior caused by stress, and the effect of relieving psychological stress is better than that of single hesperidin, and it can also effectively improve abnormal weight loss caused by stress, regulate the level of inflammatory factors in the body, and balance psychological relaxation and physiological protection.The application fills the application gap of lime in the field of psychological stress relief, and provides a new scheme for developing natural and safe stress relief products.

This invention pertains to compositions of polymeric compounds, specifically a recycled rubber powder modified asphalt based on a renewable composite activator, its preparation method, and its application. The recycled rubber powder modified asphalt comprises a base asphalt and activated rubber powder in a mass ratio of 1:(0.2~0.3). The activated rubber powder comprises waste tire rubber powder and a composite activator in a mass ratio of 10:(0.8~1.5). The composite activator comprises an organic phase and an inorganic phase in a mass ratio of (1.5~3):1. The organic phase is a chitosan-amino acid derivative, and the inorganic phase is a layered bimetallic hydroxide. Compared with existing technologies, the rubber powder modified asphalt prepared by this invention exhibits good high-temperature storage stability and interfacial structural integrity, demonstrating excellent anti-aging properties and high-temperature rutting resistance during long-term service.

The present invention discloses a thermoforming mold based on magnetocaloric effect, comprising a molding mold and a heating die head. The molding mold is composed of a plurality of molding molds, wherein an electromagnetic heating coil is arranged inside the molding mold. The heating die head cooperates with the molding mold, and the heating die head comprises a heating core rod, which extends into the mold cavity of the molding mold. The present invention has a reasonable design and a detailed principle. Based on the magnetocaloric effect, the invention is not directly applied to material heating, but the heating core rod is heated by the electromagnetic heating coil, and then the sealed blank is expanded and formed, thus filling the application gap of the magnetocaloric effect in the expansion forming direction and continuing the advantages of the magnetocaloric effect, so that the thermoforming mold has the advantages of environmental protection, accurate temperature control, high energy utilization rate, no need for combustion, no noise, etc., and is very suitable for promotion and application in the field of expansion forming.

The invention relates to a preparation method and application of three-coordinate nitrogen vacancy graphite phase carbon nitride, and the method for preparing benzaldehyde by using the three-coordinate nitrogen vacancy graphite phase carbon nitride for photocatalytic oxygen oxidation of cinnamyl aldehyde comprises the following steps: adding the three-coordinate nitrogen vacancy graphite phase carbon nitride into cinnamyl aldehyde or a solvent solution of cinnamyl aldehyde; introducing oxygen, turning on a visible light source for irradiation, and vigorously stirring for reaction; and filtering the catalyst and separating benzaldehyde. The addition amount of the three-coordination nitrogen vacancy graphite phase carbon nitride is 1-30% of the mass of the cinnamyl aldehyde. Stirring in dark for 5-30 minutes before reaction, and keeping the reaction temperature at 25 + / -2 DEG C; the visible light source is a 300 W xenon lamp, lambda gt; the wavelength is 420 nm, and the optical power density is 200-500 mW / cm < 2 >. The three-coordination nitrogen vacancy graphite phase carbon nitride solves the bottleneck that unmodified graphite phase carbon nitride is insufficient in application activity, poor in stability and weak in interference resistance, and the three-coordination nitrogen vacancy graphite phase carbon nitride is hardly attenuated in catalytic activity after being recycled, obviously reduced in by-product content and small in reaction microenvironment change and selectivity fluctuation.

The invention belongs to the technical field of medical services, and particularly relates to an artificial intelligence-based accompanying person and patient matching system, which comprises a user terminal, an accompanying terminal, a cloud server and an artificial intelligence matching module, and is characterized in that the user terminal, the accompanying terminal, the cloud server and the artificial intelligence matching module are connected through signals; the artificial intelligence matching module is embedded into the cloud server, comprises a demand analysis sub-module, an ability portrait sub-module and a matching decision sub-module, and is used for analyzing user demands, constructing an accompanying person ability model, calculating a matching priority and providing a basis for order pushing; through an AI intelligent analysis and bidirectional interaction order grabbing and sending mechanism, accurate and efficient matching of patient demands and accompanying personnel service capabilities is realized.

