14 results about "Self aggregation" patented technology

The present disclosure can improve the degree of soy protein proteolysis and the ability to produce valine, isoleucine, and leucine, which are branched-chain amino acids, as well as other amino acids, such as threonine, glycine, tyrosine, and lysine. Accordingly, the present disclosure can prevent sarcopenia and has antioxidant activity. Also, the present disclosure can maintain protein metabolic balance and relieve sarcopenia by muscle synthesis.The self-aggregation, hydrophobicity, and intestinal adhesion of a mixed strain is improved compared to a case where a single strain used for the mixed strain is used. Therefore, when the mixed strain of the present disclosure is ingested, the strain can remain for a long time in the intestine.

The present application belongs to the technical field of pharmaceutical therapy, and particularly relates to an amide-substituted tryptophan ketone derivative, a preparation method and application thereof. The structural formula of the tryptophan ketone derivative is shown in formula (A) or formula (B). In the formula, n=1 or 2, and R is any one of dimethylamine group, diethylamine group, morpholine group, 1-methylpiperazine group, cyclopropylamine group and 4-hydroxypiperidyl group. The compound can selectively inhibit the activity of acetylcholinesterase, and has the potential to develop into a drug for treating Alzheimer's disease due to the abilities of self-aggregation and the like. 1‑42 ​

The invention discloses a probiotic which is derived from human milk and has the effects of resisting oxidation, resisting inflammation, protecting tissues and protecting intestinal barriers and application of the probiotic. Lactobacillus paracasei DPUMW-M14-9 is preserved in the general microbiological center of the China Committee for Culture Collection of Microorganisms, and the preservation number is CCTCC M 20252990. The strain has the characteristics of acid resistance, bile resistance, strong oxidation resistance, high surface hydrophobicity, self-aggregation capability and the like. The lactobacillus paracasei DPUMW-M14-9 can effectively adhere to epithelial cells, promote cell proliferation and regulate and control the process of a cell cycle. The bacterial strain can be used for inhibiting proinflammatory cytokines (TNF-alpha, IL-6 and IL-1beta) induced by lipopolysaccharide (LPS) and repairing tight junction proteins (ZO-1, Occludin and Claudin-1) at the same time, so that the integrity of epithelial cells is enhanced.

The present invention relates to a method of generating an in vitro modular 3D brain tissue model (3D BTM) comprising: a. mixing 50,000 to 1,000,000 freshly splitted, single neurons (NE) and astrocytes (AS) or their precursor cells in a ratio of NE:AS = 1:3 to 10:1, followed by spinning down to introduce self-aggregation in low attachment conditions, without addition of exogenous matrices; b. treating cells obtained in step a. with a NOTCH signaling inhibitor for driving terminal neuron differentiation for at least 2 days; c. treating the cells obtained in step b. with at least one mitotic inhibitor to remove residual dividing cells for at least 3 days, thereby yielding a post-mitotic aggregated 3D culture of neurons and astrocytes; d. adding differentiated microglia (MG) to the culture obtained in step c. in a ratio of NE:MG = 1:1 to 20:1, to initiate migration of MG into the culture for 3-10 days; e. culturing the culture obtained in step d. in neuron media with addition of TGFβ1 and cytokines selected from the group comprising CSF1-R agonists to support microglia maintenance and proliferation for at least 2 weeks, thereby inducing formation of a modular in vitro 3D BTM culture.

The invention belongs to the field of organic photoelectric materials, and particularly relates to a micromolecule hole transport material with a functionalized periphery and application of the micromolecule hole transport material in the field of photoelectric devices such as perovskite solar cells. The molecular structure of the micromolecular hole transport material compound is shown as a general formula (I). Aiming at the problems of strong self-aggregation, weak passivation capability and the like of a traditional micromolecule self-assembly layer hole transport material, the invention of introducing a functional conjugated group to the periphery of a conjugated main skeleton is provided, the steric effect and cation-pi passivation effect of a peripheral functional group can be cooperated, the film-forming characteristic of a micromolecule self-assembly layer is improved, and the hole transport material has a good application prospect. And the interface defect passivation capability is enhanced. The micromolecular hole transport material based on the periphery functionalization can be used as an interface modification material to be applied to the fields of perovskite solar cells, organic solar cells, perovskite / organic electroluminescent devices, perovskite / organic photoelectric detectors and the like, and the efficiency and the stability of the devices are improved at the same time. Formula (I).

