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37 results about "Mouse Auricle" patented technology
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Functional skin care product containing purslane extractive and preparation method thereof
ActiveCN102764217AMild textureImprove securityCosmetic preparationsAntipyreticGlycerolPurslane extract
The invention is a functional skin care product containing purslane extractive. Raw materials of the functional skin care product include, by weight, 10 parts of purslane extractive, 1-2 parts of Prinsepia utilis rogle oil, 2-5 parts of glycerol, 0.3-0.5 parts of crylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer, 2-3 parts of 1,2-pentanediol, 1-5 parts of synthesized squalane, 1-2 parts of tocopheryl acetate, 2-3 parts of cetostearyl alcohol, 0.1-0.2 part of allantoin, 0.3-0.8 part of sodium hyaluronate, 3-5 parts of Butyrospermum parkii butter, and 100 parts of deionized water. Or the Prinsepia utilis rogle oil and the Butyrospermum parkii butter are not added. By the aid of animal experiments, namely, mouse auricle swelling models due to dimethlbenzene, the functional skin care product containing purslane extractive is fine in anti-inflammation and anti-allergy effects, mild in nature and fine in safety, and is free of toxic reaction and anaphylaxis. The functional skin care product has an adjuvant therapy function to skin barrier recovery of common discosmetic dermatosis such as hormone dependent dermatitis and acne, and is fine in curative effect and safety.
Owner:YUNNAN BOTANEE BIO TECH GRP CO LTD
Dihydroiso-coumarin glucoside compounds and preparation method and application thereof
The invention discloses new dihydroiso-coumarin glucoside compounds shown in a formula I, which are extracted and separated from Periplaneta americanna medicinal materials. Through mouse auricle swelling tests, rat granulation tissue hyperblastosis tests and the like, results show that the compounds have effects of resisting inflammation, promoting wounds to heal and the like; and the compounds can be used for preparing medicines for treating inflammation, ulcers, wounds, incised wounds, fistula, burn, scalding and the like, particularly medicines for preventing and treating diseases related to inflammation resistance, promotion of granulation tissue hyperblastosis, wound healing and the like, and have high clinical application value. The invention provides a preparation method for the compounds shown in the formula I.
Owner:ZHEJIANG JINGXIN PHARMA +1
Mangiferin penta-esterified derivative
InactiveCN102432601AGood anti-inflammatory effectGood treatment effectOrganic active ingredientsOrganic chemistryChemical synthesisTherapeutic effect
The invention discloses a method for chemically synthesizing a mangiferin penta-esterified derivative and a pharmacological effect of resisting inflammation and reducing blood sugar of the derivative. The chemical structural formula of the derivative is shown in the specifications. The derivative has a remarkable effect of inhibiting mouse auricle tumefaction caused by dimethylbenzene; and the derivative has a remarkable effect of treating diabetic mice induced by alloxan.
Owner:GUANGXI UNIV OF CHINESE MEDICINE
External medicament for treating bacterial vaginosis and colpitis mycotica
ActiveCN102670811BGood treatment effectEnhance anti-inflammatoryAntimycoticsHydroxy compound active ingredientsPolygonum aviculareBacterial vaginosis
Owner:HC SYNTHETIC PHARMA CO LTD
Effect of medical glue blood-nourishing syrup on freckle removal, senescence resistance and increment of skin nutrition
Effect of medical glue blood-nourishing on freckle removal, senescence resistance and increment of skin nutrition relates to the new use of the medical glue blood-nourishing syrup. The medical glue blood-nourishing syrup has effects on freckle removal, senescence resistance and increment of skin nutrition and can be used for female beauty treatment. Henan Hongxin Medicine Science Research Institute performs influence test of luteosterone induced freckle model mouse, the influence test of luteosterone D-galactose induced senescence model mouse, the influence test of polar blood stasis model rat hemorheology and the influence test of mouse auricle circulation, and the tests show that the medical glue blood-nourishing syrup has obvious effects on freckle removal, senescence resistance and increment of skin nutrition. The effects are associated with the functions that the medical glue blood-nourishing syrup inhibits generation of melanin, removes free radicals, accelerates synthesis of collagen, and improves hemorheology and microcirculation.
