32 results about "Biodegradable microsphere" patented technology

The invention discloses a method for preparing mono-disperse microemulsion, liposome and microspheres based on a microfluidic technology. The method comprises the following steps: taking aqueous solution (or oily solution) of a hydrophilic medicine (or a lipid-soluble medicine) as a disperse phase; taking an oil phase (or an aqueous phase) as a continuous phase; and respectively conveying the disperse phase and the continuous phase into corresponding micro-channels of a microfluidic chip device, shearing the phases into mono-disperse liquid drops of the encapsulated medicine, then curing the liquid drops by a certain curing method, and finally obtaining the medicine-carrying liposome, microspheres or the biodegradable microspheres with uniform size and dispersion stability. Under an optimum condition, the diameter distribution coefficients of the microemulsion and the microspheres can be less than 5%, and the diameter is 10-500microns. By utilizing the method, the problems such as uneven size, low embedding rate, poor dispersibility, poor targeting property, low bioavailability, low bioactivity of enzyme and cells, immune suppression and the like of the medicine-carrying microemulsion, the liposome and the microspheres prepared by the traditional ultrasonic method, agitation emulsification method and film hydration-dispersion method are solved.

The present invention provides biodegradable microspheres, compositions comprising a subject biodegradable microsphere, and methods of using a subject biodegradable microsphere for delivery of an agent to a site in an individual.

The invention discloses an olanzapine-containing biodegradable microsphere preparation and a preparation method thereof. The olanzapine-containing biodegradable microsphere preparation comprises 10-50wt% of olanzapine or its salt, 0.5-20wt% of release adjusting agents and 30-89.5% of PLGA. In the invention, the PLGA having a proper monomer LA:GA ratio is selected as a matrix material, and above one release adjusting agents are added, so the olanzapine loading is improved to above 30%, and the particle size distribution and the in-vitro drug release of microspheres are improved. The utilization of a biodegradable material to encapsulate olanzapine to prepare the microspheres realizes a good slow release effect and the maintenance of an in-vivo relatively-stable drug concentration for above 15-45d or more.

This invention relates to a process for preparing biodegradable microspheres and or nanospheres using an oil-in-water process for the controlled release of bioactive peptides.

A cost-effective, scalable technique for producing microspheres loaded with biologically active solid proteins is provided. The microspheres degrade over time and release biologically active VEGF, as demonstrated by the proliferation of HUVECs in vitro compared to negative controls. A defined concentration of microspheres can deliver a quantifiable level of VEGF with known release kinetics. The invention can be used with other growth factors and applied to tissue engineering applications such as the regeneration of peripheral nerve, bone, adipose tissue, and solid organs. The method of the invention includes the steps of dissolving a polymer with an organic solvent to produce a polymer solution; adding a biologically effective amount of a bioactive substance to the solution to produce a mixture of the polymer and the bioactive substance; vibrating the mixture to produce a bioactive substance-polymer complex; emulsifying the mixture to produce an emulsion comprising the bioactive substance-polymer complex; and extracting the organic solvent from the emulsion to produce microspheres comprising the polymer-bioactive substance complex, wherein the bioactivity of the bioactive substance is usefully preserved.

The invention relates to a method for preparing monodispersed biodegradable microspheres consisting in a) preparing an emulsion containing at least one polymeric phase and at least one aqueous phase at a viscosity ratio between the dispersed polymeric phase and the aqueous phase ranging from 0.12 to 10, b) exposing the thus obtained emulsion to a controlled laminar shear strength, c) removing a solvent from the polymeric phase and in d) isolating the thus obtained microspheres. The use of the prepared microspheres is also disclosed.

Disclosed are biodegradable microspheres, capable of releasing a glucose-regulating peptide in a controlled manner, comprising a biodegradable polymer carrier with the glucose-regulating peptide encapsulated therein, and methods for the preparation thereof. In addition to ensuring high encapsulation efficiency and high stability of the encapsulated drug, the microspheres shows neither an initial burst effect nor incomplete release and allows the zero-order release of drugs over a prolonged period of time, thus improving the therapeutic effect of the drug.

Disclosed are biodegradable microspheres, capable of releasing a glucose-regulating peptide in a controlled manner, comprising a biodegradable polymer carrier with the glucose-regulating peptide encapsulated therein, and methods for the preparation thereof. In addition to ensuring high encapsulation efficiency and high stability of the encapsulated drug, the microspheres shows neither an initial burst effect nor incomplete release and allows the zero-order release of drugs over a prolonged period of time, thus improving the therapeutic effect of the drug.

