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Pharmaceutical composition containing etodolac and tramadol hydrochloride and application thereof

A technology of tramadol hydrochloride and etodolac, which is applied in the field of medicine, and can solve the problem of undisclosed optimal ratio of tramadol and etodolac, undisclosed optimal ratio of tramadol and meloxicam, etc. problems, achieve good drug safety, reduce adverse reactions, and improve compliance and compliance

Inactive Publication Date: 2014-06-18
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

U.S. Patent No. 20,080,050,427 discloses a composition containing tramadol and meloxicam, wherein the content of tramadol is 25-800 mg, and the content of meloxicam is 0.5-1500 mg, but the maximum amount of tramadol and meloxicam is not disclosed Optimal ratio, not related to optimal ratio of tramadol and etodolac composition and corresponding pharmacological experiment data

Method used

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  • Pharmaceutical composition containing etodolac and tramadol hydrochloride and application thereof
  • Pharmaceutical composition containing etodolac and tramadol hydrochloride and application thereof
  • Pharmaceutical composition containing etodolac and tramadol hydrochloride and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 tablet

[0022] prescription

[0023]

[0024] Preparation Process:

[0025] Drug and adjuvant are crossed 80 mesh sieves respectively, etodolac is fully mixed with 34 grams of microcrystalline cellulose, 30 grams of pregelatinized starch and 13 grams of croscarmellose sodium, 10% starch slurry soft material, 18 Granulate with a mesh sieve and dry at 60°C to obtain Granule 1. Fully mix tramadol hydrochloride with 18 grams of microcrystalline cellulose, 12 grams of pregelatinized starch and 2 grams of croscarmellose sodium, make soft materials with 10% starch slurry, granulate with 18 mesh sieves, and dry at 60°C , get particle 2. According to the principle of equal increase, fully mix granule 1 and granule 2, sieve the granules with 16 mesh, add magnesium stearate, mix well, and compress into tablets, the tablet weight is 500 mg.

Embodiment 2

[0026] Example 2 tablet

[0027] prescription

[0028]

[0029]

[0030] The preparation process is the same as in Example 1.

Embodiment 3

[0031] Example 3 tablet

[0032] prescription

[0033]

[0034] The preparation process is the same as in Example 1.

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Abstract

The invention belongs to the field of medicine, and particularly relates to a pharmaceutical composition and an application thereof in preparation of analgesic drugs. The pharmaceutical composition takes etodolac and tramadol hydrochloride as active pharmaceutical ingredients, wherein the ratio of etodolac to tramadol hydrochloride is preferably 0.1-100:1, more preferably 4-8:1. The pharmaceutical composition can be made into an appropriate pharmaceutical preparation for drug administration, such as oral preparations. A large number of pharmacological experiments confirm that etodolac and tramadol hydrochloride have a significant synergistic effect in treatment of pains caused by various factors. The pharmaceutical composition is strong in analgesic effect, low in untoward effects, and suitable for long-term application for patients with pains.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a pharmaceutical composition for treating pain and its application, in particular to a pharmaceutical composition containing etodolac and tramadol hydrochloride and its application for pain treatment. Background technique [0002] Pain is a protective reaction produced by the body after being subjected to noxious stimuli, often accompanied by emotional activities such as fear and nervousness. In addition to feeling pain and emotional uneasiness, pain can also lead to physiological dysfunction, insomnia, and even life-threatening shock. Therefore, it is necessary to use analgesics appropriately in order to relieve severe pain and prevent shock clinically, and it is of great significance in the treatment of diseases and trauma rescue. [0003] Analgesics are divided into two categories, narcotic analgesics acting on the central nervous system and non-steroidal anti-inflammatory analgesics (NS...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/407A61K31/137A61P29/00
Inventor 赵志全冯芹赵云
Owner LUNAN PHARMA GROUP CORPORATION
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