Owner:WUHAN NO 6 PHARMA
Mangiferin hepta-propyl-esterified derivative
InactiveCN102432602AGood anti-inflammatory effectGood treatment effectOrganic active ingredientsOrganic chemistryChemical synthesisTherapeutic effect
The invention discloses a method for chemically synthesizing a mangiferin hepta-propyl-esterified derivative and a pharmacological effect of resisting inflammation and reducing blood sugar of the derivative. The chemical structural formula of the derivative is shown in the specifications. The derivative has a remarkable effect of inhibiting mouse auricle tumefaction caused by dimethylbenzene; and the derivative has a remarkable effect of treating diabetic mice induced by alloxan.
Owner:GUANGXI UNIV OF CHINESE MEDICINE
External medicament for treating bacterial vaginosis and colpitis mycotica
ActiveCN102670811AGood treatment effectEnhance anti-inflammatoryAntimycoticsHydroxy compound active ingredientsPolygonum aviculareBacterial vaginosis
The invention discloses an external medicament for treating bacterial vaginosis and colpitis mycotica. The external medicament is a medicament prepared from Chinese medicinal raw materials including 35-70 parts by weight of amur corktree bark, 30-60 parts by weight of lightyellow sophora root, 30-60 parts by weight of cortex ailanthi, 20-40 parts by weight of polygonum aviculare, 10-35 parts by weight of selinum japenious seed and 1-2.5 parts by weight of borneol according to the conventional preparation method. As proved by a pharmacodynamic test, the medicament has a remarkable in-vitro antibacterial action, and can be used for effectively killing and suppressing common pathogenic bacteria of reproductive tract infection; the medicament has a remarkable treatment effect on rabbit colpitis mycotica; compared with a model control group, a medicament group has the advantages: the vagina cleanliness and curative ratio are increased remarkably, and the pathological feature of rabbit colpitis mycotica can be improved remarkably; the medicament has a remarkable anti-inflammatory effect, and can be used for remarkably relieving dimethyl benzene-caused mouse auricle inflammation, suppressing the formation of mouse granuloma and reducing the mouse abdominal cavity capillary permeability; and the medicament has a certain itching relieving effect.
Owner:HC SYNTHETIC PHARMA CO LTD
Rhizoma imperatae water-stage extract and application thereof
The invention provides a rhizoma imperatae water-stage extract which is prepared by the following steps of: 1) performing backflow extraction of the coarse powder of rhizoma imperatae by use of 50-90% ethanol water by weight, and concentrating the extracting solution to obtain extract; and 2) adding water into the extract obtained in the step 1) and mixing to obtain suspension, extracting with petroleum ether, ethyl acetate and n-butyl alcohol sequentially, evaporating the obtained raffinate, and drying to obtain the rhizoma imperatae water-stage extract. In the invention, the effective anti-inflammation part in the rhizoma imperatae is screened through stage extraction to obtain the rhizoma imperatae water-stage extract. Among all stage extracts of rhizoma imperatae, the extract has the most obvious effect on inhibiting the mouse auricle swelling inflammation caused by paraxylene, and is expected to be used as an anti-inflammation medicine for preventing inflammation.
Owner:HEHUANG PHARMA SHANGHAI
Yupingfeng powder modified compound as well as preparation method and application thereof
InactiveCN104398572AHigh activityPromote innovationAntibacterial agentsNervous disorderNepeta catariaNepeta
The invention belongs to the technical field of traditional Chinese medicine formula compatibility, and in particular relates to a yupingfeng powder modified compound as well as a preparation method and application thereof. The yupingfeng powder modified compound can be prepared into scutellaria baicalensis yupingfeng powder modified compound when scutellaria baicalensis is added, is prepared into nepeta cataria yupingfeng powder modified compound when nepeta cataria is added, or is prepared into scutellaria baicalensis and nepeta cataria yupingfeng powder modified compound when scutellaria baicalensis and nepeta cataria are added. The research result shows that by adopting the yupingfeng powder modified compound, the auricle swelling degree of a DTH model mouse can be remarkably reduced, the spleen index is remarkably reduced, the content of IL-4 in mouse serum is remarkably increased, the content of IFN-gamma in mouse serum is remarkably reduced, the expression level of IL-6 in the spleen is remarkably reduced, particularly the inhibition functions of nepeta cataria YPF and scutellaria baicalensis and nepeta cataria YPF on the mouse auricle swelling degree are both higher than that of yupingfeng powder, the immunosuppressive action of scutellaria baicalensis YPF and scutellaria baicalensis and nepeta cataria YPF is higher than that of the yupingfeng powder, the ratio of IFN-gamma to IL-4 in nepeta cataria YPF is greatly superior to that of the yupingfeng powder, and the activation of nepeta cataria YPF in reducing the expression level of IL-6 in the spleen is also superior to that of the yupingfeng powder.
