Self-assembly system based on hydrophilic polymer and medicine and preparation method thereof

A hydrophilic polymer and self-assembly technology, which is applied in the directions of pharmaceutical formulations, non-active ingredients of polymer compounds, and medical preparations of non-active ingredients, etc., to achieve the effects of increasing dissolution, ensuring in vivo safety, and simple preparation

Active Publication Date: 2011-06-15
ARMY MEDICAL UNIV
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However, work in this area has not been reported in the literature so far.

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  • Self-assembly system based on hydrophilic polymer and medicine and preparation method thereof
  • Self-assembly system based on hydrophilic polymer and medicine and preparation method thereof

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Abstract

The invention relates to a self-assembly system based on hydrophilic polymer and medicine and a preparation method thereof. The system consists of a hydrophilic polymer and a carboxyl-containing medicine, wherein the hydrophilic polymer is polymine or beta-cyclodextrin modified polymine; and the carboxyl-containing medicine is selected from ibuprofen, ketoprofen, fenoprofen, flurbiprofene, oxaprozin, naproxen, indometacin, sulindac, etodolac, diclofenac, pontal, meclofenamic acid, flufenamic acid, tolfenamic acid, lumiracoxib, licofelone, diflunisal and aspirin. The system is prepared by dissolving the hydrophilic polymer in a certain amount of water, dissolving the medicine in a water soluble solvent, slowly adding the organic solution of the medicine into the aqueous solution of the polymer under the action of ultrasound, placing the mixed solution in a dialysis bag, dialyzing in deionized water with magnetic stirring, replacing the deionized water at certain time interval, filtering dislysate after 5 to 48 hours, cooling and drying.

Description

A self-assembly system based on hydrophilic polymer and drug and its preparation method technical field The invention relates to a high-efficiency drug delivery system based on a hydrophilic polymer-drug self-assembly and a preparation method thereof. Especially ibuprofen, ketoprofen, fenoprofen, flurbiprofen, oxaprozin, naproxen, indomethacin, sulindac, etodolac, diclofenac, mefenamic acid, meclofenac A method for preparing a polymer assembly delivery system for carboxyl-containing non-steroidal anti-inflammatory drugs such as fenamic acid, flufenamic acid, tolfenamic acid, lumiracoxib, ricofenol, diflunisal, and aspirin. Background technique Many important therapeutic compounds are widely used in clinic due to their extremely small water solubility, so it is a very important work to develop effective delivery systems. As an ideal drug delivery system, it must be able to transport the drug to a specific site in the body and release the drug at that site. At the same tim...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K47/32A61K47/40A61K47/58A61K47/69
Inventor 李晓辉张建祥李淑慧
Owner ARMY MEDICAL UNIV
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