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Preparation method and application of biocompatible nano composite hydrogel

A biocompatible and nanocomposite technology, which is applied in the field of preparation of biocompatible nanocomposite hydrogels, can solve the problems of limiting the application of hydrogels, low cross-linking density, and weak strength, and achieve excellent mechanical properties, Low production cost, reduced release effect

Inactive Publication Date: 2020-06-05
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The cross-linking reaction between sodium alginate and calcium ions is mild and fast, but its strength is usually weak
Because calcium ions are small molecules, when crosslinking with sodium alginate, one calcium ion usually reacts with two carboxyl groups on the molecular chain of sodium alginate, and the crosslinking density is low, which limits the application of the hydrogel.

Method used

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  • Preparation method and application of biocompatible nano composite hydrogel
  • Preparation method and application of biocompatible nano composite hydrogel
  • Preparation method and application of biocompatible nano composite hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) First, weigh choline chloride and oxalic acid with a molar ratio of 1:2 and place them in a three-necked flask, and heat and stir in an oil bath at 90° C. for half an hour to obtain a clear and transparent eutectic solvent; Add the above deep eutectic solvent, the solid-liquid ratio is 1:20, and carry out purification pretreatment at 110 ° C for 3 hours; then, use deionized water and absolute ethanol to wash to remove the residual deep eutectic solvent to obtain purified cellulose. Next, the purified cellulose was directly added to the ball milling tank for wet ball milling for 16 h, and then centrifuged at 8000 r / min for 8 min for 5 times. Finally, the nanofibrillated cellulose colloid with a concentration of 2% was obtained by rotary evaporation.

[0028] (2) First, take a certain volume (the content of nanofibrillated cellulose is 0.5% of sodium alginate / chitosan) of nanofibrillated cellulose colloid and disperse it in deionized water, and ultrasonically disperse ...

Embodiment 2

[0031] (1) First, weigh choline chloride and oxalic acid with a molar ratio of 1:2 and place them in a three-necked flask, and heat and stir in an oil bath at 90° C. for half an hour to obtain a clear and transparent eutectic solvent; Add the above deep eutectic solvent, the solid-liquid ratio is 1:20, and carry out purification pretreatment at 120 ° C for 1 hour; then, use deionized water and absolute ethanol to wash to remove the residual deep eutectic solvent to obtain purified cellulose. Next, the purified cellulose was directly added to the ball milling tank for wet ball milling for 20 h, then centrifuged at 8000 r / min for 8 min, centrifuged for 5 times, and finally the nanofibrillated cellulose colloid with a concentration of 2% was obtained by rotary evaporation.

[0032] (2) First, take a certain volume (the content of nanofibrillated cellulose is 1% of sodium alginate / chitosan) of nanofibrillated cellulose colloid and disperse it in deionized water, and ultrasonically di...

Embodiment 3

[0035] (1) First, weigh choline chloride and oxalic acid with a molar ratio of 1:2 and place them in a three-necked flask, and heat and stir in an oil bath at 90° C. for half an hour to obtain a clear and transparent eutectic solvent; Add the above deep eutectic solvent, the solid-liquid ratio is 1:20, and carry out purification pretreatment at 100 ° C for 5 hours; then, use deionized water and absolute ethanol to wash to remove the residual deep eutectic solvent to obtain purified cellulose. Next, the purified cellulose was directly added to the ball milling tank for wet ball milling for 12 h, and then centrifuged at 8000 r / min for 8 min for 5 times. Finally, the nanofibrillated cellulose colloid with a concentration of 2% was obtained by rotary evaporation.

[0036] (2) First, take a certain volume (the content of nanofibrillated cellulose is 1.5% of sodium alginate / chitosan) of nanofibrillated cellulose colloid and disperse it in deionized water, and ultrasonically disperse ...

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Abstract

The invention discloses a preparation method and application of a biocompatible nano composite hydrogel. The preparation method comprises the following steps: firstly, extracting nano fibrillation cellulose from cotton fiber powder by using a process with the combination of a eutecticevaporate solvent and wet-process ball milling; and secondly, by taking sodium alginate and chitosan as raw materials and the nano fibrillation cellulose as a reinforcing phase, preparing the nano composite hydrogel on the basis of an electrostatic function, a hydrogen-bond interaction and a biomass nano effect. In addition, an indometacin medicine is carried by the sodium alginate / chitosan / nano fibrillation cellulose composite hydrogel, and a slow release effect of the indometacin medicine can be achieved. not only is the preparation method simple in preparation process and rice in material source, but also the prepared composite hydrogel is of a porous three-dimensional network structure, the porosity ismaintained at 90% or greater, the swelling ratio is up to 1321%, and good mechanical properties are achieved; and meanwhile, the hydrogel has pH value sensitivity upon release of an indometacin modelmedicine, and shows a property of slow release.

Description

technical field [0001] The invention relates to the field of composite materials, in particular to a preparation method and application of a biocompatible nano-composite hydrogel. Background technique [0002] Hydrogel is a functional polymer material with a three-dimensional network structure by moderate cross-linking of natural polymers or synthetic polymers. It is insoluble in water, but can swell significantly in water, absorb a large amount of water, and has a strong water retention capacity. Smart hydrogels can sense small changes in the external environment, such as pH, temperature, ionic strength, magnetic field, electric field, etc., and respond rapidly to these stimuli by swelling or shrinking in volume. [0003] Sodium alginate is due to its biocompatibility, biodegradability, low cost and the addition of divalent cations (such as Ca 2+ ) and have good gel-forming properties and are often used as materials for the preparation of hydrogels. The crosslinking reac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/38A61K31/405
CPCA61K9/06A61K31/405A61K47/36A61K47/38
Inventor 唐艳军黄梦乐毛江淳贾歆玮
Owner ZHEJIANG SCI-TECH UNIV
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