12 results about "Biodegradable microsphere" patented technology

The invention provides a tissue repair filling composite gel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The composite gel is mainly prepared from hyaluronic acid and biodegradable microspheres through freezing and thawing physical crosslinking, the molecular weight of the hyaluronic acid is 80000-3000000, and the biodegradable microspheres are hydroxyapatite microspheres. The tissue repair filling composite gel is composed of a hyaluronic acid matrix which is obtained through freeze-thaw physical crosslinking and has a porous three-dimensional network structure and hydroxyapatite microspheres uniformly dispersed in the hyaluronic acid matrix, in the filling repair process, hyaluronic acid provides an instant filling effect, the hydroxyapatite microspheres stimulate collagen regeneration, and the tissue repair effect is improved. According to the tissue repair filling composite gel, the technical problems that the safety is poor due to the fact that existing hyaluronic acid gel obtained by relying on a cross-linking agent is used for in-vivo filling, and a regenerative microsphere filling agent is inconvenient to inject and use are effectively solved.

The invention discloses a preparation method of surface-modified degradable polymer microspheres, which comprises the following steps: (1) preparing dry microsphere powder: putting an oil-phase solution and a water-phase solution into emulsifying equipment for mixing and emulsifying to obtain emulsion; carrying out temperature rise and pressure reduction curing on the emulsion to obtain biodegradable microsphere dry powder; (2) dissolving the modification material: dissolving the modification material containing the amino group to obtain a solution containing the modification material; (3) swelling: dispersing the biodegradable microsphere dry powder in a third solvent and stirring to swell the surface structure of the biodegradable microsphere; (4) activation: adding a carbodiimide compound and an N-hydroxyl activator into the swollen biodegradable microsphere solution for activation, so that an O-acyl isourea intermediate is formed on the surface of the microsphere, and a surface-activated microsphere precipitate is obtained; and (5) modification: mixing the microsphere precipitate with a solution containing a modification material, and stirring to obtain the surface-modified degradable polymer microsphere. Compared with the prior art, the hydrogel has good hydrophilicity and biocompatibility.

This invention provides a biodegradable microsphere, its preparation method, and its application. The biodegradable microsphere comprises a porous microsphere with a continuous internal pore structure and a gelatin component loaded on the porous microsphere. The biodegradable polyester microspheres prepared by this invention using a thermally induced phase separation-crystallization method have an excellent interconnected porous structure. The microspheres formed by combining with gelatin biomacromolecules can provide an excellent adhesion and survival environment for cells.

The invention discloses a soluble microneedle loaded with high-dose microspheres, which comprises a substrate and a needle body, and the needle body is internally loaded with biodegradable microspheres in a compact stacking state. Biodegradable microspheres are coated in a needle body of a microneedle array through a soluble material, so that the soluble microneedle which is loaded with the biodegradable microspheres in a compact stacking state and is high in loading capacity is obtained, and the material selection and the structural design of the soluble microneedle are optimized; the microneedle array with various needle body lengths, geometric configurations and arrangement densities can be prepared according to different clinical requirements, and uniform distribution and dense filling of biodegradable microspheres in the needle body are realized, so that efficient delivery of the microspheres is guaranteed. Meanwhile, the biodegradable microspheres can be delivered to the required subcutaneous depth along with dissolution of the needle body by adjusting the length of the needle body, and a safe, effective and non-invasive technical path is provided for percutaneous delivery of the biodegradable microspheres.

A productivity-enhanced method for producing biodegradable microspheres, according to the present invention, uses a mixed continuous phase in which a continuous phase (water and surfactant), conventionally used for extracting an organic solvent from an emulsion, is mixed with an oil for extracting an organic solvent such that an organic solvent which has been extracted into the continuous phase is quickly absorbed into an oil phase consisting of the oil for extracting an organic solvent, and the continuous phase can thus remain fresh. Therefore, compared to the conventional method, the amount of a fresh continuous phase used can be significantly reduced and the total amount of an emulsion injectable into a microsphere production tank can be increased, thereby significantly increasing productivity.