This invention provides an expression vector for the production of human α-synuclein (αS) protein or its conserved variant that exhibits a reduced tendency to self-aggregate in the αS seed amplification assay (SAA). [Solution] The expression vector comprises a nucleic acid sequence encoding a human αS protein or a conserved variant, the nucleic acid sequence containing codons optimized to produce a human αS protein or a conserved variant when expressed by a host cell such as Escherichia coli (E. coli). The codons are optimized to avoid misincorporation of amino acids in the expressed protein. A method for purifying the expressed protein is also provided.

The invention relates to the technical field of geological exploration in the petroleum industry, in particular to a viscous-acoustic medium angle gather extraction method based on self-adaptive wave beam reverse time migration. According to the method, the self-adaptive beam operator depending on local space velocity change is introduced to realize automatic focusing of the seismic beam, and the absorption attenuation effect caused by the viscosity is compensated through the viscous sound medium during complex value travel; slowness information of a shot point is extracted based on travel time information of a self-aggregation seismic beam, a reflection field angle at an imaging point position is further calculated, an imaging value is located at a correct position according to the range and interval of the reflection field angle, and direct extraction of a viscous sound medium angle gather is achieved. According to the method, the absorption attenuation effect caused by the viscosity of the medium can be effectively compensated, the high-quality angle gather can be output, the calculation efficiency and the calculation precision are both achieved, and powerful support is provided for migration velocity analysis and oil reservoir description work of the viscous medium.

This invention discloses a time-locked fiber self-erasing material with a step-by-step decryption function for special information transmission, its preparation method, and its anti-counterfeiting applications. The material is prepared by chemically grafting amino-modified phosphors onto the surface of carboxylated cellulose nanocrystals, followed by electrostatic attraction between the phosphors and gold nanoclusters stabilized by the carboxylated cellulose nanocrystals. The material of this invention uses carboxylated cellulose nanocrystals as a bridge connecting the donor and acceptor, inhibiting the self-aggregation of gold nanoclusters, enhancing fluorescence intensity and stability, and improving the energy transfer efficiency between the donor and acceptor. Based on changes in the degree of energy transfer, the time-locked fiber self-erasing material exhibits a color pattern over a time scale, adjusted by the donor-acceptor ratio.

The invention belongs to the technical field of new materials and new energy, and particularly relates to a perovskite solar cell and a preparation method thereof, in particular to a perovskite solar cell based on a C60 electron transport layer deposited by a liquid phase method and a preparation method of the perovskite solar cell. Calixarene is selected as a cosolvent and a stabilizer, o-dichlorobenzene is selected as a dispersing solvent, and compared with an untreated C60 film, the C60 film formed through hydrotropy dispersion hinders the self-aggregation trend in a C60 solution, is smoother in morphology and better in quality, promotes uniform dispersion of C60, is higher in environmental stability, and improves the efficiency of a battery device. An effective technical scheme is provided for preparing a uniform and compact electron transport layer by a liquid phase method, a foundation is laid for obtaining an efficient and stable perovskite solar cell, the industrialization process of the perovskite solar cell is accelerated, and the method has important practical value and economic value. The method is low in cost, simple to operate, good in film forming and high in efficiency.

The invention discloses a self-aggregation photosensitizer, self-aggregation photosensitizer microsphere hydrogel and a preparation method and application thereof.The self-aggregation photosensitizer microsphere hydrogel is prepared from, by mass, 5%-20% of response type microspheres loaded with the self-aggregation photosensitizer, 10%-30% of hydrogel matrix, 1%-5% of cross-linking agent and the balance water; the self-aggregation photosensitizer-loaded response type microspheres are formed by compounding a response type carrier material and a self-aggregation photosensitizer. The self-aggregation photosensitizer microsphere hydrogel can accurately respond to pH and GSH of a tumor microenvironment, target enrichment and controllable release of the self-aggregation photosensitizer are achieved, the photodynamic therapy effect is remarkably improved, and toxic and side effects on normal tissue are reduced.

