44 results about "L-ascorbic acid 2-phosphate" patented technology

The present invention relates to a medium for culturing mesenchymal stem cells, and more particularly to a medium composition for culturing mesenchymal stem cells, which contains basal medium, L-ascorbic acid 2-phosphate, fetal bovine serum, basic fibroblast growth factor (b-FGF), non-essential amino acids (NEAAs), insulin, N-acetyl-L-cysteine, calcium chloride, and hydrocortisone, and a method of culturing mesenchymal stem cells using the same. According to the present invention, a number of mesenchymal stem cells required for stem cell therapy can be obtained in a short time, and the ability of mesenchymal stem cells to differentiate is improved so that they are useful for stem cell therapy.

It is an object to provide an L-ascorbic acid derivative which can keep the L-ascorbic acid stable to heat and light and thus has a long shelf life, which is high in permeability into the skin, which can be quickly hydrolyzed by phosphatase, an enzyme that is ubiquitous in vivo, and which exhibits physiological activities that are inherent to L-ascorbic acid and beneficial to health, a method for producing such an L-ascorbic acid derivative, and a skin-whitening cosmetic material.There is provided an ascorbic acid derivative comprising an L-ascorbic acid-2-phosphate ester or a salt thereof wherein the phosphate ester has a branched alkyl group, the L-ascorbic acid-2-phosphate ester being of formula [13]. The ascorbic acid derivative is produced by a method comprising reacting a branched alkanol with phosphorus oxychloride to synthesize monoalkyldichlorophosphate or dialkylmonochlorophosphate, reacting the thus obtained substance with 5,6-O-isopropylidene-L-ascorbic acid obtained by reacting L-ascorbic acid with acetone, and subjecting the thus obtained substance to acid hydrolysis. There is also provided a cosmetic material containing such an ascorbic acid derivative by 0.05 to 80 percent by weight.(wherein each of R1 and R2 is a hydrogen (H) atom or an alkyl group having branches and including 3 to 30 carbon atoms, but not both of R1 and R2 are hydrogen (H) atoms).

The invention discloses a quadruple linkage bad breath eliminating composition toothpaste which comprises an active ingredient consisting of the following components in percentage by weight: 0.5-1.5% of tea polyphenol, 0.5-1% of L-Ascorbic-acid-2-phosphate sodium, 1-3% of beta-cyclodextrin and 0.3-2% of a PVM / MA copolymer, and the balance being a toothpaste substrate. The toothpaste disclosed by the invention, through a linkage effect of four active ingredients, not only takes efficacy of single ingredient but also realizes a synergistic effect of all functional ingredients; by using the quadruple therapy to oral cavity, the toothpaste can inhibit odor inducing bacteria in the oral cavity through effective release of antibacterial ingredients in a process of brushing teeth; through an absorbent, bad breath in the oral cavity is absorbed; through absorption and film forming functions of the high-molecular copolymer, effective release of the active ingredients is guaranteed and residence time in the oral cavity is prolonged; meanwhile, a normal microorganism environment in the oral cavity is maintained, and effects of treating both symptoms and root causes and freshening breath for a long time are achieved, so as to meet requirements of people for improving images and pursuing healthy and green life.