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Method for researching abirritation mechanism of Chinese herbal medicinal ingredients of Xinhuang tablets

A technology of Xinhuang tablet and traditional Chinese medicine, applied in the field of analgesic drug composition, can solve the problem of insufficient analgesic effect for severe pain, and achieve good drug safety, good synergistic effect, and excellent therapeutic effect

Active Publication Date: 2013-12-11
XIAMEN TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0005] Existing technologies have shown that Xinhuang Tablet has certain analgesic and fever-relieving effects, but the analgesic effect on severe pain is not strong enough. Therefore, we look forward to the expansion of new indications for Xinhuang Tablet and the prescription of Xinhuang Tablet with better effect

Method used

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  • Method for researching abirritation mechanism of Chinese herbal medicinal ingredients of Xinhuang tablets
  • Method for researching abirritation mechanism of Chinese herbal medicinal ingredients of Xinhuang tablets
  • Method for researching abirritation mechanism of Chinese herbal medicinal ingredients of Xinhuang tablets

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Effect test

Embodiment 1

[0035] The composition of embodiment 1 Xin Huang tablet and ketorolac trometamol is to the influence of the mice writhing number of times that acetic acid causes

[0036] 1. Grouping and administration of animals

[0037] Seventy male ICR mice, (20±2) g, were randomly divided into groups according to body weight, 10 in each group, and each group was given therapeutic drugs by intragastric administration. Xinhuang Tablets, Ketorolac Tromethamine Tablets, and Tramadol Amphenol Tablets were respectively prepared into suspensions with normal saline, and then each administration group was administered intragastrically according to the dose setting; the model group was intragastrically administered equal volume of saline.

[0038] 2. Experimental methods and data processing

[0039] Intraperitoneal injection of acetic acid in mice caused large-scale and long-lasting pain stimulation in the deep abdominal cavity, resulting in writhing reactions in mice. After each dose group was a...

Embodiment 2

[0054] Effect of the composition of embodiment 2 Xin Huang tablet and ketorolac tromethamine on mouse hot plate pain response

[0055] 1. Grouping and administration of animals

[0056] Put female ICR mice (20±2) g on an intelligent hot plate instrument at 55±0.5°C, record the latency (s) from when the sole of the mouse touches the hot plate to the reaction of hind paw licking is recorded as the pain threshold index, and the reaction is eliminated Mice with latency 30s or jumping. Select 140 qualified mice with response latency within 10-30s, randomly group them into groups according to predrug pain threshold and body weight, and administer them by intragastric administration;

[0057] Model group: equal volume of normal saline, ig

[0058] Xinhuang tablet group: Xinhuang tablet 42.0mg / kg, ig

[0059] Ketorolac tromethamine: 10.5mg / kg, ig

[0060] Aminophen tramadol group: acetaminophen 91.1mg / kg + tramadol hydrochloride 10.5mg / kg, ig

[0061] Composition A group: Xinhuan...

Embodiment 3

[0082] Embodiment 3 The clinical therapeutic effect of the pharmaceutical composition of the present invention on cancer pain

[0083] 3.1 General information: Select 500 cancer pain patients from the First People's Hospital of Hebei Province between January 2009 and January 2010, aged 16-65 years, weighing more than 50kg, with an average age of 38.7 years and an average weight of 62.5kg . The diagnosis was confirmed by auxiliary examination, and no analgesic treatment was performed before seeing a doctor, and there were no complications such as pancreatitis and massive bleeding.

[0084] 3.2 Treatment method 500 patients were randomly divided into 4 groups, 125 cases in each group. Each group took medicine in the following way: Xinhuang Tablets group: take Xinhuang Tablets orally: take 3 Xinhuang Tablets orally (0.32g / tablet, produced by Xiamen Traditional Chinese Medicine Factory Co., Ltd.), three times a day; Alcohol group: take 20 mg of ketorolac tromethamine three times...

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Abstract

The invention discloses a method for researching an abirritation mechanism of Chinese herbal medicinal ingredients of Xinhuang tablets and a pharmaceutical composition comprising the Xinhuang tablets. The method for researching the abirritation mechanism comprises the following steps of preparing a Xinhuang tablet sample and an indometacin sample in a weight ratio of 95:2, establishing a living acetic acid writhing reaction model and a living planta reaction model to evaluate the drug treatment effects and the synergic index of the Chinese herbal medicinal ingredients of the Xinhuang tablets and indometacin, and establishing a naloxone occlusion reaction model to evaluate the influence of occlusion on the analgesic effect. Based on the research on the mechanism of action, and in order to improve the treatment effect for analgesia, the invention also provides an analgesic composition which is composed of the Xinhuang tablets and ketorolac tromethamine. The method is used for measuring the abirritation mechanism of the Chinese herbal medicinal ingredients of the Xinhuang tablets, is simple and clear; applicable effective drugs can be selected from the known compound medicines by the pharmacological research method.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to an analgesic pharmaceutical composition composed of Xinhuang tablets and non-steroidal anti-inflammatory analgesics. Background technique [0002] Pain is a protective reaction produced by the body after being subjected to noxious stimuli, often accompanied by emotional activities such as fear and nervousness. In addition to feeling pain and emotional uneasiness, pain can also lead to physiological dysfunction, insomnia, and even life-threatening shock. Pain is the most common symptom of cancer patients, about 30-50% of cancer patients will have moderate to severe pain, especially in advanced cancer patients, about 75-95% will have uncontrollable chronic pain, of which 45% of cancer patients The severe pain cannot be relieved, and bone cancer pain is the most common refractory type among them, which seriously affects the quality of life of patients. Although WHO has...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K45/00A61K36/258A61P29/00A61P25/04A61K35/32A61K35/413A61K35/56A61K31/407A61K31/405A61K35/618
Inventor 包侠萍胡金芳关斌申秀萍王春凤赖志成阳丽华肖顺彪南淑华墙世发刘静郑珊珊杨惠婉王杰
Owner XIAMEN TRADITIONAL CHINESE MEDICINE
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