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A preparation method of degradable hemostatic microspheres capable of reducing pigmentation

A technology of pigmentation and microspheres, which is applied in the field of preparation of degradable hemostatic microspheres, can solve the problems of regenerated cellulose degradation, no reduction of pigmentation, poor environmental adaptability, etc., and achieve industrial production, good hemostatic performance, and clear The effect of free radicals

Active Publication Date: 2017-07-25
江西博恩锐尔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] CN200410033680 discloses a preparation method of absorbable fibrin hemostatic patch, its main disadvantages are poor environmental adaptability, short shelf life and high price
Patent CN200610045418X discloses a medical powder or granule and its application, which mainly uses chitosan as a hemostatic material, and the hemostatic effect is better, but chitosan and its derivatives do not have the function of reducing pigmentation
Patent CN201410848483 discloses a preparation process of regenerated cellulose fiber absorbable hemostatic material, which uses regenerated cellulose to play a hemostatic effect, but the degradation of regenerated cellulose is controversial, and there is a certain risk in application

Method used

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  • A preparation method of degradable hemostatic microspheres capable of reducing pigmentation
  • A preparation method of degradable hemostatic microspheres capable of reducing pigmentation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Mix 100ml gelatinized 5% (g / ml) starch aqueous solution with 25ml 1% (g / ml) chitosan solution evenly, adjust the pH of the system to 8 with sodium hydroxide. Then 2g of Span 80 and 0.5g of Tween 60 were added as emulsifiers, and stirred at 50°C for 200 minutes. After stopping the reaction and standing for stratification, the upper layer solution was poured out, leaving a layer of milky white liquid. Then add 10ml of fullererol (average hydroxyl number is 10) 1% (g / ml) aqueous solution to the milky white liquid, stir for 30 minutes and mix evenly, then add 0.1g glutaraldehyde and continue stirring for 400 minutes, stop the reaction, purify and filter , and then dried at 40°C to obtain a light yellow powdery solid (yield 93.6%).

Embodiment 2

[0026] Mix 130ml gelatinized 3% (g / ml) starch aqueous solution with 15ml 2% (g / ml) chitosan solution evenly, adjust the pH of the system to 9 with sodium hydroxide. Then, 1 g of Span 80 and 1.5 g of Tween 60 were added as emulsifiers, and stirred at 45° C. for 100 minutes. After stopping the reaction and standing for stratification, the upper layer solution was poured out, leaving a layer of milky white liquid. Then add 20ml of fullererol (average hydroxyl number is 5) 1.5% (g / ml) aqueous solution to the milky white liquid, stir for 50 minutes and mix evenly, then add 0.07g formaldehyde and continue to stir for 500 minutes, stop the reaction, purify and filter, then Drying at 20°C gave a light yellow powdery solid (91.3% yield).

Embodiment 3

[0028] Mix 60ml of gelatinized 8% (g / ml) starch aqueous solution with 50ml of 0.5% (g / ml) chitosan solution, and adjust the pH of the system to 10 with sodium hydroxide. Then, 1 g of Span 80 and 1 g of Tween 60 were added as emulsifiers, and stirred at 55° C. for 250 minutes. After stopping the reaction and standing for stratification, the upper layer solution was poured out, leaving a layer of milky white liquid. Then add 1ml of fullererol (average hydroxyl number is 20) 5% (g / ml) aqueous solution to the milky white liquid, stir for 40 minutes and mix evenly, then add 0.3g epichlorohydrin and continue stirring for 60 minutes to stop the reaction purification After filtering and drying at 60°C, a light yellow powdery solid was obtained (yield: 88.9%).

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Abstract

The invention discloses a preparation method of a degradable bleeding stop microsphere capable of reducing pigmentation. The preparation method is characterized by comprising the steps: emulsifying and copolymerizing chitosan and plant starch so as to form a degradable microsphere precursor, compositing fullerenol and the microsphere by using a cross-linking agent, and performing purification, packaging and sterilization so as to obtain the degradable bleeding stop microsphere capable of reducing the pigmentation. The fullerenol and natural macromolecules are composited, so that the degradable bleeding stop microsphere not only has a favorable bleeding stop property and favorable biodegradability, but also has the effects of eliminating free radicals and reducing the pigmentation in the process of wound heal; the bleeding stop microsphere is simple in technology, lower in cost and convenient for industrial production.

Description

[0001] Technical field: [0002] The invention belongs to the field of medical dressings, and relates to a preparation method of degradable hemostatic microspheres capable of reducing pigmentation. [0003] Background technique: [0004] Traumatic hemorrhage is one of the most common injuries on the battlefield and various accident scenes, and excessive blood loss is the primary cause of death on the scene. Even if the wounded can be sent to the hospital for rescue, massive blood loss before the hospital will still cause higher mortality and serious complications (such as amputation, etc.) in the later stage. Therefore, it is of great significance to effectively control the wound at the first time of bleeding. Now hemostatic materials can be roughly divided into two categories: 1. Non-absorbable hemostatic materials (such as cotton yarn, bandages, etc.); 2. Bioabsorbable hemostatic materials (such as fibrin glue, chitosan, regenerated cellulose (soluble hemostatic Gauze), α-c...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08J3/12C08L3/02C08L5/08A61L15/28A61L15/18A61L15/44A61L15/42
Inventor 甘少磊高阳
Owner 江西博恩锐尔生物科技有限公司
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