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A kind of olanzapine-fluoxetine compound capsule preparation and preparation method thereof

A technology of olanzapine, fluoxetine, and fluoxetine, which is applied in the field of pharmaceutical preparations, can solve different problems, and achieve the effect of enhancing coordination and synergistic effects and wide application prospects

Active Publication Date: 2021-05-04
CHONGQING MEDICAL & PHARMA COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the half-life of fluoxetine is usually twice that of olanzapine, when indiscriminately mixed directly and absorbed by the body at the same time, the two cannot produce a synergistic effect due to the difference in half-life.

Method used

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  • A kind of olanzapine-fluoxetine compound capsule preparation and preparation method thereof
  • A kind of olanzapine-fluoxetine compound capsule preparation and preparation method thereof
  • A kind of olanzapine-fluoxetine compound capsule preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example

[0028] Prepare the olanzapine pellets of 100g and the fluoxetine pellets of 100g respectively according to the prescription of following table 1, the preparation method of described olanzapine enteric-coated type drug-containing sustained-release pellets comprises the steps: The coating material is dissolved in 75% ethanol solution to obtain a 5% ethanol solution of the enteric coating material; micronize olanzapine and pharmaceutical excipients, weigh the prescription amount, make a drug-containing pill core, and place the drug-containing pill core in In the coating granulator, adjust the parameters, spray 5% ethanol solution of the enteric coating material, and coat. After the coating is completed, take it out and dry at 55 ° C; the weight of the coating increases by 2%, and the average particle size is 20 mesh.

[0029] The preparation method of the fluoxetine gastric-soluble drug-containing sustained-release pellets comprises the following steps: dissolving the stomach-coat...

Embodiment 2

[0034] Preparation example

[0035]The olanzapine pellets of 100g and the fluoxetine pellets of 100g are prepared respectively according to the prescription of following table 2, and the preparation method of described olanzapine enteric-coated drug-containing sustained-release pellets comprises the steps of: The coating material is dissolved in 75% ethanol solution to obtain an 8% ethanol solution of the enteric coating material; the olanzapine and pharmaceutical excipients are micronized, and the prescription amount is weighed to make a drug-containing pill core, and the drug-containing pill core is placed in the In the coating granulator, adjust the parameters, spray 8% ethanol solution of the enteric coating material, and coat. After the coating is completed, take it out and dry at 60°C; the weight of the coating increases by 3%, and the average particle size is 40 mesh.

[0036] The preparation method of the fluoxetine gastric-soluble drug-containing sustained-release pel...

Embodiment 3

[0042] Preparation example

[0043] Prepare the olanzapine pellets of 100g and the fluoxetine pellets of 300g respectively according to the prescription of following table 2, the preparation method of described olanzapine enteric-coated type drug-containing sustained-release pellets comprises the steps: The coating material is dissolved in 75% ethanol solution to obtain an 8% ethanol solution of the enteric coating material; the olanzapine and pharmaceutical excipients are micronized, and the prescription amount is weighed to make a drug-containing pill core, and the drug-containing pill core is placed in the In the coating granulator, adjust the parameters, spray 8% ethanol solution of the enteric coating material, and coat. After the coating is completed, take it out and dry at 60° C.; the weight of the coating increases by 5%, and the average particle size is 60 mesh.

[0044] The preparation method of the fluoxetine gastric-soluble drug-containing sustained-release pellets...

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Abstract

The invention discloses an olanzapine-fluoxetine compound capsule preparation and a preparation method thereof, which are used for the drug treatment of bipolar affective disorder. The compound preparation contains two different pellets, which are respectively enteric-coated olanzapine-containing Flat sustained-release pellets and gastric-soluble fluoxetine-containing sustained-release pellets; the olanzapine-fluoxetine compound capsule preparation of the present invention is combined according to the different in vivo pharmacokinetic laws of olanzapine and fluoxetine Two types of pellets with different ratios and different release parts complete the preparation of products of different specifications; achieve rapid onset of effect, synergistic effect, and reduce the number of times of taking medicine.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an olanzapine-fluoxetine compound capsule preparation and a preparation method thereof. [0002] technical background [0003] Depression, also known as depressive disorder, is the main type of mood disorder with significant and persistent low mood as the main clinical feature. It can be seen clinically that the mood is not commensurate with the situation. The depression of mood can range from gloomy to distraught, low self-esteem and depression, even pessimistic world-weariness, and there may be suicide attempts or behaviors; even stupor; some cases have obvious anxiety and motor agitation; In severe cases, psychotic symptoms such as hallucinations and delusions may appear. Each attack lasts for at least 2 weeks, or even several years in the elderly. Most cases have a tendency to recur. Most of each attack can be relieved, and some may have residual symptoms ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/551A61K31/137A61K9/62A61K9/56A61K47/38A61K47/32A61K47/36A61P25/24A61P25/18
CPCA61K9/5026A61K9/5036A61K9/5042A61K31/137A61K31/551A61P25/18A61P25/24A61K2300/00
Inventor 张稳稳刘小东蒋文
Owner CHONGQING MEDICAL & PHARMA COLLEGE
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