37 results about "Mouse Auricle" patented technology

The invention discloses new dihydroiso-coumarin glucoside compounds shown in a formula I, which are extracted and separated from Periplaneta americanna medicinal materials. Through mouse auricle swelling tests, rat granulation tissue hyperblastosis tests and the like, results show that the compounds have effects of resisting inflammation, promoting wounds to heal and the like; and the compounds can be used for preparing medicines for treating inflammation, ulcers, wounds, incised wounds, fistula, burn, scalding and the like, particularly medicines for preventing and treating diseases related to inflammation resistance, promotion of granulation tissue hyperblastosis, wound healing and the like, and have high clinical application value. The invention provides a preparation method for the compounds shown in the formula I.

The invention discloses an external medicament for treating bacterial vaginosis and colpitis mycotica. The external medicament is a medicament prepared from Chinese medicinal raw materials including 35-70 parts by weight of amur corktree bark, 30-60 parts by weight of lightyellow sophora root, 30-60 parts by weight of cortex ailanthi, 20-40 parts by weight of polygonum aviculare, 10-35 parts by weight of selinum japenious seed and 1-2.5 parts by weight of borneol according to the conventional preparation method. As proved by a pharmacodynamic test, the medicament has a remarkable in-vitro antibacterial action, and can be used for effectively killing and suppressing common pathogenic bacteria of reproductive tract infection; the medicament has a remarkable treatment effect on rabbit colpitis mycotica; compared with a model control group, a medicament group has the advantages: the vagina cleanliness and curative ratio are increased remarkably, and the pathological feature of rabbit colpitis mycotica can be improved remarkably; the medicament has a remarkable anti-inflammatory effect, and can be used for remarkably relieving dimethyl benzene-caused mouse auricle inflammation, suppressing the formation of mouse granuloma and reducing the mouse abdominal cavity capillary permeability; and the medicament has a certain itching relieving effect.

The invention provides a rhizoma imperatae water-stage extract which is prepared by the following steps of: 1) performing backflow extraction of the coarse powder of rhizoma imperatae by use of 50-90% ethanol water by weight, and concentrating the extracting solution to obtain extract; and 2) adding water into the extract obtained in the step 1) and mixing to obtain suspension, extracting with petroleum ether, ethyl acetate and n-butyl alcohol sequentially, evaporating the obtained raffinate, and drying to obtain the rhizoma imperatae water-stage extract. In the invention, the effective anti-inflammation part in the rhizoma imperatae is screened through stage extraction to obtain the rhizoma imperatae water-stage extract. Among all stage extracts of rhizoma imperatae, the extract has the most obvious effect on inhibiting the mouse auricle swelling inflammation caused by paraxylene, and is expected to be used as an anti-inflammation medicine for preventing inflammation.

The invention belongs to the technical field of traditional Chinese medicine formula compatibility, and in particular relates to a yupingfeng powder modified compound as well as a preparation method and application thereof. The yupingfeng powder modified compound can be prepared into scutellaria baicalensis yupingfeng powder modified compound when scutellaria baicalensis is added, is prepared into nepeta cataria yupingfeng powder modified compound when nepeta cataria is added, or is prepared into scutellaria baicalensis and nepeta cataria yupingfeng powder modified compound when scutellaria baicalensis and nepeta cataria are added. The research result shows that by adopting the yupingfeng powder modified compound, the auricle swelling degree of a DTH model mouse can be remarkably reduced, the spleen index is remarkably reduced, the content of IL-4 in mouse serum is remarkably increased, the content of IFN-gamma in mouse serum is remarkably reduced, the expression level of IL-6 in the spleen is remarkably reduced, particularly the inhibition functions of nepeta cataria YPF and scutellaria baicalensis and nepeta cataria YPF on the mouse auricle swelling degree are both higher than that of yupingfeng powder, the immunosuppressive action of scutellaria baicalensis YPF and scutellaria baicalensis and nepeta cataria YPF is higher than that of the yupingfeng powder, the ratio of IFN-gamma to IL-4 in nepeta cataria YPF is greatly superior to that of the yupingfeng powder, and the activation of nepeta cataria YPF in reducing the expression level of IL-6 in the spleen is also superior to that of the yupingfeng powder.

The invention belongs to the field of traditional Chinese medicines, in particular relates to a traditional Chinese medicine for treating acne and a preparation method thereof. The traditional Chinese medicine is refined by thirteen traditional Chinese medicines of flos farfarae, coptis chinensis, honeysuckle, scutellaria baicalensis, prepared rehmannia root, moutan bark, salvia miltiorrhiza, radix rehmanniae recen, jasmine, radix scrophulariae, thunberg fritillary bulb, cortex mori and selfheal. All the medicines are compatible with each other perfectly to achieve the effect of clearing away heat, relieving poison, cooling blood and activating blood; the traditional Chinese medicine has obvious counteraction effect on the acute and chronic inflammation, has obviously antibacterial effect on the common skin pathogenic bacterium of staphylococcus aureus, staphylococcus epidermidis, beta hemolytic streptococcus, escherichia coli, pseudomonas aeruginosa and propionibacterium, can obviously reduce the swelling rate of the propionibacterium caused mouse auricle acne model, obviously improves the activity of catalase to achieve the anti-oxidation effect, and has a certain pain relieving effect; the traditional Chinese medicine has the advantages of short treatment course, quick effect and no toxic or side effects, and is a good medicine for treating the acne.

