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Preparation method of photoelectrochemical furazolidone sensor based on dual metal co-doped two-dimensional photosensitizer

A technology of furazolidone and photoelectrochemistry, which is applied in the field of photoelectrochemical furazolidone sensor preparation, can solve the problems of low sensitivity of photoelectrochemical sensors, unfavorable practical application, and weakening of photoelectric signals, so as to broaden the range of photosensitive wavelengths and increase photocatalytic activity , time-saving effect

Inactive Publication Date: 2016-12-07
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In addition, the photogenerated electron-hole pairs of a single titanium dioxide nanomaterial are easy to recombine, which leads to the weakening of the photoelectric signal, and the poor conductivity of titanium dioxide also limits the sensitivity of photoelectrochemical sensors constructed from a single titanium dioxide nanomaterial. application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 FeMn-TiO 2 / MoS 2 preparation of

[0043] (1) Add 0.6 g of molybdenum disulfide powder, 0.2 mmol of iron salt and 0.2 mmol of manganese salt into 3 mL of n-butyllithium solution, and stir for 12 hours under nitrogen protection at 60 °C to obtain the reacted solution;

[0044] (2) Wash the reacted solution in step (1) with a non-polar solvent, and then perform ultrasonic treatment in a water bath at 60 °C. After the treatment, wash the treated solution with a non-polar solvent, and dry it in vacuum to obtain iron , Molybdenum disulfide nanomaterials co-intercalated with manganese;

[0045] (3) Add 500 mg of molybdenum disulfide nanomaterials co-intercalated with iron and manganese prepared in step (2) into 5 mL of tetrabutyl titanate, and after stirring for 1 hour, slowly add 0.5 mL of hydrofluoric acid while stirring acid, then reacted in a reactor at 160°C for 18 hours;

[0046] (4) The reaction product obtained in step (3) was centrifuged and washed thre...

Embodiment 2

[0052] Example 2 FeMn-TiO 2 / MoS 2 preparation of

[0053] (1) Add 0.6 g of molybdenum disulfide powder, 1.0 mmol of iron salt and 1.0 mmol of manganese salt into 5 mL of n-butyllithium solution, and stir for 24 hours under nitrogen protection at 30 °C to obtain the reacted solution;

[0054] (2) Wash the reacted solution in step (1) with a non-polar solvent, and then perform ultrasonic treatment in a water bath at 30 °C. After the treatment, wash the treated solution with a non-polar solvent, and dry it in vacuum to obtain iron , Molybdenum disulfide nanomaterials co-intercalated with manganese;

[0055] (3) Add 200 mg of molybdenum disulfide nanomaterials co-intercalated with iron and manganese prepared in step (2) into 5 mL of tetrabutyl titanate, stir for 1 hour, then slowly add 0.6 mL of hydrofluoric acid while stirring acid, then reacted in a reactor at 180°C for 20 hours;

[0056] (4) The reaction product obtained in step (3) was centrifuged and washed three times w...

Embodiment 3

[0062] Example 3 FeMn-TiO 2 / MoS 2 preparation of

[0063] (1) Add 0.6 g of molybdenum disulfide powder, 2.0 mmol of iron salt and 2.0 mmol of manganese salt into 10 mL of n-butyllithium solution, and stir for 48 hours under nitrogen protection at 50 °C to obtain the reacted solution;

[0064] (2) Wash the reacted solution in step (1) with a non-polar solvent, and then perform ultrasonic treatment in a water bath at 50 °C. After the treatment, wash the treated solution with a non-polar solvent, and dry it in vacuum to obtain iron , Molybdenum disulfide nanomaterials co-intercalated with manganese;

[0065] (3) Add 10 mg of molybdenum disulfide nanomaterials co-intercalated with iron and manganese prepared in step (2) into 5 mL of tetrabutyl titanate, stir for 1 hour, then slowly add 0.8 mL of hydrofluoric acid while stirring acid, then reacted in a reactor at 200°C for 24 hours;

[0066] (4) The reaction product obtained in step (3) was centrifuged and washed three times w...

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Abstract

The invention discloses a preparation method of a photoelectrochemical furazolidone sensor, and belongs to the technical fields of novel nano functional materials and biosensors. According to the preparation method, a novel dual metal co-doped two-dimensional photosensitizer is prepared at first, namely, iron and manganese co-doped titanium dioxide nano blocks and molybdenum disulfide carry out in-situ synthesis to generate a two-dimensional nano composite material (FeMn-TiO2 / MoS2), which has a good biocompatibility and large specific area, then a furazolidone antibody is loaded on the two-dimensional nano composite material, alkaline phosphatase is fixed on the two-dimensional nano composite material; when the photosensitizer is used for detection, alkaline phosphatase can catalyze L-ascorbic acid-2-phosphate trisodium salt (AAP) to generate L-ascorbic acid (AA) in-situ; thus electron donors are provided for photoelectric detection; due to the influence of specific and quantitative combination between antibody and antigen on the electron transmission performance, the photoelectric current strength is correspondingly reduced, and finally a photoelectric sensor for detecting furazolidone through a label-free photoelectric method is manufactured.

Description

technical field [0001] The invention relates to a preparation method of a photoelectrochemical furazolidone sensor. It belongs to the technical field of new nanometer functional materials and biosensors. Background technique [0002] Furazolidone (furazolidone) is a nitrofuran antibiotic, which is a broad-spectrum antibacterial drug. When used as a veterinary drug, furazolidone has good medicinal effects on the prevention and treatment of certain protozoan diseases, saprolegniasis, bacterial gill rot, red skin disease, and hemorrhagic diseases. In the breeding industry, furazolidone can be used to treat intestinal infections in livestock and poultry, such as piglet yellow and pullorum. In aquaculture, furazolidone has a certain effect on the infection of Myxosoma cerebri in Salmonidae. However, the Ministry of Agriculture of my country lists furazolidone as a prohibited drug and shall not be detected in animal food. FDA also banned the use of nitrofurans (including furaz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/416G01N33/94G01N33/543
CPCG01N27/416G01N33/54386G01N33/9446
Inventor 张勇马洪敏杜斌胡丽华庞雪辉
Owner UNIV OF JINAN
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