Super micronization method for botanical medicinal, product obtained thereby and use thereof

Abstract

The invention relates to a method for making stem drug containing xylon and cellulose into ultra micro powder, wherein said method comprises that: mechanically breaking; exploding via steam, treating at low temperature, breaking via airflow, enzyme hydrolyzing via microbe enzyme and extracting and separating. The invention also provides relative product and its application for preparing drug, transferring drug element, etc.

Description

technical field [0001] The present invention relates to a method for supermicronization of plant medicinal materials, more specifically, the present invention relates to a method for supermicronization of rhizome medicinal materials rich in lignocellulose, and the supermicronization method obtained by the method. Products and their application in the development of new preparations of traditional Chinese medicine, extraction and transformation of active pharmaceutical ingredients of raw materials, and preparation of fermented products. Background technique [0002] Ultramicronization technology belongs to the field of new materials technology, and is an interdisciplinary and inter-industry high-tech born in the early 1970s. It generally refers to the pulverization process of crushing material particles above 3mm to below 25μm. After the material is ultra-micronized, it becomes an ultra-fine powder. Due to the increase of the specific surface area of ​​the particles, the incr...

AI Technical Summary

Problems solved by technology

Nevertheless, it is found in practice that the ultrafine powder Chinese herbal decoction pieces obtained by purely physical methods—especially the ultrafine powder Chinese herbal medicine pieces rich in lignocellulose-based rhizome herbal medicines—still have the following disadvantages: 1) rhizome It is one of the most prominent lignified medicinal parts in medicinal plants. The lignin, hemicellulose and cellulose content of most rhizome medicinal materials are more than 30% of the dry weight, and some even exceed 50%. Large hardness and toughness, so in the process of physical micronization, greater energy consumption and mechanical loss occur than other medicinal parts (such as seeds, leaves, etc.)

In addition, the presence of a large amount of lignocellulose makes the various organizational structures and substructures of plant cells tenaciously protected, and the structural barrier effect on active ingredients is more obvious. Separation of Active Components and Irrelevant Components in Rhizome Medicinal Materials

2) Due to the existing ultra-micronization process and the subsequent granulation process of conventional oral dosage forms (tablets, capsules, granules, granules, etc.), due to the existence of cytoskeleton structures such as lignin and cellulose, the processing raw materials have great dispersion. nature, it will produce relatively large dust pollution, which will cause harm to the health of operators to a certain extent, and will also cause certain environmental pollution.

3) The preparation process of ultrafine powder Chinese herbal pieces is currently limited to physical pulverization (mainly mechanical and airflow pulverization), and the efficiency is not high; the production process of rhizome herbal medicines rich in lignocellulose is time-consuming and energy-consuming. The proportion and state of lignin and cellulose significantly affect the uniformity of particle size and the quality control of the final product, resulting in higher production costs, which will increase the cost of medication for patients, which is not conducive to improving the ability of patients to seek medical treatment and the quality of the middle Popularization of medicine

4) Oral preparations directly prepared from ultra-fine powder Chinese herbal pieces, because they contain a large amount of lignin and cellulose components that should be discarded with the dregs in the past, not only still have structural barrier effects after taking, affecting the dissociation and absorption of active ingredients, As a result, the hepatic and intestinal first-pass effect and bioavailability are low, and the lignin and cellulose that are not digested and absorbed by the human gastrointestinal tract will further weaken the dissolved pharmaceutical active ingredients by reversely absorbing water and stimulating gastrointestinal emptying. Adhesion and absorption, resulting in unstable blood drug concentration, which affects the efficacy of the drug, and ultimately affects the therapeutic effect of oral drugs

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