27 results about "Self aggregation" patented technology

The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus plantarum, a method and application. The invention provides a strain of Lactobacillus plantarum MRS1026.3, and the preservation number of the Lactobacillus plantarum MRS1026.3 is CGMCC (China General Microbiological Culture Collection Center) No.34168. The invention further provides a preparation method of the Lactobacillus plantarum MRS1026.3. The lactobacillus plantarum MRS1026.3 has the best tolerance of 72.38% and the acid resistance of 49.5% under the cholate concentration of 0.1%, is good in acid resistance, has oxidation resistance and can degrade cholesterol, but the surface hydrophobicity and the self-aggregation capacity of the lactobacillus plantarum MRS1026.3 are poor.

The invention relates to the technical field of biological medicine, and discloses bifidobacterium adolescentis YF-01 and application thereof in fermented milk. The bifidobacterium adolescentis YF-01 is separated from adult excrement and is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC NO: M 20251308. Experiments prove that the bifidobacterium adolescentis YF-01 has good gastrointestinal fluid tolerance, the survival rate of the bifidobacterium adolescentis YF-01 can reach 90.1% after simulated gastric fluid treatment for 3 h, and the survival rate of the bifidobacterium adolescentis YF-01 can reach 72% after simulated intestinal fluid treatment for 4 h The strain has the self-aggregation rate of 88.83% and the hydrophobicity of 79.41%, has remarkable scavenging capacity on DPPH free radicals and hydroxyl free radicals, shows good antioxidant activity and adhesion capacity, and provides a theoretical basis for application of the strain in fermented milk. The strain and metabolites thereof can be used for preparing food, medicines or health care products capable of regulating intestinal flora and enhancing oxidation resistance, and have remarkable application potential in development of functional fermented milk products.

The invention relates to the technical field of photovoltaic cells, and provides a benzene ring compound modified SAM layer and a perovskite module preparation method, the benzene ring compound modified SAM layer comprises self-assembly molecules and an agglomeration inhibitor, the agglomeration inhibitor is dispersed in the self-assembly molecules, and the self-assembly molecules are dispersed in the agglomeration inhibitor. The agglomeration inhibitor is used for inhibiting agglomeration of the self-assembled molecule, the agglomeration inhibitor comprises a benzene ring and at least one X group connected to the benzene ring, the structure of the X group is-R, and-R is any one of a fluorine group, a nitrile group and a nitro group. The SAM layer modified by the benzene ring compound can solve the problems that carrier loss of an interface between a perovskite thin film and a hole transport layer is easily caused by high self-aggregation and poor wettability of self-assembled monomolecules, uneven surface appearance of the SAM layer is caused, and then the subsequent growth and covering quality of the perovskite thin film are influenced.

The invention discloses a carbazole derivative as well as a preparation method and application thereof, a pi conjugated system of carbazole is expanded by introducing a thiophene unit, and (4-(3, 6-di (thiophene-3-yl)-9H-carbazole-9-yl) butyl) phosphonic acid (4PAThCz) is designed. Compared with classical 2PACz, the 4PAThCz shows long-range orderliness and compact pi-pi accumulation, and the molecular dipole moment is enhanced. In addition, the distorted molecular structure of 4PAThCz is helpful to improve solubility and inhibit excessive self-aggregation. The characteristics facilitate hole extraction and transmission, inhibit carrier recombination in a photovoltaic device, and facilitate preparation of an efficient and stable solar cell.

The present disclosure can improve the degree of soy protein proteolysis and the ability to produce valine, isoleucine, and leucine, which are branched-chain amino acids, as well as other amino acids, such as threonine, glycine, tyrosine, and lysine. Accordingly, the present disclosure can prevent sarcopenia and has antioxidant activity. Also, the present disclosure can maintain protein metabolic balance and relieve sarcopenia by muscle synthesis.The self-aggregation, hydrophobicity, and intestinal adhesion of a mixed strain is improved compared to a case where a single strain used for the mixed strain is used. Therefore, when the mixed strain of the present disclosure is ingested, the strain can remain for a long time in the intestine.

