48 results about "Bispyrithione" patented technology

The invention discloses a preparation method for high-purity milrinone (shown as a formula (I), 1,6-dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile), and belongs to the field of chemical medicines. The method comprises: employing 4-methylpyridine as a raw material and acetylating with acetyl chloride, and hydrolyzing after the reaction is finished, so as to obtain a compound of a formula (III); mixing the compound of the formula (III) with glacial acetic acid, acetic anhydride and triethyl orthoformate, and reacting at 35 DEG C-45 DEG C, so as to obtain a compound of a formula (IV); performing cyclization on the compound of the formula (IV) and alpha-cyanoacetamide, so as to obtain a crude product of a compound of the formula (I); and refining the crude product of the formula (I) compound through an ethanol-water system, so as to obtain a high-purity refined product with the maximum interplanar spacing d of 8.39 +/- 0.02 Angstrom. The technology is relatively mild in reaction conditions and relatively simple in operation, and is capable of preparing the milrinone product with high purity and a single crystal form. The obtained milrinone crystal form is relatively excellent in solubility in normal saline or glucose, and is beneficial for improvement of the preparation quality.

The invention provides bispyridyl benzimidazole compounds and a synthesis method thereof. The method comprises the following steps of: synthesizing three monopyridyl benzimidazoles by taking pyridinecarboxylic acid and o-phenylenediamine as raw materials by a microwave radiation method; and reacting the three monopyridyl benzimidazoles and a dihaloalkane compound in N,N'-dimethylformamide (DMF) reaction medium under middle temperature water bath conditions by using inorganic base as an acid binding agent for 8 to 12 hours to obtain a series of bispyridyl benzimidazole compounds. The method iseasy to operate; moreover, the yield is high, and the product has high purity, and is easy to crystallize. The compounds have steady fluorescence emission properties at normal temperature, and can beused as blue luminescent materials with steady chemical properties. The invention fills in the gap of the research on flexible bispyridyl benzimidazole compounds at home and abroad at present, and also injects new vitality into the field of organic luminescent materials.

The invention discloses anti-dandruff oil-control shampoo. The anti-dandruff oil-control shampoo is prepared by conventionally mixing the following raw materials in percentage by weight: 21% of sodium laureth sulfate, 3.2% of sophora root extract, 3.5% of Cacumen biotae extract, 2.2% of ginger extract, 2% of cocamidopropyl, 0.8% of glycol distearate, 0.6% of cetyl stearic alcohol, 4.5% of cocamidopropyl betaine, 0.5% of guar gum hydroxypropyl trimethyl ammonium chloride, 0.2% of polyquaternium-10, 0.05% of sodium hyaluronate, 0.1% of citric acid, 0.25% of sodium citrate, 0.35% of bispyrithione, 1.2% of dimethiconol, 1.5% of vitamin B6, 0.2% of carbomer, 0.5% of panthenol, 0.1% of methylisothiazolinone, 0.5% of essence, 0.1% of EDTA-2NA and the balance of water. Compared with the anti-dandruff oil-control shampoo in the prior art, the anti-dandruff oil-control shampoo disclosed by the invention has the following beneficial effects of good anti-dandruff and oil-control effects, excellent skin friendliness and stronger penetration by selecting appropriate raw materials to form the formula. Furthermore, the anti-dandruff oil-control shampoo is a mild cleaning product which can better clean hair and scalp.

The invention discloses a compound antimicrobial composition containing microcapsules and a preparation method and application of the compound antimicrobial composition. The method includes the steps of firstly, homogenizing and evenly mixing folium artemisiae argyi essential oil, pogostemon cablin essential oil, fennel fruit essential oil and emulgator to obtain emulsified liquid I; secondly, dissolving tremella heteropolysaccharide and pectin in water, adding the emulsified liquid I to the mixture at the temperature of 45-50 DEG C, and evenly mixing the mixture to obtain emulsified liquid II; thirdly, dissolving polyamino acid in water, and dropwise adding the emulsified liquid II at the temperature of 65-75 DEG C in the stirring state; fourthly, continuing to conduct heat preservation and heating after the emulsified liquid II is dropwise added; fifthly, lowering the temperature to 40-45 DEG C, adding polyhydric alcohol, stabilizer and bispyrithione dispersion liquid, and conducting even stirring to obtain the compound antimicrobial composition containing microcapsules. The compound antimicrobial composition has the advantages of having the broad-spectrum antibacterial capacity and being high in antibacterial property and stability, and the like, and the market application potential is large.

