2 results about "Directional selection" patented technology

Provided are a high-stability recombinant type I collagen and a use thereof, relating to the technical field of collagens. By means of the directional selection of existing amino acid sequences, potential enzyme cutting sites and unstable sequence fragments are avoided during sequence design, enabling efficient expression in Pichia pastoris; and in addition, after being purified, the recombinant type I collagen still has high stability. The recombinant type I collagen takes into account factors such as related biological active sites and hydrophilicity, has related biological activity while maintaining high stability, and has good practicability.

This invention provides a method, apparatus, device, and medium for medical feature selection, relating to the field of medical data processing technology. It addresses the technical problem of insufficient accuracy in selecting optimal feature subsets. The method comprises: constructing an improved aurora optimization algorithm that includes an archive-driven population evolution strategy and a directional selection mechanism based on a reference feature subset. The former uses a search mode with the centroid of failed archives as the reference feature subset in the early stages of iteration, guiding the population away from the centroid of failed archives to avoid inferior feature regions; in the later stages of iteration, it uses a search mode with the centroid of successful archives as the reference feature subset, guiding the population to converge towards the centroid of successful archives. The latter constructs a directional update direction vector based on the difference between the reference feature subset selected by the archive-driven population evolution strategy and the current feature subset, guiding the directional update of the feature subset. This can select the optimal feature subset that better meets the data analysis needs of the target medical dataset.