The present invention belongs to the field of medicinal preparation, relates to one kind of long-acting injection, and is especially one kind of long-acting medicine injection capable of inhibiting abrupt release effect. The present invention contains blank or medicated temperature-sensitive polymer solution and medicine-carrying biodegradable microsphere or particle, which is dispersed into the polymer solution just before use. The two components are mixed before use and injected into body, and medicine preparation will have its medicine on the surface and inside the microsphere or particle released smoothly and slowly. The present invention can raise the safety and effectiveness of available preparation.

The invention belongs to the technical field of fertilizer preparation, and particularly relates to a liquid organic fertilizer preparation method capable of avoiding stink generation. The preparationmethod comprises the following processing steps: (1) separation of sulfur bacteria: separating sulfur bacteria capable of degrading hydrogen sulfide from livestock manure, domesticating and culturingto obtain a sulfur bacteria culture solution; (2) preparation of biodegradable microspheres: immobilizing the sulfur bacteria cultured in the step (1) to obtain the biodegradable microspheres which are rich in three-dimensional pores; (3) raw material treatment: preparing fermentation raw materials of the liquid organic fertilizer, and pretreating the fermentation raw materials; (4) fermentation:fermenting the fermentation raw materials, a fermentation bacterial agent and biodegradable microspheres, wherein the mass ratio of the biodegradable microspheres to the fermentation raw materials is1: (40-120); and (5) solid-liquid separation: carrying out solid-liquid separation after the fermentation is completed so as to obtain a liquid which is a liquid organic fertilizer. By using the scheme to prepare the liquid organic fertilizer, the generation of hydrogen sulfide is effectively reduced, and the stink in the fermentation process is reduced.

The invention belongs to the field of fertilizer preparation, and discloses a biodegradable microsphere coating fertilizer. The biodegradable microsphere coating fertilizer is prepared according to the following steps that step (1) a microsphere carrier is prepared; step (2) a liquid fertilizer is prepared; step (3) a composite bacteria liquid is prepared; step (4) a fertilizer microsphere is prepared; step (5) the microsphere coating fertilizer is prepared. The biodegradable microsphere coating fertilizer has the advantages that the fertilizer efficiency is durable, the preparation technologyis simple and feasible, and the microsphere coating fertilizer is suitable for scale production.

The invention discloses a biodegradable microspheres coating fertilizer, which belongs to the technical field of fertilizer preparation. The biodegradable microspheres coating fertilizer comprises the following components by mass part: 30-35 parts of microspheres coating particles, 1-2 parts of borax, 1-2 parts of white copperas zinc sulfate, 8-11 parts of peat soil, 9-12 parts of river dry mud, 3-5 parts of magnesium oxide powder, 6-8 parts of powdered steatile, 20-33 parts of rock phosphate powder, and 15-25 parts of potassium ore powder. The microspheres coating fertilizer has the beneficial effect that according to different growth period and environment of crops, the microspheres coating fertilizer can adjust the nutrition element of the fertilizer in the coating for supplying the nutrition required by different crops, fertilizer dissolution rate and the growth requirement of the crops are consistent; the coating of the fertilizer can be automatically decomposed in soil, controlled release performance of the nutrient of the fertilizer can not be influenced after decomposition, cost is low, and the microspheres coating fertilizer has wide development prospect.

The invention discloses an amoxicillin biodegradable microsphere long-acting sustained-release preparation, which is prepared by mixing a drug dispersion phase I and a continuous phase II, wherein the drug dispersion phase I comprises polyester, acetate, amoxicillin, polyethylene glycol A and Tween, and the continuous phase II is polyethylene glycol B. According to the present invention, the amoxycillin is subjected to microsphere encapsulation by using the polyester as the skeleton material, and the skeleton material encapsulated biodegradable microsphere is subjected to phase dispersion by using polyethylene glycol with good water dispersion property as the continuous phase; and the prepared amoxicillin drug preparation has the microsphere encapsulation structure, can drive the drug to be slowly released along with the entering of the water in the microsphere in the body, and is suitable for the drinking administration of animal populations under the dispersion effect of the polyethylene glycol continuous phase.

