38 results about "Skin biopsy" patented technology

An aqueous suspension of titanium dioxide, polymethylmethacrylate and Vitamin E oil is used to mark a location wherein a skin biopsy has been taken to enable subsequent identification of the biopsy location under ultraviolet light. The location is advantageously treated with Vitamin E oil on a daily basis subsequently extend the fluorescing life of the applied titanium dioxide.

A skin biopsy system covers all aspects of the biopsy procedure from initial incision to final closure. The system includes a flexible closure consisting of 4 elongated rigid members interconnected by flexible hinges. The opening within the closure is initially diamond-shaped, approximating an ellipse, which is then deformed or pinched to a narrow linear opening when the wound is closed. Included with the system is a knife which interacts with the closure to yield a guided incision of constant depth. The path of the knife is guided by interference between the blade and the inside faces of the closure while the depth is limited by interference of the handle proximal the blade and the top faces of the closure.

The invention relates to a deep learning-based skin biopsy image pathological characteristic recognition method. The method includes the following steps that: a plurality of layers of stacked automatic encoders are utilized to re-express the characteristics of a biopsy image; a series of convolutional neural networks are utilized to perform convolution and sampling on the characteristics of the image layer by layer, so that an abstract characteristic expression of the original skin biopsy image can be obtained; the characteristics obtained by the plurality of layers of stacked automatic encoders and the characteristics obtained by the convolutional neural networks are spliced together; and the recognition of pathological characteristics is completed by a multi-channel neural network. According to the deep learning-based skin biopsy image pathological characteristic recognition method of the invention, abstract concept expression is extracted through a deep learning model, and therefore, the method has high adaptability to factors such as color difference, illumination and magnification factors, and therefore, the accuracy of a computer in the recognition of pathological characteristics of skin biopsy images can be greatly improved.

Artificial dermis (1) obtained from plasma with platelets (2) and human fibroblasts. The plasma with platelets (2) is obtained from the fractionating of total blood (4) from the patient (8) by light centrifugation, and the human fibroblasts (3) from a skin biopsy (5). Clotting is obtained by adding calcium. This artificial dermis (1) provides for the rapid growth of the keratinocytes (6) seeded on its surface to build an artificial skin (7) which can easily be transplanted. Large areas of artificial dermis (1) are obtained from a small skin biopsy (5) and minimal quantities of plasma with platelets (2), which being enriched with cytokines and platelet growth factors, strengthens the proliferation of the cells seeded, both inside and on the surface. The artificial skin (7) obtained can be used to treat major burn treatments, chronic skin ulcers, etc., or be used, by employing genetically altered cells, as a vehicle for gene therapy.

Apparatus and method are for extraction of follicular units. A dermal biopsy punch is utilized in combination with a suction device for extraction purposes. The use of suction to extract the follicular unit allows for distribution of the forces over a large area of the unit, helping to keep the unit intact. A perforating device, affixed to the punch, is utilized to weaken the structural integrity of the extraction area. The perforating device, having a single spike member which is inserted into the skin at a small, previously determined depth, in several locations, surrounding the follicular unit and reducing the holding tissue around the unit. The spike member of the perforating device is relatively thin and unlikely to damage the follicular unit. Because suction is utilized to extract the follicular unit, the distal end of the apparatus may have a guard which functions to prevent the extracted follicular units from being vacuumed further therein.

A spoon-shaped skin biopsy instrument is used in the removal of superficial skin samples and skin abnormalities for subsequent laboratory analysis. The spoon-shaped skin biopsy instrument is comprised of a pair of spoon-shaped cutting edges, which surround the desired skin sample, a crossed-members apparatus with finger loops, and a pivot point that connects the crossed members. This present invention maximizes surgical efficiency and handling and minimizes operation time.

An automated skin biopsy apparatus for taking a biopsy of a lesion on skin may include a suture applicator configured to controllably suture skin surrounding the lesion before the lesion is resected from the skin, a lesion resector configured to controllably resect the lesion from the skin, a user-operated control, and a controller. The controller may be configured, in response to actuation of the user-operated control by a user, to automatically cause the suture applicator to suture skin surrounding the lesion and the lesion resector to resect the lesion from the skin while the sutures from the suture applicator are in place. Related processes are disclosed.

