3 results about "Mouse Auricle" patented technology

The present invention relates to an external-use powder for treating acute eczema and a preparation method thereof. The external-use powder comprises 96-136 parts by weight of calamine, 1-3 parts by weight of Poria extract, 8-10 parts by weight of Dictamni cortex extract, 3-5 parts by weight of Forsythia suspensa extract, 7-9 parts by weight of Paeonia suffruticosa extract, 5-7 parts by weight of Cnidium monnieri extract, and 0.6-0.85 parts by weight of borneol. The external-use powder of the present invention has a significant therapeutic effect on acute eczema, can significantly inhibit the degree of auricular swelling in an acute eczema mouse model, and improve pathological changes such as epidermal and dermal edema and inflammatory cell infiltration in the mouse auricle tissue; can effectively reduce the toxicity and dosage of calamine, and can improve the safety of calamine; can effectively overcome the adverse aspects and contradictory problems of borneol in regulating allergen-specific immunoglobulin E and leukotriene B4, and can simultaneously reduce serum IgE and LTB4 levels.

The invention provides a preparation method of nipallol granules, which comprises the following steps: soaking nipallol for 0.5-2.5 hours by using 10-14 times by weight of water, decocting for 0.5-1.5 hours for 1-5 times, collecting filtrate, and concentrating to obtain extract; uniformly mixing the nipallol extract with auxiliary materials to prepare a soft material, granulating and drying to obtain nipallol granules; the weight ratio of the Nipailuo extract to the auxiliary materials is (1: 1)-(1: 2); the auxiliary material consists of glucose and soluble starch; the weight ratio of the glucose to the soluble starch is (1: 1)-(3: 7). The nipallol granules provided by the invention can remarkably inhibit the mouse auricle swelling rate (Plt; 0.05), and has a significant anti-inflammatory effect; the average painful body twisting frequency (Plt; 0.05) and the inhibition rate of pain and body twisting, and the inhibition rate is as high as 49.11%; the traditional Chinese medicine composition has a good antidiarrheal effect on mouse diarrhea caused by folium sennae; the traditional Chinese medicine composition has a good curative effect on lamb diarrhea, and the total effective rate is 96.67%.

This invention provides a topical Chinese medicine preparation with the effects of promoting blood circulation, removing blood stasis, relieving pain, and analgesia, and its preparation method. It relates to the field of traditional Chinese medicine pharmaceutical technology. The preparation is made from *Xia Tian Wu*, *Jian Xue Fei*, *Qi Ye Lian*, *Shen Jin Cao*, *Wu Xiang Xue Teng*, *Jiu Long Pan*, *Jing Tian San Qi*, *Jiu Jie Cha*, *Ban Bian Qi*, *Huang Bai*, *Qing Hao*, and *Hei Gu Teng*. This invention's preparation has a reasonable combination of herbs and possesses the effects of promoting blood circulation, removing blood stasis, regulating qi and relieving pain, anti-inflammatory and analgesic properties, improving microcirculation, and regulating blood viscosity. It can significantly increase the pain threshold in mice and effectively relieve pain symptoms. Simultaneously, it can significantly improve microcirculatory disorders in the auricle of mice and increase the rate of change in microvascular diameter. Furthermore, this preparation can effectively improve lameness and mental state in rats with knee osteoarthritis combined with blood stasis, and can effectively improve the state of high blood viscosity, providing a new treatment option for painful diseases, microcirculatory disorders, and related conditions such as knee osteoarthritis caused by blood stasis.