Owner:NANJING UNIV
Preparation method and pharmacological effect of mangiferin hexa-butyl-esterified derivative
InactiveCN102432603AGood anti-inflammatory effectGood treatment effectOrganic active ingredientsOrganic chemistryChemical synthesisTreatment effect
The invention discloses a method for chemically synthesizing a mangiferin hexa-butyl-esterified derivative and a pharmacological effect of resisting inflammation and reducing blood sugar of the derivative. The chemical structural formula of the derivative is shown in the specifications. The derivative has a remarkable effect of inhibiting mouse auricle tumefaction caused by dimethylbenzene; and the derivative has a remarkable effect of treating diabetic mice induced by alloxan.
Owner:GUANGXI UNIV OF CHINESE MEDICINE
Dihydroiso-coumarin glucoside compounds and preparation method and application thereof
The invention discloses new dihydroiso-coumarin glucoside compounds shown in a formula I, which are extracted and separated from Periplaneta americanna medicinal materials. Through mouse auricle swelling tests, rat granulation tissue hyperblastosis tests and the like, results show that the compounds have effects of resisting inflammation, promoting wounds to heal and the like; and the compounds can be used for preparing medicines for treating inflammation, ulcers, wounds, incised wounds, fistula, burn, scalding and the like, particularly medicines for preventing and treating diseases related to inflammation resistance, promotion of granulation tissue hyperblastosis, wound healing and the like, and have high clinical application value. The invention provides a preparation method for the compounds shown in the formula I.
Owner:ZHEJIANG JINGXIN PHARMA +1
Functional skin care product containing purslane extractive and preparation method thereof
The invention is a functional skin care product containing purslane extractive. Raw materials of the functional skin care product include, by weight, 10 parts of purslane extractive, 1-2 parts of Prinsepia utilis rogle oil, 2-5 parts of glycerol, 0.3-0.5 parts of crylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer, 2-3 parts of 1,2-pentanediol, 1-5 parts of synthesized squalane, 1-2 parts of tocopheryl acetate, 2-3 parts of cetostearyl alcohol, 0.1-0.2 part of allantoin, 0.3-0.8 part of sodium hyaluronate, 3-5 parts of Butyrospermum parkii butter, and 100 parts of deionized water. Or the Prinsepia utilis rogle oil and the Butyrospermum parkii butter are not added. By the aid of animal experiments, namely, mouse auricle swelling models due to dimethlbenzene, the functional skin care product containing purslane extractive is fine in anti-inflammation and anti-allergy effects, mild in nature and fine in safety, and is free of toxic reaction and anaphylaxis. The functional skin care product has an adjuvant therapy function to skin barrier recovery of common discosmetic dermatosis such as hormone dependent dermatitis and acne, and is fine in curative effect and safety.
Owner:YUNNAN BOTANEE BIO TECH GRP CO LTD
Traditional Chinese medicine for treating acne and preparation method thereof
InactiveCN103656146AShort course of treatmentQuick resultsDermatological disorderPlant ingredientsEscherichia coliSalvia miltiorrhiza
The invention belongs to the field of traditional Chinese medicines, in particular relates to a traditional Chinese medicine for treating acne and a preparation method thereof. The traditional Chinese medicine is refined by thirteen traditional Chinese medicines of flos farfarae, coptis chinensis, honeysuckle, scutellaria baicalensis, prepared rehmannia root, moutan bark, salvia miltiorrhiza, radix rehmanniae recen, jasmine, radix scrophulariae, thunberg fritillary bulb, cortex mori and selfheal. All the medicines are compatible with each other perfectly to achieve the effect of clearing away heat, relieving poison, cooling blood and activating blood; the traditional Chinese medicine has obvious counteraction effect on the acute and chronic inflammation, has obviously antibacterial effect on the common skin pathogenic bacterium of staphylococcus aureus, staphylococcus epidermidis, beta hemolytic streptococcus, escherichia coli, pseudomonas aeruginosa and propionibacterium, can obviously reduce the swelling rate of the propionibacterium caused mouse auricle acne model, obviously improves the activity of catalase to achieve the anti-oxidation effect, and has a certain pain relieving effect; the traditional Chinese medicine has the advantages of short treatment course, quick effect and no toxic or side effects, and is a good medicine for treating the acne.
