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Medicine composition for treating constipation and/or haemorrhoids and application thereof

A technology for treating constipation and treating drugs, applied in the field of medicine, can solve problems such as unsatisfactory curative effect, large trauma, anal incontinence, etc., and achieve the effects of excellent clinical treatment effect, small drug toxicity and side effects, and exact curative effect.

Inactive Publication Date: 2014-02-05
海门市凤城旅游景点开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many treatment methods, the curative effect is not satisfactory
Surgical treatment takes a long time, involves large trauma, and complications suc

Method used

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  • Medicine composition for treating constipation and/or haemorrhoids and application thereof
  • Medicine composition for treating constipation and/or haemorrhoids and application thereof
  • Medicine composition for treating constipation and/or haemorrhoids and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of embodiment 1 compound suppositories

[0019] Prescription: lubiprostone 60g, ketorolac tromethamine 6g, Tween 80 5g, glycerin 2500g, gelatin 1000g, purified water added to 4500g.

[0020] Preparation process: Weigh the prescribed amount of gelatin, add the prescribed amount of purified water to the vessel, let it swell and soften, then add the prescribed amount of glycerin and heat it on a water bath to dissolve the gelatin, continue heating and stirring; take Lu Biprostone, ketorolac tromethamine, and Tween 80 are mixed evenly and then added to the prepared glycerin gelatin solution. After stirring evenly, pour it into the bolt mold coated with lubricant while it is hot, cool, and peel off The part overflowing from the die mouth is demoulded, quality inspected and packaged.

Embodiment 2

[0021] The preparation of embodiment 2 compound suppositories

[0022] Prescription: lubiprostone 6g, ketorolac tromethamine 10g, semi-synthetic fatty acid glyceride 300g, Tween 80 1.2g.

[0023] Preparation process: put semi-synthetic fatty acid glyceride in a vessel, heat and melt in a water bath, wait until the temperature drops to about 50°C, add Tween 80, stir evenly, add lubiprostone, ketorolac tromethamine, stir evenly, Afterwards, pour it into the plug mold coated with lubricant until it slightly overflows the die opening, cool, cut off the overflowing part after solidification, demould, quality check, and pack.

Embodiment 3

[0024] The preparation of embodiment 3 compound gel

[0025] Prescription: 10g of lubiprostone, 10g of ketorolac tromethamine, 10g of carbomer, 60ml of propylene glycol, 50ml of glycerin, appropriate amount of triethanolamine, and add purified water to 1000g.

[0026] Preparation process: slowly add carbomer to water with about 50% of the prescription amount, stir while adding until a transparent gel matrix is ​​formed, dissolve lubiprostone and ketorolac tromethamine in an appropriate amount of water, and then add In the matrix, stir evenly, add propylene glycol, glycerin, purified water to the full amount, adjust the pH value to neutral with triethanolamine, and obtain.

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PUM

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Abstract

The invention discloses a medicine composition for treating constipation and/or haemorrhoids and belongs to the field of medicines. Aiming at providing a medicine for treating constipation and/or haemorrhoids with a definite curative effect and specific ingredients, the invention discloses a medicine composition used for treating haemorrhoids, the medicine composition used for treating the haemorrhoids contains two ingredients, namely lubiprostone and ketorolac tromethamine, and the ratio of lubiprostone to ketorolac tromethamine is (0.02-10):1, preferably (0.1-5):1, and more preferably (0.5-2):1. A large number of experimental studies show that the medicine composition has an obvious treatment effect on anorectal diseases such as the haemorrhoids.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating constipation and / or hemorrhoids and its application, in particular to a pharmaceutical composition containing lubiprostone and ketorolac tromethamine and its preparation for treating constipation and / or use in hemorrhoid medicine. Background technique [0002] Constipation, especially chronic constipation, is a common symptom with complex etiology, which brings a lot of distress to patients and seriously affects the quality of life of patients. With the development of society, the increase of survival pressure, fierce competition, and the change of living habits such as diet structure, the incidence of constipation is on the rise. [0003] In terms of diagnosis, pathophysiology and treatment of functional gastrointestinal diseases, including constipation, the Rome I criteria were launched in 1994, and the Rome II criteria we...

Claims

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Application Information

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IPC IPC(8): A61K31/558A61K31/5575A61P1/10A61P9/14A61K31/407
Inventor 刘学键
Owner 海门市凤城旅游景点开发有限公司
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