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Salmon calcitonin nasal spray

A technology of salmon calcitonin and nasal spray, which is applied in the direction of nebulizers for treatment, etc., can solve the problems of increasing the economic burden of patients, less effective spraying times, and increasing the waste of liquid medicine, so as to reduce the filling equipment Requirements, mature processing technology, cost-saving effect

Inactive Publication Date: 2013-09-11
北京天衡药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disadvantages: 1. Long-term medication is required for osteoporosis and other diseases, frequent injections and administration bring a lot of inconvenience and pain to patients, and patients have poor medication compliance
2. There are many adverse reactions of injections, mainly allergic reactions, nausea, vomiting, drowsiness, etc.
[0005] The salmon calcitonin nasal spray produced by Novartis fills the liquid medicine in an ordinary spray bottle. Due to the large volume of the spray bottle, the small volume of the liquid medicine (2.0ml) only exists at the bottom of the spray bottle. The height of the surface is low, and the depth of the immersion pipette is insufficient, resulting in incomplete absorption of the liquid medicine, resulting in fewer effective spray times, more residues, and large waste. Although the lack of effective spray times can be solved by increasing the filling volume of the liquid medicine However, it further increases the waste of expensive liquid medicine, resulting in high drug prices and increasing the financial burden on patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] 1. Prescription (1000 bottles, 0.09ml / spray)

[0049]

[0050] Second, the preparation process:

[0051] 1. Dosing: Weigh the raw and auxiliary materials of the prescription amount into 90% of the prescription amount of water, stir to dissolve them, add an appropriate amount of hydrochloric acid to adjust the pH value to 3.7, add water to constant volume, and obtain the salmon calcitonin aqueous solution.

[0052] 2. Filling: fill the salmon calcitonin aqueous solution prepared above into the attached figure 2 In the spray bottle shown, fill each bottle with 2.0ml, tighten the spray head (the spray volume of the spray head is 0.09ml / spray), that is, the final product is shown in the attached Figure 4 .

[0053] 3. Tests of effective spray times, spray uniformity and spray residual rate

[0054] The content of main ingredient per spray: same as comparative example

[0055] The preparation of reference substance solution: with comparative example

[0056] Residu...

Embodiment 2

[0069] 1. Prescription (1000 bottles, 0.09ml / spray)

[0070] With embodiment 1.

[0071] Second, the preparation process:

[0072] 1. Dosing: Weigh the raw and auxiliary materials of the prescription amount into water of 90% of the prescription amount, stir to dissolve them, adjust the pH value to 3.7 with hydrochloric acid, add water to make up the volume, and get ready.

[0073] 2. Filling: fill the salmon calcitonin aqueous solution prepared above into the attached image 3 In the spray bottle shown, fill each bottle with 2.0ml, tighten the spray head (the spray volume of the spray head is 0.09ml / spray), that is, the final product is shown in the attached Figure 5 .

[0074] 3. Tests of effective spray times, spray uniformity and spray residual rate

[0075] The content of main ingredient per spray: same as comparative example

[0076] The preparation of reference substance solution: with comparative example

[0077] Residual main drug content in the bottle:

[0078...

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Abstract

The invention provides a salmon calcitonin nasal spray. A used spraying device comprises a spray bottle and a spray nozzle, and is characterized in that the spray bottle comprises an outer casing (1) and a liner (2) with a volume of 3.0 ml, wherein the shape of the liner of the spray bottle adopts a cylinder plus a cone or a cylinder plus a cone and an another cylinder with a smaller diameter; the outer casing of the spray bottle has a shape, a size and an interface part which are the same as those of a conventional 10 ml spray device sold in the market; and the spray nozzle adopts a spray nozzle of the conventional 10 ml spray device sold in the market. The salmon calcitonin nasal spray has the advantages that the residue is small, the security is high, and the salmon calcitonin nasal spray can be effectively sprayed for a plurality of times; and the production cost can be reduced, and medicine waste is completely prevented.

Description

Technical field: [0001] The invention relates to a salmon calcitonin nasal spray, which includes a liquid medicine and a spray device, in particular to a salmon calcitonin nasal spray which uses a spray bottle with a volume of 3.0ml as the spray device. Background technique: [0002] Salmon calcitonin is a single-chain cyclic polypeptide composed of 32 amino acids. It is the most active bone metabolism hormone among several calcitonins from different sources. Its biological activity is 30-60 times higher than that of mammalian calcitonin. It acts on osteoclast receptors to inhibit the activity of osteoclasts and reduce the number of osteoclasts, thereby finally inhibiting bone resorption, stimulating the formation of osteoblasts, and improving calcium balance. Osteoporosis (early and late postmenopausal osteoporosis, senile osteoporosis, secondary osteoporosis) and hypercalcemia, in addition to osteolysis and / or osteopenia pain, osteitis deformans, hypercalcic crisis, and n...

Claims

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Application Information

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IPC IPC(8): A61M11/00
Inventor 姜庆伟衣伟锋吕玉珠唐亚坤刘俊轶
Owner 北京天衡药物研究院有限公司
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