The invention provides an in-situ tissue solidification engineering scaffold which is formed by carrying out in-situ solidification on polylactide-glycolide and biodegradable microspheres with the existence of a polarity organic solvent. The in-situ tissue solidification engineering scaffold provided by the invention uses the biodegradable microspheres as a pore-forming agent; the microspheres in the in-situ tissue solidification engineering scaffold are gradually degraded; a pore structure of the in-situ tissue solidification engineering scaffold is gradually formed; porosity is gradually increased; and in vivo gradient pore forming from outside to inside can be implemented, so that pore forming of the in-situ tissue solidification engineering scaffold is matched with tissue penetration. In the initial stage of in-situ solidification of the in-situ tissue solidification engineering scaffold provided by the invention, due to existence of part of undegraded pore-forming agent, the initial intensity of the in-situ tissue solidification engineering scaffold provided by the invention is obviously improved. Moreover, the in-situ tissue solidification engineering scaffold provided by the invention uses the biodegradable microspheres as the pore-forming agent, has good biocompatibility and avoids damage of high permeability of particles, such as salt, to tissue cells.

The present invention pertains to complexes comprising sterols and saponins. The complexes are capable of binding a genetic determinant including a polynucleotide. The complexes may further comprise a lipophilic moiety, optionally a lipophilic moiety comprising a contacting group and / or a targeting ligand, and / or a saccharide moiety. The complexes may further comprise an immunogenic determinant and / or an antigenic determinant and / or a medicament and / or a diagnostic compound. The complexes may in even further embodiments be encapsulated by an encapsulation agent including a biodegradable microsphere. The present invention also pertains to pharmaceutical compositions and methods of treatment of an individual by therapy and / or surgery, methods of cosmetic treatment, and diagnostic methods practised on the human or animal body.

The invention discloses a near-infrared responsive pramipexole-loaded degradable microsphere preparation. The near-infrared responsive pramipexole-loaded microspheres (PRX / HGNS-PLGA MS) are prepared by using HGNS as a photothermal effect material and by a polyvinylpyrrolidone protective technology, and a near-infrared controlled-release microsphere drug delivery system is formed. Pramipexole whichis administered three times a day is optimized to be the microsphere preparation which is administered once every two weeks, and the instantaneous rapid drug release can be achieved by a near-infrared button in PD patients with sudden illness. The constructed near-infrared responsive pramipexole-loaded biodegradable microsphere preparation is an excellent drug delivery system, has good application prospect and is expected to be applied to the treatment of PD.

A cost-effective, scalable technique for producing microspheres loaded with biologically active solid proteins is provided. The microspheres degrade over time and release biologically active VEGF, as demonstrated by the proliferation of HUVECs in vitro compared to negative controls. A defined concentration of microspheres can deliver a quantifiable level of VEGF with known release kinetics. The invention can be used with other growth factors and applied to tissue engineering applications such as the regeneration of peripheral nerve, bone, adipose tissue, and solid organs. The method of the invention includes the steps of dissolving a polymer with an organic solvent to produce a polymer solution; adding a biologically effective amount of a bioactive substance to the solution to produce a mixture of the polymer and the bioactive substance; vibrating the mixture to produce a bioactive substance-polymer complex; emulsifying the mixture to produce an emulsion comprising the bioactive substance-polymer complex; and extracting the organic solvent from the emulsion to produce microspheres comprising the polymer-bioactive substance complex, wherein the bioactivity of the bioactive substance is usefully preserved.

This invention provides a method for causing weight loss in a subject comprising introducing biodegradable microspheres into one or more of the subject's gastric arteries, wherein the microspheres (i) have a d90 value from 40 μm to 500 μm; (ii) comprise polylactic acid (PLA) and / or polylactic co-glycolic acid (PLGA); (iii) carry a therapeutically effective amount of pharmaceutical octreotide; (iv) embolize gastric arterial vessels supplied by the one or more arteries into which they are introduced; and (v) release octreotide during embolization.

