Preparation method of solid dispersant containing fucoidin and curcumin and application thereof

A technology of solid dispersion and fucoidan is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. The preparation method is complex and other problems, so as to achieve the effect of preventing and treating gastric Helicobacter pylori infection, repairing ulcer tissue and reducing gastrointestinal inflammatory response.

Active Publication Date: 2018-12-21
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in the current research, in order to improve the dissolution rate of curcumin, curcumin was prepared into solid dispersion by melting method and solvent evaporation method to improve the dissolution rate and bioavailability of curcumin, but these preparation methods are relatively complicated
[0008] Currently, there is no report on the combination of fucoidan and curcumin

Method used

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  • Preparation method of solid dispersant containing fucoidin and curcumin and application thereof
  • Preparation method of solid dispersant containing fucoidin and curcumin and application thereof
  • Preparation method of solid dispersant containing fucoidin and curcumin and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1. Preparation of solid dispersion: weigh curcumin 0.4g and fucoidan 1.6g, PEG6000 2.0g (curcumin: fucoidan: PEG6000 is 1:4:5), mix well, put in a mortar and grind, The rotation speed is 500rpm, the grinding time is 90min, take it out, and pass through a 90-mesh sieve to obtain the product.

[0040] Comparative example experiment: accurately take by weighing about 0.04g of pure curcumin (according to the curcumin content in the solid dispersion is 10% calculation); The physical mixture (curcumin content 10%) of curcumin and PGE6000 is about 0.4g; Curcumin and PGE6000 Solid dispersion (curcumin content 10%) 0.4g, adopts above-mentioned same grinding method.

[0041] 2. Dissolution test evaluation.

[0042] ① Chromatographic conditions: Chromatographic column: DiamonsilC from Dikma Company (250mm×4.6mm); mobile phase: methanol: water: acetic acid (77:22:1); detection wavelength: 428nm; flow rate: 1.0mL / min; column temperature: 25°C .

[0043]②Standard curve: Accurately...

Embodiment 2

[0048] The difference from Example 1 is that 0.4g of curcumin, 2.0g of fucoidan, and 1.6g of PEG4000 are weighed, mixed evenly, and ground in a mortar with a rotation speed of 300rpm and a grinding time of 80min, taken out, and passed through an 80-mesh sieve to obtain Solid dispersion. The detection method is the same.

Embodiment 3

[0050] The difference from Example 1 is that 0.4g of curcumin, 2.0g of fucoidan, and 1.6g of PEG10000 are weighed, mixed evenly, and ground in a mortar with a rotation speed of 500rpm and a grinding time of 100min, taken out, and passed through a 90-mesh sieve to obtain . The detection method is the same.

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Abstract

The invention discloses a preparation method of a solid dispersant and application. The preparation method is characterized in that fucoidin with low molecular weight and PEG (polyethylene glycol) with molecular weight of 4000 to 10000 are used as combined dispersing mediums, curcumin is used as a dispersing substance, and a grinding method is adopted, so as to prepare the solid dispersion. Compared with the solid dispersion single using PEG6000 or curcumin, the solid dispersion has the advantages that the solubilization effect is better; the fucoidin and curcumin compound preparation is usedfor preventing and treating the helicobacter pylori infection and protecting the gastric mucosa; particularly, on the basis of anti-sticking property and immunity-regulating function of the fucoidin,and the anti-oxidizing and inflammation-diminishing functions of the fucoidin and the curcumin, the greater prospect is realized on overcoming the drug resistance of helicobacter pylori, and preventing and treating the infection of helicobacter pylori; the solid dispersion can be further prepared into the fucoidin and curcumin compound preparation, such as powders, tablets, capsules, granules or dry-mix suspenions.

Description

technical field [0001] The invention relates to a preparation method and application of a solid dispersion with low molecular weight fucoidan and PEG4000-10000 as a joint dispersion medium and curcumin as a dispersant for preventing and treating gastric Helicobacter pylori infection and protecting gastric mucosa. Background technique [0002] Helicobacter pylori (Hp) infection is an important cause of chronic gastritis and most peptic ulcers, and is closely related to gastric mucosa-associated lymphoid tissue (MALT) malignant lymphoma. WHO has listed Hp as the first carcinogen . Drug resistance is a very difficult problem in the treatment of Helicobacter pylori, 15-20% of the cases cannot eradicate the pathogen due to drug resistance, and most of the successfully treated patients may still be re-infected in the next 3-5 years, looking for New ways to combat the disease are an urgent problem. [0003] Fucoidan is extracted from brown algae. It is a kind of seaweed polysacch...

Claims

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Application Information

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IPC IPC(8): A61K31/737A61K31/12A61K9/14A61K47/10A61P31/04A61P1/04
CPCA61K9/14A61K31/12A61K31/737A61K47/10A61P1/04A61P31/04A61K2300/00
Inventor 翟光喜王汝娟
Owner SHANDONG UNIV
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