Method for preparing folic acid
A technology of folic acid and sulfate, applied in the direction of organic chemistry, can solve the problems of high production cost, low yield, complicated process, etc., and achieve the effect of improving product quality, increasing product yield, and enhancing product quality
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Embodiment 1
[0037] (1) First prepare the intermediate product N-p-aminobenzoylglutamic acid:
[0038] a. Weigh the raw materials:
[0039] P-Nitrobenzoyl chloride: 100Kg
[0040] Sodium glutamate: 100Kg
[0041] b. The condensation reaction and the reduction reaction are carried out in sequence:
[0042] Condense the p-nitrobenzoyl chloride and sodium glutamate that meet the above-mentioned ratio requirements for 1 to 2.5 hours at a temperature of 5-15°C and a pH of 7-9; then add hydrochloric acid to adjust the pH to 4.0- 6.5, then use hydrogen in the nickel-aluminum alloy catalyst at a temperature of 30-70℃ to carry out the reduction reaction. The amount of the nickel-aluminum alloy catalyst is 1 / 15 of the weight of the reduced substance; after the reaction is completed, the pH is adjusted to 1.0~3.0 with hydrochloric acid , Get the intermediate product N-p-aminobenzoyl glutamic acid;
[0043] (2) Re-preparing the intermediate product 6-hydroxy-2,4,5-triaminopyrimidine sulfate:
[0044] a. W...
Embodiment 2
[0060] (1) First prepare the intermediate product N-p-aminobenzoylglutamic acid:
[0061] a. Weigh the raw materials:
[0062] P-Nitrobenzoyl chloride: 100Kg
[0063] Sodium glutamate: 110Kg
[0064] b. The condensation reaction and the reduction reaction are carried out in sequence:
[0065] Condense the p-nitrobenzoyl chloride and sodium glutamate that meet the above requirements for 2.5-3.5 hours at a temperature of 10-15°C and a pH of 9-10; then add hydrochloric acid to adjust the pH to 6.5- 7.0, then use hydrogen in the nickel-aluminum alloy catalyst at a temperature of 70-90℃ to carry out the reduction reaction. The amount of the nickel-aluminum alloy catalyst is 1 / 10 of the weight of the reduced substance; after the reaction is completed, the pH is adjusted to 3.0~3.5 with hydrochloric acid. Obtain the intermediate product N-p-aminobenzoyl glutamic acid;
[0066] (2) Re-preparing the intermediate product 6-hydroxy-2,4,5-triaminopyrimidine sulfate:
[0067] a. Weigh the raw ...
Embodiment 3
[0083] (1) First prepare the intermediate product N-p-aminobenzoylglutamic acid:
[0084] a. Weigh the raw materials:
[0085] P-Nitrobenzoyl chloride: 100Kg
[0086] Sodium glutamate: 200Kg
[0087] b. The condensation reaction and the reduction reaction are carried out in sequence:
[0088] Condense the p-nitrobenzoyl chloride and sodium glutamate that meet the above-mentioned ratio requirements for 3 to 5 hours at a temperature of 15-30°C and a pH of 9 to 11; then add hydrochloric acid to adjust the pH to 6.0 to 7.0, then use hydrogen under the action of a palladium-carbon catalyst at a temperature of 80-100℃ to carry out the reduction reaction. The amount of the palladium-carbon catalyst is 1 / 15 of the weight of the reduced product; Product N-p-aminobenzoyl glutamic acid;
[0089] (2) Re-preparing the intermediate product 6-hydroxy-2,4,5-triaminopyrimidine sulfate:
[0090] a. Weigh the raw materials:
[0091] Methyl cyanoacetate: 100Kg
[0092] Guanidine nitrate: 200Kg
[009...
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