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Externally applied ointment of ketorolac tromethamine and its preparation method

A technology of ketorolac tromethamine and external ointment, which is applied in the field of analgesic ointment and its preparation, can solve the problems of poor anti-inflammatory drug effect, achieve good subcutaneous penetration effect, fast drug release, and easy washing and removal Effect

Inactive Publication Date: 2008-11-19
SHENYANG MINGHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] 1. Purpose of the invention: the present invention provides ketorolac tromethamine topical ointment and preparation method, its purpose is to solve the problem of external analgesia and anti-inflammatory drugs, and use ketorolac tromethamine as topical ointment problems in stability and subcutaneous penetration

Method used

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  • Externally applied ointment of ketorolac tromethamine and its preparation method
  • Externally applied ointment of ketorolac tromethamine and its preparation method
  • Externally applied ointment of ketorolac tromethamine and its preparation method

Examples

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Embodiment 1

[0043] Ketorolac tromethamine ointment for external use of the present invention, the prescription of this ointment contains the medicine of following percentage by weight:

[0044] Ketorolac Tromethamine 2%

[0045] Vaseline 91%

[0046] Benzalkonium Chloride 0.01%

[0047] Azone 1.2%

[0048] Borax 0.2%

[0049] Propylene Glycol 1%

[0050] Others are distilled water

[0051] The preparation method of ketorolac tromethamine external ointment of the present invention, the method comprises the steps:

[0052] A, get each component by the prescription described in claim 1 for subsequent use;

[0053] b. Preparation of medicinal solution: Weigh distilled water, add azone, propylene glycol and benzalkonium chloride to fully dissolve, then weigh ketorolac tromethamine and stir until completely dissolved;

[0054] c. Preparation of ointment: add an appropriate amount of base material to the liquid medicine in step b, stir fully to a homogeneous system, adjust the pH value of...

Embodiment 2

[0056] Ketorolac tromethamine gel for external use of the present invention, the prescription of this gel contains the medicine of following percentage by weight:

[0057] Ketorolac Tromethamine 2%

[0058] Carbomer 0.5%

[0059] Benzalkonium Chloride 0.01%

[0060] Azone 1%

[0061] Borax 0.2%

[0062] Propylene Glycol 1%

[0063] Others are distilled water

[0064]The preparation method of ketorolac tromethamine external gel of the present invention, the method comprises the steps:

[0065] a. Take each component according to the above formula for subsequent use;

[0066] b. Preparation of blank matrix: weigh the matrix according to twice the weight percentage of the prescription, add water for injection to swell for later use;

[0067] c. Preparation of medicinal solution: Weigh distilled water, add azone, propylene glycol and benzalkonium chloride to fully dissolve, then weigh ketorolac tromethamine and stir until completely dissolved;

[0068] d. Preparation of oi...

Embodiment 3

[0070] Ketorolac tromethamine ointment for external use of the present invention, the prescription of this ointment contains the medicine of following percentage by weight:

[0071] Ketorolac Tromethamine 2%

[0072] Glycerin Gelatin 92%

[0073] Benzalkonium Chloride 0.01%

[0074] Azone 0.8%

[0075] Borax 0.2%

[0076] Propylene Glycol 0.7%

[0077] Others are distilled water

[0078] The preparation method of ketorolac tromethamine external ointment of the present invention, the method comprises the steps:

[0079] A, get each component by the prescription described in claim 1 for subsequent use;

[0080] b. Preparation of medicinal solution: Weigh distilled water, add azone, propylene glycol and benzalkonium chloride to fully dissolve, then weigh ketorolac tromethamine and stir until completely dissolved;

[0081] c. Preparation of ointment: add an appropriate amount of base material to the liquid medicine in step b, stir fully to a homogeneous system, adjust the p...

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Abstract

The invention relates to an externally applied ointment of ketorolac tromethamine and its preparation method, wherein the ointment comprises 1-5 wt% of ketorolac tromethamine, 0.5-95 wt% of ointment matrix, 0.2-2 wt% of bactericidal agent, 1-4 wt% of penetration enhancer, 1-2 wt% of propylene glycol and aqueous medium. The preparing process comprises (1) preparing ketorolac tromethamine soup, (2) preparing blank ointment, (3) preparing the ointment.

Description

1. Technical field: [0001] The invention relates to an analgesic ointment and a preparation method thereof, in particular to an ointment containing the non-steroidal anti-inflammatory analgesic drug ketorolac trometamol as an active ingredient and a preparation method thereof. 2. Background technology: [0002] Ketorolac tromethamine, like other NSAIDs, works by synthesizing prostaglandin inhibitors. But its systemic analgesic effect is stronger. In the standard animal model of analgesic activity, the analgesic activity of ketorolac tromethamine is 800 times that of aspirin, much stronger than indomethacin and naproxen, and equal or better than phenylbutazone. In many tests, its anti-inflammatory activity is equal to or stronger than indomethacin, stronger than naproxen, and obviously better than phenylbutazone. In the rat model, the antipyretic activity of ketorolac tromethamine was stronger than that of aspirin and phenylbutazone, and it was equivalent to that of indomet...

Claims

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Application Information

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IPC IPC(8): A61K31/40A61K9/06A61P25/04A61P29/00
Inventor 唐世军
Owner SHENYANG MINGHUA PHARMA
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