Biosafety blade devices that aid in the manipulation and safety of either single-edged or double-edged razor blades are disclosed. The devices include finger guards that assist with holding and manipulating a razor blade. The device also includes various embodiments of blade guards that prevent accidental contact with the sharp edge of a razor blade, securely lock a blade preventing reuse, minimize recoil and flying projectiles, control the depth of a skin biopsy, reversibly fix blade curvature and allow for tissue to be measured and securely held to the blade or easily expelled into a specimen container. The components of the biosafety blade, i.e., the finger guards and blade guards, can be used separately or they can be combined to provide for maximum comfort, accuracy, versatility and safety.

The disclosure provides methods and compositions for the evaluation of neuropathic pain and neurotrophic or other activity of a drug or drug candidate. In the disclosed methods, expression of certain gene(s) in tissue extracts from skin biopsies serves as a proxy of a relevant endpoint.

Biosafety blade devices that aid in the manipulation and safety of either single-edged or double-edged razor blades are disclosed. The devices include finger guards that assist with holding and manipulating a razor blade. The device also includes various embodiments of blade guards that prevent accidental contact with the sharp edge of a razor blade, securely lock a blade preventing reuse, minimize recoil and flying projectiles, control the depth of a skin biopsy, reversibly fix blade curvature and allow for tissue to be measured and securely held to the blade or easily expelled into a specimen container. The components of the biosafety blade, i.e., the finger guards and blade guards, can be used separately or they can be combined to provide for maximum comfort, accuracy, versatility and safety.

An automated skin biopsy apparatus for taking a biopsy of a lesion on skin. The apparatus may include a lesion stabilizer configure to controllably stabilize the lesion while on the skin, a lesion resector configured to controllably resect the lesion from the skin, a user-operated control, and a controller. The controller may be configured to automatically cause, in response to actuation of the user-operated control by a user, the lesion stabilizer to stabilize the lesion while attached to the skin and the lesion resector to resect the lesion from the skin while the lesion is being stabilized by the lesion stabilizer. Related processes are also disclosed.

The invention relates to an automatic device for performing skin biopsies, comprising a casing (2) housing a rod (3) on the distal end (3a) of which there is a circular blade (4), and means for causing simultaneous rotation and longitudinal advancement of the rod (3) from a first retracted position wherein the blade (4) of the rod (3) does not project via the distal end (2a) of the casing (2), to a second extended position wherein the blade (4) of the rod (3) projects via the distal end (2a) of the casing, followed by simultaneous rotation and longitudinal retraction of said rod (3) from said second extended position to said first retracted position.

The invention discloses a skin biopsy trephine device which comprises a cylindrical trephine body with the two ends open. An annular cutter is arranged at the front end of the trephine body. A piston is arranged in the trephine body and connected with a push-pull rod. The free end of the push-pull rod extends out of a rear end opening of the trephine body and provided with a pushing handle. A cutting edge of the annular cutter is of a shuttle shape. Scale marks are arranged on the outer surface of the annular cutter in the length direction of the annular cutter. According to the skin biopsy trephine device, the cutting edge of the annular cutter is of the shuttle-shaped structure, compared with a circular cutting edge of an existing annular cutter, the shuttle-shaped cutting edge has the advantages that a wound surface is small, alignment suture is easy, healing is fast, and the phenomena of a dog ear and scars are not prone to generation; the scale marks are arranged on the outer surface of the annular cutter, the incision depth can be displayed and the material obtaining depth can be effectively controlled conveniently; in addition, the skin biopsy trephine device is made of metal except for the piston so that the device can be reused after being sterilized and disinfected and use cost can be reduced.