The invention discloses an efficient scurf removing and itch relieving composite as well as a preparation method and an application thereof in shampoos. The efficient scurf removing and itch relieving composite comprises bispyrithione and a water-soluble chitosan derivative, and has the following advantages that (1) the composite is a solid powder, thus being convenient to use; (2) the composite can be evenly distributed in the shampoos, has enough contact surface with bacteria and fungi which cause the scurf during hair washing, thus being capable of giving a full play to the efficacy; (3) the efficacies of the antibiosis, the moisture preservation, and the chelation and the like of the water-soluble chitosan derivative are combined with the efficacies of the bispyrithione, thus improving the scurf removing effect of the bispyrithione, lowering the degrease capability of the bispyrithione, reducing the sensitive degree of the bispyrithione to the metal icons, and achieving the purpose of synergism; and (4) the composite is used to greatly improve the color stability in the shampoos, and has less acrimony to the skin. The shampoos prepared by the efficient scurf removing and itch relieving composite have preferable stability as well as scurf removing and itch relieving properties.

The invention discloses an anti-hair loss shampoo and a preparation method thereof. The shampoo is composed of the following components by weight percentage: 70-90% of a shampoo matrix and 10-30% of aChinese herb extracted liquid. The shampoo matrix is prepared from sodium polyoxyethylene fatty alcohol sulfate, soapnut saponin, fatty alcohol polyoxyethylene ether phosphate potassium salt, cetearyl glucoside, triethanolamine cocoyl glutamate, coconut diethanolamide, polyquaternium-7, cationic guar gum, bispyrithione, betaine salicylate, water and other raw materials. The Chinese herb extractedliquid is prepared from safflower, euonymus fortunei, multiflora rose root, garden balsam stem, seed of Intermediate Peashrub, leaf of carya cathayensis, root-bark of ovate catalpa, herba ecliptae, cacumen platycladi, cortex mori, sesame flower and other raw materials. The shampoo provided by the invention has the characteristics of cleaning and dandruff removing, mite killing and itching relieving, hair care and hair strengthening, hair nourishing and hair growing, has significant effects of preventing hair loss and promoting hair growth, also is free of alcohol and silicone oil, and is safeand reliable.

The invention discloses a self-antibacterial mask material as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, homogeneously mixing mugwort leaf essential oil, patchouli essential oil, foeniculum vulgare essential oil and one or more emulsifiers to obtain an emulsion I; secondly, dissolving a tremella fuciformis sporocarp extract and pectin in water, cooling to 45-50 DEG C, and adding the emulsion I for uniform stirring, thereby obtaining an emulsion II; thirdly, dissolving polyamino acid in water, heating to 65-75 DEG C, dropwise adding the emulsion II in a stirring state, and continuing stirring under a heat preservation condition after the dropwise addition is finished; finally, cooling to 40-45 DEG C, and adding one or more polyatomic alcohols, one or more stabilizers and a bispyrithione dispersion liquid, carrying out uniform stirring to obtain a microcapsule emulsion, coating the surface of mask paper with the microcapsule emulsion, and carrying out drying to obtain the self-antibacterial mask material. The microcapsule emulsion has the advantages of being broad-spectrum in antibacterial capability, high in stability, and non-toxic and harmless to skin; therefore, the self-antibacterial mask material containing the microcapsule emulsion is strong in antibacterial capability, and no preservative is needed.

The invention relates to an isothiazolinone composition. The isothiazolinone composition is characterized by comprising 1 to 15wt% of a 3-isothiazolinone compound, 0.05 to 0.2wt% of bispyrithione, 0.2 to 5wt% of 1,3,5-triazaphosphorine and the balance of one or more solvents. The isothiazolinone composition has excellent stability, does not contain inorganic salts and organic solvents, can be used in a dispersion solution or an emulsion or latex, has a wide application range and can effectively inhibit growth of harmful microorganisms.

