5 results about "Mouse Auricle" patented technology

The invention discloses a Li medicine containing a chaenomeles speciosa seed oil cyclodextrin inclusion compound and a preparation method of the Li medicine. According to the method, on the basis of an original traditional Li medicine, a chaenomeles cathayensis seed oil cyclodextrin inclusion compound is added, so that the Li medicine is developed. A mouse auricle swelling anti-inflammatory test, wound healing rate comparison, wound colony count comparison and wound tissue pathological change analysis are carried out on the Li medicine, and the results show that the Taiwan crabapple seed oil cyclodextrin inclusion compound, the traditional Li medicine and the Li medicine containing the Taiwan crabapple seed oil cyclodextrin inclusion compound have remarkable anti-inflammatory and antibacterial effects. In addition, the anti-inflammatory and antibacterial effects of the Li medicine are better than those of the single use of the tamanu seed oil cyclodextrin inclusion compound or the traditional Li medicine, so that the Li medicine can be used for preparing the anti-inflammatory and antibacterial medicine.

The present invention relates to an external-use powder for treating acute eczema and a preparation method thereof. The external-use powder comprises 96-136 parts by weight of calamine, 1-3 parts by weight of Poria extract, 8-10 parts by weight of Dictamni cortex extract, 3-5 parts by weight of Forsythia suspensa extract, 7-9 parts by weight of Paeonia suffruticosa extract, 5-7 parts by weight of Cnidium monnieri extract, and 0.6-0.85 parts by weight of borneol. The external-use powder of the present invention has a significant therapeutic effect on acute eczema, can significantly inhibit the degree of auricular swelling in an acute eczema mouse model, and improve pathological changes such as epidermal and dermal edema and inflammatory cell infiltration in the mouse auricle tissue; can effectively reduce the toxicity and dosage of calamine, and can improve the safety of calamine; can effectively overcome the adverse aspects and contradictory problems of borneol in regulating allergen-specific immunoglobulin E and leukotriene B4, and can simultaneously reduce serum IgE and LTB4 levels.

On the basis of a traditional Li medicine for relieving cervical spondylosis, a new Li medicine for relieving cervical spondylosis was developed by adding copper pen flower fruit extract. The copper pen flower fruit extract has bergenin, various phenolic acids and alcohol compounds as the main active ingredients, and has analgesic and anti-inflammatory activities. By improving the traditional Li medicine prescription, a new Li medicine for relieving cervical spondylosis was developed. After the hot plate pain threshold reaction experiment on mice, the acetic acid-induced painful writhing experiment on mice, and the anti-inflammatory experiment on xylene-induced ear swelling in mice, it is fully proved that the copper pen flower fruit extract, the traditional Li medicine for relieving cervical spondylosis, and the new Li medicine compounded with the copper pen flower fruit extract and traditional Li medicine all have the effects of dredging meridians, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, and dispelling wind and cold, and have anti-inflammatory and analgesic effects. The analgesic and anti-inflammatory effects of the new Li medicine prescription for relieving cervical spondylosis are better than those of the copper pen flower fruit extract and the traditional Li medicine prescription for relieving cervical spondylosis.

The invention provides a preparation method of nipallol granules, which comprises the following steps: soaking nipallol for 0.5-2.5 hours by using 10-14 times by weight of water, decocting for 0.5-1.5 hours for 1-5 times, collecting filtrate, and concentrating to obtain extract; uniformly mixing the nipallol extract with auxiliary materials to prepare a soft material, granulating and drying to obtain nipallol granules; the weight ratio of the Nipailuo extract to the auxiliary materials is (1: 1)-(1: 2); the auxiliary material consists of glucose and soluble starch; the weight ratio of the glucose to the soluble starch is (1: 1)-(3: 7). The nipallol granules provided by the invention can remarkably inhibit the mouse auricle swelling rate (Plt; 0.05), and has a significant anti-inflammatory effect; the average painful body twisting frequency (Plt; 0.05) and the inhibition rate of pain and body twisting, and the inhibition rate is as high as 49.11%; the traditional Chinese medicine composition has a good antidiarrheal effect on mouse diarrhea caused by folium sennae; the traditional Chinese medicine composition has a good curative effect on lamb diarrhea, and the total effective rate is 96.67%.

This invention provides a topical Chinese medicine preparation with the effects of promoting blood circulation, removing blood stasis, relieving pain, and analgesia, and its preparation method. It relates to the field of traditional Chinese medicine pharmaceutical technology. The preparation is made from *Xia Tian Wu*, *Jian Xue Fei*, *Qi Ye Lian*, *Shen Jin Cao*, *Wu Xiang Xue Teng*, *Jiu Long Pan*, *Jing Tian San Qi*, *Jiu Jie Cha*, *Ban Bian Qi*, *Huang Bai*, *Qing Hao*, and *Hei Gu Teng*. This invention's preparation has a reasonable combination of herbs and possesses the effects of promoting blood circulation, removing blood stasis, regulating qi and relieving pain, anti-inflammatory and analgesic properties, improving microcirculation, and regulating blood viscosity. It can significantly increase the pain threshold in mice and effectively relieve pain symptoms. Simultaneously, it can significantly improve microcirculatory disorders in the auricle of mice and increase the rate of change in microvascular diameter. Furthermore, this preparation can effectively improve lameness and mental state in rats with knee osteoarthritis combined with blood stasis, and can effectively improve the state of high blood viscosity, providing a new treatment option for painful diseases, microcirculatory disorders, and related conditions such as knee osteoarthritis caused by blood stasis.