The invention provides a skin tissue pathological specimen collection tool, relates to a spring mode skin biopsy ring cutter, and belongs to the technical field of medical apparatus and instruments. The spring mode skin biopsy ring cutter comprises an outer sleeve, a middle sleeve, a depth regulating sleeve, a center slide bar, a reset cutting ferrule, a bayonet lock, a pressure spring, a reset spring, a ring cutter bit, an outer hoop, a release button and a depth dividing rule. The spring mode skin biopsy ring cutter is characterized in that the depth regulating sleeve is screwed onto the middle sleeve; the center slide bar penetrates into the middle sleeve; the reset cutting ferrule is glidingly arranged at the upper end of the center slide bar through the pressure spring and the reset spring; the outer sleeve is screwed onto the reset cutting ferrule; the ring cutter bit is screwed onto the lower end of the center slide bar; the outer hoop is fixedly arranged on the middle sleeve; the release button is arranged between the outer hoop and the middle sleeve. As a spring mode is adopted by the spring mode skin biopsy ring cutter, cutter feeding is finished instantly, and therefore, the operation time is greatly shortened, and the pain of a patient is reduced. The spring skin biopsy ring cutter is simple and convenient in operational process, and suitable for being clinically popularized and applied.

An embodiment in accordance with the present invention provides a device for performing a skin biopsy that includes a generally curved blade to cut the skin at a predetermined depth disposed within or an integral part of a blade holder assembly. The blade holder assembly has an outer surface and the generally curved blade is coupled to the outer surface of the blade holder assembly. The device also includes a housing having an outer wall and said outer wall defining an interior space within the housing, such that the blade holder assembly and generally curved blade are disposed substantially within the inner space of the housing. The device also includes a handle coupled to the blade holder assembly and configured to rotate the blade holder assembly and in turn the generally curved blade within the inner space of the housing to perform the skin biopsy or removal of skin conditions.

Skin-biopsy devices are provided that include a retractable coring assembly. Methods of acquiring a skin biopsy are provided that can include placing a lower portion of a skin-biopsy device proximate skin to be sampled, and extending at least a portion of a coring assembly from the device to acquire at least a portion of the skin to be sampled, and retracting the portion of the coring assembly to within the device, and discharging the portion of skin for analysis.

The invention discloses a skin biopsy trepan, belonging to a medical instrument. The skin biopsy trepan comprises a drill rod, a drill bit and a handle, wherein a piston and a push-pull rod are arranged in the drill rod; the handle is vertically arranged on one side of the upper end of the drill rod; a sliding pin is arranged in the handle and is provided with a wedged head for positioning the push-pull rod; the drill bit comprises a drill bit main body, a circular cutter and a slide bushing; the slide bushing is positioned outside the drill bit main body; a return spring is arranged below the slide bushing; the circular cutter is arranged outside the slide bushing; the lower end of the drill bit main body is provided with a perforated plate; and the lower end of the perforated plate is provided with a rubber pad. The skin biopsy trepan has the advantages of rational structure, convenience in operation and capabilities of greatly improving the sampling efficiency of pathological specimens and reliving the pain of a patient.

The invention provides a skin tissue pathological specimen collection tool, relates to a press-type skin biopsy ring cutter, and belongs to the technical field of medical apparatus and instruments. The press-type skin biopsy ring cutter comprises a press handle, a center slide bar, a reset spring, an outer sleeve, a middle sleeve, a cutter bit sheath and a ring cutter bit. The press-type skin biopsy ring cutter is characterized in that the outer sleeve and the cutter bit sheath are respectively screwed onto the middle sleeve; the press handle and the ring cutter head are respectively screwed onto the center slide bar; the center slide bar is arranged in the middle sleeve through the reset spring. According to the press-type skin biopsy ring cutter provided by the invention, the cylindrical stalloy ring cutter bit is adopted, and the outer wall of the middle sleeve is provided with a depth dividing rule, and thus, a sampled specimen has a regular edge, and is in the shape of a standard cylinder; moreover, depth is controllable, so that the sampling success rate is greatly improved. The press-type skin biopsy ring cutter provided by the invention is reasonable in structural design, capable of enhancing the operational stability, shortening the operation time, reducing the pain of patients, simple and convenient in operational process, and suitable for being clinically popularized and applied.

