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Medicine composition containing matrine class alkaloid, preparation method and pharmaceutical application

A technology of matrine and alkaloids, which is applied in the field of medical drugs and can solve the problems of single drug varieties and pharmaceutical uses

Inactive Publication Date: 2010-06-09
QINGDAO QIYUAN BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a compound medicine containing matrine alkaloids, a preparation method and a pharmaceutical application, which can solve the problems in the prior art such as single drug variety and pharmaceutical use

Method used

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  • Medicine composition containing matrine class alkaloid, preparation method and pharmaceutical application
  • Medicine composition containing matrine class alkaloid, preparation method and pharmaceutical application
  • Medicine composition containing matrine class alkaloid, preparation method and pharmaceutical application

Examples

Experimental program
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Effect test

Embodiment 1

[0039] This embodiment provides a kind of aspirin (also known as acetylsalicylic acid; HOOCC) in matrine and non-steroidal anti-inflammatory drugs 6 h 4 OCOCH 3 ; Molecular weight: 180.16) is prepared into the injection of compound medicine.

[0040] The molar ratio of matrine and aspirin is 1:4.

[0041] First, choose aspirin 720.64g (molecular weight: 180.16), matrine 248.36g (molecular weight: 248.36), and water for injection 10000ml.

[0042] The preparation method is as follows: weigh 720.64 g of aspirin and 248.36 g of matrine in an aseptic operation room, the molar ratio of aspirin and matrine is 4:1, place them in a sterile container, add about 1000 ml of sterile water for injection, Stir to dissolve, use sodium hydroxide to adjust the pH value within the range of 6.5 to 7.5, add sterile water for injection to 10000ml, stir well, then add 0.02% activated carbon, stir for 5-10 minutes, and spread 2 layers with a sterile suction filter funnel Filtrate with sterilized...

Embodiment 2

[0044] This example provides a preparation method for making compound tablets from inorganic salts of sophocarpine and berberine. Berberine Hydrochloride Molecular Formula C 20 h 18 NO 4 .Cl, molecular weight: 384.43.

[0045] Choose berberine 38.443g, sophocarpine 24.635g (molecular formula C 15 h 22 N 2 O; molecular weight 246.35), the mol ratio of berberine and sophocarpine is 1: 1, starch 40g, starch slurry 24g, dry starch 23g, magnesium stearate 3g.

[0046] The preparation method is as follows: pass berberine and sophocarpine through an 80-mesh sieve, mix them evenly with starch, add 10% starch slurry to make a soft material, use a 14-mesh sieve to make granules, dry at 70-80°C, and then 12-mesh Sieve for granulation, add dry starch and magnesium stearate for mixing, and press into tablets to prepare.

Embodiment 3

[0048] This example provides a preparation method of diclofenac sodium and matrine total alkaloid capsules.

[0049] (1) Extraction of total alkaloids of Sophora flavescens: take 100 g of Sophora flavescens root powder, wet and expand with 50ml 0.1% hydrochloric acid solution, put it into the percolation cylinder, add 500ml 0.1% hydrochloric acid to soak for 4 hours, pass through 732 strong acidic cation exchange resin, Pass through the column at 4-5ml / min, pour the resin from the column, put it in the disk to dry; adjust the resin to pH8 with 10% ammonia water, put the resin into a Soxhlet extractor, extract with ethanol reflux, concentrate under reduced pressure, The ethanol was recovered to obtain a brown syrup, which was dried under reduced pressure. The experiment was repeated 5 times, and the average yield was 3.10%.

[0050] (2) Choose 120g of diclofenac sodium (molecular weight 318.13), 80g of Sophora flavescens extract (the total alkali content is 60-80%, which contai...

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Abstract

The invention provides a medicine composition containing matrine class alkaloid, a preparation method and pharmaceutical applications. The medicine composition is the combination of the matrine class alkaloid and inflammation-resisting pain-relieving class medicines. The inflammation-resisting pain-relieving medicine comprises the non-steroidal inflammation-resisting medicines of aspirin, acetaminophen, indometacin, ibuprofen, oxyphenbutazone, naproxen, mefenamic acid, diclofenac sodium, celecoxib, rofecoxib, valdecoxib and the like and also comprises the vegetable inflammation-resisting pain-relieving class medicines of escin, ferulic acid, berberine, wilfordine, ephedrine and the like and the pain-relieving class medicines of morphia, demerol and the like. The matrine class alkaloid and one or various of the inflammation-resisting pain-relieving class medicines can form a medicine composition used for the pharmaceutical applications of resisting cold, allaying a fever and treating the swelling and pain of the bone joint and the muscle, rheumatic diseases, cardiovascular diseases, arteriosclerotic diseases, tumors, anaphylactic diseases, senile dementia, mosquito bite, insect bite and the like.

Description

technical field [0001] The invention relates to medical drugs, in particular to a pharmaceutical composition containing matrine alkaloids, a preparation method and a pharmaceutical application. Background technique [0002] Sophora flavescens is one of the commonly used traditional Chinese medicine. It contains a variety of alkaloids, currently isolated chemical components are matrine (matrine), oxymatrine (also known as matrine, oxymatrine), sophocarpine (l-sophocarpine), sophoridine (sophoridine), N-oxysophocarpine (N-oxysophocarpine) and isomatrine, etc. [0003] The drugs developed by matrine alkaloids include matrine, matrine, and sophocarpine. So far, it is mainly used clinically for the treatment of chronic hepatitis, anti-virus, anti-tumor and cardiovascular diseases. It has anti-virus, anti-hepatic fibrosis, immune regulation and anti-inflammatory, anti-allergic effects. However, the scope of application of matrine is limited to the above-mentioned pharmaceutica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61P11/00A61P29/00A61P19/00A61P21/00A61P25/28A61P9/00A61P9/10A61P35/00A61P37/08A61P17/02A61K31/4375
Inventor 孙小杰宋健彭康康马维富
Owner QINGDAO QIYUAN BIO TECH CO LTD
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