Method for preparing L-ascorbic acid-2-phosphate

A technology of ascorbic acid and phosphate ester, which is applied in chemical instruments and methods, compounds of group 5/15 elements of the periodic table, animal feed, etc., can solve problems such as VC loss and incomplete reaction, and achieve high material specificity and water solubility small effect

Active Publication Date: 2010-03-10
宜兴市江山生物科技有限公司
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  • Abstract
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Problems solved by technology

[0003] The characteristic of the prior art is that free VC does not participate in the reaction yield, and some VC is lost, the loss is about 1.5-5%, because it will be oxidized and decomposed by itself under the influence of temperature during the dissolution process of VC, and the reaction is not complete and other factors, the existing technology still cannot overcome the above-mentioned defects

Method used

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  • Method for preparing L-ascorbic acid-2-phosphate

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) Acceptance of raw materials: after the raw materials are put into storage, the quality department will take samples and test them, and pass the inspection and put them into the warehouse;

[0019] (2) VC raw powder, sodium trimetaphosphate, calcium chloride, calcium hydroxide: the raw materials are transported to the synthesis station for review, and the outer packaging is removed for use;

[0020] (3) Deionized water, disodium ethylenediamine tetraacetate, sodium bisulfite: the water should be clean and transparent, meeting drinking water standards, the catalysts should be weighed separately, and kept clean for use;

[0021] (4) Catalytic esterification reactor

[0022] Preparation of calcium hydroxide solution: add 240kg of water to 120kg of calcium hydroxide and stir evenly. Add 350kg of deionized water to the reaction kettle, start stirring after adding water, slowly add 100g of disodium ethylenediaminetetraacetic acid (EDTA-2Na), keep the temperature below 20°...

Embodiment 2

[0042] In the (4) step catalytic esterification reactor, the amount of material added is different from Example 1, specifically as follows:

[0043] Preparation of calcium hydroxide solution: add 230kg of water to 115kg of calcium hydroxide and stir evenly. Add 340kg of deionized water to the reaction kettle, start stirring immediately after adding water, slowly add 100g of disodium ethylenediaminetetraacetic acid (EDTA-2Na), keep the temperature below 20°C and stir; put in 250kg of VC, and add 10kg of calcium chloride at the same time , stir and dissolve for 20 minutes; start to add calcium hydroxide solution dropwise, when the pH value reaches (4.5-5), add 400 g of sodium bisulfite, continue to adjust the pH value to (6.4-7.0), turn off the dropwise addition, and add three Sodium metaphosphate 170kg (1 ~ 2) minutes to complete, the above control temperature is the best state below 20 ℃; open the calcium hydroxide solution and continue to drop, control the temperature below 2...

Embodiment 3

[0046] In the (4) step catalytic esterification reactor, the amount of material added is different from Example 1, specifically as follows:

[0047] Preparation of calcium hydroxide solution: add 250kg of water to 125kg of calcium hydroxide and stir evenly. Add 360kg of deionized water to the reaction kettle, start stirring immediately after adding water, slowly add 100g of disodium ethylenediaminetetraacetic acid (EDTA-2Na), keep the temperature below 20°C and stir; put in 250kg of VC, and add 16kg of calcium chloride at the same time , stir and dissolve for 20 minutes; start to add calcium hydroxide solution dropwise, when the pH value reaches (4.5-5), add 400 g of sodium bisulfite, continue to adjust the pH value to (6.4-7.0), turn off the dropwise addition, and add three Sodium metaphosphate 190kg (1 ~ 2) minutes to complete, the above control temperature is the best state below 20 ℃; open the calcium hydroxide solution and continue to drop, control the temperature below 2...

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Abstract

The invention discloses a method for preparing L-ascorbic acid-2-phosphate. The preparation method comprises the following steps: taking VC raw powder, sodium trimetaphosphate, calcium chloride and calcium hydroxide as raw materials to perform catalytic esterification reaction; and standing and curing a catalytic esterification product for 18+/2 hours, and drying the product to obtain the L-ascorbic acid-2-phosphate. The L-ascorbic acid-2-phosphate has the characteristics of large specific gravity of materials, small water solubility and the like, and is particularly suitable for compound feed of aquatic animals.

Description

technical field [0001] The invention relates to a preparation method of a compound used as a feed additive, in particular to a preparation method of L-ascorbic acid-2-phosphate. Background technique [0002] Currently, L-ascorbic acid-2-tripolyphosphate is a derivative of vitamin C and is used in the preparation of feed. It has the following advantages: 1. High bioavailability; 2. It is easy to use; 3. It is not easy to be lost in water; 4. It has a remarkable effect and can indeed improve immunity and disease resistance, increase weight gain and survival rate. Therefore, it is widely used as a feed additive. [0003] The characteristic of the prior art is that free VC does not participate in the reaction yield, and some VC is lost, the loss is about 1.5-5%, because it will be oxidized and decomposed by itself under the influence of temperature during the dissolution process of VC, and the reaction is not complete Factors such as cause, and current prior art still can't ov...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/655A23K1/16A23K20/174A23K50/80
Inventor 张国忠
Owner 宜兴市江山生物科技有限公司
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