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Antifungal compound extract, preparation and preparation method of extract

An extract and antifungal technology, applied in the field of preparations and preparations, and antifungal compound extracts, can solve the problems of chemically synthesized drugs with large toxic and side effects, inconvenient medication forms, short curative effects, etc. Convenience, solubility enhancement effect

Inactive Publication Date: 2019-12-20
SHENZHEN BOTON FLAVORS & FRAGRANCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, most of the antifungal drugs sold in the market are chemically synthesized drugs, and sprays and liniments are more common. Human body brings greater harm, therefore, in order to influence the impact of fungal infection on people's life and health, the demand for research and development of related antifungal compound extract products is very important and urgent

Method used

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  • Antifungal compound extract, preparation and preparation method of extract
  • Antifungal compound extract, preparation and preparation method of extract
  • Antifungal compound extract, preparation and preparation method of extract

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Preparation of Antifungal Compound Extract and Preparation 1

[0035] (1) Weigh respectively 300g of patchouli, galangal, Galla gall, Cnidium chinensis, Sophora flavescens, Clematis clematis, and Kochia scoparia medicinal materials and pulverize to 40 orders;

[0036] (2) Place the crushed patchouli raw material in step (1) in a three-necked flask, add 2.4L 60% ethanol-water solution, heat to reflux for 2h, cool and filter; add 2.4L 60% ethanol-water solution to the filter residue Carry out secondary extraction, heat and reflux for 1 hour, and combine the filtrate obtained twice through a rotary evaporator for vacuum concentration to a crude drug concentration of about 1 g / mL; the other medicinal raw materials obtained by pulverizing in step (1) are carried out in the same manner Extraction, to obtain the extract of each medicinal material raw material respectively;

[0037] (3) After the extracts obtained in step (3) are adsorbed by a macroporous adsorption resin, the...

Embodiment 2

[0041] Preparation of Antifungal Compound Extract and Preparation 2

[0042] 1) Take respectively 300g of patchouli, galangal, Galla gall, Cnidium chinensis, Sophora flavescens, Clematis clematis and Kochia scoparia medicinal materials and pulverize to 60 mesh;

[0043] (2) Place the patchouli medicinal raw material pulverized in step (1) in a three-necked flask, add 3.0L 60% ethanol-water solution, heat to reflux for 2h, cool and filter; add 3.0L 60% ethanol-water solution to the filter residue Carry out secondary extraction, heat and reflux for 1 hour, and combine the filtrate obtained twice through a rotary evaporator for vacuum concentration to a crude drug concentration of about 1 g / mL; the other medicinal raw materials obtained by pulverizing in step (1) are carried out in the same manner Extraction, to obtain the extract of each medicinal material raw material respectively;

[0044] (3) After the extracts obtained in step (3) are adsorbed by a macroporous adsorption re...

Embodiment 3

[0048] Preparation of Antifungal Compound Extract and Preparation 3

[0049] 1) Weigh respectively 300g of patchouli, galangal, gallnut, cnidium, flavescens, clematis, and Kochia scoparia medicinal materials and pulverize to 50 mesh;

[0050] (2) Place the crushed patchouli raw material in step (1) in a three-necked flask, add 3.0L hot water to soak, then heat and reflux for 2h, cool and filter; add 3.0L hot water to the filter residue for secondary extraction, heat Reflux for 1 hour, and combine the filtrate obtained twice through a rotary evaporator to concentrate under reduced pressure in vacuum until the crude drug concentration is about 1g / mL; extract other medicinal materials obtained by pulverizing in step (1) in the same way to obtain each medicinal material extracts of raw materials;

[0051] (4) each extract that step (2) obtains is followed successively according to the mass ratio of Galla chinensis, Fructus Cnidii, Patchouli, Galangal, Sophora flavescens, Clematis...

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Abstract

The invention discloses an antifungal compound extract, a preparation and a preparation method of the extract. The antifungal compound extract comprises the following components in parts by weight: 1-3 parts of a gallnut extract, 1-3 parts of a fructus cnidii extract, 1-3 parts of a pogostemon cablin extract, 0.5-1.5 parts of a galangal extract, 0.5-1.5 parts of a radix sophorae flavescentis extract, 0.5-1.5 parts of a radix clematidis extract, 0.5-1.5 parts of a fructus kochiae extract and 0-80 parts of an ethanol-water solution. The components of the antifungal compound extract are extractedby adopting a hot reflux extraction method; and ethanol-separated and purified liquid obtained after separation and purification of macroporous adsorption resin has an obvious effect of resisting trichophyton rubrum and tritirachium album and can be used for preventing and treating fungal infection of human skin, hair and nails. Meanwhile, plant extracts are compounded to be prepared into powderygranules, the solubility is increased, the state is good, the medicine curative effect is long, and the medication form is convenient.

Description

technical field [0001] The invention relates to the technical field of plant medicine, in particular to an antifungal compound extract, preparation and preparation method thereof. Background technique [0002] Fungi are a type of eukaryote. In biological classification, it belongs to the superclass of fungi in algal plants. Among microorganisms, only fungi have true nuclei and complete organelles, so they are also called eukaryotic microorganisms. The most common fungi are various types of mushrooms, molds and yeasts. Fungi are widely distributed in nature. The fungi that are pathogenic to humans are divided into superficial fungi and deep fungi. The former invades the skin, hair, and nails, which is chronic and obstinate to treatment, but affects the body less. The latter can invade the internal organs of the whole body. Severe cases can cause death. For example, athlete's foot is a kind of common skin disease, belongs to superficial fungus, refers to that foot is subje...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61K9/16A61P31/10A61P17/00A61K35/64
CPCA61K9/1676A61K9/1682A61K35/64A61K36/185A61K36/234A61K36/489A61K36/532A61K36/716A61K36/9062A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61P17/00A61P31/10A61K2300/00
Inventor 王晶杨文慧李杰锋郝天翊吴志伟林谦强耀锋
Owner SHENZHEN BOTON FLAVORS & FRAGRANCES
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