The present application belongs to the technical field of pharmaceutical therapy, and particularly relates to an amide-substituted tryptophan ketone derivative, a preparation method and application thereof. The structural formula of the tryptophan ketone derivative is shown in formula (A) or formula (B). In the formula, n=1 or 2, and R is any one of dimethylamine group, diethylamine group, morpholine group, 1-methylpiperazine group, cyclopropylamine group and 4-hydroxypiperidyl group. The compound can selectively inhibit the activity of acetylcholinesterase, and has the potential to develop into a drug for treating Alzheimer's disease due to the abilities of self-aggregation and the like. 1‑42 ​

The invention discloses a probiotic which is derived from human milk and has the effects of resisting oxidation, resisting inflammation, protecting tissues and protecting intestinal barriers and application of the probiotic. Lactobacillus paracasei DPUMW-M14-9 is preserved in the general microbiological center of the China Committee for Culture Collection of Microorganisms, and the preservation number is CCTCC M 20252990. The strain has the characteristics of acid resistance, bile resistance, strong oxidation resistance, high surface hydrophobicity, self-aggregation capability and the like. The lactobacillus paracasei DPUMW-M14-9 can effectively adhere to epithelial cells, promote cell proliferation and regulate and control the process of a cell cycle. The bacterial strain can be used for inhibiting proinflammatory cytokines (TNF-alpha, IL-6 and IL-1beta) induced by lipopolysaccharide (LPS) and repairing tight junction proteins (ZO-1, Occludin and Claudin-1) at the same time, so that the integrity of epithelial cells is enhanced.

The invention provides a nano silicon dioxide-graphene aerogel microsphere with high-efficiency oil absorption and self-aggregation recovery functions and a preparation method thereof. The preparation method is characterized in that water-soluble anions and nonionic polymers are synergistically adopted as a dispersion regulating agent and a self-sacrifice pore-forming agent of a graphene oxide (GO) water dispersion system; a preparation method of graphene aerogel microspheres, namely high-pressure spraying, in-situ freeze-drying, nano silicon dioxide in-situ doping and high-temperature reduction, is established, and the graphene aerogel microspheres are prepared by utilizing the dispersion / stacking regulation and control effect of a water-soluble polymer on a GO sheet layer, the skeleton supporting effect on micro-droplets and the self-sacrifice pore-forming / carbon-forming function of the water-soluble polymer. The microspheres are endowed with high sphericity, rich porous structures and excellent mechanical properties; on the other hand, in the silicon doping process, a large amount of hydrophobic nano silicon dioxide is formed on the surface and inside the microspheres in situ, a microsphere hydrophobic micro-nano coarse structure is formed, formation of liquid bridges among the microspheres in the oil absorption process is promoted, spontaneous aggregation of the microspheres is driven, and the microspheres are endowed with excellent oil stain adsorption capacity and recycling performance.

The present invention relates to a method of generating an in vitro modular 3D brain tissue model (3D BTM) comprising: a. mixing 50,000 to 1,000,000 freshly splitted, single neurons (NE) and astrocytes (AS) or their precursor cells in a ratio of NE:AS = 1:3 to 10:1, followed by spinning down to introduce self-aggregation in low attachment conditions, without addition of exogenous matrices; b. treating cells obtained in step a. with a NOTCH signaling inhibitor for driving terminal neuron differentiation for at least 2 days; c. treating the cells obtained in step b. with at least one mitotic inhibitor to remove residual dividing cells for at least 3 days, thereby yielding a post-mitotic aggregated 3D culture of neurons and astrocytes; d. adding differentiated microglia (MG) to the culture obtained in step c. in a ratio of NE:MG = 1:1 to 20:1, to initiate migration of MG into the culture for 3-10 days; e. culturing the culture obtained in step d. in neuron media with addition of TGFβ1 and cytokines selected from the group comprising CSF1-R agonists to support microglia maintenance and proliferation for at least 2 weeks, thereby inducing formation of a modular in vitro 3D BTM culture.

The invention belongs to the field of organic photoelectric materials, and particularly relates to a micromolecule hole transport material with a functionalized periphery and application of the micromolecule hole transport material in the field of photoelectric devices such as perovskite solar cells. The molecular structure of the micromolecular hole transport material compound is shown as a general formula (I). Aiming at the problems of strong self-aggregation, weak passivation capability and the like of a traditional micromolecule self-assembly layer hole transport material, the invention of introducing a functional conjugated group to the periphery of a conjugated main skeleton is provided, the steric effect and cation-pi passivation effect of a peripheral functional group can be cooperated, the film-forming characteristic of a micromolecule self-assembly layer is improved, and the hole transport material has a good application prospect. And the interface defect passivation capability is enhanced. The micromolecular hole transport material based on the periphery functionalization can be used as an interface modification material to be applied to the fields of perovskite solar cells, organic solar cells, perovskite / organic electroluminescent devices, perovskite / organic photoelectric detectors and the like, and the efficiency and the stability of the devices are improved at the same time. Formula (I).