The invention discloses a blue fluorescence N,N-bis(4-cyanophenyl)glycine zinc complex and a preparation method thereof. The chemical formula of the complex is (Zn(L)2(BYBP) )n, wherein L is a N,N-bis(4-cyanophenyl)glycine anion ligand, bpe is 4,4'-bispyridyl diphenyl. A synthetic method of the complex comprises the following steps: dissolving the N,N-bis(4-cyanophenyl)glycine anion ligand, 4,4'-bispyridyl diphenyl and metal zinc salt in water under a hydrothermal condition to prepare a solution, sealing the solution in a reaction kettle, heating the solution to 80-120 DEG C at the rate of 10DEG C/h, performing heat preservation for 3 days, performing natural cooling to room temperature to obtain pale yellow bulk crystals, separating the pale yellow bulk crystals, and then performing washing and drying to obtain the blue fluorescence complex. The complex has the advantages of high stability, simple preparation method, high yield and the like, and has potential application as a novel luminescent material in the field of LED luminescent materials.

The invention relates to antiseptic and anti-pollution polyvinyl acetate emulsion white glue, belongs to the technical field of adhesive materials, and aims at solving the problem of low antiseptic and anti-pollution performances caused by poor anti-bacterial performance in the prior art. The white glue is prepared through the following raw materials in percentage by mass: 30-50% of VAc monomer, 1.2-3.0% of emulsifying agent, 0.1-0.3% of initiator, 1.2-3.0% of plasticizer, 3.0-5.0% of isothiazolinone compound, 1.0-3.0% of coalescing agent, 0.02-0.04% of bispyrithione, and the balance water. The antiseptic and anti-pollution polyvinyl acetate emulsion white glue is high in sterilizing effect and high in adhering intensity.

The invention belongs to the technical field of shampoo, and particularly relates to hair-care and anti-dandruff shampoo and a preparation method thereof. The hair-care and anti-dandruff shampoo is prepared from, by weight, 5-10 parts of a traditional Chinese medicine extract and 90-95 parts of a shampoo matrix, wherein the shampoo matrix is prepared from the following raw materials in parts by weight: 2 to 15 parts of an anionic surfactant, 10 to 25 parts of an ampholytic surfactant, 1 to 3 parts of cationic guar gum, 6 to 8 parts of emulsified silicone oil, 5 to 12 parts of bispyrithione, 4 to 8 parts of betaine salicylate, 3 to 5 parts of propylene glycol, 2 to 5 parts of fatty acid glycol ester, 1 to 2 parts of citric acid and 20 to 30 parts of deionized water. According to the invention, grinding blocks are integrated with annular blocks, the grinding blocks can rotate relative to the annular blocks through rotation of a rotating shaft, and then part of a traditional Chinese medicine extract can be extruded and ground, so that the situation that the stirring effect is affected due to caking of the traditional Chinese medicine extracts is avoided, materials can be further refined, the dispersion effect of the materials can be further improved, and the purpose of homogenizing is achieved.

The invention discloses an anti-dandruff shampoo composition with a synergistic effect. The composition is characterized by comprising, by weight: 0.1-1.2% of one of bispyrithione and zinc pyrithione or a mixture of the two, and 0.05%-4.0% of long carbon chain quaternary ammonium phosphate ester. By utilizing the synergistic characteristic of bispyrithione, zinc pyrithione and long carbon chain quaternary ammonium phosphate ester, the invention realizes the same control of scalp microbe quantity under a low adding amount of bispyrithione or zinc pyrithione, and further realizes the purpose ofdandruff removal. Meanwhile, the composition form in the invention is also in favor of reducing the using amounts of conditioning agents in the shampoo composition.

The invention provides a domestic sterilizing agent and application thereof. The sterilizing agent at least comprises a solute and a solvent, wherein the solute comprises a pyrithiones substance and inorganic base; the pyrithiones substance is selected from optional one or more of the following components: hydroxy pyridinethione, bispyrithione, pyrithione or pyrithione urea; and the inorganic base is selected from optional one or more of the following components: potassium hydroxide, sodium hydroxide or lithium hydroxide. The sterilizing agent is suitable for families, and is safe, environmentally friendly and pollution-free.

The invention discloses a 2',6'-bispyridinyl substituted cannabidiol ether compound as shown in a formula I and a preparation method and application thereof. The 2',6'-bispyridinyl substituted cannabidiol ether compound is a novel compound and is obtained through synthesis, and cell experiments find that the compound has good anti-tumor cell proliferation activity and especially has an obvious tumor cell proliferation inhibition effect in lung cancer cells. The compound obtained by the method is high in purity, good in stability and good in biological activity. When the compound is combined with gemcitabine for use, the effect of inhibiting tumor cell proliferation is more obvious.