The invention provides a plant-derived active polypeptide and application thereof in prevention or treatment of Parkinson's syndrome, and belongs to the technical field of polypeptide bioengineering. The amino acid sequence of the active polypeptide is MKGASSIMYALG, and the active polypeptide is prepared from Fuding white tea raw materials through a directional two-step enzymolysis process. According to the polypeptide, the damage of 6-OHDA induced BZ555 nematode dopaminergic neurons can be remarkably reduced, and the dyskinesia of Parkinson's syndrome model animals can be remarkably improved; meanwhile, the expression level of proinflammatory factors such as IL-1beta and IL-18 in serum of a model mouse can be lowered, the content of dopamine in a nigra area of brain tissue of the model mouse can be increased, and the activity of monoamine oxidase B can be reduced. The results show that the Fuding white tea-derived active polypeptide has exact prevention and treatment effects on Parkinson's syndrome, and has important development value and wide application prospects in the field of medicines.

The invention relates to a preparation method and application method of a copper-based catalyst for electrochemical CO2 reduction, and the preparation method of the copper-based catalyst for electrochemical CO2 reduction comprises the following steps: S100: obtaining copper powder, dissolving the copper powder in a solvent, and ultrasonically mixing uniformly to obtain a copper-based mixed solution; and S200, the copper-based mixed solution is transferred into a high-pressure kettle to be heated, after the temperature rises to the preset temperature, CO2 gas is introduced into the high-pressure kettle till the high-pressure kettle is in a supercritical state, constant-temperature reaction is conducted for 3-24 h, the high-pressure kettle is cooled to the room temperature, then centrifugation is conducted, solid at the bottom is taken, washing and drying are conducted, and the copper-based catalyst for electrochemical CO2 reduction is obtained.

The invention belongs to the field of early disease diagnosis, and particularly relates to a core-shell nanoparticle labeled portable dual-mode immunoassay platform based on dynamic driving, which comprises an antibody-gold nanoparticle biological coupling system, an amplification system, a color development system and a colorimetric-atomic emission spectrum detection system. The Au-coated Cu core-shell nano-particles are dynamically driven to realize signal amplification, colorimetric preliminary screening and atomic emission accurate quantification are combined, CEA (0.02 ng / mL), cTnI (0.35 fg / mL) and A beta (10.3 pg / mL) can be detected in an ultra-sensitive manner, and the Au-coated Cu core-shell nano-particles are suitable for bedside detection of early diseases.

The application belongs to but is not limited to the technical field of indoor positioning and navigation, and discloses a GNSS signal forwarding-based indoor floor identification method and system based on CNN-SVM; the method obtains GNSS original observation data by deploying a GNSS signal forwarding system in an indoor environment, extracts satellite observation features mainly including satellite number, pseudo-range, carrier phase, signal-to-noise ratio and carrier-to-noise density ratio, extracts deep features by using a convolutional neural network, and completes floor classification by using a support vector machine, so that indoor floor identification is realized under the condition of reducing dependence on Wi-Fi or a barometer.

The present invention discloses a method for evaluating the impact of hydrological conditions on wetland bird food plants. The method first obtains bird food plant types, normalized vegetation index grid data, plant spatial distribution patterns, and hydrological data in a survey and research area, and constructs a hydrodynamic model based on the above data to obtain the spatial distribution pattern of accurate inundation time and average water depth; then, extracts food plant normalized vegetation index grid data from the data obtained in the survey and research area, and normalizes these data, then uses a random forest model for fitting regression, and combines the SHAP method to calculate the SHAP value of the sample point in the independent variable inundation time and average water depth, and then obtains the average absolute SHAP value of the sample point. By combining the hydrodynamic model and the SHAP method, the present invention can accurately obtain the two hydrological elements of the independent variable inundation time and average water depth, and quantify their impact on food plants.

The invention discloses a high-proportion new energy power system inertia response determination method and system based on frequency lowest point constraint and a storage medium. Firstly, the influence of inertia response and primary frequency modulation response on system frequency is deduced, and substitution modes of related control parameters of the inertia response and the primary frequency modulation response are obtained; then, in combination with a typical unit frequency domain control block diagram, establishing a related model in simulink; and finally, traversing possible control parameters in the system to obtain an alternative relationship between inertia response and primary frequency modulation response under the constraint of the lowest point of the frequency, and further determining the inertia response capability required by the system for maintaining safe and stable operation of the frequency.

The application provides a kind of waste oil-immersed transformer disassembly sequence planning method and system based on improved genetic algorithm, belongs to waste power transformer disassembly and recycling technical field.For the existing disassembly process of single waste oil-immersed transformer relies on artificial experience, ignores multi-physical process constraints and traditional genetic algorithm is not suitable for the problem, the disassembly task of single waste oil-immersed transformer is taken as the planning object, the tool switching time consumption in actual operation environment, the disassembly process change caused by the rust of parts, the cumulative effect of worker fatigue, the compatibility of disassembly task and specific process and the physical factors such as process safety specification are converted into computer processable mathematical constraint model by introducing multi-physical process constraints, and the optimal parallel disassembly sequence considering time efficiency and economic profit is output by constructing adaptive optimization framework based on improved genetic algorithm.The application is suitable for waste oil-immersed transformer disassembly and recycling and electric power equipment material recycling field.