The invention discloses a biodegradable Carbomer core-shell structure polymer microsphere, a preparation method and application thereof. The method comprises the steps that a biodegradable microsphere is taken as a base material, polyacrylic acid is grafted on the surface of the biodegradable microsphere, and crosslinking is carried out, so that the polymer microsphere which takes a biodegradable polymer as a core and cross-linked polyacrylic acid as a shell, the core and the shell are connected through chemical bonds, and the core is taken as a part of cross-linking points of the shell is prepared. According to the invention, according to the polymer microsphere, a biodegradable component is used as a core cross-linking point of carbomer resin, so that the problem that the carbomer resin cannot be degraded and forms micro-plastic in a water body to pollute the environment is solved; and the biodegradable component is introduced through a core-shell structure, so that compared with other synthetic methods in which biodegradable components are introduced, the carbomer resin has good storage performance and use performance.

The invention discloses a preparation method of a degradable bleeding stop microsphere capable of reducing pigmentation. The preparation method is characterized by comprising the steps: emulsifying and copolymerizing chitosan and plant starch so as to form a degradable microsphere precursor, compositing fullerenol and the microsphere by using a cross-linking agent, and performing purification, packaging and sterilization so as to obtain the degradable bleeding stop microsphere capable of reducing the pigmentation. The fullerenol and natural macromolecules are composited, so that the degradable bleeding stop microsphere not only has a favorable bleeding stop property and favorable biodegradability, but also has the effects of eliminating free radicals and reducing the pigmentation in the process of wound heal; the bleeding stop microsphere is simple in technology, lower in cost and convenient for industrial production.

This invention provides methods for treating prostate cancer and benign prostatic hyperplasia. Each method comprises introducing biodegradable microspheres into one or more of a subject's prostate arteries, wherein the microspheres (i) have a d90 value from 40 gm to 500 gm; (ii) comprise polylactic acid (PLA) and / or polylactic co-glycolic acid (PLGA); (iii) carry a therapeutically effective amount of pharmaceutical flutamide; (iv) embolize prostate arterial vessels supplied by the one or more arteries into which they are introduced; and (v) release flutamide during embolization. This invention also provides flutamide-carrying biodegradable microspheres and related articles of manufacture.

A method of treating or preventing infection at a surgical site comprising a bony defect and an implanted metal device is disclosed. Biodegradable microspheres are placed at the site and are capable of near-linear controlled release of an antibiotic agent for a predetermined period of time. The microspheres are configured to be large enough to avoid being phagocytosed and removed from the body, and small enough in diameter to not physically inhibit bone growth at said bony defect site. The microspheres are formed of polylactic-co-glycolic acid (PLGA), with or without polyethylene glycol (PEG), and sufficient antibiotic agent to produce bactericidal levels in body tissues. The microspheres exhibit near-linear delivery of the antibiotic agent for at least 4 weeks at levels exceeding the minimum inhibitory concentration (MIC) for organisms commonly found to be the cause of infections, and facilitate bone ingrowth or regrowth at the site.

This invention provides a biodegradable microsphere, wherein the microsphere (i) has a diameter of from 1 ?m to 500 ?m; (ii) comprises a polylactic-co-glycolic acid copolymer (PLGA) matrix; (iii) carries pharmaceutical celecoxib; and (iv) when present in a suitable joint-related tissue, releases celecoxib for at least one month. This invention also provides related injectable formulations, methods for treating joint-related disorders, and kits.

The present invention relates to treatment methods and methods for sustained delivery of one or more exogenous factors to desired nervous system sites. In certain embodiments, the invention relates to the use of biodegradable microspheres to deliver exogenous factors, such as the morphogenic factor, sonic hedgehog (Shh), to the site of spinal cord injury. In certain embodiments, the Shh-releasing microspheres are administered together with stem cells, which may be spinal cord neural stem cells. In certain embodiments, the invention relates to regrowth of neural cells in both the central and peripheral nervous systems.

A hydrogel delivery composition, including degradable microcapsules suspended in a degradable thermo-responsive hydrogel. The hydrogel is thermo-responsive at a physiological temperature and changes after application to a more solid state due to body temperatures. The composition includes one or more treatment agents to be released over time as the composition degrades. The composition can be varied to modify the structure and / or release of the treatment agent.

The present invention provides biodegradable microspheres, wherein microspheres (i) have a diameter of from 1 [mu] m to 500 [mu] m; (ii) a matrix comprising a polylactic acid-glycolic acid copolymer (PLGA); (iii) carrying the medicine celecoxib; and (iv) releasing the celecoxib for at least one month when present in a suitable joint-related tissue. The invention also provides related injectable formulations, methods for treating joint-related diseases, and kits.