Chlorine-containing compound and application thereof as antifungal drug

A compound and drug technology, applied to chlorine-containing compounds and their application fields as antifungal drugs, can solve problems such as large doses, and achieve the effects of small MIC value and excellent antifungal effect
CN112778234APending Publication Date: 2021-05-11BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
Publication Date
2021-05-11

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Abstract

The invention discloses a chlorine-containing compound and application thereof as an antifungal drug. The invention claims to protect a compound as shown in a formula I or pharmaceutically acceptable salts, esters and solvates thereof. In the formula I, R is -NH2 or -N=C(CH3)2. Compared with itraconazole, fluconazole and amphotericin B, the compound as shown in the formula I provided by the invention has a smaller MIC value, which shows that the compound has a more excellent antifungal effect.
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Description

technical field

[0001] The invention belongs to the field of medicine, and relates to a chlorine-containing compound and its application as an antifungal drug. Background technique

[0002] Fungal infection seriously threatens the healthy life of human beings. For patients whose immune system has been compromised, fungal infection is particularly serious, and about 40% of infected patients die. With the spread of chronic diseases such as hypertension, hyperlipidemia, and diabetes, the increase in the number of patients with cancer radiotherapy, chemotherapy, and organ transplantation, the widespread use of immunosuppressants, and the global epidemic of AIDS have led to the decline of human immunity and the onset of fungal infections. rate increased significantly. Currently clinically used antifungal drugs mainly include polyenes, allylamines, triazoles, imidazoles, echinocandins, and morpholines. ) and flucytosine (Flucytosine) and other drugs, but the drug resistance of p...

Claims

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