The invention relates to a layered nickel-molybdenum-oxygen cluster crystal, a preparation method thereof and application of the layered nickel-molybdenum-oxygen cluster crystal to ammonia production through electro-catalysis nitrate reduction. The chemical formula of the crystal is [Ni (H2O) 3] 4 [Ni (H2O) 6] 2 [P28Mo16Ni20O170] 2.20 H2O, crystallographic parameters are an orthorhombic system, a space group is Cccm, and cell parameters a = 23.9730 (16), b = 36.550 (3), c = 20.4477 (15), alpha = 90 degrees, beta = 90 degrees, gamma = 90 degrees, and V = 17916 (2). The preparation method adopts a one-step hydrothermal synthesis method, and comprises the following steps: dispersing sodium molybdate and nickel chloride in an ethanol-water system, adding phosphoric acid to adjust the pH value, and reacting at a constant temperature of 160 DEG C for 3 days to obtain a yellow flaky crystal with a unique two-dimensional layered stacking structure. After being prepared into a working electrode, the working electrode shows good performance in the reaction of preparing ammonia by electro-catalysis nitrate reduction, the Faraday efficiency can reach 75.20% under the potential of-0.9 V vs.RHE, the ammonia yield is 10.51 mg h <-1 > mg <-1 > cat., and the working electrode has high catalytic activity, selectivity and structural stability. The invention provides a novel efficient catalyst for green low-carbon synthesis ammonia and wastewater resourceful treatment, and the application prospect is wide.

The invention discloses a preparation method of a high-bearing-capacity corrosion-resistant PAI / PTFE / BTO composite coating bottomed by terminated diisocyanate, and belongs to the technical field of functional coating materials. According to the technical scheme, the preparation method is characterized by comprising the following steps: carrying out surface modification on nano barium titanate by adopting gamma-aminopropyltriethoxysilane to obtain KH550 modified BTO; micron-sized PTFE is ground and dispersed through a conical mill; preparing a phenol-terminated diisocyanate bottoming solution; compounding the modified BTO, the dispersed PTFE and PAI resin, and performing ultrasonic dispersion to obtain a composite coating; the end-capped MDI priming solution is sprayed to a metal matrix to form a wetting layer, then the composite coating is sprayed, and the target coating is obtained through two-stage curing treatment. According to the coating, the low friction coefficient is kept, meanwhile, the bearing capacity, the wear resistance and the neutral salt mist resistance are remarkably improved, and the coating is suitable for metal friction pair surface protection under the severe working conditions of heavy loads, wet corrosion and the like.

This invention relates to a method for recovering associated zinc from copper concentrate during copper smelting, belonging to the field of non-ferrous metal smelting and mineral processing technology. The method includes: preparing and grinding copper concentrate to obtain a finely ground slurry; the -0.074 mm particles in the finely ground slurry constitute 92-95% of the total solid particles; mixing the finely ground slurry with a copper collector and a zinc inhibitor; the zinc inhibitor contains sulfur dioxide, and the mixing temperature of the zinc inhibitor and the finely ground slurry is 40-50°C; and using microbubble flotation technology to separate copper from zinc concentrate using flotation, obtaining copper concentrate and zinc concentrate; the foam diameter of the microbubble flotation is 30-80 μm. This invention achieves efficient inhibition of zinc minerals by controlling the copper flotation separation temperature, at which waste sulfur dioxide is used synergistically as a zinc inhibitor, further controlling the particle size of the fine grinding and the foam diameter during flotation, thus constructing an integrated copper-zinc separation and zinc recovery process.

The application discloses an oral care toothpaste containing snake lily original medicinal material powder and a preparation method thereof, and belongs to the oral care preparation field. The core innovation is that the snake lily original medicinal material superfine powder prepared by a specific process is used as a core component, and a plurality of auxiliary materials are compounded to form a synergistic system, so that the effects of analgesia, anti-inflammation, caries prevention and anti-allergy are achieved; the snake lily original medicinal powder is treated through raw material screening, vinegar preparation detoxification, superfine crushing and multi-step coating embedding process, so that the toxicity and bitterness are effectively reduced, and the active component extraction efficiency is improved. The application solves the problems of the existing anti-inflammatory and analgesic toothpaste, such as large side effects and limited effects, and provides a new scheme for oral care.