This invention provides a tissue repair and filling composite gel, its preparation method, and its application, relating to the field of biomedical materials technology. The composite gel is mainly prepared by freeze-thaw physical cross-linking of hyaluronic acid and biodegradable microspheres, wherein: the hyaluronic acid has a molecular weight of 800,000 to 3,000,000, and the biodegradable microspheres are hydroxyapatite microspheres. The tissue repair and filling composite gel of this application consists of a hyaluronic acid matrix with a porous three-dimensional network structure obtained by freeze-thaw physical cross-linking and uniformly dispersed hydroxyapatite microspheres. During the filling and repair process, the hyaluronic acid provides an immediate filling effect, while the hydroxyapatite microspheres stimulate collagen regeneration. This tissue repair and filling composite gel effectively alleviates the technical problems of poor safety associated with existing hyaluronic acid gels obtained by cross-linking agents for in vivo filling, and the inconvenience of injecting regenerated microsphere fillers.

This invention provides a biodegradable microsphere, wherein the microsphere (i) has a diameter of from 1 ?m to 500 ?m; (ii) comprises a polylactic-co-glycolic acid copolymer (PLGA) matrix; (iii) carries pharmaceutical celecoxib; and (iv) when present in a suitable joint-related tissue, releases celecoxib for at least one month. This invention also provides related injectable formulations, methods for treating joint-related disorders, and kits.

This invention provides a biodegradable microsphere, wherein the microsphere (i) has a diameter of from 1 μm to 500 μm; (ii) comprises a polylactic-co-glycolic acid copolymer (PLGA) matrix; (iii) carries pharmaceutical tirzepatide; and (iv) when present subcutaneously or intramuscularly, releases tirzepatide for at least four weeks. This invention also provides related microsphere compositions, injectable formulations, therapeutic methods, and articles of manufacture.

The present invention relates to a method for producing biodegradable microspheres, whereby a greater amount of microspheres is produced per batch. In the method, a fresh continuous phase is supplied from the moment the supply of an emulsion solution is begun, and at the same time a continuous phase mixed with an organic solvent is discharged, and thus a dispersed solution can be additionally and continuously supplied in an amount exceeding that which can be supplied in a single batch to an emulsion tank in a conventional process, thus having the effect of increasing the production amount per batch. In addition, the residual concentration of the organic solvent mixed in the continuous phase can be constantly maintained at or below an appropriate level, thus having the effect of preventing agglomeration or deformation of microspheres that are in a soft state.

This invention provides a biodegradable microsphere, wherein the microsphere (i) has a diameter of from 1 μm to 500 μm; (ii) comprises a polylactic-co-glycolic acid copolymer (PLGA) matrix; (iii) carries pharmaceutical semaglutide; and (iv) when present subcutaneously or intramuscularly, releases semaglutide for at least four weeks. This invention also provides related microsphere compositions, injectable formulations, therapeutic methods, and articles of manufacture.

The invention belongs to the technical field of biodegradable microspheres, and particularly relates to application of surface heterogeneous microspheres in preparation of tissue filling products. The surface heterogeneous microsphere takes a pharmaceutically acceptable degradable polymer as a matrix, the surface of the surface heterogeneous microsphere is provided with a compact area and a porous area containing internal extending pore channels, the average particle size is 20-55 microns, and the surface area ratios of the compact area and the porous area are both 20-80%. The injection can be prepared by regulating and controlling the ratio of a pore-foaming agent to a polymer through an emulsification volatilization method, is used for preparing a regenerative tissue filling product for injection, and can recruit fibroblast migration, stimulate proliferation of fibroblast and collagen synthesis after subcutaneous implantation to realize volume filling and improve skin aging defects. The microspheres have excellent dispersity and a unique surface heterogeneous structure, can give consideration to early-stage rapid regeneration efficiency and long-term stable maintenance effect, ensure uniform and natural filling form, and provide an efficient and lasting solution for regenerative tissue filling.