The invention belongs to the technical field of shampoo, and particularly relates to a preparation method and system of hair-care and anti-dandruff shampoo, and the hair-care and anti-dandruff shampoo comprises the following raw materials in parts by weight: 5-10 parts of traditional Chinese medicine extract and 90-95 parts of shampoo matrix, the shampoo substrate is prepared from the following raw materials in parts by weight: 2 to 15 parts of anionic surfactant, 10 to 25 parts of ampholytic surfactant, 1 to 3 parts of cationic guar gum, 6 to 8 parts of emulsified silicone oil, 5 to 12 parts of bispyrithione, 4 to 8 parts of betaine salicylate, 3 to 5 parts of propylene glycol, 2 to 5 parts of fatty acid glycol ester, 1 to 2 parts of citric acid and 20 to 30 parts of deionized water; according to the preparation system, the grinding block can be integrated with the annular block, the grinding block can rotate relative to the annular block through rotation of the rotating shaft, then part of the traditional Chinese medicine extract can be extruded and ground, the phenomenon that the stirring effect is affected due to caking of the traditional Chinese medicine extract is avoided, meanwhile, materials can be further refined, the dispersion effect of the materials can be further improved, and the purpose of homogenization is achieved.

A method of treating a fabric including contacting the fabric with an aqueous liquor comprising a bispyridinium alkane antimicrobial active wherein the aqueous liquor is substantially free of anionic surfactant.

The invention relates to a supercapacitor electrolytic solution additive, an electrolytic solution and an application of the electrolytic solution. The supercapacitor electrolytic solution additive comprises bispyridine salt conjugated organic molecules, the structure of the bispyridine salt conjugated organic molecule is shown as a formula (I), R1 and R1' are independently selected from substituted or unsubstituted alkyl, substituted or unsubstituted aryl and substituted or unsubstituted alkoxy, R2 is selected from a substituted or unsubstituted heteroaryl group and a substituted or unsubstituted five-membered heterocyclic group, and X1 and X2 are independently selected from groups consisting of fluorine-containing anions. According to the electrolytic solution additive and the electrolytic solution, the electrochemical performance of the supercapacitor can be greatly improved, the internal resistance of the electrolytic solution is effectively reduced, the current density is enhanced, and the specific capacitance, the energy density, the rate capability and the cycling stability of the supercapacitor are improved.

The invention relates to the field of preparation of bispyrithione, and discloses a synthesis method of high-content bispyrithione. The synthesis method comprises the following steps: dropwise adding an oxidant into a mixed system of 2-mercaptopyridine-N-oxide and an anionic surfactant, carrying out heating, keeping a temperature and successively carrying out suction filtration, washing, refining and drying to obtain solid bispyrithione, wherein the oxidant is a hypochlorous acid-urea solution. The content of the prepared bispyrithione is 98.0% or above, yield is increased to 90% or above, the quality requirements of daily chemical products can be met, a process is simple, and industrial application and popularization are easy.

The invention discloses a preparation method for 5,11-dihydro-6H-bispyridino-[3,2-b:2',3'-e][1,4]diazepines. The method comprises a step of subjecting a compound represented by a formula III and monosubstituted amine to a coupling reaction under the catalysis of a metal catalyst so as to produce a compound represented by a general formula IV and a step of subjecting the compound represented by the general formula IV to an intramolecular cyclization reaction to produce a compound represented by a general formula I. Concrete reaction route is described in the specification. According to the invention, copper/iron metal catalysis is creatively employed for preparation of a target object, construction of a carbon-nitrogen bond by using copper/iron metal catalysis under mild conditions is realized, and technical biases are overcome; as a copper/iron metal is used as a catalyst, the advantages of convenient storage, a cheap price, wide sources, easy recovery and the like are obtained, the usage amount of monosubstituted amine is reduced, post-treatment is simplified, cost is saved, and the method is more applicable to industrial large-scale production and has a better industrial practical value.

The present invention relates to a dinuclear monovalent gold complex containing a bipyridine group, which has both aggregation-induced luminescence and mechanochromic properties, and its application. A dinuclear monovalent gold complex containing a bipyridine group, which has both aggregation-induced luminescence and mechanochromic properties, has the structure described in formula 1. This metal complex exhibits an aggregation-induced luminescence effect from colorless to yellow, and the photoluminescence of the solid sample can be changed from green to bright yellow after mechanical grinding, and the yellow luminescence after grinding The green luminescence can be restored after the methyl chloride solvent vapor treatment. Therefore, such gold-containing complexes are expected to be used in the fields of luminescent materials and mechanical sensors.