The invention belongs to the technical field of new materials and new energy, and particularly relates to a perovskite solar cell based on a hydroxylation-enriched hole transport layer and a preparation method of the perovskite solar cell. The preparation method sequentially comprises the following steps: cleaning a conductive glass substrate and performing surface plasma treatment; preparing an SAM molecular'landing layer ', an SAM hole transport layer and a perovskite thin film on the substrate, and preparing an electron transport layer; and constructing an electrode on the electron transport layer to prepare the perovskite solar cell. The'landing layer 'molecules firstly react with hydroxyl groups on the substrate and are firmly combined on the substrate, so that a foundation is laid for subsequent preparation of anchoring SAM molecules. Through the quantum tunneling effect, on the premise that the charge transmission performance is not affected, the self-aggregation trend of SAM molecules is hindered, uniform distribution of the SAM molecules is promoted, an effective technical scheme is provided for preparing a uniform and compact hole transmission layer, and carrier transmission is promoted. The method is low in cost and has important practical value and economic value.

This invention relates to the field of intelligent organic optoelectronic materials technology, specifically disclosing a photostimulation-responsive organic long-afterglow material and its preparation method. This invention is based on benzo[a]carbazole or naphthylamine derivatives with excellent long-afterglow performance, and by introducing diphenylphosphoxy groups to form a resonance system, it endows the material with excellent stimulus-response characteristics. Furthermore, using polymethyl methacrylate (PMMA) as the main component significantly avoids the quenching effect caused by self-aggregation. It also protects triplet excitons from quenching by triplet oxygen molecules, thereby enabling room-temperature phosphorescence. This material system exhibits significant photoactivation performance under photostimulation, with a visible afterglow exceeding 8 s, and possesses the characteristic that steady-state luminescence and afterglow luminescence can be co-activated. The material system provided by this invention has the following advantages: simple preparation process, low cost, and easy product purification; the obtained composite film exhibits long-lifetime and highly stable organic afterglow; its unique steady-state and afterglow synergistic photostimulation response characteristics provide a new solution for dynamic information encryption and afterglow imaging.

The invention discloses a preparation method of an Hg < 2 + > sensor based on a graphene-gold nanoparticle composite nanomaterial and an Hg < 2 + > detection method.The preparation method of the Hg < 2 + > sensor based on the graphene-gold nanoparticle composite nanomaterial comprises the following steps that S1, a substrate silicon wafer is cleaned; s2, growth and transfer of graphene; s3, preparing the graphene-gold nanoparticle composite nano material sensor; according to the Hg < 2 + > sensor based on the graphene-gold nanoparticle composite nanomaterial prepared by the invention, by combining AuNPs with graphene, the problems of irreversible self-aggregation, low colloidal stability and the like when graphene is independently used are effectively solved; the excellent conductivity and catalytic performance of AuNPs and the high specific surface area and good biocompatibility of graphene generate a synergistic effect, and the electrical property and detection sensitivity of the sensor are remarkably improved.

The present disclosure relates to a display device and a display panel. The present disclosure provides a display device including a display panel including a display area including an optical area in which at least one transmissive area and at least one light emitting area are defined, and a normal area located outside of the optical area and including a plurality of light emitting areas, a gate driving circuit configured to supply at least one gate signal to the display panel, a data driving circuit configured to convert image data into a data voltage and supplying the resulted data voltage to the display panel, and a display controller for controlling the gate driving circuit and the data driving circuit, the at least one transmissive area including an emission layer, a cohesive cathode layer disposed with a reference thickness at which self-aggregation occurs on the emission layer, and a capping layer disposed on the cohesive cathode layer.