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Application of papaya saponin in anti-Malassezia furfur and Candida albicans products

A Malassezia, heavy building technology, applied in applications, antifungals, chemicals for biological control, etc., can solve problems such as narrow antibacterial spectrum

Inactive Publication Date: 2021-04-27
FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mechanism of action of fluconazole is similar to that of itraconazole, but the antibacterial spectrum is narrower

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Inhibitory effect of saponins from papaya to Malassezia furfur and Candida albicans

[0026] 1 Materials and methods

[0027] 1.1 Materials: four monomeric components of papaya saponins I, II, VI, and VII and total papaya saponins. The relevant information is as follows:

[0028] Ⅰ, CAS number: 50773-41-6; molecular formula: C44H70O16; molecular weight: 855.02; Ⅱ, CAS number: 76296-72-5; molecular formula: C44H70O16; molecular weight: 855.017; : C39H62O13; molecular weight: 738.90; VII, CAS number: 76296-75-8; molecular formula: C51H84O22; molecular weight: 1049.22 were purchased from Shanghai Yuanye Biotechnology Co., Ltd.

[0029] 1.2 Test strain: Malassezia furfur standard strain (CBS1878) was purchased from the Medical Fungi Collection Center, Institute of Dermatology, Chinese Academy of Medical Sciences, and Malassezia furfur was inoculated in Sabouraud medium containing rapeseed oil, placed at 37°C Cultivate in an incubator for 3-4 days; Candida albic...

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Abstract

The invention relates to the field of microbial antibacterial technology, in particular to the application of papaya saponins in anti-Malassezia furfur and Candida albicans products. The inventors have found through in vitro drug susceptibility tests that papaya saponins have inhibitory effects on Malassezia furfur and Candida albicans. The MICs of saponins I, VI, VII, and total saponins of papaya on Malassezia furfur were 2 μg / mL, 19 μg / mL, 39 μg / mL, and 0.5 μg / mL; saponins I, II, The inhibitory MICs of VI, VII and total saponins of Papaya to Candida albicans were 0.125μg / mL, 0.03125μg / mL, 78μg / mL, 0.625g / L, and 0.5g / L, respectively. Compared with the existing bacteriostatic agents, papaya saponins have a smaller MIC value against Malassezia furfur and Candida albicans, and have good antibacterial activity.

Description

technical field [0001] The invention relates to the field of microbial antibacterial technology, in particular to the application of papaya saponins in anti-Malassezia furfur and Candida albicans products. Background technique [0002] Malassezia furfur and Candida albicans are two common pathogenic fungi clinically. Malassezia furfur is one of the normal flora parasitic on the surface of the human body, and it can cause disease under certain conditions. Due to its wide pathogenic spectrum, it has been paid more and more attention. Diseases currently associated with Malassezia furfur infection include pityriasis versicolor, Malassezia furfur folliculitis, seborrheic dermatitis, and atopic dermatitis. Candida albicans is also an opportunistic pathogen. It often invades the skin and mucous membranes, and can also cause internal organs or systemic infections. The fungal diseases caused by it are collectively called candidiasis. One, severe cases can even be life-threatening. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P31/10A01N43/16A01P3/00
CPCA01N43/16A61K31/7048A61P31/10
Inventor 孙东杰朱纹懿黄云丽王奇飒李国星
Owner FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
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