Curcumin preparation and its making method

A technology of curcumin fat emulsion and curcumin, which is applied in the field of medicine, can solve the problems of easily causing allergic reactions and hemolytic reactions, low bioavailability, and increasing the dosage of patients, so as to increase pharmacological effects and curative effects, and reduce adverse drug effects Response, prolonging the effect of drug action time

Inactive Publication Date: 2007-01-17
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although curcumin has promising development prospects, its poor water solubility and fat solubility not only bring difficulties to the research and development of preparations, but also lead to extremely low bioavailability, which limits its clinical application
The domestic patent CN03143234.4 describes a soft capsule characterized by curcumin and vegetable oil or polyethylene glycol content. Only a small amount of curcumin can be dissolved in the above content, thereby increasing the dosage of patients; The long-chain fatty acid vegetable oil has a slow metabolism in the body and cannot reflect the advantage of improving bioavailability
[0009] Domestic patent CN200410036402.3 proposes to improve the bioavailability of curcumin in the form of simple phospholipid complex, but its effect is limited
Also CN200510042547.9 proposes the self-emulsification of curcumin, but the poor fat-soluble properties of curcumin make it only possible to dissolve in a small amount in the content, using the

Method used

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  • Curcumin preparation and its making method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] (1) Preparation of curcumin precursor:

[0076] Weigh 37.0g of curcumin and 75.0g of soybean lecithin, add them into ethyl acetate, and react for 50 minutes at 40°C through a heating and reflux reaction device until the solution is clear, add 200.0g of caprylic triglyceride, and volatilize with a rotating film Solvent method to evaporate ethyl acetate until completely removed, that is.

[0077] (2) Preparation of curcumin pre-concentrate:

[0078] Add 53.0 g of polyoxyethylene (35) castor oil to the curcumin precursor prepared above, ultrasonicate until the system is uniform and clear, fill and seal to prepare about 1000 hard capsules.

Embodiment 2

[0080] (1) Preparation of curcumin precursor:

[0081] Weigh 37.0 g of curcumin and 150.0 g of egg yolk lecithin, add them into tetrahydrofuran, and react for 90 minutes at 60° C. through a heating reflux reaction device until the solution is clear, add 413.0 g of capric triglycerides, 50 g of corn oil, and Spin the thin film to evaporate the solvent and evaporate the tetrahydrofuran until it is completely removed.

[0082] (2) Preparation of curcumin pre-concentrate:

[0083] Add 100.0 g of polyoxyethylene (35) hydrogenated castor oil to the curcumin precursor prepared above, heat at 60° C. until the system is uniform and clear, and use a compression method to prepare about 1,000 soft capsules with an automatic rotary encapsulation machine.

Embodiment 3

[0085] (1) Preparation of curcumin precursor:

[0086] Weigh 74.0g of curcumin and 225.0g of dipalmitoylphosphatidylcholine, add them into chloroform, and react for 160 minutes at 80°C through a heating reflux reaction device until the solution is clear, and add 500.0 caprylic acid diglycerides g, 200 g of soybean oil, obtained by volatilizing chloroform until completely removed by the method of rotating thin film volatilization solvent.

[0087] (2) Preparation of curcumin pre-concentrate:

[0088] Add 200.0 g of polysorbate 80 to the curcumin precursor prepared above, sonicate until the system is uniform and clear, fill and seal to prepare about 2000 hard capsules.

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Abstract

A curcumin medicine for preventing and treating cancer and cardiovascular and cerebrovascular disease includes a pre-concentrated curcumin liquid in the form of softgel and prepared from the precursor of curcumin and emulsifier and a fatty curcumin emulsion prepared from the precursor of curcumin, emulsifier, antioxidant, isotonic regulator, stabilizer, pH regulator, and the water for injection. It can also provide energy to the patient.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a curcumin preparation capable of greatly improving bioavailability and a preparation method thereof. Background technique [0002] Curcumin is the orange crystal or powder extracted and refined from the roots or rhizomes of turmeric, curcuma, and turmeric. There are three main components: 1 is curcumin (Curcumin), also known as curcumin I; 2 is demethoxycurcumin (Demethoxycurcumin), that is, curcumin II; 3 is bisdemethoxycurcumin (Bjsdemethoxycurcumin) , namely curcumin III, the three structural formulas are as follows: [0003] [0004] 1. Curcumin: R1=R2=OMe [0005] 2. demethoxyeurcumin: RI=H, R2=OMe [0006] 3. bisdemethyoxycurcumin RI=R2=H [0007] Curcumin has a wide range of pharmacological effects, and has various biological activities such as anti-inflammation, anti-oxidation, anti-coagulation, hypolipidemic, anti-atherosclerosis, anti-mutagenesis, anti-virus an...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61K36/9066A61K9/48A61K9/107A61K47/24A61K47/44A61P29/00A61P39/06A61P3/06A61P9/10A61P31/12A61P35/00A61P1/16
Inventor 陈建明熊俊峰高保安
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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