To provide a method for controlling cell arrangement that increases positional accuracy of droplets and enhances self-aggregability of cells when forming a spheroid in which three or more droplets are connected.SOLUTION: A substrate for supplying cells to be cultured is prepared. A first coating liquid application step for applying a first coating liquid (A) containing a first solvent onto the substrate is performed one or more times. A second coating liquid (B) is dropped so as to cover the first coating liquid (A). Cells are included in at least one application among the one or more times of application of the first coating liquid (A) in the first coating liquid application step. The substrate is a low cell adhesion substrate.SELECTED DRAWING: Figure 16

This invention provides an expression vector for the production of human α-synuclein (αS) protein or its conserved variant that exhibits a reduced tendency to self-aggregate in the αS seed amplification assay (SAA). [Solution] The expression vector comprises a nucleic acid sequence encoding a human αS protein or a conserved variant, the nucleic acid sequence containing codons optimized to produce a human αS protein or a conserved variant when expressed by a host cell such as Escherichia coli (E. coli). The codons are optimized to avoid misincorporation of amino acids in the expressed protein. A method for purifying the expressed protein is also provided.

The invention relates to the technical field of geological exploration in the petroleum industry, in particular to a viscous-acoustic medium angle gather extraction method based on self-adaptive wave beam reverse time migration. According to the method, the self-adaptive beam operator depending on local space velocity change is introduced to realize automatic focusing of the seismic beam, and the absorption attenuation effect caused by the viscosity is compensated through the viscous sound medium during complex value travel; slowness information of a shot point is extracted based on travel time information of a self-aggregation seismic beam, a reflection field angle at an imaging point position is further calculated, an imaging value is located at a correct position according to the range and interval of the reflection field angle, and direct extraction of a viscous sound medium angle gather is achieved. According to the method, the absorption attenuation effect caused by the viscosity of the medium can be effectively compensated, the high-quality angle gather can be output, the calculation efficiency and the calculation precision are both achieved, and powerful support is provided for migration velocity analysis and oil reservoir description work of the viscous medium.

This invention discloses a time-locked fiber self-erasing material with a step-by-step decryption function for special information transmission, its preparation method, and its anti-counterfeiting applications. The material is prepared by chemically grafting amino-modified phosphors onto the surface of carboxylated cellulose nanocrystals, followed by electrostatic attraction between the phosphors and gold nanoclusters stabilized by the carboxylated cellulose nanocrystals. The material of this invention uses carboxylated cellulose nanocrystals as a bridge connecting the donor and acceptor, inhibiting the self-aggregation of gold nanoclusters, enhancing fluorescence intensity and stability, and improving the energy transfer efficiency between the donor and acceptor. Based on changes in the degree of energy transfer, the time-locked fiber self-erasing material exhibits a color pattern over a time scale, adjusted by the donor-acceptor ratio.

The invention belongs to the technical field of new materials and new energy, and particularly relates to a perovskite solar cell and a preparation method thereof, in particular to a perovskite solar cell based on a C60 electron transport layer deposited by a liquid phase method and a preparation method of the perovskite solar cell. Calixarene is selected as a cosolvent and a stabilizer, o-dichlorobenzene is selected as a dispersing solvent, and compared with an untreated C60 film, the C60 film formed through hydrotropy dispersion hinders the self-aggregation trend in a C60 solution, is smoother in morphology and better in quality, promotes uniform dispersion of C60, is higher in environmental stability, and improves the efficiency of a battery device. An effective technical scheme is provided for preparing a uniform and compact electron transport layer by a liquid phase method, a foundation is laid for obtaining an efficient and stable perovskite solar cell, the industrialization process of the perovskite solar cell is accelerated, and the method has important practical value and economic value. The method is low in cost, simple to operate, good in film forming and high in efficiency.

The invention discloses a self-aggregation photosensitizer, self-aggregation photosensitizer microsphere hydrogel and a preparation method and application thereof.The self-aggregation photosensitizer microsphere hydrogel is prepared from, by mass, 5%-20% of response type microspheres loaded with the self-aggregation photosensitizer, 10%-30% of hydrogel matrix, 1%-5% of cross-linking agent and the balance water; the self-aggregation photosensitizer-loaded response type microspheres are formed by compounding a response type carrier material and a self-aggregation photosensitizer. The self-aggregation photosensitizer microsphere hydrogel can accurately respond to pH and GSH of a tumor microenvironment, target enrichment and controllable release of the self-aggregation photosensitizer are achieved, the photodynamic therapy effect is remarkably improved, and toxic and side effects on normal tissue are reduced.