The use of an iontophoresis electrode assembly for delivery of a drug formulation is described. The drug formulation includes an anaesthetic and a vasoconstrictor. It is administered to a patient prior to a procedure to produce clinically acceptable depth and duration of dermal anaesthesia at the portion of skin to subject to a painful procedure or to reduce or eliminate pain. The procedure is one selected from the group consisting of venipuncture, IV cannulation, needle aspirations, body piercings, blood donations, electrolysis, tattoo removal, tattoo application, injections, dermabrasion, skin peeling, high velocity particle ablation, pace maker implantation, pace maker replacement, epidural puncture, lumbar puncture, regional nerve blocks, skin harvesting, small skin incisions, skin biopsies, circumcisions or excisions. The iontophoresis electrode assembly may also be used to reduce or temporarily eliminate neuropathic pain.

The invention provides a gathering tool of skin tissue pathological samples, in particular relates to a negative pressure skin biopsy trephine, and belongs to the technical field of medical instruments. The negative pressure skin biopsy trephine comprises a cylinder-shaped trephine body with two ends opened, and a ring-shaped ringing knife is arranged at the front end of the trephine body. The negative pressure skin biopsy trephine is characterized in that an annular rubber plug is arranged in the trephine body and is perpendicular to the inner wall of the trephine body; the front end of a metal pull rod is hinged with the rubber plug, and the rear end extends out of the rear end of the trephine body. The edges of the samples gathered by the ringing knife are tidy and are standard column-shaped, so that the phenomenon is avoided that since the samples are extruded by tweezers, the tissues are damaged, and the quality of samples is improved; the operation stability is increased due to a reasonable structural design; and meanwhile, the surgical time is shortened, the pain of a patient is reduced, and the operation process is simple, easy and convenient.

The subject of the present invention is to provide a detection method for latent viral infections by detecting a gene product related to latent infections without going through an invasive procedure involving pain and bleeding, caused by skin biopsy and blood collection. Further, the subject of the present invention is to provide a kit for examination using in the detection of latent viral infections described above. As crusts and scales in a lesion contain large amounts of virus-infected cells which are in a state of dry necrosis, the method collects crusts and / or scales for a test sample and detects a gene product related to latent infections which may be present in the test sample. The kit for examination comprises (1) antisense oligonucleotide for reverse transcription of a gene product related to latent viral infections, (2) a primer set for amplifying a gene product related to latent viral infections and (3) a primer set for amplifying a housekeeping gene.

Briefly stated, the present invention provides compositions and methods for treating or preventing joint injuries utilizing hair follicle derived Non-Bulbar Dermal Sheath (“NDBS”) cells. Within one aspect of the invention methods are provided for isolating NBDS cells, comprising the steps of: (a) preparing vital hair; (b) cleaving the hair prepared in step (a) to remove the hair follicle bulb; (c) isolating Non-Bulbar Dermal Sheath tissue; and (d) cultivating the isolated Non-Bulbar Dermal sheath tissue to produce NBDS cells. Within one embodiment of the invention the vital hair is obtained by full skin biopsy from the occipital scalp of a subject.

Artificial dermis (1) obtained from plasma with platelets (2) and human fibroblasts. The plasma with platelets (2) is obtained from the fractionating of total blood (4) from the patient (8) by light centrifugation, and the human fibroblasts (3) from a skin biopsy (5). Clotting is obtained by adding calcium.This artificial dermis (1) provides for the rapid growth of the keratinocytes (6) seeded on its surface to build an artificial skin (7) which can easily be transplanted. Large areas of artificial dermis (1) are obtained from a small skin biopsy (5) and minimal quantities of plasma with platelets (2), which being enriched with cytokines and platelet growth factors, strengthens the proliferation of the cells seeded, both inside and on the surface.The artificial skin (7) obtained can be used to treat major burn treatments, chronic skin ulcers, etc., or be used, by employing genetically altered cells, as a vehicle for gene therapy.

The invention relates to an automatic device for performing skin biopsies, comprising a casing (2) housing a rod (3) on the distal end (3a) of which there is a circular blade (4), and means for causing simultaneous rotation and longitudinal advancement of the rod (3) from a first retracted position wherein the blade (4) of the rod (3) does not project via the distal end (2a) of the casing (2), to a second extended position wherein the blade (4) of the rod (3) projects via the distal end (2a) of the casing, followed by simultaneous rotation and longitudinal retraction of said rod (3) from said second extended position to said first retracted position.

