63 results about "Ketorolac Tromethamine" patented technology

Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical devices are also provided.

Disclosed is ketorolac tromethamine, which is a pyrrole acid derivative developed by the Syntex company in the U.S. The invention can effectively inhibit prostaglandin (PG) from synthesizing with functions of analgesia, anti-inflammation, antipyresis and inhibiting the platelets from aggregating. The invention provides a preparation method of ketorolac tromethamine injection, which well improvesthe stability and the clarity of the preparation with stable process.

Compositions comprising ketorolac tromethamine at a therapeutically effective concentration of less than 0.5% are disclosed herein. Methods of treating or preventing ocular pain using said compositions are also disclosed herein.

The invention provides a preparation method of ketorolac tromethamine. 5-benzoyl-2, 3-dihydro-1H-dilazine-1 and 1-diethyl azodicarboxylate are the starting materials and are prepared into salt by alkaline hydrolysis and acidification when reducers exist, and finally, the salt is prepared into ketorolac tromethamine. The method does not need complicated decarboxylation process, and effectively solves the problems of low purity, poor color and the like caused by the oxidizability of ketorolac. The invention has the advantages of simple operation, high yield and high purity (the total yield in two steps reaches 95% and the purity reaches more than 99.9%); thus, the preparation method is suitable for large-scale commercial process.