The invention relates to a preparation method and application of metoclopramide nitrosamine impurities. The preparation method comprises the following steps: adding 4-amino-5-chloro-N-[2-(ethylamino) ethyl]-2-methoxybenzamide and a reaction solvent into a beaker, stirring while adding a nitrosation reagent, controlling the temperature at 20-30 DEG C, and reacting for 5-20 hours; after the reaction is finished, column chromatography silica gel is added, a sample is stirred, after concentration, the stirred sample is subjected to column chromatography purification, and 4-amino-5-chloro-N-(2-(ethyl (nitroso) amino) ethyl)-2-methoxybenzamide is obtained; the application blank of the impurity in a high-end quality control scene in metoclopramide is filled.

This invention provides a plant-derived bioactive polypeptide and its use in the prevention or treatment of Parkinson's syndrome, belonging to the field of polypeptide bioengineering technology. The amino acid sequence of the bioactive polypeptide is MKGASSIMYALG, and it is prepared from Fuding white tea raw materials through a directed two-step enzymatic hydrolysis process. This polypeptide can significantly alleviate 6-OHDA-induced damage to dopaminergic neurons in BZ555 nematodes and significantly improve motor dysfunction in Parkinson's syndrome model animals. Simultaneously, it can downregulate the expression levels of pro-inflammatory factors such as IL-1β and IL-18 in the serum of model mice, upregulate dopamine content in the substantia nigra region of brain tissue in model rats, and reduce monoamine oxidase B activity. These results indicate that the Fuding white tea-derived bioactive polypeptide of this invention has definite preventive and therapeutic effects on Parkinson's syndrome, and has significant development value and broad application prospects in the pharmaceutical field.

The application provides a multi-stage cavitation steam generator, which comprises a shell, a motor, a multi-stage cavitation assembly arranged in the shell, the multi-stage cavitation assembly comprising alternating dynamic cavitation discs and static cavitation discs, the dynamic cavitation discs being connected with the driving shaft of the motor and rotating synchronously with the driving shaft, and the static cavitation discs being connected with the inner wall of the shell; the opposite end faces of the dynamic cavitation discs and the static cavitation discs are respectively provided with radially distributed inclined tooth structures, the inclined teeth of the dynamic cavitation discs and the inclined teeth of the static cavitation discs form interlocking engagement, and the engagement gap is adjustable. The multi-stage cavitation steam generation system comprises a heat preservation water tank, a water supply pump, the multi-stage cavitation steam generator, a steam-water separator, a steam reciprocating pump, a steam distribution cylinder, a first reheater and a second reheater. The application can improve the thermal energy conversion efficiency, realize large-flow and high-efficiency heating, and has the advantages of green environmental protection, strong anti-fouling capacity and the like. The generated steam is suitable for heating, drying and disinfection, industrial humidification, rubber and plastic plasticization and other scenes requiring steam.

The invention belongs to the technical field of plant molecular breeding, and particularly relates to a group of Indel molecular markers related to soybean phytophthora resistance traits and application. The molecular marker provided by the invention is developed aiming at a GmLLG1 gene and a GmLLG2 gene in a soybean Gmlg1Gmlg2 double mutant. The molecular marker group provided by the invention can accurately identify the double-mutation genotype of soybean Gmlg1Gmlg2, and soybean materials containing the double-mutation genotype can be quickly and efficiently screened by utilizing the group of molecular markers, so that early directional selection and molecular marker-assisted breeding of soybean phytophthora resistance traits are realized; the breeding efficiency of a new soybean variety resisting phytophthora sojae is remarkably improved, and a key technical support is provided for green prevention and control of the phytophthora sojae.

The application discloses a preparation method and application of a discodermolide compound. Aspergillus nidulans The discodermolide compound is obtained from a strain of Aspergillus nidulans SE44 Aspergillus nidulans The strain of Aspergillus nidulans SE44 is preserved in the Guangdong Microbial Culture Collection Center on April 15, 2026, and has a preservation number of GDMCC No:68088. It is found that discodermolide A can target the activation of LXR alpha by covalently combining with the R305 site of the LXR alpha protein, thereby regulating the LXR alpha-SLC31A1 signal pathway, inhibiting the generation of ROS, reducing the damage of oxidative stress to kidney tissue, and achieving the treatment effect on acute kidney injury.