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Medicinal composition for treating hemorrhoids

A technology of composition and medicine, which is applied in the new field of medicine, can solve the problems such as lack of pentoxifylline, achieve good therapeutic effect, promote hemorrhoidal venous return, and improve the effect of varicose veins

Active Publication Date: 2010-06-23
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is also no technical indication that pentoxifylline or ketorolac tromethamine can be used in the treatment of hemorrhoids

Method used

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  • Medicinal composition for treating hemorrhoids
  • Medicinal composition for treating hemorrhoids
  • Medicinal composition for treating hemorrhoids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The experiment of embodiment 1 composition to rat croton oil hemorrhoid model

[0015] 50 SD rats (about 200 grams) were randomly divided into five groups according to body weight, i.e. model control group, pentoxifylline group (containing pentoxifylline 1%), ketorolac tromethamine group (containing ketorolac Tromethamine 0.5%), composition group (pentoxifylline 1%, ketorolac tromethamine 0.5%), Ma Yinglong group, 10 rats in each group.

[0016] experimental method:

[0017] Dosing: Rats are administered rectally two days in advance, twice a day, with 10 mg cotton balls covered with medicine, and the cotton balls are stuffed into the rectum. When administering next time, first check whether there are cotton balls in the rectum (such as Cotton balls should be removed). The last administration should be 2 hours after modeling.

[0018] Modeling: Croton oil is a commonly used inflammatory agent, and the common croton oil mixture is prepared with 1 part of distilled wate...

Embodiment 2

[0025] Example 2 Xylene Anti-inflammatory Experiment in Mice

[0026] 60 KM mice, half male and half female, weighing 25-30 grams, were randomly divided into five groups according to body weight, namely model control group (blank auxiliary material), pentoxifylline group (containing pentoxifylline 0.5%), ketorolac Tromethamine group (containing 0.5% ketorolac tromethamine), composition group (0.5% pentoxifylline, 0.5% ketorolac tromethamine), Ma Yinglong group, 12 rats in each group.

[0027] experimental method:

[0028] Take 20 μl of xylene and apply it to the right ear of each mouse. After 30 minutes, each test drug was evenly applied to the right ear of the mouse, and the right ear was sacrificed after being given xylene for 3.5 hours.

[0029] Experimental indicators:

[0030] Ear weight difference: cut two ears along the base line of the auricle, and use an 8mm punch to punch ear pieces in the same part of the left and right ears, and weigh them. The difference in ear...

Embodiment 3

[0036] Example 3 Administration of each group to mice analgesic effect experiment

[0037] 48 KM mice, half male and half female, with a body weight of 25-30 grams, were randomly divided into four groups according to body weight, i.e. model control group (blank auxiliary material), ketorolac tromethamine group (containing ketorolac tromethamine 1 %), composition group (pentoxifylline 0.5%, ketorolac tromethamine 1%), Ma Yinglong group, 12 rats in each group. For anal administration of mice, 10 mg cotton balls are soaked with the drug, and the cotton balls are stuffed into the rectum, once a day, for three consecutive days, 30 minutes after the last administration, 5% of the rectal wall is injected at a distance of 3.5 cm from the anus Formalin 0.2ml. The number of writhing times in 20 minutes was recorded. The specific results are shown in Table 3

[0038] Table 3 Comparison of writhing times in each experimental group

[0039]

[0040] Composition compared with the con...

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Abstract

The hemorrhoids are more suitable to be treated conservatively by medicaments mainly. The invention discloses a medicinal composition for treating hemorrhoids, which comprises two components, i.e. pentoxifyllinum and ketorolac tromethamine, wherein the ratio of pentoxifyllinum to ketorolac tromethamine is 0.02-10:1, preferably 0.1-5:1, more preferably 0.5-2:1. A mass of experimental studies show that the medicinal composition has obvious treatment effect on anorectal diseases, such as hemorrhoids and the like.

Description

technical field [0001] The invention belongs to new medicine technology and relates to a pharmaceutical composition for treating hemorrhoids, in particular to a pharmaceutical composition containing pentoxifylline and ketorolac tromethamine. Background technique [0002] Hemorrhoids are a common and frequently-occurring disease. Since ancient times, there has been a saying that "nine out of ten people have hemorrhoids". Hemorrhoids are clumps formed by pathological hypertrophy and displacement of anal cushions and blood stasis in the perianal subcutaneous vascular plexus. The main clinical manifestations are symptoms such as blood in the stool, pain, edema, swelling, pruritus, increased secretions and prolapse. Relevant studies have shown that the incidence of hemorrhoids in my country is about 46%, and it is as high as 70% among adults in some areas. Data from Europe, America and Japan The surveyed incidence rate is about 40%-60%. Symptoms such as hematochezia, prolapse and...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K31/407A61P9/14
Inventor 赵志全
Owner LUNAN HOPE PHARM CO LTD
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