Anti-gout broadleaf holly leaf preparation and preparation method and application thereof

A technology of anti-gout and Kudingcha, which is applied in the field of Kudingcha preparation and its preparation, can solve the problems of no scientific basis for the mechanism of action, insignificant curative effect, and large liver and kidney damage, and achieve low cost, obvious effect, and reduced Effect of Uric Acid Levels

Inactive Publication Date: 2019-05-31
TONGHUA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing clinical medicines for the treatment of gout have no obvious curative effect, great liver and kidney damage, and are expensive.
[0006] So far, there is no scientific basis for whether the extract of Kudingcha can reduce the level of uric acid in the blood and its mechanism of action

Method used

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  • Anti-gout broadleaf holly leaf preparation and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] A kind of Kudingcha tablet with anti-gout effect, the preparation method steps are as follows:

[0014] Extraction: Take 2 kg of Kudingcha, soak and extract, concentrate the extract, dry (freeze-drying), pulverize and sieve (pass through a 120-mesh sieve) for later use.

[0015] Mixing: Mix the crushed Kudingcha extract with the auxiliary dextrin in a weight ratio (5:1).

[0016] Granulation: The above mixture is granulated by wet method or dry method, and the moisture in the granules is controlled to be 5-8% after drying.

[0017] Mixing: the granules after strong drying are granulated, and talc powder is added after finishing, and after mixing, it is put into a three-dimensional mixer for total mixing for 10-15 minutes.

[0018] Compression: Compress the blended granules to obtain a tablet with an average tablet weight of 0.5 g.

[0019] Efficacy: Kudingcha tablets prepared by this method are suitable for gout caused by various reasons. It is suitable for inflammat...

Embodiment 2

[0022] A Kudingcha capsule with anti-gout effect, the preparation method steps are as follows:

[0023] Take 2 kg of Kudingcha, soak and extract, concentrate the extract, dry (freeze-drying), pulverize and sieve (pass through a 120-mesh sieve) for use. Fill the crushed extract into No. 0 capsules, and wait for the anti-gout effect Kudingcha capsules.

[0024] Efficacy: Kudingcha tablets prepared by this method are suitable for gout caused by various reasons. It is suitable for inflammation, fever and joint pain caused by ventilation.

[0025] Dosage: Oral capsule 3 times a day, 2 capsules each time.

Embodiment 3

[0027] A kind of Kudingcha oral liquid with anti-gout effect, the preparation method steps are as follows:

[0028] The preferred Kuding tea leaves (coarse powder) 200g, soaked in water for 2 hours, after supplementing the water absorption, add 10 times the amount of water to decoct for 1 hour, filter, add 8 times the amount of water for the residue and decoct for 1 hour, combine the two filtrates, and filter again , concentrated to 200mL, and slowly added 95% ethanol when cooled to 40°C to make the alcohol content reach 600mL·L -1 , After fully stirring, let stand for 24h, filter the supernatant, and recover ethanol until it is tasteless. Add ethanol again to make the alcohol content reach 750mL·L -1 , Fully stirred, let stand for 24h, the supernatant was collected by filtration, and ethanol was recovered until it was odorless. The filtrate is added with an appropriate amount of flavoring agent, and dissolved to 1000ml to obtain Kudingcha oral liquid with anti-gout effect. ...

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Abstract

The invention relates to an anti-gout broadleaf holly leaf preparation and a preparation method and application thereof. The broadleaf holly leaf is fragrant with a bitter taste, and then sweet and cool, and has the effects of clearing heat and relieving summer heat, improving eyesight and intelligence, achieving dieresis and strengthening the heart, wetting the whistle and relieving a cough, lowering blood pressure and losing weight, resisting and preventing cancer, resisting aging and activating blood circulation and can also be used for treating gout diseases. Oral administration and injection of an extract have an obvious effect on a hyperuricemia model of mice caused by sodium urate, and are close to a positive control group of allopurinol. The anti-gout broadleaf holly leaf preparation has small toxic and side effects due to the fact that the anti-gout broadleaf holly leaf is homologous in drugs and food. At the same time, the preparation has cardiovascular and cerebrovascular protection and anti-inflammatory effects, and is an ideal anti-gout drug.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a Kudingcha preparation with anti-gout effect and a preparation method and application thereof. Background technique [0002] In the prior art, gout (scientific name: metabolic arthritis) is a disease caused by purine metabolism disorder and the accumulation of uric acid. It belongs to a type of arthritis, also known as metabolic arthritis. The clinical manifestations are hyperuricemia, gouty acute arthritis, tophi deposition, characteristic chronic arthritis and arthritic deformities, often involving the kidney, causing chronic interstitial nephritis and renal uric acid stones. Epidemiology shows that the prevalence of gout in Europe and the United States is 0.2%-1.7%. In my country, the incidence of gout has been on the rise in recent years, and the prevalence of the general population in my country is about 1.14%. The incidence of gout in wealthy areas of my count...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P19/06
Inventor 刘雪坤王艳秋朱俊义李靖媛耿晓宇马珑廷
Owner TONGHUA NORMAL UNIV
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