Oxytocin nasal spray

A technology of nasal spray and oxytocin, applied in the field of oxytocin nasal spray, can solve the problems of increasing the economic burden of patients, unacceptable to patients with pain, increasing waste of expensive medicinal liquid, etc., and reducing filling equipment. Requirements, mature processing technology, stable source effect

Inactive Publication Date: 2013-09-11
北京天衡药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cons: Pain at the injection site after administration makes it difficult for many patients
[0005] The oxytocin nasal spray produced by Novartis fills the liquid medicine in an ordinary spray bottle. Due to the large volume of the spray bottle, a small volume of liquid medicine (5.0ml) is filled into the spray bottle, and the liquid level is Low, the depth of the immersion pipette is insufficient, resulting in incomplete absorption of the liquid medicine, resulting in less effective spraying times, more residues, and large waste. Although the defect of insufficient effective spraying times can be solved by increasing the filling volume of the liquid medicine , but further increased the waste of expensive liquid medicine, resulting in high drug prices and increasing the financial burden on patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1. Prescription (based on 1000 bottles, 0.1ml / spray)

[0036]

[0037] Second, the preparation process:

[0038] 1. Dosing: Weigh the raw and auxiliary materials of the prescription amount into water of 95% of the prescription amount, stir to dissolve, add water to make up the volume, and get ready.

[0039] 2. Filling: Fill the oxytocin aqueous solution prepared above into the attached figure 2 In the spray bottle shown, fill each bottle with 5.0ml, tighten the spray head (0.1ml / spray), that is, the final product is attached Figure 4 .

[0040] 3. Tests of the number of effective sprays and the residual rate of sprays

[0041] Test method: same as comparative example

[0042] Calculation formula: same as comparative example

[0043] The test results are as follows:

[0044] Table 2 embodiment 1 spray test result table

[0045]

[0046] The result calculated according to the above formula is as follows:

[0047] The total amount of liquid medicine in the s...

Embodiment 2

[0051] 1. Prescription (based on 1000 bottles, 0.1ml / spray)

[0052]

[0053] Second, the preparation process:

[0054] 1. Dosing: Weigh the raw and auxiliary materials of the prescription amount into water of 95% of the prescription amount, stir to dissolve, add water to make up the volume, and get ready.

[0055] 2. Filling: Fill the oxytocin aqueous solution prepared above into the attached image 3 In the spray bottle shown, fill each bottle with 5.0ml, tighten the spray head (0.1ml / spray), that is, the final product is attached Figure 5 .

[0056] 3. Tests of the number of effective sprays and the residual rate of sprays

[0057] Test method: same as comparative example

[0058] Calculation formula: same as comparative example

[0059] The test results are as follows:

[0060] Table 3 embodiment 2 spray test result table

[0061]

[0062] The result calculated according to the above formula is as follows:

[0063] The total amount of liquid medicine in the ...

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Abstract

The invention provides an oxytocin nasal spray. A spraying device comprises a spraying bottle and a spraying head, and is characterized in that the spraying bottle comprises a casing (1) and a liner (2) with the volume of 6.0 ml; the liner of the spraying bottle is in a shape of a cylinder, the combination of a cylinder and an eggplant shape, or the combination of a cylinder, a sphere and a cylinder with a smaller diameter; the casing of the spraying bottle has the same appearance, size and connector part as those of a conventional 10 ml spray sold in the market; and the spraying head adopts a praying head of the conventional 10 ml spray sold in the market. The oxytocin nasal spray has the advantages of few residues, high safety and multiple effective spraying times, the production cost can be reduced, and the medicine waste is prevented.

Description

Technical field: [0001] The invention relates to an oxytocin nasal spray, in particular to an oxytocin nasal spray using a spray bottle with a volume of 6.0ml inner liner. Background technique: [0002] Oxytocin is a peptide chain composed of 9 amino acids containing disulfide bonds. It is a polypeptide hormone uterotonic drug. The main mechanism of action is to promote the contraction of uterine smooth muscle. 1. Promote lactation, promote postpartum milk discharge, increase breastfeeding rate, and increase milk discharge; 2. Promote postpartum body recovery and reduce milk stasis, preventing mastitis and lumps. [0003] The earliest (1980) formulation of oxytocin on the market abroad was injection, the original research manufacturer was Novartis, the trade name: Syntocinon, specification: 10 units / ml. The advantages of the injection: fast onset (3.5 minutes), significant uterine contraction effect. Disadvantages: Pain at the injection site after administration makes it u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M11/00A61J1/05
Inventor 姜庆伟衣伟锋吕玉珠唐亚坤刘俊轶
Owner 北京天衡药物研究院有限公司
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