The invention relates to the field of gene engineering, in particular to a self-aggregation protein and application thereof. According to the self-aggregation protein, the amino acid sequence of the self-aggregation protein is as shown in SEQ ID NO. 1. The self-aggregation protein is a specific protein tag with efficient and stable self-aggregation characteristics. The protein is the basis of all subsequent inventions (carriers, strains and immobilized enzymes), the determined sequence ensures the repeatability and reliability of the self-aggregation behavior, the uncertainty caused by using other self-aggregation proteins which are possibly low in efficiency or unknown in property is avoided, and a uniform and optimal performance standard is provided for the whole technical scheme.

The invention relates to a preparation method of a self-aggregation composite hemostatic material, which comprises the following steps: dissolving sodium carboxymethyl starch in pure water to prepare an anionic polysaccharide solution, mixing chitosan and calcium salt, dissolving in an acid solution to prepare a cationic polysaccharide solution, quantitatively mixing the anionic polysaccharide solution and the cationic polysaccharide solution, and preparing the self-aggregation composite hemostatic material. A compact, stable and high-mechanical-strength flocculent precipitate with a three-dimensional network structure can be formed through electrostatic complexing and ionic cross-linking reaction, finally the flocculent precipitate is washed, dried, crushed and sieved, the self-aggregation composite hemostatic material is prepared, the whole preparation process is mild in reaction condition, a toxic cross-linking agent does not need to be used, the process is simple and environmentally friendly, and the cost is low. The preparation method is simple and easy for large-scale production, meanwhile, the prepared self-aggregation composite hemostatic material has unique hydrophilicity, can swell but not dissolve, can quickly absorb liquid, permeate and diffuse, can quickly form a hemostatic physical barrier after absorbing liquid, and has a synergistic hemostatic effect.

The present invention relates to the field of water decontamination, and more precisely refers to a colloidal floating membrane useful in the decontamination of an aqueous medium and to the procedure for obtaining it. Said membrane comprises nanoparticles formed by self-aggregates of a zeolitic imidazolate framework (ZIF) in the presence of acetate species on the surface of the nanoparticle.

The invention belongs to the technical field of new materials and new energy, and particularly relates to a perovskite solar cell based on a hydroxylation-enriched hole transport layer and a preparation method of the perovskite solar cell. The preparation method sequentially comprises the following steps: cleaning a conductive glass substrate and performing surface plasma treatment; preparing an SAM molecular'landing layer ', an SAM hole transport layer and a perovskite thin film on the substrate, and preparing an electron transport layer; and constructing an electrode on the electron transport layer to prepare the perovskite solar cell. The'landing layer 'molecules firstly react with hydroxyl groups on the substrate and are firmly combined on the substrate, so that a foundation is laid for subsequent preparation of anchoring SAM molecules. Through the quantum tunneling effect, on the premise that the charge transmission performance is not affected, the self-aggregation trend of SAM molecules is hindered, uniform distribution of the SAM molecules is promoted, an effective technical scheme is provided for preparing a uniform and compact hole transmission layer, and carrier transmission is promoted. The method is low in cost and has important practical value and economic value.

The invention discloses pichia pastoris separated from kefir grains and application thereof.The pichia pastoris strain is named as FMES-LF4, belongs to pichia kluyveri, has the preservation number of CCTCC NO: M 2025160, has remarkable self-aggregation, film-forming property and polysaccharide production capacity, has potential application value in dairy products and fermented food, and can be widely applied to the fields of dairy products and fermented food. Theoretical support is provided for research on a kefir grain formation mechanism, and meanwhile, a yeast strain resource library is enriched.

This invention relates to the field of intelligent organic optoelectronic materials technology, specifically disclosing a photostimulation-responsive organic long-afterglow material and its preparation method. This invention is based on benzo[a]carbazole or naphthylamine derivatives with excellent long-afterglow performance, and by introducing diphenylphosphoxy groups to form a resonance system, it endows the material with excellent stimulus-response characteristics. Furthermore, using polymethyl methacrylate (PMMA) as the main component significantly avoids the quenching effect caused by self-aggregation. It also protects triplet excitons from quenching by triplet oxygen molecules, thereby enabling room-temperature phosphorescence. This material system exhibits significant photoactivation performance under photostimulation, with a visible afterglow exceeding 8 s, and possesses the characteristic that steady-state luminescence and afterglow luminescence can be co-activated. The material system provided by this invention has the following advantages: simple preparation process, low cost, and easy product purification; the obtained composite film exhibits long-lifetime and highly stable organic afterglow; its unique steady-state and afterglow synergistic photostimulation response characteristics provide a new solution for dynamic information encryption and afterglow imaging.