Owner:SHANDONG ZHONGDA PHARMA
Preparation method and application of blumea balsamifera effective component
The invention discloses a preparation method and application of a blumea balsamifera effective component. A preparation process comprises the following steps: taking blumea balsamifera and extracting the blumea balsamifera with an ethanol water solution to obtain an extracting solution; concentrating the extracting solution until the extracting solution has no alcohol taste; adding water for diluting and extracting by utilizing ethyl acetate and n-butyl alcohol respectively to obtain ethyl acetate extract and n-butyl alcohol extract; drying a water part and an n-butyl alcohol extracting part to obtain the effective component. The preparation method and the application of the blumea balsamifera effective component have the beneficial effects that a xylol caused mouse ear swelling test and a mouse abdominal cavity capillary permeability increasing test determine that the obtained effective component has good anti-inflammatory activity.
Owner:GUIZHOU MEDICAL UNIV
Application of gymnema sylvestre schult fruits in anti-inflammatory drug and composition of application of gymnema sylvestre schult fruits
InactiveCN106420875AAvoid damageRejuvenate SODAntipyreticAnalgesicsCarrageenanAnti-inflammatory analgesics
The invention discloses application of gymnema sylvestre schult fruits in an anti-inflammatory drug and a composition of the application of the gymnema sylvestre schult fruits in the anti-inflammatory drug. The composition of the application of the gymnema sylvestre schult fruits in the anti-inflammatory drug is characterized in that the composition contains the gymnema sylvestre schult fruits having an anti-inflammatory effect, and the gymnema sylvestre schult fruits exist in a form of gymnema sylvestre schult fruit water extract or gymnema sylvestre schult fruits and 70-percent alcohol total extract. The anti-inflammatory action of the gymnema sylvestre schult fruit water extract and the gymnema sylvestre schult fruits and 70-percent alcohol total extract is researched by using xylene, a glacial acetic acid and carrageenan as pro-inflammatory cytokines, a result shows that mouse auricle swelling reaction caused by the xylene can be inhibited by the gymnema sylvestre schult fruit water extract and the gymnema sylvestre schult fruits and 70-percent alcohol total extract, increment of mouse peritoneal vascular permeability induced by the glacial acetic acid can be reduced, mouse toe swelling caused by the carrageenan can be inhibited, an anti-inflammatory effect is obtained, fewer adverse effects exist after taking the composition, and the safety is better; an extracting method and an extracting preparation method in the invention are simple in operation and easy to understand.
Owner:GUANGXI UNIV OF CHINESE MEDICINE
Application of dry paste powder of Ardisia brevicaulis Diels in preparation of anti-inflammatory and analgesic drugs
ActiveCN113712999AReduce package lossGood anti-inflammatory and analgesic effectAntipyreticAnalgesicsAcetic acidGranuloma
The invention belongs to the technical field of Zhuang medicines of traditional Chinese medicines, and particularly relates to application of dry paste powder of Ardisia brevicaulis Diels in preparation of anti-inflammatory and analgesic drugs. The Ardisia brevicaulis Diels is a whole dry plant of Ardisia brevicaulis Diels, and the dry paste powder of Ardisia brevicaulis Diels is extracted by adopting a water extraction and alcohol precipitation method. The invention discloses the application of the dry paste powder of Ardisia brevicaulis Diels in preparation of the anti-inflammatory and analgesic drugs for the first time. Pharmacological tests show that the dry paste powder of Ardisia brevicaulis Diels can obviously reduce the xylene-induced mouse auricle inflammation swelling degree, obviously reduce the mouse cotton ball granuloma quality, obviously improve the mouse hot plate pain threshold and obviously reduce the acetic acid-induced mouse pain writhing reaction frequency, has obvious anti-inflammatory and analgesic effects, and can be applied to preparation of the anti-inflammatory and analgesic drugs.
Owner:GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
Mangiferin penta-esterified derivative
InactiveCN102432601BGood anti-inflammatory effectGood treatment effectOrganic active ingredientsOrganic chemistryChemical synthesisTherapeutic effect
The invention discloses a method for chemically synthesizing a mangiferin penta-esterified derivative and a pharmacological effect of resisting inflammation and reducing blood sugar of the derivative. The chemical structural formula of the derivative is shown in the specifications. The derivative has a remarkable effect of inhibiting mouse auricle tumefaction caused by dimethylbenzene; and the derivative has a remarkable effect of treating diabetic mice induced by alloxan.