The invention discloses a preparation method and application of a blumea balsamifera effective component. A preparation process comprises the following steps: taking blumea balsamifera and extracting the blumea balsamifera with an ethanol water solution to obtain an extracting solution; concentrating the extracting solution until the extracting solution has no alcohol taste; adding water for diluting and extracting by utilizing ethyl acetate and n-butyl alcohol respectively to obtain ethyl acetate extract and n-butyl alcohol extract; drying a water part and an n-butyl alcohol extracting part to obtain the effective component. The preparation method and the application of the blumea balsamifera effective component have the beneficial effects that a xylol caused mouse ear swelling test and a mouse abdominal cavity capillary permeability increasing test determine that the obtained effective component has good anti-inflammatory activity.

The invention discloses application of gymnema sylvestre schult fruits in an anti-inflammatory drug and a composition of the application of the gymnema sylvestre schult fruits in the anti-inflammatory drug. The composition of the application of the gymnema sylvestre schult fruits in the anti-inflammatory drug is characterized in that the composition contains the gymnema sylvestre schult fruits having an anti-inflammatory effect, and the gymnema sylvestre schult fruits exist in a form of gymnema sylvestre schult fruit water extract or gymnema sylvestre schult fruits and 70-percent alcohol total extract. The anti-inflammatory action of the gymnema sylvestre schult fruit water extract and the gymnema sylvestre schult fruits and 70-percent alcohol total extract is researched by using xylene, a glacial acetic acid and carrageenan as pro-inflammatory cytokines, a result shows that mouse auricle swelling reaction caused by the xylene can be inhibited by the gymnema sylvestre schult fruit water extract and the gymnema sylvestre schult fruits and 70-percent alcohol total extract, increment of mouse peritoneal vascular permeability induced by the glacial acetic acid can be reduced, mouse toe swelling caused by the carrageenan can be inhibited, an anti-inflammatory effect is obtained, fewer adverse effects exist after taking the composition, and the safety is better; an extracting method and an extracting preparation method in the invention are simple in operation and easy to understand.

The invention belongs to the technical field of Zhuang medicines of traditional Chinese medicines, and particularly relates to application of dry paste powder of Ardisia brevicaulis Diels in preparation of anti-inflammatory and analgesic drugs. The Ardisia brevicaulis Diels is a whole dry plant of Ardisia brevicaulis Diels, and the dry paste powder of Ardisia brevicaulis Diels is extracted by adopting a water extraction and alcohol precipitation method. The invention discloses the application of the dry paste powder of Ardisia brevicaulis Diels in preparation of the anti-inflammatory and analgesic drugs for the first time. Pharmacological tests show that the dry paste powder of Ardisia brevicaulis Diels can obviously reduce the xylene-induced mouse auricle inflammation swelling degree, obviously reduce the mouse cotton ball granuloma quality, obviously improve the mouse hot plate pain threshold and obviously reduce the acetic acid-induced mouse pain writhing reaction frequency, has obvious anti-inflammatory and analgesic effects, and can be applied to preparation of the anti-inflammatory and analgesic drugs.

The invention provides a drug combination with antiinflammatory action and abirritation, which is prepared by lappaconitine hydrobromide and lamiophlomis rotate flavone as bulk pharmaceutical chemicals. In the invention, pharmacological research on the mutual effect and the compatibility of medicines of the lappaconitine hydrobromide and the lamiophlomis rotate flavone is carried out. The result shows that the drug combination of the invention can obviously improving the threshold value of mice compared with the situation that lappaconitine hydrobromide or the lamiophlomis rotate flavone is respectively used. The drug combination of the invention is subject to a mouse acetic acid writhing test, a mouse hot-water bath tail flick test, a rat carrageenin paw swelling test and a mouse auricle swelling test caused by dimethyl benzene so as to obtain the optimal formula of the drug combination. The drug combination of the invention has obvious antiinflammatory action and abirritation and has wide application prospects.

The invention provides a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components in parts by weight: 1-100 parts of sedum sarmentosum, 1-100 parts of honeysuckles, 1-100 parts of radix paeoniae rubra, 1-100 parts of moutan bark, 1-100 parts of prepared rhubarb and 1-100 parts of liquorice roots. The traditional Chinese medicine composition has an improvement effect on phlebitis vascular injury of marginal vein of rabbit ears, caused by vinorelbine tartrate, has an improvement effect on mouse caudal phlebitis vascular injury caused by fluorouracil, and has an inhibition effect on mouse auricle acute inflammation caused by xylene.

The invention discloses an application of Eurycomanol in preparation of a medicine, food and a health care product for preventing and treating abacterial prostatitis. According to the application disclosed by the invention, through a hypogastrium incision test of a male rat under aseptic operation and mouse auricle inflammation swelling caused by xylene, the Eurycomanol is found to have good anti-inflammatory and non-bacterial prostatitis prevention and treatment effects under the conditions of smearing and oral administration, and the application range of the Eurycomanol is widened.

The invention relates to the use of straw extract, wherein experimental results on straw extract show that, the straw extract has the functions of improving mouse's blood rheology, lowering blood density and coagulation tendency, depressing blood uric acid level, treating diseases caused by hyperuricemia, adjusting blood fat, postponing atherosclerosis development, and preventing cardiovascular and cerebrovascular diseases. Thus the straw extract can be used as active constituents for preparing medicaments of various dosage types.