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Application of traditional Chinese medicine composition in preparation of drug for treating osteoarthritis

A technology for osteoarthritis and a composition, which is applied in the application field of preparing a drug for treating osteoarthritis, can solve problems such as unclear treatment mechanism, and achieve the effects of exact curative effect, inhibition of inflammatory factors, and good inflammatory factors.

Inactive Publication Date: 2014-03-26
GUANGZHOU CHEN LI JI PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In clinical use, Shujin Jianyao Wan is used to improve pain symptoms according to its functions and indications. Due to the unknown treatment mechanism, it cannot be used for diagnosed OA.

Method used

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  • Application of traditional Chinese medicine composition in preparation of drug for treating osteoarthritis
  • Application of traditional Chinese medicine composition in preparation of drug for treating osteoarthritis
  • Application of traditional Chinese medicine composition in preparation of drug for treating osteoarthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1, preparation Shujinjianwaist pill

[0044]

[0045] Add water to the woody parts of dog ridge, golden cherry fruit, Caulis Spatholobus, Qianjinba, and black tiger of the above weight (the amount of water added: the first time is 8 times the total weight of the medicinal materials, and the second time is 6 times the total weight of the medicinal materials) and decocted For the second time, filter, combine the filtrates, and condense into a thick paste (relative density is 1.17); after pulverizing the other eight flavors such as Niu Dali and the skin of the black tiger, add the above thick paste, mix well, dry, and grind into fine powder. Sieve (120-mesh sieve) and mix to obtain powder; every 100g of powder is pan-balled with 35g of refined honey, coated, dried, and polished to obtain Shujinjianwaist Pill.

Embodiment 2

[0046] Example 2, Experimental Study of Shujin Jianyao Pills in Treating Knee Osteoarthritis

[0047] 1. Model preparation and grouping

[0048] 90 healthy SD rats were adaptively fed for 1 week. Referring to the literature (Lin YS, Huang MH, Chai CY. Effects of helium-neon laser on the mucopoly saccharide induction in experimental osteoarthritis cartilage [J]. Osteoarthritis Cartilage, 2005, 12: 339-346), the rat knee joint cavity Inject 0.2ml of 4% papain solution, once every 3 days, and inject 3 times continuously to form the model. The model rats were divided into Diacerein group, Shujin Jianyao Pill low-dose group, Shujin Jianyao Pill middle-dose group, Shujin Jianyao Pill high-dose group, model group and blank group, with 15 rats in each group. The conversion formula of animal dosage [adult dosage × 0.018 × 5 × average body weight of animals (according to 0.2kg)], the calculated dosage is the equivalent dose, the equivalent dose × 1 / 2 is the low dose, and the equivalen...

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Abstract

The invention discloses an application of traditional Chinese medicine composition in preparation of a drug for treating osteoarthritis. The traditional Chinese medicine composition comprises traditional Chinese medicines in parts by weight as follows: 600 parts of rhizoma cibotii, 192 parts of fructus rosae fruit, 360 parts of caulis spatholobi, 144 parts of philippine flemingia roots, 360 parts of kadsura coccinea, 240 parts of beautiful millettia roots, 30 parts of glossy privet fruit, 180 parts of mistletoe, 30 parts of semen cuscutae, 26 parts of rhizoma corydalis, 26 parts of radix zanthoxyli, 12 parts of mastic and 20 parts of myrrh. Research demonstrates that the traditional Chinese medicine composition has anti-inflammatory and analgesic effects, has a good inhibiting effect on inflammatory factors causing the osteoarthritis, and is definite in curative effect compared with indometacin and diacerein used clinically. The traditional Chinese medicine composition is used as a traditional Chinese patent medicine and has no adverse effect during decades of clinical use, so that the high-efficiency and low-toxicity treatment drug is provided for patients with the osteoarthritis, and the significant progress is achieved.

Description

technical field [0001] The invention relates to the application of a traditional Chinese medicine composition in the preparation of medicines for treating osteoarthritis. Background technique [0002] Osteoarthritis (OA) is a pathological change characterized by degeneration of articular cartilage, and is a chronic osteoarthropathy with joint pain, swelling, and limited mobility as the main clinical symptoms. The pathogenesis is mainly due to the participation of biomechanical factors, genetic factors, and exogenous factors that lead to metabolic changes in synovium, cartilage, and bone, resulting in inflammation and structural damage. The most basic pathological change is the damage and degeneration of articular cartilage. In the pathogenesis of OA, IL-1, IL-6, and TNF-α play an important role. Shujinjianwaist Pills are composed of Gouji, Rosa Rosa, Caulis Spatholobus, Qianjinba, Black Tiger, Niu Dali, Ligustrum lucidum, Sangjisheng and other Chinese medicinal materials. ...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61P19/02A61P29/00
Inventor 吴启富洪毅东接红宇王笑丹谢琳谢晗何风雷
Owner GUANGZHOU CHEN LI JI PHARMA FACTORY
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