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Application of ketorolac tromethamine in preparation of drug for treating mental diseases

A technology of ketorolac tromethamine and its use, which is applied in the field of medicine, can solve problems such as limitations of drug treatment methods, and achieve pain relief, significant effect, and low side effects

Inactive Publication Date: 2020-07-10
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Due to the current technical status, the current drug treatment methods for postoperative delirium are relatively limited, and there is a lack of a safe and effective drug to relieve the pain of patients with postoperative delirium

Method used

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  • Application of ketorolac tromethamine in preparation of drug for treating mental diseases
  • Application of ketorolac tromethamine in preparation of drug for treating mental diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Improvement effect of ketorolac tromethamine on delirium mice

[0026] 1.1 Experimental location: Central Laboratory of New Drug Pharmacology, Research Department of Lunan Pharmaceutical Group Co., Ltd.

[0027] 1.2 Rat handling

[0028] Sixty healthy mice (Lunan Pharmaceutical Group Co., Ltd., SY×K (Lu) 2018 0008) weighing 20.0-30.0 g were randomly divided into a blank group, a model group, and an experimental group, with 20 mice in each group. The mice in the model group and the experimental group were injected intraperitoneally with scopolamine butylbromide 8mg / kg (capacity 8ml / kg), and the blank group was injected with an equivalent amount of 8ml / kg of normal saline intraperitoneally. After 4 weeks, the mice in the model group and the experimental group were accompanied by Typical symptoms of delirium include decreased concentration, weight loss, decreased interest, and dull coat color.

[0029] Get 10 rats in each group of successful modeling rats, and...

Embodiment 2

[0062] Embodiment 2: Ketorolac tromethamine tablet

[0063]

[0064] Preparation method: Dissolve ketorolac tromethamine in ethanol, and gradually add poloxamer, then dissolve PEG4000 in ethanol solution with stirring, remove ethanol by rotary evaporation, pulverize, and mix the pulverized product with micro Crystalline cellulose, sodium carboxymethyl starch and magnesium stearate are uniformly mixed and film-coated ketorolac tromethamine tablets.

Embodiment 3

[0065] Embodiment 3: Ketorolac tromethamine injection (10000)

[0066]

[0067] Preparation Process:

[0068] Weigh the prescribed amount of ketorolac tromethamine and medicinal absolute ethanol, stir with a small amount of water for injection until completely dissolved, then add the prescribed amount of propylene glycol and add water for injection to 80% of the prescribed amount, stir evenly, and use 1 1mol / L NaoH solution to adjust the pH to 6.8. Decolorize and filter with activated carbon, add water for injection to the prescribed amount, adjust the pH to 7.2 with 1 1mol / L NaoH solution, filter with a microporous membrane until clarified, fill each clean ampoule with 1ml of qualified medicinal solution with nitrogen, and pack it into a plate , Sterilized under steam, lamp inspection to get injection.

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to application of ketorolac tromethamine in preparation of a drug for treating mental diseases. The medicine is particularly applicable to treatment of depression and delirium patients, pharmacological experiments of animal models find that the drug prepared with ketorolac tromethamine as an active component can significantly improve distraction and depression states of model mice and has significant therapeutic effects on mental disease patients suffering from the symptoms.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the use of ketorolac trometamol in the preparation of drugs for treating mental diseases. Background technique [0002] Postoperative delirium (postoperative delirium, POD) is a state of acute mental confusion, usually occurs early after surgery, the course of the disease is fluctuating, the basic clinical features are consciousness, attention, cognition and perception impairment, and it is the most common symptom in elderly patients after surgery. One of the most common and harmful complications, it is defined by the National Institutes of Health as "sudden severe confusion and rapid changes in brain function that accompany physical or mental illness." [0003] As China gradually enters an aging society, the number of elderly patients undergoing major operations is also increasing. The incidence of postoperative delirium in elderly patients also showed a linear upw...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/407A61K45/06A61P25/24A61P25/20A61P25/18
CPCA61K31/407A61K45/06A61P25/18A61P25/20A61P25/24A61K2300/00
Inventor 公茂霞石碗莹巩恒
Owner LUNAN PHARMA GROUP CORPORATION
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