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Fluticasone propionate nasal spray

A technology of fluticasone propionate and nasal spray, which is applied in the direction of nebulizer for treatment, etc., can solve the problems of increasing the economic burden of patients, insufficient frequency, increasing waste of expensive liquid medicine, etc., and achieves reduction of filling equipment requirements. , the processing technology is mature, the effect of cost saving

Inactive Publication Date: 2013-09-11
北京天衡药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Fluticasone Propionate Nasal Spray produced by Glaxo, due to the large volume of the spray bottle, the small volume of liquid medicine (4.0ml) only exists at the bottom of the spray bottle, the liquid level is low, and the depth of the immersion pipette is not enough , resulting in incomplete absorption of the liquid medicine, resulting in less effective spraying times, more residues, and large waste. Although the defect of insufficient effective spraying times can be solved by increasing the filling volume of the liquid medicine, it further increases the cost of expensive liquid medicine. The waste of medicines leads to high drug prices and increases the economic burden of patients

Method used

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  • Fluticasone propionate nasal spray
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  • Fluticasone propionate nasal spray

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] 1. Prescription (1000 bottles, 25μg / spray)

[0067]

[0068] Second, the preparation process:

[0069] 1. Micronize the fluticasone propionate bulk drug, and set aside.

[0070] 2. Dosing: Weigh the raw and auxiliary materials of the prescription amount into water of 90% of the prescription amount, stir to make it evenly mixed, add water to make up the volume, and the product is ready.

[0071] 3. Filling: Fill the fluticasone propionate suspension prepared above into the attached figure 2 In the spray bottle shown, fill each bottle with 4.0ml, and tighten the spray head (spray volume 50μl / spray, equivalent to 25μg / spray), that is, the final product is shown in the attachment Figure 4 .

[0072] 3. Tests of effective spray times, spray uniformity and spray residual rate

[0073] Every spray main ingredient content: same as comparative example 1

[0074] Reference substance solution preparation: with comparative example 1

[0075] Residual main drug content in...

Embodiment 2

[0089] 1. Prescription (1000 bottles, 25μg / spray)

[0090]

[0091] Second, the preparation process:

[0092] 1. Micronize the fluticasone propionate bulk drug, and set aside.

[0093] 2. Dosing: Weigh the raw and auxiliary materials of the prescription amount into water of 90% of the prescription amount, stir to make it evenly mixed, add water to make up the volume, and the product is ready.

[0094] 3. Filling: Fill the fluticasone propionate suspension prepared above into the attached image 3 In the spray bottle shown, fill each bottle with 4.0ml, and tighten the spray head (spray volume 50μl / spray, equivalent to 25μg / spray), that is, the final product is shown in the attachment Figure 5 .

[0095] 3. Tests of effective spray times, spray uniformity and spray residual rate

[0096] Every spray main ingredient content: same as comparative example 1

[0097] Reference substance solution preparation: with comparative example 1

[0098] Residual main drug content in ...

Embodiment 3

[0112] 1. Prescription (1000 bottles, 50μg / spray)

[0113]

[0114]

[0115] Second, the preparation process:

[0116]1. Micronize the fluticasone propionate bulk drug, and set aside.

[0117] 2. Dosing: Weigh the raw and auxiliary materials of the prescription amount into water of 90% of the prescription amount, stir to make it evenly mixed, add water to make up the volume, and the product is ready.

[0118] 3. Filling: Fill the fluticasone propionate suspension prepared above into the attached figure 2 In the spray bottle shown, fill each bottle with 4.0ml, and tighten the spray head (spray volume 100μl / spray, equivalent to 50μg / spray), that is, the final product is attached Figure 4 .

[0119] 3. Tests of effective spray times, spray uniformity and spray residual rate

[0120] Every spray main ingredient content: same as comparative example 1

[0121] Reference substance solution preparation: with comparative example 1

[0122] Residual main drug content in th...

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Abstract

The invention provides a fluticasone propionate nasal spray. A used spraying device comprises a spray bottle and a spray nozzle, and is characterized in that the spray bottle comprises an outer casing (1) and a liner (2) with a volume of 5.0 ml, wherein the shape of the liner of the spray bottle adopts a cylinder plus an eggplant shape or a cylinder plus a sphere and an another cylinder with a smaller diameter; the outer casing of the spray bottle is provided with a shape, a size and an interface part which are the same as those of a conventional 10 ml spray device sold on the market; and the spray nozzle adopts a spray nozzle of the conventional 10 ml spray device sold on the market. The fluticasone propionate nasal spray has the advantages that the residue is small, the security is high, and the fluticasone propionate nasal spray can be effectively sprayed for a plurality of times; and the production cost can be reduced, and medicine waste is completely prevented.

Description

Technical field: [0001] The invention relates to a fluticasone propionate nasal spray, in particular to a fluticasone propionate nasal spray using a spray bottle with a volume of 5.0ml of an inner container. Background technique: [0002] Fluticasone propionate is a glucocorticoid. Compared with similar drugs, it has the following characteristics: 1. It is highly fat-soluble and easily penetrates cell membranes. Compared with beclomethasone dipropionate and budesonide, fluticasone propionate has the fastest binding time to glucocorticoid receptors and the slowest dissociation; 2. It has high selectivity and high affinity for glucocorticoid receptors; 3. The anti-inflammatory effect is stronger than that of beclomethasone dipropionate and budesonide; 4. The bioavailability after oral administration is lower than 1%, and the systemic absorption is almost completely inactivated after liver metabolism; 5. The hypothalamus-pituitary-adrenal gland ( HPA) has a small inhibitory ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M11/00
Inventor 姜庆伟衣伟锋吕玉珠唐亚坤刘俊轶
Owner 北京天衡药物研究院有限公司
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