The invention discloses a preparation method of an Hg < 2 + > sensor based on a graphene-gold nanoparticle composite nanomaterial and an Hg < 2 + > detection method.The preparation method of the Hg < 2 + > sensor based on the graphene-gold nanoparticle composite nanomaterial comprises the following steps that S1, a substrate silicon wafer is cleaned; s2, growth and transfer of graphene; s3, preparing the graphene-gold nanoparticle composite nano material sensor; according to the Hg < 2 + > sensor based on the graphene-gold nanoparticle composite nanomaterial prepared by the invention, by combining AuNPs with graphene, the problems of irreversible self-aggregation, low colloidal stability and the like when graphene is independently used are effectively solved; the excellent conductivity and catalytic performance of AuNPs and the high specific surface area and good biocompatibility of graphene generate a synergistic effect, and the electrical property and detection sensitivity of the sensor are remarkably improved.

The present disclosure relates to a display device and a display panel. The present disclosure provides a display device including a display panel including a display area including an optical area in which at least one transmissive area and at least one light emitting area are defined, and a normal area located outside of the optical area and including a plurality of light emitting areas, a gate driving circuit configured to supply at least one gate signal to the display panel, a data driving circuit configured to convert image data into a data voltage and supplying the resulted data voltage to the display panel, and a display controller for controlling the gate driving circuit and the data driving circuit, the at least one transmissive area including an emission layer, a cohesive cathode layer disposed with a reference thickness at which self-aggregation occurs on the emission layer, and a capping layer disposed on the cohesive cathode layer.

The invention discloses a near-infrared light thermal material as well as a preparation method and application thereof. The near-infrared light thermal material is a nano material which takes a ZIF-8 metal organic framework to load theabrownin carbon quantum dots and responds to near-infrared light. The preparation method comprises the following steps: mixing theabrownin carbon quantum dots and ZIF-8, adding deionized water for dispersing, stirring, centrifuging, retaining precipitate, and drying to obtain the near-infrared thermal material TB-CQDs ZIF-8. According to the near-infrared photothermal material prepared by the invention, due to complementary and synergistic effects between the TB-CQDs and the ZIF-8, the self-aggregation problem of the TB-CQDs is solved, so that the TB-CQDs can have better photothermal property than original carbon dots under a near-infrared excitation condition, and can be used as a bactericide in vivo and in vitro.

The invention provides a water system-based composite electrolyte membrane and a solid-state battery. The water system-based composite electrolyte membrane is prepared from the following raw materials: a polymer material, water, a modified inorganic solid-state electrolyte material and a modified lithium salt, the modification method of the modified inorganic solid electrolyte material and the modified lithium salt comprises the following steps: drying the inorganic solid electrolyte material or the lithium salt to obtain a dried material; mixing the dried material with an organic ether surface modifier to obtain a mixture; and sintering the mixture to obtain the modified inorganic solid electrolyte material or modified lithium salt. By modifying the inorganic solid electrolyte material and the lithium salt, not only can the self-aggregation phenomenon of the inorganic solid electrolyte material be reduced, but also the water absorption of the lithium salt can be reduced, so that the composite electrolyte membrane can be prepared in a water system; the composite electrolyte membrane based on the water system has the advantages of high ionic conductivity, high mechanical strength, high decomposition voltage, high environmental stability, low cost and large-scale production.

The invention relates to the technical field of solar cells, in particular to a self-assembly monomolecular material based on a meta-position dicarbazole substitution structure and application of the self-assembly monomolecular material. In the monomolecular material, two carbazole derivatives are connected to two meta-positions of a phosphonic acid group; the meta-position disubstituted structure can restrain self-aggregation in the self-assembly process, a more compact and uniform film is formed, and high-quality growth of an upper-layer solar cell material is facilitated; due to the meta-position disubstituted structure, carbazole large rings on the two sides of a single molecule are exposed in a manner that the front surfaces face upwards, and large-area contact can be formed between the carbazole large rings and perovskite growing on the carbazole large rings; the side surface of a carbazole ring of the para-position monocarbazole substituted structure is upward, so that the contact area between the para-position monocarbazole substituted structure and an upper solar cell material is small; the disubstituted structure has larger dipole moment, energy level matching is better, conductivity is higher, and efficient extraction of holes can be promoted; and by tightly contacting with an upper-layer solar cell material, the defects of a buried interface can be passivated, non-radiative recombination is reduced, and the efficiency and the stability of the solar cell are improved.