Owner:GUANGXI UNIV OF CHINESE MEDICINE
Application of salvia miltiorrhiza polysaccharide in preparation of anti-inflammatory drug
InactiveCN102362869AHas anti-inflammatory effectsOrganic active ingredientsAntipyreticSalvia miltiorrhizaAberrant spleen
The invention discloses an application of salvia miltiorrhiza polysaccharide in preparation of anti-inflammatory drug or health care products. An applicant observes influence of salvia miltirorrhiza polysaccharide to DNFB (dinitrofluorobenzene) induced mice auricle allergic reaction, influence of salvia miltirorrhiza polysaccharide to in vitro mice spleen lymphopoiesis and influence of salvia miltirorrhiza polysaccharide to expression of a DNFB induced mice contact dermatitis spleen inflammatory factor by virtue of in vitro cells and molecular biological experiments and finds that the salvia miltirorrhiza polysaccharide has anti-inflammatory effect, thus new application of the salvia miltirorrhiza polysaccharide is found.
Owner:GUANGZHOU HANFANG PHARMA
Rhododendron molle diterpene effective part as well as preparation process method and application thereof
InactiveCN111195277AThe content is easy to controlEfficient processSkeletal disorderPlant ingredientsXylyleneRhododendron molle
The invention discloses a rhododendron molle diterpene effective part and a preparation process method thereof. The preparation process comprises the following steps: crushing medicinal parts such asrhododendron molle (Rhododendron molle G.Don) fruits, flowers or roots into coarse powder; extracting with ethanol, concentrating, centrifuging or filtering, taking a supernatant, sequentially passingthrough macroporous resin and normal-phase silica gel column chromatography to obtain the rhododendron molle diterpene effective part, and calculating according to the total content of rhododendron molle toxin III and rhododendron molle toxin VI to be more than 50%. The invention further discloses an application of the rhododendron molle diterpene effective part in preparation of anti-rheumatoidarthritis drugs, a type II collagen-induced arthritis model, an xylene-induced mouse auricle swelling inflammation model, an acetic acid twisting method analgesia model and a hot plate method analgesia model prove that the medicine has an obvious rheumatoid arthritis resisting effect, and a new medicine choice is provided for clinic application.
Owner:SHANGHAI ZHANGJIANG ENG RES CENT OF MODERN PREPARATION TECH OF TRADITIONAL CHINESE MEDICINE
A kind of anti-inflammatory traditional Chinese medicine compound and its preparation method and application
ActiveCN113288937BEnhance anti-inflammatoryInhibit the degree of swellingAntipyreticAnalgesicsXylyleneMedicinal herbs
The invention belongs to the technical field of traditional Chinese medicine compound, and in particular relates to an anti-inflammatory traditional Chinese medicine compound and its preparation method and application. The composition of the compound comprises the following raw materials in parts by weight: 5-15 parts of golden fruit olive, 20-45 parts of red plum, and 10 parts of arhat tea ‑25 parts, 10‑25 parts of Siberian Crane, and 6‑18 parts of Scutellaria baicalensis, 10‑25 parts of forsythia, 10‑25 parts of Nanlangen, 10‑25 parts of mountain silver flower Compound. The anti-inflammatory traditional Chinese medicine compound provided by the present invention can significantly inhibit the degree of mouse auricle swelling caused by xylene, and significantly reduce the levels of NO, IL-6 and TNF-α produced by LPS-stimulated RAW264.7 cells. Experiments have shown that the anti-inflammatory Chinese medicine compound provided by the invention has significant anti-inflammatory and anti-inflammatory effects, has definite curative effect, high safety, and easy-to-get raw materials. When it is prepared into a pharmaceutical preparation, a pharmaceutically acceptable carrier can be added. Conventional techniques of pharmacy prepare different dosage forms, which can be used to prepare drugs with anti-inflammatory effects.
Owner:广西壮族自治区药物研究所有限公司
Drug combination with antiinflammatory action and abirritation and preparation method and application thereof
ActiveCN101940618AExcellent anti-inflammatory and analgesic effectRaise pain thresholdOrganic active ingredientsAntipyreticWater bathsAcetic acid
The invention provides a drug combination with antiinflammatory action and abirritation, which is prepared by lappaconitine hydrobromide and lamiophlomis rotate flavone as bulk pharmaceutical chemicals. In the invention, pharmacological research on the mutual effect and the compatibility of medicines of the lappaconitine hydrobromide and the lamiophlomis rotate flavone is carried out. The result shows that the drug combination of the invention can obviously improving the threshold value of mice compared with the situation that lappaconitine hydrobromide or the lamiophlomis rotate flavone is respectively used. The drug combination of the invention is subject to a mouse acetic acid writhing test, a mouse hot-water bath tail flick test, a rat carrageenin paw swelling test and a mouse auricle swelling test caused by dimethyl benzene so as to obtain the optimal formula of the drug combination. The drug combination of the invention has obvious antiinflammatory action and abirritation and has wide application prospects.
Owner:TIBET QIZHENG TIBETAN MEDICINE
Medicament for treating acute inflammation and preparation method thereof
InactiveCN101732380BEnhanced inhibitory effectGood effectAntipyreticAnalgesicsAlcoholDistilled water
The invention relates to a medicament for treating acute inflammation, which is characterized in that the medicament is prepared by performing water extraction or alcohol extraction on an edelweiss medicament, loading on macroporous adsorbing resin column, eluting by using distilled water and ethanol and performing decompression and drying. The medicament is an effective medicament for resisting the acute inflammation, and an animal anti-inflammatory test for the medicament proves that the medicament has the obvious inhibiting effect on mouse auricle swelling caused by auricle; and the medicament has better effect than that of basic solution extracted directly by using water or dilute ethanol in the aspect of treating the acute inflammation.
Owner:辽宁省中医药研究院
Preparation method and pharmacological effect of mangiferin hexa-butyl-esterified derivative
InactiveCN102432603BGood anti-inflammatory effectGood treatment effectOrganic active ingredientsOrganic chemistryChemical synthesisHEXA
The invention discloses a method for chemically synthesizing a mangiferin hexa-butyl-esterified derivative and a pharmacological effect of resisting inflammation and reducing blood sugar of the derivative. The chemical structural formula of the derivative is shown in the specifications. The derivative has a remarkable effect of inhibiting mouse auricle tumefaction caused by dimethylbenzene; and the derivative has a remarkable effect of treating diabetic mice induced by alloxan.
Owner:GUANGXI UNIV OF CHINESE MEDICINE
Mangiferin hepta-propyl-esterified derivative
InactiveCN102432602BGood anti-inflammatory effectGood treatment effectOrganic active ingredientsOrganic chemistryChemical synthesisTherapeutic effect
The invention discloses a method for chemically synthesizing a mangiferin hepta-propyl-esterified derivative and a pharmacological effect of resisting inflammation and reducing blood sugar of the derivative. The chemical structural formula of the derivative is shown in the specifications. The derivative has a remarkable effect of inhibiting mouse auricle tumefaction caused by dimethylbenzene; and the derivative has a remarkable effect of treating diabetic mice induced by alloxan.
Owner:GUANGXI UNIV OF CHINESE MEDICINE
Traditional Chinese medicine composition as well as preparation method and application thereof
ActiveCN113967229AIncrease painEnhanced inhibitory effectAntipyreticAnalgesicsSedum sarmentosumBiology
The invention provides a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components in parts by weight: 1-100 parts of sedum sarmentosum, 1-100 parts of honeysuckles, 1-100 parts of radix paeoniae rubra, 1-100 parts of moutan bark, 1-100 parts of prepared rhubarb and 1-100 parts of liquorice roots. The traditional Chinese medicine composition has an improvement effect on phlebitis vascular injury of marginal vein of rabbit ears, caused by vinorelbine tartrate, has an improvement effect on mouse caudal phlebitis vascular injury caused by fluorouracil, and has an inhibition effect on mouse auricle acute inflammation caused by xylene.
Owner:上海图锋医药科技有限公司
Application of Eurycomanol in preparation of drugs, food and health care products for preventing and treating abacterial prostatitis
The invention discloses an application of Eurycomanol in preparation of a medicine, food and a health care product for preventing and treating abacterial prostatitis. According to the application disclosed by the invention, through a hypogastrium incision test of a male rat under aseptic operation and mouse auricle inflammation swelling caused by xylene, the Eurycomanol is found to have good anti-inflammatory and non-bacterial prostatitis prevention and treatment effects under the conditions of smearing and oral administration, and the application range of the Eurycomanol is widened.
Owner:XIANGNAN UNIV
Application of merremia yunnanensis extract in drug preparation
InactiveCN108186707AProlong survival timeIncrease blood flowNervous disorderCardiovascular disorderBlood flowThrombus
The invention relates to new application of a natural plant extract in drug preparation, in particular to the application of the natural plant extract in preparing drugs for treating cerebrovascular diseases. The invention relates to application of merremia yunnanensis extract in preparing the drugs for treating the cerebrovascular diseases. The extract is merremia yunnanensis ethanol extract or merremia yunnanensis water extract. According to the merremia yunnanensis extract, underground parts of merremia yunnanensis serve as raw materials, and water or ethanol is adopted to carry out heatingextraction to obtain extract dry powder or liquid extract. Experiment results show that the merremia yunnanensis extract can significantly prolong the survival time of mice under an ordinary pressureand oxygen deficient condition, wherein the average P is smaller than 0.01; the merremia yunnanensis extract has the effect of resisting mouse brain ischemia caused by carotid artery occlusion and has a good protection effect on mouse brain ischemia reperfusion injuries caused by a suture method, and the survival time of the mice can be obviously prolonged after collagen-adrenaline induced in-vivo thrombosis. Besides, the merremia yunnanensis extract can obviously improve the blood flow states of mouse auricle capillaries, can significantly expand the arteriole diameters of the mouse auriclecapillaries and has the effect of improving microcirculation.
Owner:YUNNAN INST OF MATERIA MEDICA
Application of common turnip in preparation of medicines for relieving swelling and pain
PendingCN114146105AHas analgesic and analgesic effectsLittle side effectsAntipyreticAnalgesicsSalvia miltiorrhizaCommon turnip
The invention discloses application of common turnip in preparation of swelling and pain relieving medicines. The invention discloses the analgesic effect of the common turnip for the first time. The common turnip extract has an obvious detumescence effect on mouse auricle swelling caused by xylene and rat egg white foot swelling, has a good analgesic effect on mouse pain reaction and mouse acetic acid writhing reaction in a hot plate test, and has obvious effects on adjuvant therapy and prevention and treatment of pain. Due to the medicinal and edible dual-purpose characteristic of the common turnip, the common turnip has small side effects when being used as the swelling and pain relieving medicine, and the common turnip has a wide application prospect in the swelling and pain relieving field. The common turnip extract is combined with the Sichuan lovage rhizome, the turmeric, the salvia miltiorrhiza, the motherwort herb and the herba lycopi plant extract, so that a synergistic effect can be achieved, and the effects of relieving swelling and pain are remarkably improved.
Owner:JIANGNAN UNIV
Rhizoma imperatae water-stage extract and application thereof
The invention provides a rhizoma imperatae water-stage extract which is prepared by the following steps of: 1) performing backflow extraction of the coarse powder of rhizoma imperatae by use of 50-90% ethanol water by weight, and concentrating the extracting solution to obtain extract; and 2) adding water into the extract obtained in the step 1) and mixing to obtain suspension, extracting with petroleum ether, ethyl acetate and n-butyl alcohol sequentially, evaporating the obtained raffinate, and drying to obtain the rhizoma imperatae water-stage extract. In the invention, the effective anti-inflammation part in the rhizoma imperatae is screened through stage extraction to obtain the rhizoma imperatae water-stage extract. Among all stage extracts of rhizoma imperatae, the extract has the most obvious effect on inhibiting the mouse auricle swelling inflammation caused by paraxylene, and is expected to be used as an anti-inflammation medicine for preventing inflammation.
Owner:HEHUANG PHARMA SHANGHAI
Use of straw extract
InactiveCN1736466AImprove blood rheologyImprove microcirculationSkeletal disorderPlant ingredientsDiseaseAtheroma
The invention relates to the use of straw extract, wherein experimental results on straw extract show that, the straw extract has the functions of improving mouse's blood rheology, lowering blood density and coagulation tendency, depressing blood uric acid level, treating diseases caused by hyperuricemia, adjusting blood fat, postponing atherosclerosis development, and preventing cardiovascular and cerebrovascular diseases. Thus the straw extract can be used as active constituents for preparing medicaments of various dosage types.
Owner:刘明
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