7 results about "Genetic linkage" patented technology

To provide simple and efficient means for predicting the risk of side effects in chemotherapy for pancreatic cancer.SOLUTION: The single nucleotide polymorphism of any of (a) to (c): (a) a single nucleotide polymorphism identified by rs1980576 in APCDD1 L gene or a single nucleotide polymorphism in linkage disequilibrium or genetic linkage with the single nucleotide polymorphism; (b) a single nucleotide polymorphism identified by rs2272761 in R3HCC1 gene or a single nucleotide polymorphism in linkage disequilibrium or genetic linkage with the single nucleotide polymorphism; and (c) a single nucleotide polymorphism identified by rs9425343 in EDEM3 gene or a single nucleotide polymorphism in linkage disequilibrium or genetic linkage with the single nucleotide polymorphism, which are present on the genomic DNA in a biological sample taken from a subject, is analyzed, the genotype for the single nucleotide polymorphism is determined, and based on the determined genotype, the prediction of the risk of side effects when chemotherapy for pancreatic cancer is performed is assisted.SELECTED DRAWING: None

Systems and methods that integrate structural biology, artificial intelligence, and psychology / psychiatry to explore the physical boundaries of self-consciousness are described. Parallels between protein interactions and psychological self-structures are drawn to analyze and visualize patterns in self-report questionnaire data. Variation in self-report response patterns across individuals can be leveraged to map the topology of self-consciousness boundary, akin to genetic linkage mapping. It is thus possible to conduct whole psyche analysis and leverage variations in the response patterns across individuals to solve the physical topology of the self-boundary.

The invention relates to the technical field of plant molecular biology, in particular to application of a Unicaulis gene for regulating and controlling growth of tomato axillary buds in tomato breeding. The Uniicaures gene is used for positively regulating and controlling the elongation and growth of lateral branches of tomatoes, and the nucleotide sequence of the Uniicaures gene is as shown in SEQ ID NO. 1; the amino acid sequence of the encoding protein of the Unicaulis gene is as shown in SEQ ID NO. 2. The tomato lateral branch elongation growth gene Unicaulis is positively regulated and controlled by constructing a genetic linkage group, finely positioning and cloning, and by overexpressing the Unicaulis gene in a tomato lateral branch-free plant or increasing the content of the encoding protein of the Unicaulis gene, the accumulation amount of auxin at the axilla part of a transgenic plant is reduced, and the lateral branch of the tomato can normally sprout and obviously grow. The Unicaulis gene or the encoded protein thereof provided by the invention can significantly reduce the accumulation amount of auxin in the axillary part of the tomato plant, relieve the apical dominance of the tomato plant to lateral branches, accelerate the extension and growth of axillary buds of the axillary part of the tomato plant into lateral branches, and provide gene resources and new germplasm for cultivating tomato varieties with strong lateral branches.

The application discloses a molecular marker, a primer combination, a kit and application related to fruit orientation of Chinese pepper. The application successfully locates a key variation site related to fruit orientation of Chinese pepper on the upstream of Up gene by combining comparative genomics and resequencing analysis, designs a molecular marker primer based on the variation site, and verifies that the variation can affect fruit orientation by using a Chinese pepper population. The development and utilization of the molecular marker can precisely identify fruit orientation of Chinese pepper at the seedling stage. Unlike traditional genetic linkage markers, the molecular marker of the application is located on the upstream of the gene, not a linkage marker, and therefore has higher identification effect and accuracy.

The present application is related to markers which have been determined to be genetically linked to a locus which provides resistance to southern leaf blight (SLB). Maize plants comprising newly conferred or increased resistance to SLB, relative to control plants, are also provided herein.

The invention relates to a method for detecting nucleoplasm gene loci having an interaction effect with agronomic traits, which comprises the following steps: pairing nuclear genome SNP data and mitochondrial genome SNP data, calculating a genetic linkage imbalance coefficient between the nuclear genome SNP data and the nucleoplasm of each mitochondrial genome SNP, taking each nuclear genome SNP as a core, and calculating the genetic linkage imbalance coefficient between the nuclear genome SNP data and each mitochondrial genome SNP; nuclear genome SNP and mitochondrial genome SNP pairs with abnormal and prominent linkage strength are screened out to serve as candidate cytoplasmic interaction coupling pairs, a mixed linear model is constructed to implement GWAS analysis, and cytoplasmic gene loci with an interaction effect with agronomic traits are screened out. According to the method, the nucleoplasm gene loci with high relevance with the agronomic traits to be detected are screened out, so that the calculation power and time required by analysis can be greatly reduced, and the workload of molecular genetic research on the agronomic traits of the crops is reduced. According to the method, the result is obtained through analysis by software, the analysis steps are simple, the consumed time is short, the nucleoplasm gene loci are accurately detected, and the application range is wide.

The current disclosure relates to methods and compositions for improving plant varieties through plant breeding and plant genetics. For instance, the disclosure concerns increasing the recombination frequency of a heterozygous trait genetically linked to a second trait within plants. Further, the disclosure concerns breaking the genetic linkage between a first allele and a second allele.