Cells are generated from skin biopsies for use in cell implantation by identifying a source of skin cells that have a surface concentration of at least one cell selected from the group consisting of keritinocytes and / or melanocytes; taking a sample of tissue from the surface area; mechanically disaggregating the tissue samples; collecting the disaggregated cells; washing the disaggregated cells; filtering the washed disaggregated cells; providing a cell suspension with filtered and washed keritinocytes and / or melanocytes; and suspending the cell suspension in a medium. In greater particularity, the method may comprise a) identifying a source of skin cells that have a surface concentration of at least 400 cells per square millimeter of surface area of at least one cell selected from the group consisting of keritinocytes and / or melanocytes; b) taking a sample of those skin cells and culturing them to enrich for cells selected from the group consisting of keritinocytes and melanocytes to form cultured cells for transplantation purposes c) concentrating the cells selected from the group consisting of keritinocytes and / or melanocytes from the cultured mass of cells; and d) differentiating the concentrated cells selected from the group consisting of keritinocytes an / or melanocytes.

The invention discloses a skin cancer classification method based on the optical intensity and gradient of an OCT imaging image, and the method comprises the steps: (1) collecting a skin cancer imagethrough an OCT device, and normalizing the intensity in the OCT image into [0, 1]; (2) performing noise reduction on the OCT image through noise reduction processing; (3) extracting optical intensitycharacteristic parameters; (4) calculating to obtain the discrete value of each parameter of the marked sample, and then obtaining the difference and ROC analysis of each characteristic parameter in the marked control group through a mathematical statistics method to obtain a boundary value; and (5) calculating to obtain the discrete value of each parameter of the unknown sample, comparing the discrete value with the boundary value in the step (4), and classifying the unknown sample according to the comparison result. According to the invention, normal skin tissues, melanoma and melanin nevuscan be quickly and accurately judged; discomfort and trauma brought to a patient by an invasive method of skin biopsy are avoided.

A skin biopsy device and a method of operating a skin biopsy device are disclosed. The skin biopsy device comprises a base member configured to be placed onto a skin surface; an cutting member configured to be received by the base member and to be movable relative to the base member in a direction substantially orthogonal to the skin surface; and an actuation member configured to drive the cutting member to travel a predetermined distance at a predetermined velocity in said direction.

This invention relates to a novel approach for the generation of human induced neural border stem cells (iNBSCs) by the direct conversion of somatic cells (peripheral blood, skin biopsies) and to novel uses of such cells, including the differentiation of these stem cells into cell types of the CNS and the neural crest lineages, and the uses of such cells.

Briefly stated, the present invention provides compositions and methods for treating or preventing joint injuries utilizing hair follicle derived Non-Bulbar Dermal Sheath (“NDBS”) cells. Within one aspect of the invention methods are provided for isolating NBDS cells, comprising the steps of: (a) preparing vital hair; (b) cleaving the hair prepared in step (a) to remove the hair follicle bulb; (c) isolating Non-Bulbar Dermal Sheath tissue; and (d) cultivating the isolated Non-Bulbar Dermal sheath tissue to produce NBDS cells. Within one embodiment of the invention the vital hair is obtained by full skin biopsy from the occipital scalp of a subject.

Disclosed is an ex-vivo model of inflamed skin, an in-vitro method for obtaining the same and uses thereof for screening anti-inflammatory compounds. The method includes injecting, into the dermis of a healthy skin biopsy previously taken from a mammal, a composition including an effective amount for activating dermal resident T cells of an anti-CD3 antibody and an anti-CD28 antibody; and b) incubating the injected skin biopsy obtained in step a) in the presence of a composition including an effective amount, for obtaining the polarization of the T cells activated in step a) into LTh1 and / or LTh17 and the synthesis of inflammation markers, of at least one mixture of IL-1β, IL-23, and TGF-β.