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Kojic acid producing process

A production process and technology of kojic acid, applied in the field of preparation of ketone organic compounds, can solve the problems of imperfect production process of kojic acid, many production equipment, low purity of kojic acid, etc. The effect of high acidity

Inactive Publication Date: 2003-05-14
山东中舜科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the production technology of kojic acid in China is still in the research and pilot stage, and the production process of kojic acid is not perfect; the saccharification and purification process in the production process of kojic acid mostly adopts traditional technology, with many production equipment and complicated operation, and consumes a lot of energy , low purity of kojic acid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Example 1 Put 6 tons of cornstarch into the fermenter, add water to adjust the slurry, put 15 kg of α-amylase, and indirectly raise the temperature to 100°C for liquefaction and saccharification. Use iodine reagent to detect liquefaction and saccharification. When the saccharification reaches the point where the iodine reagent does not turn blue but turns brown-red, add a reasonable amount of magnesium chloride nutrient salt, directly raise the temperature to 130°C, and keep it warm for 30 minutes for disinfection. Cool to 36°C, insert Aspergillus oryzae (Aspergillus soryzae), carry out ventilated culture and fermentation, the acidity of acid production is 6.7%, and the color of the fermentation liquid is slightly yellow. After the fermented liquid is filtered through a plate and frame filter press, kojic acid clear liquid is obtained, and the clear liquid is concentrated, crystallized and centrifuged several times to obtain multiple crystals of kojic acid. Put multiple...

Embodiment 2

[0008] Example 2 Put 6 tons of cornstarch into the fermentation tank, add water to adjust the slurry, put in 45 kg of α-amylase, and indirectly raise the temperature to 70°C for liquefaction and saccharification. Check the saccharification situation. When the saccharification reaches the point where the iodine reagent does not turn blue but turns brownish red, add a reasonable amount of potassium chloride nutrient salt, directly raise the temperature to 110°C, and keep it warm for 40 minutes for disinfection. Cool to 32°C, insert Aspergillus oryzae (Aspergillus soryzae), carry out ventilated culture and fermentation, the acidity of acid production is 6.5%, and the color of the fermentation liquid is slightly yellow. After the fermented liquid is filtered through a plate and frame filter press, kojic acid clear liquid is obtained, and the clear liquid is concentrated, crystallized and centrifuged several times to obtain multiple crystals of kojic acid. Put multiple crystallized...

Embodiment 3

[0009] Example 3 Repeat Example 1 according to the same steps as described, but the input α-amylase is 30 kg, the starch liquefaction and saccharification temperature is 85°C, the sugar liquid disinfection temperature is 120°C, and the disinfection time is 35 minutes. The temperature is 34°C, the acidity is 6.7%, the crystal purity is 98.2%, and the crystal is uniform.

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PUM

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Abstract

The present invention relates to a production process of kojic acid and belongs to the preparation of oxygenous organic compound. The production process includes liquefying and saccharifying starch in a fermenting tank; inoculating to sterilized saccharide liquid to culture kojic acid via fermentation; and refining kojic acid through concentration and crystallization of kojic acid liquid, dissolving crystallized product, decoloring, cooling and crystallization to obtain kojic crystal. The product is homogeneous crystal with purity over 98%.

Description

Technical field [0001] The invention belongs to the preparation of oxygen-containing organic compounds, in particular to the preparation of ketone organic compounds. Background technique [0002] The scientific name of kojic acid is 5-hydroxy-2-hydroxymethyl-1,4-pyrone, and the English name is Kojicacid (5-hydroxy-2-hydroxymethyl-1,4-pyrone). High-purity kojic acid is white or beige needle-like crystal; easily soluble in water, alcohol, acetone, slightly soluble in ether, ethyl acetate, chloroform and pyridine, insoluble in benzene; its molecular formula is C 6 h 6 o 4 , the molecular weight is 142.1, and the melting point is 153-156°C. It is an important organic compound and has important uses in food, cosmetics, medicine and other fields. It can remove free radicals in the human body and enhance cell vitality. It is a safe and versatile product. [0003] Kojic acid is an organic acid produced by fermentation. In terms of kojic acid synthesis technology, starch is mostl...

Claims

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Application Information

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IPC IPC(8): C12P17/06
Inventor 王廷刚李大林谭黎明张艳阮毅
Owner 山东中舜科技发展有限公司
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