9 results about "Isocoumarin" patented technology

The invention discloses a preparation method of a 3-substituted isocoumarin compound, and belongs to the technical field of coumarin compound synthesizing.The preparation method comprises the steps that a 2-bromophenylboronic acid compound and alkyne serve as reaction substrates, a bidentate nitrogen ligand is added and dissolved in a solvent, under the action of alkali and a copper catalyst, a normal-pressure one-step cyclization reaction is conducted in the CO2 atmosphere, and the 3-substituted isocoumarin compound is obtained. The 3-substituted isocoumarin compound is obtained. According to the method, CO2, alkyne and 2-bromophenylboronic acid are used as reaction raw materials, cheap copper is used as a catalyst, the use amount is small, the 3-substituted isocoumarin is obtained through carbon-carbon coupling-cyclization by a CO2 activation one-step method under normal pressure, the conditions are mild, the cost is low, and the method is environmentally friendly.

To provide a compound having an action of inhibiting the proliferation of fungi, and to provide a composition containing the same.SOLUTION: Wherein R0 is - OH, - SH, - NHR6, or a halogen atom; R6 is H or a C1 - 6 alkyl group; one of R1 and R2 is - X - R3, and the other is H or a C1 - 6 alkyl group; X is a single bond or a C1 - 6 alkylene group; is H, -, or - C (= O) H; is H or a - 6 alkyl group; wetter is H or a wetter - 6 alkyl group, or wetter and wetter, together with the C of the - isochromene ring to which they are attached, form a 5 - or 6-membered ring containing O as a ring atom; C1 R3 1H R1 R5 OR5 R2 C1 R4. An antifungal composition comprising a compound represented by formula (I): SELECTED DRAWING: None

The invention discloses a method for selectively synthesizing 4-seleno-isocoumarin-1-imine in an electrochemical driving region and application of the 4-seleno-isocoumarin-1-imine, and belongs to the technical field of synthesis of organic heterocyclic compounds. According to the method, N-substituted 2-alkynyl benzamide and organic diselenide are used as raw materials, in an organic solvent containing electrolyte, a carbon-based material is used as an electrode, an electrolytic reaction is carried out under the condition of constant current, and a target product is obtained through separation and purification. According to the method, an electrochemical oxidation strategy is utilized, the problem of selectivity of competitive O-attack and N-attack cyclization paths is effectively solved by regulating and controlling the electronic effect of substituent groups on amide nitrogen, and O-cyclization products are guided in a high-regioselectivity manner. The method does not need to use a transition metal catalyst and an external chemical oxidant, and has the advantages of mild reaction conditions, wide substrate application range, high atom economy, easiness in amplification and the like; the obtained product has good antifungal activity and has application potential in the field of agricultural chemicals.

The invention provides an application of an isocoumarin compound (8-hydroxy-6-methylox-3-pentyliso coumarin) as shown in a formula I or pharmaceutically acceptable salts, esters and solvates of the isocoumarin compound in preparation of drugs or functional foods for reducing blood sugar and preventing and / or treating diabetes mellitus, and a preparation method of the isocoumarin compound and the pharmaceutically acceptable salts, esters and solvates of the isocoumarin compound and the pharmaceutically acceptable salts, esters and solvates of the isocoumarin compound. The invention further provides a pharmaceutical composition which comprises the compound shown in the formula I and pharmaceutically acceptable pharmaceutic adjuvants and is used as a pharmaceutical preparation, and the medicine is a hypoglycemic medicine and a medicine for preventing and / or treating diabetes.

The present application relates to a novel isocoumarin derivative, or a tautomer, stereoisomer, racemate, non-identical mixture of enantiomers, geometric isomer, solvate, pharmaceutically acceptable salt or prodrug thereof, and a pharmaceutical composition comprising the compound. The present application also discloses a preparation method of the novel isocoumarin derivative and its application in pro-angiogenic drugs. It is found through a transgenic zebrafish model that the isocoumarin derivative provided by the present application has strong pro-angiogenic activity and low toxicity, and has the potential to be developed into a pro-angiogenic drug.

The invention belongs to the technical field of biological enzymes and microorganisms, and particularly relates to a chimeric enzyme and application thereof in synthesis of isocoumarin compounds. Specifically, a polyketide synthase coding gene ColB in the Chaetomium olivum SD-80A and a polyketide synthase coding gene TerA from Aspergillus terreus are used for constructing the chimeric enzyme in a structural domain replacement manner for the first time, heterologous expression of the chimeric enzyme coding gene ColB-TerA-IV is realized by constructing a heterologous expression cassette, the function of the chimeric enzyme is determined, and the polyketide synthase coding gene ColB in the Chaetomium olivum SD-80A and the polyketide synthase coding gene TerA derived from Aspergillus terreus are used for preparing the polyketide synthase. The biosynthetic pathway of the fungus metabolite isocoumarin compound normal sporine is expanded, and lead compounds can be provided for novel herbicides and related drugs, so that the method has good practical application value.

This invention belongs to the field of bioenzyme and microbial technology, specifically relating to a chimeric enzyme and its application in the synthesis of isocoumarin compounds. Specifically, this invention is the first to utilize olive-colored hairy shells (… Chaetomium olivaceum A polyketide synthase encoding gene in SD-80A ColB With Aspergillus terreus ( Aspergillus terreus A polyketide synthase encoding gene from ( ) TerA Chimeric enzymes were constructed using domain substitution, and heterologous expression cassettes were built to achieve expression of the chimeric enzyme encoding gene. ColB‑TerA‑Ⅳ The heterologous expression of this chimeric enzyme confirmed its function, expanded the biosynthetic pathway of orthosporain, a fungal metabolite, and helped provide lead compounds for novel herbicides and related drugs, thus having good practical application value.

The invention relates to the technical field of biology, in particular to an endophytic fungus Perconia macrospinosa F35 of acrostichum brachystachys and a fermentation product and application of the endophytic fungus Perconia macrospinosa F35 of acrostichum brachystachys. The invention discloses an acropteris macrostachys coepiphytic fungus, namely a strain of Periconia macrostachys, and the strain is classified and named as Periconia macrostachys F35. The invention also discloses a preparation method of the Periconia macrostachys F35. Experimental verification shows that the strain can be used for synthesizing unsaturated cyclic compounds through a metabolic pathway, and the unsaturated cyclic compounds are respectively dichloro isocoumarin and dichloro cyclopentene derivatives. Further functional verification results show that the unsaturated cyclic compounds can significantly reduce expression of inflammatory factors NO in macrophages in an inflammatory state, and have significant anti-inflammatory activity. On the basis, the strain and metabolites thereof have important application prospects in the aspect of preparing anti-inflammatory drugs.

This invention provides a 3-substituted isocoumarin compound that combines aggregation-induced emission and antifungal properties, relating to the field of aggregation-induced emission and antibacterial materials technology. The 3-substituted isocoumarin compound has the following structural formula and is a light yellow solid powder that exhibits cyan fluorescence under 300-400 nm wavelength light. Specifically, it has the advantages of aggregation-induced emission effect, antifungal properties, readily available raw materials, rapid synthesis, and high yield.