Composition of total saponins of panax notoginseseng and fluconazole of anti-candida albicans and drug-resisting bacterial strain and application of composition

Abstract

The invention relates to a composition of total saponins of panax notoginseseng and fluconazole of an anti-candida albicans and drug-resisting bacterial strain and application of the composition. The composition is prepared from the fluconazole and the total saponins of panax notoginseseng, wherein the weight ratio of the fluconazole to the total saponins of panax notoginseseng is 1 to (2 to 16). When the total saponins of panax notoginseseng and the fluconazole are combined, the composition has a remarkable synergistic antibacterial effect on drug-resisting candida albicans, so that the total saponins of panax notoginseseng can be used for replacing part of the fluconazole, the usage of the fluconazole is reduced and the toxic and side effect and drug resistance, caused by the fluconazole, are reduced; meanwhile, an anti-fungus effect is remarkably enhanced and the composition has a wide application prospect on clinic.

Description

technical field [0001] The invention relates to a pharmaceutical composition related to traditional Chinese medicine extracts, in particular to a composition of Panax notoginseng saponins and fluconazole against drug-resistant strains of Candida albicans and its application. Background technique [0002] Candida is a clinically important pathogenic fungus. Candida has a wide spectrum of pathogenic diseases and can cause infections of the skin, mucous membranes and internal organs. In recent years, due to the increase of tumors and AIDS patients, the incidence of Candida infection is on the rise. In a survey in the United States, it was found that nosocomial infections caused by Candida ranked fourth. Candida albicans is a common pathogen causing clinical deep fungal infection, accounting for more than 80%. Traditional antifungal drugs have a low clinical cure rate, are prone to drug resistance, and have obvious adverse reactions to some drugs. According to figures from th...

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Problems solved by technology

[0003] Fluconazole is an antifungal drug that interferes with the lipid synthesis of fungal cell membranes, but it is prone to drug resistance and greatly reduces the curative effect, and because the cell membrane components of fungal cells and human host cells are similar or have many common metabolic characteristics, While using fluconazole antifungal, it has a certain degree of toxic and side effects on human body cells

At present, there is no report on the combination of fluconazole and traditional Chinese medicine for antifungal, especially the combination of fluconazole and Panax notoginseng saponins to reduce its toxic side effects and drug resistance.

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