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Method for preparing externally-used medicine gel for treating perianal ulcer

A kind of external medicine, perianal ulcer technology, applied in the field of medicine, to achieve the effect of accelerating healing, eliminating ulcer exudate, and curing perianal ulcer

Inactive Publication Date: 2015-12-16
崔新明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, in the treatment of anorectal diseases, there is no therapeutic drug that uses tetrahydropalmatine or tetrahydropalmatine in combination with indomethacin as the main active ingredient.

Method used

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  • Method for preparing externally-used medicine gel for treating perianal ulcer

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Effect test

Embodiment 1

[0015] The preparation of embodiment 1 gel

[0016] Prescription: 5g of L-tetrahydropalmatine, 10g of indomethacin, 10g of carbomer, 60ml of propylene glycol, 50ml of glycerin, 150ml of ethanol, appropriate amount of triethanolamine, and add purified water to 1000g.

[0017] Preparation process: Slowly add carbomer to water with about 50% of the prescription amount, stir while adding until a transparent gel matrix is ​​formed, dissolve L-tetrahydropalmatine and indomethacin in ethanol, and then add the matrix , stir evenly, add glycerin and purified water to the full amount, adjust the pH value to neutral with triethanolamine, and obtain.

Embodiment 2

[0018] The preparation of embodiment 2 gel

[0019] Prescription: Tetrahydropalmatine 10g, Indomethacin 10g, Carbomer 10g, Propylene Glycol 60ml, Glycerin 50ml, Ethanol 200ml, Triethanolamine amount, Purified water added to 1000g.

[0020] Preparation process: Slowly add carbomer to water with about 50% of the prescription amount, stir while adding until a transparent gel matrix is ​​formed, dissolve L-tetrahydropalmatine and indomethacin in ethanol, and then add the matrix , stir evenly, add propylene glycol, glycerin, and purified water to the full amount, and adjust the pH value to neutral with triethanolamine to obtain the product.

Embodiment 3 4

[0021] Example 3 Experimental Study on Treating Perianal Ulcer in Rats with Tetrahydropalmatine Combined with Indomethacin

[0022] 40 SD rats, half male and half male, body weight 200-220g. After one week of adaptive feeding, the rat perianal ulcer model was produced as follows: take filter paper and use a puncher with an inner diameter of 6 mm to make filter paper pieces of equal size, fully soak them in 99.0% acetic acid solution, and soak the soaked filter paper Put the sheet around the anus of the rat after anesthesia, so that the filter paper sheet is in close contact with the perianal skin and mucous membranes, use a piece of filter paper each time, change the filter paper sheet after 1 minute for each rat, and remove the filter paper sheet after sticking it three times.

[0023] On the second day after modeling, all the rats were randomly divided into the following four groups: model control group, tetrahydropalmatine group, indomethacin group and combined drug group, ...

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Abstract

The invention discloses a method for preparing externally-used medicine gel for treating perianal ulcer. The method comprises the following steps of weighing raw materials, preparing a gel substrate, dissolving L-tetrahydropalmatine and indomethacin in ethanol, then adding the solution into the substrate, performing even stirring, adding propylene glycol, glycerin and purified water to reach total amount and regulating a pH value of triethanolamine to be neutral to obtain the externally-used medicine gel. The externally-used medicine gel prepared by means of the method contains the tetrahydropatine and indomethacin, can remove ulcerative exudate and accelerate healing of ulcerative surface and accordingly achieves the purpose of curing the perianal ulcer.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine for external use for treating perianal ulcer. Background technique [0002] Perianal ulcers are sores in the mucous membrane or lining tissue at the end of the anal cavity. People with perianal ulcers often have anal pain or bleeding, especially during and after defecation. [0003] Tetrahydropalmatine, one of the effective alkaloid components of Corydalis Corydalis in traditional Chinese medicine, has the chemical structure of racemic tetrahydropalmatine (dl-tetrahydropalmatine, THP), which belongs to tetrahydroprotoberberines (THPBs). THP can be divided into left-handed body (1-THP) and right-handed body (d-THP) after chemical separation. Research results over the years have shown that only l-THP has central analgesic, sedative, and stable effects, while d-THP has no obvious analgesic effect, and is a dopamine (DA) emptying agent in the brain. The cli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61K9/06A61P1/04A61K31/405
Inventor 王新
Owner 崔新明
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