Ketorolac tromethamine nasal spray

The technology of ketorolac tromethamine and nasal spray is applied in the directions of nebulizer for treatment, packaged food, packaging, etc., and can solve the problems of increasing the economic burden of patients, many adverse reactions, weak analgesic effect, etc. , to reduce the filling equipment requirements, the processing technology is mature, and the price is cheap.

Inactive Publication Date: 2013-09-11
北京天衡药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral, intramuscular and intravenous injection all have significant analgesic effects, but have the following disadvantages: 1. Intramuscular injection often causes discomfort; 2. Intravenous injection is inconvenient; Weak, especially not suitable for elderly patients and critically ill patients with dysphagia
4. There are many adverse reactions, and there have been reports of death due to gastrointestinal bleeding, postoperative bleeding, acute renal insufficiency and allergic reactions
[0005] The ketorolac tromethamine nasal spray produced by LUITPOLD is filled with the liquid medicine in an ordinary spray bottle. Due to th

Method used

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  • Ketorolac tromethamine nasal spray
  • Ketorolac tromethamine nasal spray
  • Ketorolac tromethamine nasal spray

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] 1. Prescription (based on 1000 bottles, 0.1ml / spray, 15.75mg / spray)

[0048]

[0049] Second, the preparation process:

[0050] 1. Dosing: Weigh the raw and auxiliary materials of the prescription amount into water of 95% of the prescription amount, stir to dissolve them, add water to make up the volume, and get ready.

[0051] 2. Filling: Fill the ketorolac tromethamine aqueous solution prepared above into the attached figure 2 In the spray bottle shown, fill each bottle with 1.0ml, tighten the spray head (spray volume 0.1ml / spray, 15.75mg / spray), and the final product is attached Figure 4 .

[0052] 3. Tests of effective spray times, spray uniformity and spray residual rate

[0053] The content of main ingredient per spray: same as comparative example

[0054] Reference substance solution preparation: with comparative example

[0055] Residual amount of the main drug in the bottle:

[0056] Take out all the residual liquid in the spray bottle, dilute it int...

Embodiment 2

[0069] 1. Prescription (based on 1000 bottles, 0.1ml / spray, 15.75mg / spray)

[0070]

[0071] Second, the preparation process:

[0072] 1. Dosing: Weigh the raw and auxiliary materials of the prescription amount into water of 95% of the prescription amount, stir to dissolve them, add water to make up the volume, and get ready.

[0073] 2. Filling: Fill the ketorolac tromethamine aqueous solution prepared above into the attached image 3 In the spray bottle shown, fill each bottle with 1.0ml, tighten the spray head (spray volume is 0.1ml / spray, 15.75mg / spray), and the final product is shown in the attached Figure 5 .

[0074] 3. Tests of effective spray times, spray uniformity and spray residual rate

[0075] The content of main ingredient per spray: same as comparative example

[0076] Reference substance solution preparation: with comparative example

[0077] Residual amount of the main drug in the bottle:

[0078] Take out all the residual liquid in the spray bottle...

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PUM

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Abstract

The invention provides a ketorolac tromethamine nasal spray. A spraying device comprises a spraying bottle and a spraying head, and is characterized in that the spraying bottle comprises a casing (1) and a liner (2) with the volume of 1.5 ml; the liner of the spraying bottle is in a shape of a cylinder, the combination of a cylinder and a cone, or the combination of a cylinder, a cone and a cylinder with a smaller diameter ; the casing of the spraying bottle has the same appearance, size and connector part as those of a conventional 10 ml spray sold in the market; and the spraying head adopts a praying head of the conventional 10 ml spray sold in the market. The ketorolac tromethamine nasal spray has the advantages of few residues, high safety and multiple effective spraying times, the production cost can be reduced, and the medicine waste is prevented.

Description

Technical field: [0001] The invention relates to a ketorolac tromethamine nasal spray, in particular to a ketorolac tromethamine nasal spray which adopts a spray bottle with a volume of 1.5ml. Background technique: [0002] Ketorolac tromethamine is a non-steroidal anti-inflammatory drug that produces analgesic effects by inhibiting the biosynthesis of prostaglandins. It is used for short-term treatment of acute and severe pain, usually for postoperative analgesia, not applicable For the treatment of mild or chronic pain. The drug acts on the peripheral nervous system, so it generally has no adverse effects on the central nervous system. The drug has the advantages of no addiction, no dependence, no respiratory depression, no irritation to tissues, and no peculiar smell. [0003] Ketorolac tromethamine was first marketed abroad (1989) in the form of injection, the original manufacturer was Roche, the specifications: 15, 30mg / ml, and the trade name: TORADOL. Roche launched...

Claims

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Application Information

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IPC IPC(8): A61M11/00A61J1/05
Inventor 姜庆伟衣伟锋吕玉珠唐亚坤刘俊轶
Owner 北京天衡药物研究院有限公司
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