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Self-assembly compound system of cellulose nanometer fibril and indometacin and preparation method of self-assembly compound system

A technology of indomethacin and nanofibrils, which can be used in drug combinations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. Short time and other problems, to achieve the effect of reducing the number of doses, long drug action time, and prolonging drug action time

Inactive Publication Date: 2014-01-22
NORTHEAST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention aims to solve the problems of low drug loading, short drug action time and frequent administration times in the existing drug loading system, and provides a self-assembled composite system of cellulose nanofibrils and indomethacin and a preparation method thereof

Method used

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  • Self-assembly compound system of cellulose nanometer fibril and indometacin and preparation method of self-assembly compound system
  • Self-assembly compound system of cellulose nanometer fibril and indometacin and preparation method of self-assembly compound system
  • Self-assembly compound system of cellulose nanometer fibril and indometacin and preparation method of self-assembly compound system

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specific Embodiment approach 1

[0036] Specific embodiment one: a kind of cellulose nanofibril and indomethacin self-assembly composite system of this embodiment is characterized in that a kind of cellulose nanofibril and indomethacin self-assembly composite system is composed of cellulose nanofibril The aqueous solution of silk is mixed with indomethacin solution, and then obtained by ultrasonic treatment or ultrasonic treatment and high-pressure homogeneous treatment, vacuum filtration and drying; in the aqueous solution of cellulose nanofibrils, cellulose nanofibrils and indole The mass ratio of indomethacin in the methacin solution is 1: (1-5).

specific Embodiment approach 2

[0037] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the aqueous solution of cellulose nanofibrils is prepared according to the following steps: put purified cellulose into distilled water and stir evenly to obtain an aqueous solution of cellulose, Then the cellulose aqueous solution is subjected to ultrasonic treatment at a power of 800W to 1500W, and the ultrasonic treatment time is 10min to 30min to obtain the aqueous solution of cellulose nanofibrils; the mass ratio of the distilled water to purified cellulose is (99 to 999 ): 1; the purified cellulose is purified cellulose without derivatization. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0038] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that the indomethacin solution is prepared according to the following steps: an organic solvent is mixed with distilled water to obtain a water-soluble organic solvent, and then Add indomethacin to a water-soluble organic solvent and stir magnetically to obtain an indomethacin solution; the volume ratio of the distilled water to the organic solvent is (0-2.333):1; the concentration of the indomethacin solution It is 0.003mol / L~0.015mol / L. Others are the same as in the first or second embodiment.

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Abstract

The invention provides a preparation method of the self-assembly compound system of cellulose nanometer fibril and indometacin, relating to a preparation method of a novel drug delivery system and solving the problem that an existing drug delivery system has low drug loading capacity, short action time of the drug and frequent dosing. The preparation method of the self-assembly compound system of cellulose nanometer fibril and indometacin comprises the following steps of firstly, preparing the water solution of the cellulose nanometer fibril; secondly, preparing the solution of indometacin; thirdly, preparing the mixed liquor of cellulose nanometer fibril and indometacin; fourthly, ultrasonic processing or ultrasonic processing and high pressure homogeneity processing; fifthly, vacuum filtering; and sixthly, drying so as to obtain the self-assembly compound system of cellulose nanometer fibril and indometacin. The self-assembly compound system of cellulose nanometer fibril and indometacin prepared by the method has the advantages of high drug loading capacity, long action time of the drug, and less dosing time, and is mainly used in a novel drug delivery system.

Description

technical field [0001] The invention relates to a novel drug-carrying system and a preparation method thereof. Background technique [0002] Indomethacin has anti-inflammatory, antipyretic and analgesic effects, and its usage includes oral administration, application and suppositories, etc. It can be used for acute and chronic rheumatoid arthritis, gouty arthritis and cancer pain, etc. It is widely used . However, the water solubility of indomethacin is poor, the common tablet releases rapidly, and the blood drug concentration in a short period of time is high; the action time is short, requiring frequent medication, which brings inconvenience to patients. [0003] In order to improve the application of such hydrophobic drugs, researchers increase the dissolution rate of drugs by increasing the surface area, reducing the particle size of the drug and changing the crystal form of the drug. In addition, the development of an effective drug loading system is the current soluti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/405A61P29/00A61P19/02A61P19/06A61P35/00
Inventor 高佳丽于海鹏刘一星李勍
Owner NORTHEAST FORESTRY UNIVERSITY
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