Antifungal application of fraxetin

A technology of fencetin and antifungal drugs, which is applied in the field of medicine, can solve the problems of no fencetin and no antifungal effect of fencetin, and achieve the effects of improving antifungal effect, saving medical expenses, and enhancing the inhibitory effect

Active Publication Date: 2018-11-09
SHAANXI UNIV OF SCI & TECH
View PDF2 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern pharmacological studies have shown that fencetin has pharmacological effects such as antibacterial, anti-oxidation, anti-tumor, and liver protection. However, there are no reports on the antifungal effect of fencetin at home and abroad, and there is no report of fencetin as an antifungal drug synergist. A report on the combined use of antifungal azoles in the treatment of fungal diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antifungal application of fraxetin
  • Antifungal application of fraxetin
  • Antifungal application of fraxetin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0020] 1. The effect of fencetin alone on different fungi

[0021] 1. Test drug

[0022] Echinocetin: purchased from Chengdu Desite Biotechnology Co., Ltd., purity ≥ 99%, batch number DST170411-006.

[0023] Fluconazole (FLC)): sigma company, lot number 036M4709V.

[0024] Dimethyl sulfoxide: Tianjin Tianli Chemical Reagent Co., Ltd.

[0025] All reagents were stored at -20°C. Before the experiment, the drug was taken out and placed in a 35°C incubator to melt, mixed well, and pharmacodynamic tests were carried out respectively.

[0026] 2. Strains

[0027] Strains used, including:

[0028] 1) Sensitive strains: sensitive Candida albicans (SC5314), Candida parapsilosis (22019) and Cryptococcus neoformans (32609);

[0029] 2) Drug-resistant strains: drug-resistant strains: drug-resistan...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses antifungal application of fraxetin, belonging to the technical field of medicines. In-vitro experiments show that fraxetin has relatively good inhibition effect to the fungi, is capable of restoring the effect of an antifungal drug, namely fluconazole to drug-resistant fungi and therefore can be taken as the antifungal drug and a synergist for the antifungal drug. Accordingto the antifungal application, the new use of fraxetin is opened up, fraxetin is used as the antifungal drug and the synergist for the antifungal drug, a new candidate drug is provided for the fungustreatment, and the antifungal effects of existing drugs are improved. Under the conditions that clinical fungus drug resistance becomes common increasingly and the drug resistance level becomes serious increasingly, the effect of an antifungal drug to the drug-resistant fungi is restored, and the use dosage of the antifungal drug is reduced, so that the medical expense of a patient is saved, andthe toxic and side effects of the drugs are reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the antifungal application of afracetin. Background technique [0002] Auretin belongs to coumarin compounds and is one of the active ingredients contained in the leaves of water rhinoceros and Hima ash. It has the effect of resisting Shigella, and is clinically used to treat children with acute bacillary dysentery. Modern pharmacological studies have shown that fencetin has pharmacological effects such as antibacterial, anti-oxidation, anti-tumor, and liver protection. However, there are no reports on the antifungal effect of fencetin at home and abroad, and there is no report of fencetin as an antifungal drug synergist. Reports of combined use with antifungal azoles in the treatment of mycoses. Contents of the invention [0003] The object of the present invention is to provide the antifungal application of afracetin. [0004] The present invention is achieved...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61K45/06A61K31/4196A61P31/10
CPCA61K31/37A61K31/4196A61K45/06A61P31/10A61K2300/00
Inventor 刘伟乔欣悦张子悦
Owner SHAANXI UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap