Medicinal composition for treating mycotic infection at superficial part and application thereof

A fungal infection and composition technology, which is applied in the field of pharmaceutical compositions for the treatment of superficial fungal infections, can solve the problems of not very good clinical curative effect, high prevalence of superficial fungal infections, and high recurrence rate

Inactive Publication Date: 2011-12-28
PEKING UNIV FIRST HOSPITAL
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  • Abstract
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  • Application Information

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Problems solved by technology

[0003] Miconazole belongs to imidazole antifungal drugs, and is currently the main drug used for the treatment of superficial fungal infections. Bacterial infections; although widely used, the clinical efficacy is not very good, recurrent vulvovaginal candidiasis and tinea manuum are still very common superficial fungal infections
Moreover, due to the increasing numbe

Method used

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  • Medicinal composition for treating mycotic infection at superficial part and application thereof

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Effect test

Embodiment 1

[0026] Example 1, the killing effect of the composition of miconazole and tetrandrine on superficial fungal disease pathogens

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Abstract

The invention discloses a medicinal composition for treating mycotic infection at the superficial part and application thereof. The medicinal composition comprises miconazole and hanfangchin A, wherein the concentration of the hanfangchin A in a miconazole and hanfangchin A combined system is more than or equal to 40mug/ml. The medicinal composition can be used for an active component for preparing a medicament for treating the mycotic infection at the superficial part. After being verified by an in-vitro antimicrobial test, the hanfangchin A can be used for enhancing the antimycotic effect of the miconazole on dermatophyte and monilial to different degrees, in particular bacteriostasis effect on medicament-resistant fungi; and meanwhile, the dosage of the miconazole is reduced.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating superficial fungal infection and its application. Background technique [0002] Superficial fungal infection is a group of fungal infectious diseases caused by pathogenic fungi infecting human mucous membranes, skin and their appendages such as nails and hair. It is a very common fungal infectious disease in the population, and its incidence has been increasing in recent years. , Seriously affecting people's physical and mental health, quality of life and beauty needs. The incidence of superficial fungal infections has obvious population distribution characteristics. For example, tinea capitis mainly occurs in children, onychomycosis mainly occurs in the elderly or malnourished patients, tinea corporis and tinea manus and pedis mainly occur in young adults, and candida infection of the mucosa It is mainly seen in the vulva and vagina of women and the oral mucosa of immunocompromised pa...

Claims

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Application Information

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IPC IPC(8): A61K31/4748A61K31/4174A61P31/10
Inventor 刘伟刘伟霞李若瑜
Owner PEKING UNIV FIRST HOSPITAL
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